Alina Sadaf, MD¹, Charles T. Quinn, MD^2,3,4, Jennifer B Korpik^3*, Amanda Pfeiffer, BS, MA^2*, Mary Reynaud, MA, MT(ASCP)^3*, Omar Niss, MD⁵, Punam Malik, MD², Russell E. Ware, MD, PhD², Theodosia A. Kalfa, MD, PhD^2,3 and Patrick T. McGann, MD^4,6

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Erythrocyte Diagnostic Laboratory, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁵Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH
⁶Division of Hematology, Children's Hospital Medical Center, Cincinnati, OH

Darla Liles, MD¹, Kim Smith-Whitley, MD², R Clark Brown, MD, PhD³, Nirmish Shah, MD⁴, Santosh M Nair, MD⁵, Chiaki Tanaka, PhD^6*, Shankaranand Bodla^7*, Gessami Sanchez-Olle, PhD^8*, Urs Albers, PhD^8* and Julie Kanter, MD⁹

¹Division of Hematology–Oncology, East Carolina University, Greenville, NC
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
⁴Duke University Medical Center, Durham, NC
⁵Mid Florida Hematology and Oncology Center, Orange City, FL
⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁷GCE Solutions, Manchester, United Kingdom
⁸Novartis Pharma AG, Basel, Switzerland
⁹Division of Hematology–Oncology, University of Alabama, Birmingham, AL

Jo Howard, MBBChir, MRCP, FRCPath¹, Kenneth I. Ataga, MD², R. Clark Brown, MD, PhD³, Maureen Achebe, MD, MPH⁴, Videlis Nduba, MD^5*, Amal El-Beshlawy, MD⁶, Hoda Hassab, MD^7*, Irene Agodoa, MD^8*, Margaret Tonda, PharmD^8*, Sarah Gray, PhD^8*, Joshua Lehrer-Graiwer, MD, MPhil, FACC⁸ and Elliott Vichinsky, MD⁹

¹Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
²University of Tennessee Health Science Center at Memphis, Memphis, TN
³Department of Pediatrics, Aflac Cancer & Blood Disorders Center of Children’s Healthcare of Atlanta and the Department of Pediatrics, Emory University, Atlanta, GA
⁴Division of Hematology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
⁵Kenya Medical Research Institute, Kisumu, Kenya
⁶Cairo University, Cairo, Egypt
⁷Pediatric Department and Clinical Research Center Faculty of Medicine, Alexandria University Hospital, Alexandria, Egypt
⁸Global Blood Therapeutics, South San Francisco, CA
⁹UCSF Benioff Children's Hospital, Oakland, CA

Minke A.E. Rab, MD^1,2*, Celeste K. Kanne, BA^3*, Brigitte A. van Oirschot^4*, Jennifer Bos^5*, Camille Boisson^6,7*, Maite E. Houwing, MD^8*, Celine Renoux, PhD^7,9,10*, Marije Bartels, MD, PhD^11*, Erfan Nur, MD, PhD¹², Marjon H. Cnossen, MD, PhD^13*, Philippe Joly, PhD^7,9,10*, Romain Fort, MD^14*, Philippe Connes, PhD^7,9,15*, Richard van Wijk, PhD^4*, Vivien A. Sheehan, MD, PhD³ and Eduard van Beers, MD, PhD^16*

¹Van Creveldkliniek, UMC Utrecht, Utrecht University, Utrecht, Netherlands
²Department of Central Diagnostic Laboratory Research, University Medical Center Utrecht, Utrecht University, Utrecht, Utrecht, Netherlands
³Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX
⁴Department of Central Diagnostic Laboratory-Research, UMC Utrecht, Utrecht University, Utrecht, Netherlands
⁵Department of Central Diagnostic Laboratory-Research, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
⁶Laboratory of Excellence GR-Ex, Lyon, France
⁷Laboratory LIBM EA7424, University of Lyon 1, “Vascular Biology and Red Blood Cell” team, Lyon, France
⁸Department of Pediatric Hematology, Erasmus University Medical Center – Sophia Children’s Hospital, Rotterdam, The Netherlands, Rotterdam, Netherlands
⁹Laboratory of Excellence GR-Ex, Paris, France
¹⁰Laboratory of Biochemistry and Molecular Biology, UF Biochemistry of Red Blood Cell diseases, Est Center of Biology and Pathology, Hospices Civils de Lyon, Lyon, France
¹¹Van Creveldkliniek, University Medical Center, Utrecht University, Utrecht, Netherlands
¹²Department of Clinical Hematology, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, Netherlands
¹³Dept. of Pediatric Hematology, Erasmus MC–Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, Netherlands
¹⁴Department of Internal Medicine, Hospices Civils de Lyon, Lyon, France
¹⁵Université Claude Bernard Lyon, Villeurbanne, FRA
¹⁶Van Creveldkliniek, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands

