Dipti Gupta^1,2, Yannis Hara, PhD^1*, Samuel Lessard, PhD^1*, Sarah Sturtevant, BSc^1*, Yukio Nakamura, MD, PhD^3*, Sriram Krishnamoorthy, PhD¹, Melanie Demers, PhD^1* and Alexandra Hicks, PhD^1*

¹Rare Blood Disorders, Sanofi, Waltham, MA
²Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL
³Cell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Japan

Kobina Dufu, PhD^*, Carsten Alt, MSc, PhD^*, Steven Strutt, PhD^*, Tzechiang Tang^*, Hilary Liao-Zou^*, Yue Yuan^*, Brian E Cathers, PhD^* and Donna Oksenberg, PhD

Global Blood Therapeutics, South San Francisco, CA

Anu Marahatta, PhD¹, Jonathan M. Flanagan, PhD², Thad A. Howard, MS^3*, Nicole Mortier, MHS, PA-C^4*, William Schultz, MHS, PA^1*, Kathryn L McElhinney, BS^1*, Leon Tshilolo, MD PhD^5*, Thomas N. Williams, MD PhD^6*, Peter Olupot-Olupot, MD PhD^7*, Brigida Santos, MD^8*, Chandy C. John, MD, MS^9*, Robert Opoka, MMED^10*, Rosa M. Nieves, MD^11*, Rafael Mena, MD^12*, Marvin E Reid, MB, BS, PhD^13*, Angela Rankine-Mullings, MBBS^14*, Jasmine Baker, PhD², Patrick T. McGann, MD^15,16, Banu Aygun, MD¹⁷, Adam Lane, PhD^18*, George A. Tomlinson, PhD, BSc, MSc^19*, Teresa Latham, MA^1*, Susan E. Stuber, MA^1* and Russell E. Ware, MD, PhD^1,16

¹Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Pediatrics - Hematology/Oncology, Baylor College of Medicine, Houston, TX
³Division of Hematology, Cincinnati Children's Research Hospital, Cincinnati, OH
⁴George Washington University, Washington DC
⁵Centre Hospitalier Monkole, Kinshasa, Congo (The Democratic Republic of the)
⁶KEMRI-Wellcome Trust Programme, Kilifi, Kenya
⁷Mbale Clinical Research Institute, Mbale, Uganda
⁸Hospital Pediatrico David Bernardino, Luanda, Angola
⁹Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University, Indianapolis, IN
¹⁰Pediatrics and Child Health, Makerere University, Kampala, Uganda
¹¹Robert Reid Cabral Hospital, Santo Domingo, Dominican Republic
¹²Centro de Obstetricia y Ginecología, Santo Domingo, Dominican Republic
¹³Caribbean Institute for Health Research, University of the West Indies, Kingston, Jamaica
¹⁴Caribbean Institute for Health Research, Sickle Cell Unit, University of the West Indies, Kingston, Jamaica
¹⁵Division of Hematology, Children's Hospital Medical Center, Cincinnati, OH
¹⁶Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹⁷Pediatric Hematology Oncology and Stem Cell Transplantation, Cohen Children's Medical Center, New Hyde Park, NY
¹⁸Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹⁹Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada

Danitza Nebor, PhD^1*, Celeste K. Kanne, BA^1*, Mira Pochron, PhD^2*, Donna Oksenberg, PhD² and Vivien A. Sheehan, MD, PhD¹

¹Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX
²Global Blood Therapeutics, South San Francisco, CA

Xin Geng^1*, Radu Mihaila^1*, Yue Yuan^1*, Steven Strutt, PhD^1*, Jörg Benz^2*, Tzechiang Tang^1*, Christina Mayer, PharmD^1* and Donna Oksenberg, PhD¹

¹Global Blood Therapeutics, South San Francisco, CA
²F. Hoffmann-La Roche AG, Basel, Switzerland

Celeste K. Kanne, BA^1*, Danielle Guffey, MS^2*, Charles Minard, PhD^2*, Eduard van Beers, MD, PhD^3*, Richard van Wijk, PhD^4*, Minke A.E. Rab, MD^5* and Vivien A. Sheehan, MD, PhD¹

¹Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, TX
²Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX
³Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
⁴Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, Netherlands
⁵Department of Central Diagnostic Laboratory Research, University Medical Center Utrecht, Utrecht University, Utrecht, Utrecht, Netherlands

Gonzalo De Luna^1*, Nicolas Lemonier, MD^1*, Alexis Aidan, MD^2*, Lea Bontemps, MD^2*, Manuel Hautefaye, MD^2*, Hadrien Diakonoff, MD^2*, Cecile Aubrun^1*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^2*, Dora Bachir, MD^3,4*, Françoise Driss, MD^2*, Amna Jebali, MD^2*, Anoosha Habibi, MD, PhD^5* and Pablo Bartolucci, MD, PhD^6*

¹APHP Hôpital Henri Mondor, Creteil, France
²APHP Hôpital Henri Mondor, Créteil, France
³Hôpital Henri Mondor, Creteil, FRA
⁴Sickle Cell Disease Center, Créteil, FRA
⁵Hopital Henri Mondor, Creteil Cedex, France
⁶Sickle cell referral center, Internal Medicine Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Creteil, France

Xu Zhang, PhD^1*, Binal N. Shah, PhD^1*, Taif Hassan^1*, Sergei Nekhai, PhD², Roberto Machado, MD^3* and Victor R. Gordeuk, MD⁴

¹Department of Medicine, University of Illinois at Chicago, Chicago, IL
²Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, DC
³Department of Medicine, Indiana University, Indianapolis, IN
⁴Sickle Cell Center, Division of Hematology and Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL

Ran An, PhD¹, Yuncheng Man^1*, Erdem Kucukal, PhD^1*, Kevin Cheng^1*, William Wulftange^1*, Jane A. Little, MD² and Umut A. Gurkan, PhD¹

¹Case Western Reserve University, Cleveland, OH
²University of North Carolina at Chapel Hill, Chapel Hill, NC

Yamna Ouchtar^1*, Christian Kassasseya, MD^2*, Kene Sekou, MD^3*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^4*, Mehdi Kellaf, MD, PhD^5*, Dapa Aly Diallo, MD, PhD^3*, Laurent Najman, PhD^1* and Pablo Bartolucci, MD, PhD^6*

¹ESIEE Paris, Paris, France
²IMRB – Inserm U955 Transfusion et maladies du globule rouge (Equipe 2) Etablissement Français du Sang, APHP Henri Mondor Hospital, Créteil, France
³Centre de Recherche et de Lutte contre la Drépanocytose (CRLD), Bamako, Mali
⁴APHP Hôpital Henri Mondor, Créteil, France
⁵Emergency Department, APHP Henri Mondor hospital, Créteil, France
⁶Sickle cell referral center, Internal Medicine Unit, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Creteil, France

Jaime Luis Betancourt, MSN, NP^1*, Shuo You, MD, PhD^2*, Sean Campbell^3*, Sabrina Pink^1*, Merin Thomas, NP^4*, Susanna A Curtis, MD, MS⁵ and Caterina P. Minniti, MD⁶

¹Montefiore Medial Center, Nyack, NY
²Albert Einstein College of Medicine, Bronx, NY
³Montefiore Medical Center, New York, NY
⁴Department of Hematology, Montefiore Medical Center, Bronx, NY
⁵Montefiore Health Systems, Truckee, CA
⁶Division of Hematology, Montefiore Medical Center.Albert Einstein College of Medicine, Bronx, NY