Aijing Shang, MD, PhD^1*, Nives Selak Bienz^1*, Ravi Gadiraju^1*, Tiffany Chang² and Peter Kuebler^2*

¹F. Hoffmann-La Roche Ltd, Basel, Switzerland
²Genentech, Inc., South San Francisco, CA

Jonathan R Day, MD, PharmD^1*, Ashwin Gupta², Calvin Abro, MD^3*, Kyungsuk Jung, MD, MPH^3*, Lakshmanan Krishnamurti, MD^4,5, Clifford Takemoto, MD^6* and Ruchika Goel, MD, MPH^3,7

¹Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
²Vanderbilt University, Nashville, TN
³Division of Hematology/Oncology, Simmons Cancer Institute, SIU School of Medicine, Springfield, IL
⁴Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University, Atlanta, GA
⁵Emory Healthcare, Atlanta, GA
⁶Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁷Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University, Baltimore, MD

Elizabeth Federici, MD, Matthew Evans, MD, Charles E Dye, MD^* and M. Elaine Eyster, MD

Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA

Genevieve Moyer, MD, MSc¹ and Patricia Huguelet, MD^2,3*

¹Hematology, University of Colorado Hospital, Denver, CO
²Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora
³Obstetrics and Gynecology, Children's Hospital Colorado, Aurora

Lucy Emma Rosenbaum, MD^1*, Ayesha Zia², Joseph R Stanek, MS^3*, Fareeda W. Haamid, DO⁴, Myra Christian-Rancy, BS^1*, Nicole Kendel, MD^5* and Sarah H. O'Brien, MD⁶

¹Nationwide Children's Hospital, Columbus, OH
²University of Southwestern Medical Center, Dallas, TX
³Division of Biostatistics, Nationwide Children's Hospital, Columbus, OH
⁴Department of Pediatrics, Division of Adolescent Medicine, The Ohio State University College of Medicine, Nationwide Children’s Hospital, Columbus, OH
⁵Department of Hematology and Oncology, Nationwide Children's Hospital, Columbus, OH
⁶Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, Nationwide Children's Hospital, Columbus, OH

Daria V Madeeva, MD^1*, Jana Christian, MD^2*, George Goshua, MD³, Hyung J. Chun, MD^4*, Alfred Ian Lee, MD, PhD⁵ and Alexander B Pine, MD, PhD⁶

¹Yale New Haven Hospital, New Haven, CT
²Department of Medicine, Yale University School of Medicine, New Haven, CT
³Section of Hematology, Yale University School of Medicine, New Haven, CT
⁴Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT
⁵Section of Hematology, Department of Internal Medicine, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
⁶Department of Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT

Bilgimol Chumappumkal Joseph, PhD¹ and Annette von Drygalski, MD, Pharm D^2,3

¹University of California, San Diego, CA
²Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, CA
³Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA

Maria Helena Podolak-Dawidziak, professor^1*, Janusz Zawilski^2*, Mariola Bober^2*, Ewa Stefanska-Windyga, MD, PhD^3*, Anna Buczma, MD^4* and Iwona Prajs, PhD^1*

¹Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University, Wroclaw, Poland
²INTERLAB, Poznan, POL
³Institute of Haematology and Transfusion Medicine, Warsaw, Poland
⁴Institute of Hematology and Blood Transfusion, Warsaw, Poland

Claude Négrier¹, Margaret V. Ragni, MD, MPH², John Pasi, MB, ChB, PhD, FRCP, FRCPath, FRCPCH³, Steven W. Pipe, MD⁴, Gili Kenet⁵, Savita Rangarajan, MBBS, MD, FRCP, FRCPath⁶, Salim Kichou^7*, Baisong Mei⁷ and Shauna R. Andersson^7*