Jin Han^1*, Andrew Srisuwananukorn, MD^2*, Michel Gowhari, DO³, Faiz Ahmed Hussain, MD^4*, Franklin Njoku, MD^5*, Robert E. Molokie, MD⁶, Victor R. Gordeuk, MD⁷ and Santosh L. Saraf, MD⁵

¹Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL
²University of Illinois at Chicago, Chicago
³Division of Hematology/Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL
⁴Division of Hematology/Oncology, University of Illinois College of Medicine, Chicago, IL
⁵Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁶Department of Medicine, Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL
⁷Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL

Richard Onalo, MBBS^1*, Peter Cooper, MBBS^2*, Barend C. Vorster, MD^3*, Marli Dercksen, PhD^4*, Antoinette Cilliers, MBBS^5*, Uche Nnebe-Agumadu, MBBS^6* and Claudia R. Morris, MD^7,8

¹Department of Pediatrics, University of Abuja, Abuja, Nigeria
²Department of Paediatrics, University of the Witwatersrand, Johannesburg, South Africa
³Centre for Human Metabolomics, North West University, Potchefstroom, South Africa
⁴North West University, Potchefstroom, South Africa
⁵Chris Hani Baragwanath Academic Hospital, University of Witwatersrand, Johannesburg, South Africa
⁶Department of Pediatrics, University of Abuja Teaching Hospital, Abuja, Nigeria
⁷Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁸Children's Healthcare of Atlanta, Atlanta, GA

Andrew M Heitzer, PhD^1*, Jennifer Longoria, PhD^1*, Evadnie Rampersaud, PhD^2*, Sara Rashkin, PhD^2*, Jeremie H. Estepp, MD³, Victoria Okhomina, MS^4*, Winfred Wang, MD³, Darcy Raches, PhD^1*, Brian Potter, PhD^1*, Allison A. King, MD, MPH, PhD⁵, Guolian Kang, PhD^4* and Jane S. Hankins, MD, MS⁶

¹Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN
²Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN
³Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁵Program in Occupational Therapy, Washington University in St. Louis, School of Medicine, Clayton, MO
⁶Associate Member, Director of the Sickle Cell Program, St. Jude Children's Research Hospital, Memphis, TN

Mahir Khan, MD^1*, Andrew Srisuwananukorn, MD^2*, Santosh L. Saraf, MD³, Faiz Ahmed Hussain, MD^4*, Robert E. Molokie, MD⁵, Michel Gowhari, DO⁶, Victor R. Gordeuk, MD¹ and Franklin Njoku, MD^1*

¹Department of Medicine, University of Illinois at Chicago, Chicago, IL
²University of Illinois at Chicago, Chicago
³Comprehensive Sickle Cell Center, Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
⁴Division of Hematology/Oncology, University of Illinois College of Medicine, Chicago, IL
⁵Department of Medicine, Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL
⁶Division of Hematology/Oncology, University of Illinois at Chicago College of Medicine, Chicago, IL

Daniel Adamkiewicz^1*, Hongyan Xu, PhD^2*, Latanya Bowman, RN^1*, Leigh Wells, MSN^1*, Niren Patel, MBBS^1*, Ryan Harris, PhD, CEP, FACSM^3*, Jennifer Pollock, PhD^4*, David M. Pollock, PhD^4*, Steffen E. Meiler, MD^5* and Abdullah Kutlar, MD⁶

¹Center for Blood Disorders, Augusta University/Medical College of Georgia, Augusta, GA
²Department of Epidemiology, Biostatistics and Population Science, Augusta University/Medical College of Georgia, Augusta, GA
³Georgia Prevention Institute, Augusta University/Medical College of Georgia, Augusta, GA
⁴Department of Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL
⁵Dept. of Anesthesiology and Perioperative Medicine, Augusta University/Medical College of Georgia, Augusta, GA
⁶Center for Blood Disorders, Dr. William N. Agostas and Josephine R. Agostas Chair in Internal Medicine Medical College of Georgia, Augusta, GA

Modupe Idowu, MD¹, Anam Haque, BS^2* and Elisa M. Williams, BS^2*

¹Associate Professor, Medical Director, UT Physicians Comprehensive Sickle Cell Center, University of Texas Health Science Center, McGovern Medical School, Houston, TX
²UTHealth McGovern Medical School, Houston, TX

