-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

612.O1.6 612. Acute Lymphoblastic Leukemia: Clinical Studies: Innovative Chemotherapy and Immunotherapy Strategies in Frontline and Relapsed Disease

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
ALL, Leukemia, Biological, antibodies, Adult, CRS, survivorship, therapy sequence, Diseases, Non-Biological, neurotoxicity, Therapies, Combinations, CAR-Ts, Pediatric, chemotherapy, Adverse Events, Young Adult, Technology and Procedures, immunotherapy, Xenograft models, Lymphoid Malignancies, Study Population, Clinically relevant, Quality Improvement , transplantation, TKI, molecular testing, NGS
Saturday, December 5, 2020: 2:00 PM-3:30 PM
Moderators:
Deepa Jeyakumar, MD, UC Irvine Medical Center and Jonathan Webster, MD, Johns Hopkins University
Disclosures:
No relevant conflicts of interest to declare.
2:00 PM

David T. Teachey, MD1, Meenakshi Devidas, PhD2*, Brent L Wood, MD, PhD3, Zhiguo Chen, MS4*, Robert James Hayashi, MD5*, Robert D Annett, PhD6*, Barbara L Asselin, MD7, Keith J August, MD, MS8, Steve Y Cho, MD9*, Kimberly P. Dunsmore, MD10*, Brian T. Fisher, DO, MSCE11*, Jason L. Freedman, MD11*, Paul J. Galardy, MD12, Paul Harker-Murray, MD, PhD13, Michelle L. Hermiston, MD, PhD14, Terzah M Horton, MD, PhD15, Alok I Jaju, MD16*, Allison Lam, BCPS17*, Yoav H. Messinger, MD18, Rodney R. Miles, MD, PhD19, Maki Okada, RN17*, Samir I Patel, MD20*, Eric S. Schafer, MD, MHS21, Tal Schechter-Finkelstein, MD22, Kristin A. Shimano, MD14, Neelam Singh, PhD23*, Amii C. Steele, PhD24*, Maria L. Sulis, MD25*, Sarah L Vargas, PhD26*, Stuart S. Winter, MD27, Charlotte Wood, CCRP4*, Patrick Zweider McKay, MD, PhD28*, Catherine M. Bollard, MD, MBChB29, Mignon L. Loh, MD30, Stephen P. Hunger, MD11 and Elizabeth A. Raetz, MD31

1Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania, Rutledge, PA
2Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
3Department of Laboratory Medicine, University of Washington, Seattle, WA
4Children's Oncology Group Data Center, Gainesville, FL
5Siteman Cancer Center, Pediatric Hematology/Oncology (PD), St Louis, MO
6University of Mississippi Medical Center, Jackson, MS
7Golisano Children's Hospital at URMC, University of Rochester Strong Memorial Hospital, Rochester, NY
8Chidren's Mercy Hospital, Kansas City, MO
9Wisconsin Institute for Medical Research, Madison, WI
10Department of Pediatrics, Virginia Tech Carilion School of Medicine, Roanoke, VA
11Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
12Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN
13Children's Hospital of Wisconsin, Milwaukee, WI
14Department of Pediatrics, University of California Benioff Children’s Hospital, San Francisco, CA
15Baylor College of Medicine, Houston, TX
16Lurie Children's Hospital, Chicago, IL
17Miller Children's and Women’s Hospital, Long Beach, CA
18Children's Hospitals and Clinics, Minneapolis, MN
19Dept. of Pathology and ARUP Institute for Clinical & Experimental Pathology, University of Utah, Salt Lake City, UT
20University of Alberta- Stollery Children’s Hospital, Edmonton, AB, Canada
21Texas Children's Hospital, Baylor College of Medicine, Houston, TX
22Haematology/Oncology, Child Health Evaluative Services (CHES) Program Research Institute, The Hospital for Sick Children, Toronto, Canada
23Michigan State University Clinical Center, Lansing, MI
24Carolinas Medical Center/Levine Cancer Institute, Charlotte, NC
25Department of Pediatric Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
26Children's Oncology Group, Monrovia, CA
27Children's Minnesota Research Institute, Children's Minnesota Research Institute and Cancer and Blood Disorders Program, Minneapolis, MN
28ImmunoGen, Inc., Waltham, MA
29Children's National Hospital and The George Washington University, Washington, DC
30Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, San Francisco, CA
31New York University Langone Medical Center, New York, NY