¹Hôpital Cardiologique Louis Pradel, Lyon, France
²Department of Medicine - Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
³Royal London Haemophilia Centre, Barts and the London School of Medicine and Dentistry, London, United Kingdom
⁴Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI
⁵Israel National Hemophilia Center and Thrombosis Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
⁶Guy's & St. Thomas' NHS Foundation Trust, Basingstoke, ENG, United Kingdom
⁷Sanofi, Cambridge, MA

Genevieve Moyer, MD, MSc¹ and Patricia Huguelet, MD^2,3*

¹Hematology, University of Colorado Hospital, Denver, CO
²Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora
³Obstetrics and Gynecology, Children's Hospital Colorado, Aurora

Courtney D Thornburg, MD^1,2, Kenneth D Friedman, MD³, Michael F Guerrera, MD⁴, Chunla He^5*, Lynn M Malec, MD³, Mindy L Simpson, MD⁶, Michael D Tarantino, MD⁷, H. Marijke Van Den Berg^3*, Crystal Watson, BS^5* and Shannon L Carpenter, MD⁸

¹UC San Diego, La Jolla, CA
²Rady Children's Hospital, San Diego, CA
³Versiti BloodCenter of Wisconsin, Milwaukee, WI
⁴Children's National Hospital, Washington, DC
⁵American Thrombosis and Hemostasis Network, Rochester, NY
⁶Rush University Medical Center, Chicago, IL
⁷The Bleeding & Clotting Disorders Institute, Peoria, IL
⁸Children's Mercy Kansas City, Kansas City, MO

Amy D Shapiro, MD¹, Giancarlo Castaman, MD^2*, Katarina Cepo, MD^3*, Sidsel Marie Tønder, MSc^4*, Tadashi Matsushita, MD, PhD⁵, Lone Hvitfeldt Poulsen^6*, Guy Young, MD⁷, Silva Zupancic-Šalek, MD^8* and Victor Jimenez Yuste, MD, PhD^9*

¹Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
²Azienda Ospedaliera Universitaria Careggi, Florence, Italy
³Biopharm Medical & Science, Novo Nordisk A/S, Søborg, Denmark
⁴Biostatistics Biopharm 1, Novo Nordisk A/S, Søborg, Denmark
⁵Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan
⁶The Haemophilia Centre, Department of Haematology, Aarhus University, Aarhus, Denmark
⁷Keck School of Medicine, University of Southern California, Los Angeles, CA
⁸Department of Hemostasis, Thrombosis and Non-Aligned Hematology, Hematology Institute Zagreb, Zagreb, Croatia
⁹Haematology Department, La Paz University Hospital, Madrid, Spain

Steven W. Pipe, MD¹, Michael Recht, MD, PhD², Michael U. Callaghan, MD³, Robert F. Sidonio Jr., MD, MSc.⁴, Jerry Grandoni, PhD^5*, Veronique Duretz^6*, Daniel Bonzo, PhD^5*, Jean Luc Plantier, PhD^7*, Sean Evans, PhD, RPh^5*, Ian S Mitchell, PhD^8* and Cedric Hermans, MD, MRCP, PhD⁹

¹Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI
²American Thrombosis and Hemostasis Network, Rochester, NY
³Children's Hospital of Michigan, Detroit, MI
⁴Aflac Cancer and Blood Disorders and Emory University, Atlanta, GA
⁵LFB, Framingham, MA
⁶LFB, Lille, France
⁷LFB, Loos, France
⁸GLOVAL, LLC, Lafayette, CO
⁹Cliniques Univ. Saint-Luc, Brussels, Belgium

Dimitrios A. Tsakiris, MD^1*, Johannes Oldenburg^2*, Robert Klamroth, MD, PhD^3*, Benoît Guillet^4*, Kate Khair^5*, Angela Huth-Kühne, MD^6*, Karin Kurnik^7*, Stephan Regensburger^8*, Jaco Botha^9*, Alejandro Fernandez^9*, Leilei Tang^9* and Margareth C. Ozelo¹⁰

