Sarah A Hale, MS, PhD^1*, Alexander Bauer^2*, Giovanni Smania^3*, Sofia Friberg-Hietala^3* and Martin J Wolfsegger, PhD^2*

¹Bleeding Disorders, Takeda Pharmaceutical Company Limited, Lexington, MA
²Baxalta Innovations GmbH, a Takeda company, Vienna, MA, Austria
³Pharmetheus AB, Uppsala, Sweden

Amy D Shapiro, MD¹, Barbara A. Konkle, MD^2,3, Stacy E. Croteau, MD⁴, Wolfgang A. Miesbach, MD, PhD^5*, Charles Richard Morris Hay, MD, FRCP, FRCPath⁶, Rashid Kazmi, MBBS^7*, Marina Mihova^8*, Savita Rangarajan, MD, MBBS⁹ and John Pasi, MB, ChB, PhD, FRCP, FRCPath, FRCPCH¹⁰

¹Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
²University of Washington, Seattle, WA
³University of Washington, Washington Center for Bleeding Disorders, Seattle, WA
⁴Boston Children's Hospital, Boston, MA
⁵Hemophilia Centre, University Hospital Frankfurt, Frankfurt, Germany
⁶Manchester Royal Infirmary, Manchester, United Kingdom
⁷University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⁸Sigilon Therapeutics, Cambridge, MA
⁹University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Southampton, United Kingdom
¹⁰Barts and the London School of Medicine and Dentistry, London, United Kingdom

Gavin Ling, MBBS, FRCPath, PhD¹, Aderonke Ajidahun, RN^2*, Steve K. Austin, BMedSci, MBBS^2*, Gerard Dolan, MBChB, FRCP, FRCPath^2* and Aine McCormick, PhD^2*

¹Department of Haematology, Guy's & St Thomas' NHS Foundation Trust, London, Eng, United Kingdom
²Haemostasis and Thrombosis Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Shaobin Wang, PhD^1*, Sravya Kattula, PhD^2*, Ayman Ismail, PhD^3*, Nina Leksa, PhD^4*, Arjan van Der Flier, PhD^5* and Joe Salas, PhD⁵

¹Rare Disease: Hemophilia, sanofi, Waltham, MA
²Rare Disorder: Hemophila, Sanofi, Waltham, MA
³Rare Disorders: Hemophila, Sanofi, Waltham, MA
⁴Rare Disorders: Hemophilia, Sanofi, Waltham, MA
⁵Rare Disease: Hemophilia, Sanofi, waltham, MA

Kanza Naveed^1*, Grace H Tang, MSc^2*, McKenzie Quevillon, RN, BScN, MN^1*, Filomena Meffe, MD, MSc^3*, Rachel Martin, MD^4*, Jillian M Baker, MD, MSc^5,6* and Michelle Sholzberg, MDCM, FRCPC, MSc^7,8,9

¹Department of Hematology and Oncology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
²Division of Hematology-Oncology, Department of Medicine, St. Michael’s Hospital, Toronto, ON, Canada
³Department of Obstetrics and Gynecology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada
⁴Department of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
⁵Department of Pediatrics, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
⁶Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
⁷Department of Hematology and Oncology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
⁸Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada
⁹Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada

Claudia Khayat, MD, BS ^1*, Irina Kruzhkova^2*, Cristina Solomon^2*, Bruce A. Schwartz, PhD³ and Flora Peyvandi⁴

¹Department of Pediatrics, Hotel Dieu de France, Beirut, Lebanon
²Octapharma AG, Lachen, Switzerland
³Octapharma US, Atlantic City, NJ
⁴Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

Neelan Sriranjan, MD^1*, Donald S. Houston, MD, PhD², Sara J. Israels, MD³, Emily Rimmer, MD, FRCPC^2,4, Tracy Nacionales, RN, BN^5* and Tracy Voth, RN, BN^5*

¹Internal Medicine, University of Manitoba, winnipeg, MB, Canada
²Section of Hematology and Medical Oncology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
³Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
⁴University of Manitoba / CancerCare Manitoba, Winnipeg, MB, Canada
⁵Pediatric Hematology, University of Manitoba, Winnipeg, Canada