William B Ershler, MD¹, Laura M De Castro, MD, MHSc², Zahra Pakbaz, MD³, Aaron Moynahan^4*, Derek Weycker, PhD^4*, Nhat Pham^4*, Thomas E Delea, MSIA^4*, Irene Agodoa, MD^5* and Ze Cong, PhD^5*

¹Benign Hematology Division, Inova Schar Cancer Institute, Falls Church, VA
²UPMC Hillman Cancer Center, Pittsburgh, PA
³UC Irvine Chao Family Cancer Center, Irvine, CA
⁴Policy Analysis Inc. (PAI), Brookline, MA
⁵Global Blood Therapeutics, South San Francisco, CA

Ashwin P Patel, MPH^1*, Dorothy Kim Waller, PhD^2* and Vivien A. Sheehan, MD, PhD³

¹The University of Texas Health Science Center at Houston, Houston, TX
²The University of Texas Health Science Center-Houston (UTHealth), School of Public Health, Houston campus, Houston, TX
³Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX

Lanetta Bronte-Hall, MD, MPH, MSPH^1*, Biree Andemariam, MD², Blyden Gershwin, MD^1*, Sanne Lugthart, MD, PhD^3*, Timothy Mant, MB, FFPM, FRCP^4*, Jo Howard, MBBChir, MRCP, FRCPath⁴, Henry Fok, MBBS, PhD^4*, Perla Eleftheriou, FRCPath, MRCP^5*, Robert Ward Hagar, MD⁶, James Mason, DO⁷, Rahul Ballal, PhD^8*, Joelle Lufkin, MPH^8* and Eleanor Lisbon, MD, MPH⁸

¹Foundation for Sickle Cell Disease Research, Hollywood, FL
²University of Connecticut, Farmington, CT
³University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom
⁴Guy's and St. Thomas' Hospital, London, United Kingdom
⁵University College Hospital, London, United Kingdom
⁶UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁷Baylor Scott and White, Temple, TX
⁸Imara, Boston, MA

Andrea Nowlin^1*, Kristina Lai, MPH^2*, Alexander Maillis, MPH^3*, Patricia Waters, RN^3*, Beatrice Gee, MD⁴ and Peter A. Lane, MD⁵

¹Aflac Cancer and Blood Disorders Service, Children's Healthcare of Atlanta, ATLANTA, GA
²Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
³Aflac Cancer and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, GA
⁴Children's Healthcare of Atlanta, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA

Lauren E. Merz, MD MSc^1*, Kavita Mistry, MD, PhD^2*, Revital Freedman, PhD^3*, Katherine L Jolley^3*, Hae Soo Park^3*, David M. Dorfman, MD, PhD⁴, Donna S. Neuberg, ScD⁵ and Maureen Achebe, MD, MPH³

¹Department of Internal Medicine, Brigham & Women’s Hospital, Boston, MA
²Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA
³Division of Hematology, Brigham and Women's Hospital, Boston, MA
⁴Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁵Department of Data Science, Dana-Farber Cancer Institute, Boston, MA

Ho Pui Jeff Lam^1*, Jayanthi Alamelu^2*, James Brighouse, MBBS FRPCH^3*, Owen Miller, FRCPCH^4*, Jonathan Lillie, PRCPCH^5* and Baba PD Inusa, MD, MBBS^6,7

¹Paediatric Haematology , Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
²Guy's & St. Thomas' NHS Trust, London, GBR
³Evelina London Children's Hospital, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
⁴Department of Cardiology, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
⁵Paediatric Intensiv Care Unit, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom
⁶Paediatric Haematology, Evelina Children's Hospital, Guy's and St Thomas' Hospital, London, United Kingdom
⁷Department of Women and Children, King's College London, London, United Kingdom

Alexandra Boye-Doe¹, Elizabeth Brown^2*, Charu Puri-Sharma, MS^3*, Anjulika Chawla, MD³, Joshua J Field^4*, Lynne D. Neumayr, MD⁵, Susan Padrino, MD^6*, Payal Desai, MD⁷, Deepa Manwani, MD⁸, Sophie M. Lanzkron, MD, MHS⁹ and Jane A. Little, MD¹⁰

¹Department of Medicine, University of North Carolina, Chapel Hill, NC
²Johns Hopkins University, Baltimore, MD
³bluebird bio, Cambridge, MA
⁴Bloodcenter of Wisconsin, Milwaukee, UMI
⁵Dept. of Hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁶University Hospital Cleveland Medical Center, Cleveland, OH
⁷The Ohio State University, Columbus, OH
⁸Division of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
⁹Department of Medicine, Division of Hematology, Johns Hopkins Medicine, Baltimore, MD
¹⁰University of North Carolina at Chapel Hill, Chapel Hill, NC