¹Diagnostic Hematology, University Hospital Basel, Basel, Switzerland
²Institute of Experimental Hematology and Transfusion Medicine, Bonn University Clinic, Bonn, Germany
³Department for Internal Medicine, Vascular Medicine and Haemostaseology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
⁴Hemophilia Treatment Centre, Inserm U1085 IRSET, University Hospital of Rennes, Rennes, France
⁵Centre for Outcomes and Experience Research in Children’s Health, Illness and Disability (ORCHID), Great Ormond Street Hospital for Children, London, United Kingdom
⁶SRH Kurpfalzkrankenhaus and Haemophilia Centre Heidelberg GmbH, Heidelberg, Germany
⁷Dr. von Haunersches Kinderspital Klinikum der Universität München, Munich, Germany
⁸Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany
⁹Takeda Pharmaceutical International AG, Zürich, Switzerland
¹⁰Hemocentro UNICAMP, University of Campinas, Campinas, Brazil

Janna M. Journeycake, MD¹, Cedric Hermans, MD, MRCP, PhD², Jonathan M. Ducore, MD, MPH³, Miguel A. Escobar, M.D.^4*, Guy Young, MD⁵, Michael Wang, MD⁶, Doris Quon, MD, PhD⁷, W Allan Alexander, MD^8*, Ian S Mitchell, PhD^9*, Ahmad Al-Sabbagh, MD^10* and Daniel Bonzo, PhD^10*

¹Jimmy Everest Center for Cancer and Blood Disorders, University of Oklahoma Health Sciences Center, Oklahoma City, OK
²Cliniques Univ. Saint-Luc, Brussels, Belgium
³Hemostasis and Thrombosis Center, UC Davis, Sacramento, CA
⁴University of Texas Health Science Center, Houston, TX
⁵University of Califormia Los Angeles, Children's Hospital Los Angeles, Los Angeles, CA
⁶Hemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora, CO
⁷Orthopaedic Institute for Children, Los Angeles, CA
⁸HEMA Biologics, Louisville, KY
⁹GLOVAL, LLC, Lafayette, CO
¹⁰LFB, Framingham, MA

Craig D. Seaman¹, Margaret V. Ragni, MD, MPH², Jonathan G. Yabes, PhD^3* and Christina Lalama^3*

¹University of Pittsburgh, Warrendale, PA
²Department of Medicine - Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
³Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, PA

Trine Høyer Rose, PhD^*, Christian Hollensen, MSc, PhD^*, Henrik Agersø, DVM, PhD^* and Rune Viig Overgaard, PhD^*

Quantitative Clinical Pharmacology, Novo Nordisk A/S, Søborg, Denmark

François Stephan^1*, Laure Gutermann^1*, Martine Pennetier^2*, Stephanie Bourget^3*, Sarah Djabarouti^4*, Johanna Berdugo^5*, Yann Fardini^6*, Pierre Clerson^6* and Bruce A. Schwartz, PhD⁷

¹Hôpital Marie Lannelongue, Le Plessis Robinson, France
²Hôtel Dieu, Pharmacie Clinique, Nantes, France
³Centre Hospitalier de Valence, Valence, France
⁴Groupe Hospitalier Sud, CHU de Bordeaux, Pessac, France
⁵Hôpital Saint-Joseph, Marseille, France
⁶Soladis Clinical Studies, Roubaix, France
⁷Octapharma US, Atlantic City, NJ

Anne Flem Jacobsen, MD^1*, Joseph M Parker, MD^2*, Diane Trybul, BS^2* and Per Morten Sandset, MD³

¹Oslo University Hospital, Oslo, Norway
²Prometic Biotherapeutics, Rockville, MD
³Department of Haematology and Research Institute of Internal Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway

Mark Reding, MD¹, Thomas Moulton, MD², Erika Soltes Rak^2* and Mindy L Simpson, MD³

¹Center for Bleeding and Clotting Disorders, University of Minnesota Medical Center, Minneapolis, MN
²Bayer, Whippany, NJ
³Rush University Medical Center, Chicago, IL