Arash Mahajerin¹, Rahul Khairnar^2*, Craig S. Meyer^2*, Ibrahim M. Abbass^2*, Rongrong Wang^2*, Lucy Lee^2*, Eunice Tzeng^2* and Karina Raimundo^2*

¹CHOC Children's Hospital, Orange, CA
²Genentech, Inc., South San Francisco, CA

Beatrice Nolan, FRCPath^1*, Anna Klukowska, MD, PhD^2*, Amy D Shapiro, MD³, Antoine Rauch^4*, Michael Recht, MD, PhD⁵, Margaret V. Ragni, MD, MPH⁶, Julie Curtin⁷, Sriya Gunawardena^8*, Stacey Poloskey^8*, Deepthi Jayawardene^8*, Bent Winding^9*, Kathelijn Fischer^10* and Raina Liesner^11*

¹Children Health Ireland at Crumlin, Dublin, Ireland
²Medical University of Warsaw, Warsaw, Poland
³Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
⁴Lille University Hospital Center (CHU) Lille, Lille, France
⁵Oregon Health and Science University, Portland, OR
⁶University of Pittsburgh Medical Center, Pittsburgh, PA
⁷The Children's Hospital at Westmead, Sydney, NSW, Australia
⁸Sanofi, Waltham, MA
⁹Swedish Orphan Biovitrum AB (Sobi), Stockholm, Sweden
¹⁰University Medical Center Utrecht, Utrecht, Netherlands
¹¹Great Ormond Street Hospital, London, United Kingdom

Margaret V. Ragni, MD, MPH¹, Frederico Xavier, MD, MS², Craig D. Seaman³, Suchitra Acharya, MD⁴, Catherine E. McGuinn, MD⁵, Eric J. Werner, MD^6*, Courtney Elizabeth Lawrence, MD, MS^7*, Allison P. Wheeler, MD⁸, Ulrike Reiss, MD⁹, Irmel Ayala, MD^10*, Erin Cockrell, DO¹¹, Cristina Tarango, MD¹², Amy Dunn¹³, Roshni Kulkarni, MD¹⁴, Sanjay P Ahuja, MD¹⁵, Meera B. Chitlur, MD¹⁶, Steven W. Pipe, MD¹⁷, Lynn M Malec, MD¹⁸, Vilmarie Rodriguez, MD¹⁹, Shelley Crary, MD, MS²⁰, Deborah Brown, MD²¹, Rosa Diaz, MD^22*, Maria Velez, MD^23*, Cindy A. Leissinger, MD²⁴, Shannon L Carpenter, MD²⁵, Christine M. Knoll, MD²⁶, Michael Wang, MD²⁷, Guy Young, MD²⁸, Courtney D Thornburg, MD²⁹, Joseph L Lasky III, MD^30*, Tiffany Lin Lucas, MD³¹, Nina Hwang, MD^32*, Deborah Vehec, MSN, RN^33*, Dana Ivanco^34*, Tamara L. Haller, BS^35*, Marnie Bertolet, PhD^36* and Maria M Brooks, PhD^37*