2:15 PM

Matthias Stelljes, MD1, Simon Raffel, MD2*, Ralph Wäsch3, Sebastian Scholl4*, Mustafa Kondakci, MD5*, Andreas Rank, PD Dr6*, Mathias Haenel, MD7*, Sonja Martin, MD8*, Katjana Schwab, MD9*, Julian Knaden10*, Klaus Wethmar, MD11*, Tim Sauer, MD12*, Wolfgang E. Berdel, Prof., MD13, Georg Lenz14, Martin Dugas15*, Monika Brüggemann, MD16*, Nicola Goekbuget, MD17 and Nael Alakel, MD18*

1Deptartment of Medicine A, University of Muenster, Muenster, Germany
2Department of Medicine V, University of Heidelberg, Heidelberg, Germany
3Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg, Germany
4Universitatsklinikum Jena, Jena, Germany
5Dept. of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
6Klinikum Augsburg, Augsburg, DEU
7Klinikum Chemnitz, Chemnitz, Germany
8Department of Hematology and Oncology, Robert-Bosch-Hospital, Stuttgart, Germany
9University of Bonn, Bonn, Germany
10University of Frankfurt, Frankfurt, Germany
11University Hospital Muenster, Muenster, DEU
12Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany
13Department of Medicine A, University Hospital Muenster, Muenster, Germany
14Department of Medicine A, University Hospital Muenster, Munster, Germany
15Institute of Medical Informatics, Universitiy of Muenster, Münster, DEU
16Department of Internal Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany
17University Hospital, Department of Medicine II, Hematology/Oncology, Head of Study Center Depart of Medicine II, Hematology/Oncology Goethe University Hospital, Frankfurt, Germany
18University Hospital, Dresden, Germany

2:30 PM

Franco Locatelli, MD, PhD1, Gerhard Zugmaier2, Carmelo Rizzari, MD3*, Joan Morris4*, Bernd Gruhn5*, Thomas Klingebiel6, Rosanna Parasole7*, Christin Linderkamp8*, Christian Flotho, MD9*, Arnaud Petit, MD, PhD10*, Concetta Micalizzi11*, Noemi Mergen, MD12*, Abeera Mohammad, MSc13*, Cornelia Eckert, PhD14*, Anja Moericke, MD15*, Mary Sartor, BSc, PhD16*, Ondrej Hrusak, MD, PhD17, Christina Peters18*, Vaskar Saha, MD, PhD19* and Arend von Stackelberg, MD20

1Department of Pediatric Hematology/Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
2Amgen Research (Munich) GmbH, Munchen, Germany
3San Gerardo Hospital, University of Milano-Bicocca, Monza, ITA
4Amgen Inc.,, Thousand Oaks, CA
5Department of Pediatrics, Department of Pediatrics, Jena, Germany
6Department for Children and Adolescents, University Hospital Frankfurt, Frankfurt am Main, Germany
7Dept Pediatric Hemato-Oncology, Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon, Napoli, Italy, NAPOLI, Italy
8Medizinische Hochschule Hannover, Hanover, Germany
9Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
10Hopital Trousseau, PARIS, France
11Istituto Pediatrico di Ricerca e Cura a Carattere Scientifico G Gaslini, Genova, Italy
12Amgen Research (Munich), Munich, Germany
13Global Biostatistical Science, Amgen Ltd, Uxbridge, United Kingdom
14Department of Pediatric Oncology/Hematology, Campus Rudolf Virchow, Charité University Hospital, Berlin, Germany
15Department of Pediatrics, University Medical Center of Schleswig-Holstein, Campus Kiel, Kiel, Germany
16Westmead Institute for Medical Research, Sydney, Australia
17CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Charles University CLIP, Prague, Czech Republic
18St Anna's Childrens Hospital, Vienna, Austria
19Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India
20Department of Pediatric Oncology/Hematology, Charite Medical Center, Berlin, Germany

