Binbin Zheng, MD, MSc¹, Qian Wang, MD, MPH^2*, Sridevi Rajeeve, MD³, Biyue Dai, PhD^4*, Cynthia Zevallos, MD^4*, Darko Quispe-Orozco, MD^4*, Mudassir Farooqui, MD MPH^4*, Jorge Ares-Morcuende^4* and Santiago Ortega-Gutierrez, MD MSc^4*

¹Department of Medicine, Icahn School of Medicine, Mount Sinai Morning and Mount Sinai West, NEW YORK, NY
²Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
³Division of Hematology and Oncology - Department of Medicine, Icahn School of Medicine At Mount Sinai Hospital, New York, NY
⁴Department of Neurology, Carver College of Medicine, Iowa City, IA

Mackenzie Parker, BS^1*, Ayesha Zia², Tony Babb, Ph.D.^1* and Michael D. Nelson, Ph.D.^1*

¹University of Texas Southwestern Medical Center, Dallas, TX
²University of Southwestern Medical Center, Dallas, TX

Elena Monzón Manzano^1*, Ihosvany Fernandez-Bello, BSPharm, PhD^2*, Raul Justo Sanz^2*, Ángel Robles Marhuenda^3*, Paula Acuña^2*, María Teresa Alvarez Román, MD, PhD^4*, Elena G Arias-Salgado, PhD^5*, Sara García Barcenilla^5*, Miguel A Canales, MD, PhD^4,6, Victor Jimenez-Yuste, Medical Degree. PhD^5,6* and Nora V. Butta, PhD^4*

¹Hospital Universitario La Paz-IdiPaz, Madrid, Spain
²Hospital Universitario La Paz-Idipaz, Madrid, Spain
³Internal Medicine Unit, Hospital Universitario La Paz, Madrid, Spain
⁴Hematology and Hemotherapy Unit, La Paz University Hospital-IdiPAZ, Madrid, Spain
⁵Hospital Universitario La Paz-IdiPAZ, Madrid, Spain
⁶Universidad Autónoma de Madrid, Madrid, Spain

Jihyun Song, PhD¹, Adelina Sergueeva, MD^2*, Galina Miasnikova, MD^3*, Soo Jin Kim, MS^4*, Binal N. Shah, PhD^5*, Tsewang Tashi, MD⁴, Xu Zhang, PhD^6*, Perumal Thiagarajan, MD⁷, Victor R. Gordeuk, MD⁸ and Josef T. Prchal, MD⁴

¹Division of Hematology, University of Utah, Salt Lake City, UT
²I. N. Ulianov Chuvash State University, Cheboksary, Russian Federation
³Chuvash Republic Clinical Hospital, Cheboksary, Russian Federation
⁴Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁵Department of Medicine, University of Illinois At Chicago, Chicago, IL
⁶University of Illinois At Chicago, Chicago, IL
⁷Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX
⁸Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL

Damian Ratano, MD^1*, Caragata Rebecca, MD^2*, Eddy Fan, MD, PhD, FRCPC^1*, Ewan C Goligher, MD, PhD, FRCPC^1*, Rita Selby, MBBS, FRCPC^3,4, Niall D Ferguson, MD, FRCPC^1*, Keyvan Karkouti, MD, MSc, FRCPC^5* and Stuart A McCluskey, MD, PhD, FRCPC^2*

¹Department of Medicine, Interdepartmental Division of Critical Care Medicine, University Health Network, University of Toronto, Toronto, ON, Canada
²Department of Anesthesia and Pain Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada
³Laboratory Medicine and Medicine, University Health Network and Sunnybrook Health Sciences Centre, Toronto, ON, Canada
⁴Department of Medicine, Division of Hematology, University of Toronto, Toronto, Canada
⁵Department of Anesthesiology and Pain Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada

Jihyun Song, PhD¹, Jahnavi Gollamudi, MD², Soo Jin Kim, MS^3*, Radhika Gangaraju, MD⁴, Tsewang Tashi, MD³, Victor R. Gordeuk, MD⁵, Perumal Thiagarajan, MD⁶ and Josef T. Prchal, MD⁷

¹Division of Hematology,, University of Utah, Salt Lake City, UT
²Department of Pathology and Medicine, Baylor College of Medicine, Houston, TX
³Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁴Division of Hematology and Oncology, Department of Medicine, University Of Alabama at Birmingham, Birmingham, AL
⁵Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁶Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX
⁷Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT

Thomas Bertsch^1*, Wilhelm Behringer^2*, Sabine Blaschke^3*, Richard Body^4*, Simon Davidson^5*, Anna Rieger^6*, Daniel Horner^7*, Ulrich Sonner^8*, Yuli Sun^6*, Lucia Turnes^8* and Michael Hoffman^6*

¹Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, Nuremberg, Germany
²Centre of Emergency Medicine, Jena University Hospital, Jena, Germany
³Interdisciplinary Emergency Care Department, University Medical Center Göttingen, Göttingen, Germany
⁴Central Manchester NHS Foundation Trust, Manchester, United Kingdom
⁵Roche Diagnostics International Ltd, Rotkreuz, Switzerland
⁶Roche Diagnostics GmbH, Penzberg, Germany
⁷Salford Royal NHS Foundation Trust, Salford, United Kingdom
⁸Agent representing Roche Diagnostics GmbH, Penzberg, Germany