¹University of Pittsburgh Medicine, Division Hematology/Oncology, Pittsburgh, PA
²Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center and Hemophilia Center of Western PA, Pittsburgh, PA
³University of Pittsburgh, Warrendale, PA
⁴Pediatric Hematology, Oncology and Cellular Therapy, Cohen Children's Medical Center of New York, New Hyde Park, NY
⁵Weill Cornell Medical College, New York, NY
⁶Children's Hospital of The King's Daughters, Norfolk, VA
⁷Division of Pediatric Hematology / Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁸Dept. of Pediatric Hem./Onc., Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
⁹Department of Surgery, St. Jude Children's Rsch. Hosp., Memphis, TN
¹⁰Pediatric Cancer and Blood Disorders Center, Johns Hopkins All Children's Outpatient Care Center, St. Petersburg, FL
¹¹St. Joseph's Children's Hospital, Tampa, FL
¹²Division of Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
¹³Nationwide Children's Hospital, Columbus, OH
¹⁴Michigan State University Center for Bleeding and Clotting Disorders, East Lansing, MI
¹⁵University Hospitals Cleveland Medical Center, Rainbow Babies and Children's Hospital, Cleveland, OH
¹⁶Hemostasis and Thrombosis Center, Children's Hospital of Michigan, Detroit, MI
¹⁷Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI
¹⁸Blood Research Institute, Versiti, Milwaukee, WI
¹⁹Division of Pediatric Hematology, Mayo Clinic, Rochester, MN
²⁰University of Arkansas for Medical Sciences, Little Rock, AR
²¹Department of Pediatrics- Hematology Division, University of Texas Health Science Center at Houston, Houston, TX
²²Texas Children's Hospital, Houston, TX
²³Children's Hospital New Orleans, Louisiana State University, New Orleans, LA
²⁴Tulane University, New Orleans, LA
²⁵Children's Mercy Hospital, Kansas City, MO
²⁶Arizona Hemophilia and Thrombosis Center, Phoenix Children's Hospital, Phoenix, AZ
²⁷Anschutz Medical Campus, University of Colorado, School of Medicine, Hemophilia and Thrombosis Center, Aurora, CO
²⁸University of Califormia Los Angeles, Children's Hospital Los Angeles, Los Angeles, CA
²⁹Rady Children's Hospital, San Diego, CA
³⁰University of Nevada, Cure 4 the Kids Foundation, Las Vegas, NV
³¹University of California, San Francisco, San Francisco, CA
³²CHOC Children's Hospital, Orange County, Center for Inherited Blood Disorders (CIBD), Orange, CA
³³Hemophilia Center of Western PA, Institute for Transfusion Medicine, Vitalant, Pittsburgh, PA
³⁴Institute for Transfusion Medicine, Hemophilia Center of Western PA, Pittsburgh, PA
³⁵Department of Epidemiology, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA
³⁶Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA
³⁷Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA

Guilherme Sacchi De Camargo Correia, MD^1*, Sridevi Rajeeve, MD² and Lawrence Cytryn, MD³

¹Department of Medicine, Icahn School of Medicine at Mount Sinai West and Morningside, New York, NY
²Division of Hematology and Oncology - Department of Medicine, Icahn School of Medicine At Mount Sinai Hospital, New York, NY
³Division of Hematology and Oncology - Department of Medicine, Icahn School of Medicine at Mount Sinai West and Morningside, New York, NY

Janna M. Journeycake, MD¹, Michael Recht, MD, PhD², Christine Guelcher, Hemostasis RN-BC, MS, PPCNP-BC^3*, Ellis J. Neufeld⁴, Margaret V. Ragni, MD, MPH⁵, Robert F. Sidonio Jr., MD, MSc.⁶, Cliff Takemoto^7*, Michael D Tarantino, MD⁸, Dunlei Cheng, PhD^2*, Susan U. Lattimore, R.N.^9*, Jorge Caicedo^10* and Michael Denne, PharmD¹¹

¹Jimmy Everest Center for Cancer and Blood Disorders, University of Oklahoma Health Sciences Center, Oklahoma City, OK
²American Thrombosis and Hemostasis Network, Rochester, NY
³Children's National Health System, Center for Cancer and Blood Disorders, Washington, DC
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Department of Medicine - Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA
⁶Hemophilia of Georgia Center for Bleeding and Clotting Disorders, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Decatur, GA
⁷St. Jude Research Hospital, Memphis, TN
⁸Bleeding & Clotting Disorders Institute, Peoria, IL
⁹The Hemophilia Center, Oregon Health & Science University, Portland, OR
¹⁰Takeda Pharmaceuticals U.S.A., Inc, Boston, MA
¹¹Takeda, Cambridge, MA

Daniel Lindsay^1*, Jerome M. Teitel, MD, FRCPC^2,3 and Michelle Sholzberg, MDCM, FRCPC, MSc^4,5,6,7

¹Hematology-Oncology Clinical Research Group, St. Michael's Hospital, Toronto, ON, Canada
²Division of Hematology/Oncology, St. Michael's Hospital, Toronto, ON, Canada
³Department of Medicine, University of Toronto, Toronto, ON, Canada
⁴University of Toronto, Toronto, ON, Canada
⁵Division of Hematology/Oncology, St. Michael’s Hospital, Toronto, ON, Canada
⁶Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada
⁷Department of Laboratory Medicine and Pathobiology, St. Michael’s Hospital, Toronto, ON, Canada

Evan C. Chen, MD¹, William J. Gibson, MD, PhD^1*, Paula Temoczko, NP^2*, Nathan T. Connell, MD, MPH², Robert Handin, MD^2* and Aric D. Parnes, MD²