2:45 PM

Agne Taraseviciute, MD1*, Seth M. Steinberg, PhD2*, Regina M. Myers, MD3, Lia Gore, MD4, Adam J. Lamble, MD5, Patrick A. Brown, MD6, Jennifer Sheppard7*, Bonnie Yates, NP8*, Perry Chung, MD9*, Lee Chen10*, Colleen Annesley, MD11*, Deepa Bhojwani, MD1, Theodore W. Laetsch, MD9,12*, Rebecca A Gardner, MD11, Susan R. Rheingold, MD13, Michael A Pulsipher, MD14 and Nirali N. Shah, MD15

1Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
2Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, MD
3Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
4Peds Heme/Onc/BMT-CT, University of Colorado, Children's Hospital Colorado, Aurora, CO
5Division of Hematology and Oncology, Seattle Children's Hospital, Portland, OR
6Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
7Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Health Dallas, Dallas, TX
8National Cancer Institute/ Center for Cancer Research, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD
9Children's Hospital of Philadelphia, Philadelphia, PA
10Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, CA
11Seattle Children's Hospital, Seattle, WA
12Department of Pediatrics, The University of Texas Southwestern Medical Center/Children's Health, Dallas, TX
13Division of Oncology, Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
14Children's Hospital of Los Angeles, Los Angeles, CA
15Pediatric Oncology Branch, National Cancer Institute/Nih, Bethesda, MD

3:00 PM

Xian Zhang, MD1,2, Jiasheng Wang3*, Yue Liu3*, Junfang Yang1,2*, Jingjing Li1,2*, Gailing Zhang, MD.2*, Yanze Shi2*, Jiujiang He2*, Dan Song2*, Wenqian Li2*, Shulian Xia2*, Min Zhang2*, Zhixiao Zhou3*, Lemei Jia3*, Hongli Zheng4*, Xin Lin5* and Peihua Lu, MD1,2

1Beijing Lu Daopei Institute of Hematology, Beijing, China
2Hebei Yanda Lu Daopei Hospital, Langfang, China
3Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China
4China Immunotech (Beijing) Biotechnology Co. Ltd., Beijing, China
53. Department of Basic Medical Sciences and Institute for Immunology, Tsinghua University School of Medicine, Beijing, China

3:15 PM

Giacomo Gotti, MD1*, Maneka Puligandla, MS2*, Kristen E. Stevenson, MS3*, Brenton G. Mar, MD, PhD4*, Barbara L Asselin, MD5, Uma Athale, MD, MBBS, MSc6, Luis A. Clavell, MD7, Peter D. Cole, MD8, Lisa M. Gennarini, MD9*, Justine M. Kahn, MD, MSc10, Kara M. Kelly, MD11, Caroline Laverdiere, MD, FRCPC12*, Jean-Marie Leclerc13*, Bruno Michon, MD, FRCPC14*, Marshall A. Schorin, MD15, Maria L. Sulis, MD16*, Thai Hoa Tran, MD17, Jennifer J.G. Welch, MD18*, Kimberly Stegmaier, MD1, Marian H. Harris, MD, PhD19*, Lewis B. Silverman, MD20 and Yana Pikman, MD21

1Dana-Farber Cancer Institute, Boston, MA
2Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
3Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
4Blueprint Medicines, Cambridge, MA
5Golisano Children's Hospital at URMC, University of Rochester Strong Memorial Hospital, Rochester, NY
6McMaster Children's Hospital, McMaster University, Division of Pediatric Hematology/Oncology, Hamilton, ON, Canada
7Division of Pediatric Oncology, San Jorge Children's Hospital, San Juan, PR
8Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ
9Children's Hospital at Montefiore, Bronx, NY
10Division of Pediatric Hematology/Oncology, Columbia University Irving Medical Center, New York, NY
11Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
12Hematology-Oncology Division, Charles Bruneau Cancer Center, Sainte-Justine University Hospital, Montreal, QC, CAN
13CHU Ste-Justine, Montreal, Qc, CAN
14Division of Hematology-Oncology, Centre Hospitalier de l'Universite Laval (CHUL), Quebec, QC, Canada
15Inova Fairfax Hospital for Children, Falls Church, VA
16Memorial Sloan Kettering Cancer Center, New York, NY
17Centre Hospitalier Universitaire De Quebec, Montreal, Canada
18Division of Pediatric Hematology-Oncology, Hasbro Children's Hospital, Providence, RI
19Boston Children's Hospital, Department of Pathology, Boston
20Dana-Farber Cancer Inst., Boston, MA
21Dana Farber Cancer Institute, Boston, MA

*signifies non-member of ASH