Alexander Glaros, MD¹, Michael U. Callaghan, MD^2,3 and Ahmar Urooj Zaidi, MD^4,5

¹Children's Hospital of Michigan, Department of Pediatrics, Division of Pediatric Hematology-Oncology, Central Michigan University, Detroit, MI
²Department of Pediatrics, Wayne State University, Detroit, MI
³Central Michigan University, Children’s Hospital of Michigan, Detroit, MI
⁴Wayne State University/Children's Hospital of Michigan/Detroit Medical Center, Carmen and Ann Adams Department of Pediatrics, Division of Hematology Oncology, Detroit, MI
⁵Central Michigan University, Children's Hospital of Michigan, Detroit, MI

Rita V Masese, MSc, MD^1*, Dominique Bulgin, BSN, RN^2*, Mitchell Knisely, PhD, RN^1*, Liliana Preiss^3*, Eleanor Stevenson, PhD, RN^1*, Jane S. Hankins, MD, MS⁴, Marsha Treadwell, PhD^5,6*, Allison A. King, MD, MPH, PhD^7,8,9,10,11, Victor R. Gordeuk, MD^12,13,14, Julie Kanter, MD^{15,16,17,18,19,20,21,22}, Robert Gibson, MD^23*, Jeffrey A. Glassberg, MD^24,25, Paula Tanabe, PhD, RN²⁶ and Nirmish Shah, MD^{27,28,29,30,31}

¹School of Nursing, Duke University, Durham, NC
²Duke University School of Nursing, Durham, NC
³RTI International, Durham, NC
⁴Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁵Children's Hospital and Research Center, Oakland, Oakland, CA
⁶UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁷Washington University, St. Louis, Clayton, MO
⁸Program in Occupational Therapy, Washington University in St. Louis, School of Medicine, Clayton, MO
⁹Washington University in St. Louis, Clayton, MO
¹⁰Washington University, Saint Louis, MO
¹¹Washington University School of Medicine, St. Louis, MO
¹²Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
¹³University of Illinois at Chicago, Chicago, IL
¹⁴Department of Medicine, University of Illinois at Chicago, Chicago, IL
¹⁵Director, Adult Sickle Cell Program, Comprehensive Sickle Cell Center,, Birmingham, AL
¹⁶Division of Hematology–Oncology, University of Alabama, Birmingham, AL
¹⁷Hematology/Oncology, Comprehensive Sickle Cell Center, University of Alabama at Birmingham, Birmingham, AL
¹⁸University of Alabama, Director of the UAB Adult Sickle Cell Clinic Associate Professor in the Division of Hematology and Oncology, Birmingham, AL
¹⁹University of Alabama at Birmingham, Birmingham, AL
²⁰Division of Pediatrics, Medical University of South Carolina, Charleston, SC
²¹Division of Hematology-Oncology, University of Alabama-Birmingham, Birmingham, AL
²²Medical University Of South Carolina, Charleston, SC
²³Medical College of Georgia, Augusta University, Augusta, GA
²⁴Division of Hematology and Oncology, Department of Medicine and Department of Emergency Medicine, Mount Sinai Medical Center, New York, NY
²⁵Division of Hematology Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²⁶School of Nursing/ School of Medicine, Duke University, Durham, NC
²⁷Division of Hematology, Duke University School of Medicine, Durham, NC
²⁸Duke University Medical Center, Durham, NC
²⁹Duke University Health System, Durham, NC
³⁰Duke University, Cary, NC
³¹Duke Adult Comprehensive Sickle Cell Center, Durham, NC

Jennifer G. Davila, MD¹, W. Beau Mitchell, MD¹, Kerry A Morrone, MD², Ellen J Silver, PhD^3*, Caterina P. Minniti, MD⁴, Henny H. Billett, MD, MSc⁵, Payal Desai, MD⁶, Sarah H. O'Brien, MD⁷ and Deepa Manwani, MD^3,8

¹Albert Einstein College of Medicine, Bronx, NY
²Children's Hospital At Montefiore, Bronx, NY
³Albert Einstein College of Medicine, Bronx
⁴Albert Einstein College of Medicine, New York, NY
⁵Division of Hematology, Department of Internal Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁶The Ohio State University, Columbus, OH
⁷Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, Nationwide Children's Hospital, Columbus, OH
⁸Children's Hospital at Montefiore, Bronx, NY