¹Dana Farber Cancer Institute, Boston, MA
²Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA

Saad Z Ahmed, MBBS¹, Michelle O’Rourke, FACSLM^2*, Vince Jenkins, PhD^3*, Caitriona Keenan, PhD^3*, Irene Ellen Regan, BSc, FRCPath, MBA^4* and Beatrice Nolan, FRCPath^5*

¹Haematology Department, National Coagulation Cenre, Dublin, Dublin, Ireland
²Hematology Department, Children's Health Ireland at Crumlin, Dublin, Ireland
³St. James's Hospital, National Coagulation Centre, Dublin, Ireland
⁴Children Health Ireland at Crumlin, Dublin 12, IRL
⁵Children Health Ireland at Crumlin, Dublin, Ireland

Gili Kenet^1,2, Thomas Moulton, MD³, Erika Soltes Rak^3*, Brian M. Wicklund, MD, MPH⁴ and Sanjay P Ahuja, MD⁵

¹National Hemophilia Center, Sheba Medical Center, Tel HaShomer, Israel
²The Amalia Biron Thrombosis Research Institute, Tel Aviv University, Tel Aviv, Israel
³Bayer, Whippany, NJ
⁴Children’s Mercy-Kansas City, Kansas City, MO
⁵Rainbow Babies & Children’s Hospital, Cleveland, OH

Mark Crowther, MD¹, David A. Garcia, MD², Jason Hill, MD, MSc^3*, Bryan Savage^4*, Shira Peress^5*, Kevin Chang^6* and Steven Deitelzweig, MD^7*

¹McMaster University, Hamilton, ON, Canada
²Division of Hematology, University of Washington School of Medicine, Seattle, WA
³Ochsner Health and University of Queensland, Slidell, LA
⁴Ochsner Health, Jefferson, LA
⁵Ochsner, Jefferson, LA
⁶Oschner Health and University of Queensland, Jefferson, LA
⁷Department of Hospital Medicine, Ochsner Clinic Foundation, New Orleans, LA

Mo Yang^1,2*, Huixia Deng^3*, Liuming Yang^1*, Liang Li, PhD^2*, Jieyu Ye, PhD^3*, Yucai Cheng^4*, Yafang Tan^5*, Beng H Chong, MBBS, PhD^6,7 and Qiang Li^8*

¹Lianjiang People's Hospital, Lianjiang, China
²The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴The seventh affiliated hospital, Sun Yat-sen University, Shenzhen, China
⁵Department of Otolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁶Medicine, University of New South Wales, Kogarah, Australia
⁷St George Hospital, Sydney, Australia
⁸Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China

Sylvia Von Mackensen^1*, Pratima Chowdary^2*, Sarah Mangles^3*, Qifeng Yu^4*, Baisong Mei⁴, Shauna R. Andersson^4* and Pronabesh Dasmahapatra, MBBS, MPH^4*

¹Department of Medical Psychology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
²Katharine Dormandy Haemophilia and Thrombosis Centre Unit, Royal Free Hospital, London, United Kingdom
³Haemophilia, Haemostasis and Thombosis Centre, Basingstoke and North Hampshire Hospital, Basingstoke, United Kingdom
⁴Sanofi, Cambridge, MA

Alexander Solms^1*, Anita Shah^2*, Sara Wiegmann^3*, Maurice Ahsman^4*, Erik Berntorp^5*, Andreas Tiede, MD⁶, Alfonso Iorio, MD, PhD⁷, Maria Elisa Mancuso^8*, Tihomir Zhivkov^9* and Toshko Lissitchkov^9*

¹Bayer, Berlin, Germany
²Bayer, Whippany
³Bayer, Wuppertal, Germany
⁴LAP&P Consultants BV, Leiden, Netherlands
⁵Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden
⁶Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁷McMaster-Bayer Endowed Research Chair in Clinical Epidemiology of Congenital bleeding Disorders, Department of Medicine, McMaster University, Hamilton, Canada
⁸Center for Thrombosis and Hemorrhagic Diseases, Humanitas Clinical and Research Center – IRCCS, Milan, Italy
⁹Specialized Hospital for Active Treatment, Sofia, Bulgaria