-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

604.O1.6 604. Molecular Pharmacology and Drug Resistance in Myeloid Diseases

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
AML, apoptosis, therapy sequence, Diseases, Combinations, Therapies, Biological Processes, Technology and Procedures, Lymphoid Malignancies, Clinically relevant, genomics, Myeloid Malignancies, integrative -omics, NGS, metabolomics, microenvironment, molecular interactions, pathways, proteomics, signal transduction
Saturday, December 5, 2020: 2:00 PM-3:30 PM
Moderators:
Paul Brent Ferrell Jr., MD, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center and Thorsten Braun, MD, PhD, EA3518 Leukemia Translational Laboratory
Disclosures:
Ferrell: Forma Therapeutics: Research Funding; Astex Pharmaceuticals: Research Funding; Incyte: Research Funding.
2:00 PM

Junhua Lyu1*, Yuxuan Liu, PhD1*, Hui Cao, MS1*, Mingyi Chen, MD, PhD2*, Yazan F. Madanat, MD3, Yuannyu Zhang, PhD1*, Zhimin Gu, PhD1, Pranita Kaphle, MS1*, Kathryn E. Dickerson, MD4, Paul Yenerall, PhD5*, Rahul Kollipara, PhD5*, Ralf Kittler, PhD5*, John Minna, MD6*, Weina Chen, MD, PhD2*, Stephen Chung, MD7, Robert H. Collins, MD7, Xin Liu, PhD8* and Jian Xu, PhD1

1Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX
2Department of Pathology, UT Southwestern Medical Center, Dallas, TX
3UT Southwestern Medical Center, Dallas, TX
4Children's Medical Center/Ut Southwestern, Dallas, TX
5Hamon Center for Therapeutic Oncology, Department of Internal Medicine and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX
6McDermott Center for Human Growth and Development, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX
7Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
8Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX

2:15 PM

Sunil K Joshi, BA1,2, Tamilla Nechiporuk, PhD3*, Daniel Bottomly4*, Paul Piehowski, Paul.Piehowski@pnnl.gov5*, Julie Reisz, PhD6*, Janét Pittsenbarger, BA7*, Sara J Gosline5*, Andy Kaempf, MS8*, Yi-Ting Wang5*, Jamie Moon5*, Özgün Babur7*, Kevin M Watanabe-Smith, Ph.D.9, Emek Demir7*, Liu Tao, BS, PhD5*, Cristina E. Tognon, PhD10, Angelo D’Alessandro, PhD11*, Jeffrey W. Tyner, PhD12, Shannon K. McWeeney, PhD4*, Karin Rodland, rodland@ohsu.edu5,7*, Brian J. Druker, MD12 and Elie Traer13

1Knight Cancer Institute, Oregon Health & Science University, Portland, OR
2Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR
3Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
4Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
5Pacific Northwest National Laboratory, Richland, WA
6Biochemistry, University of Colorado, Aurora, CO
7Oregon Health & Science University, Portland, OR
8Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
9Oregon Health and Science University, Portland, OR
10Knight Cancer Institute, Division of Hematology & Medical Oncology, OHSU, Portland, OR
11Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO
12Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
13Division of Hematology and Medical Oncology, Oregon Health & Sciences University, Portland, OR

2:30 PM

Yazan Numan, MD1*, Zaid Abdel Rahman, MD2, Justin Grenet, MD3*, Stephanie Boisclair, MD4, Jan Philipp Bewersdorf, MD5*, Dylan Barth, PharmD, BCPS6*, Amer M. Zeidan, MBBS, MHS7, Musa Yilmaz, MD8, Shira Dinner, MD9, Yehuda E. Deutsch, MD10, Olga Frankfurt, MD11*, Mark Litzow, MD12, Aref Al-Kali, MD12, James M. Foran, MD2, Lisa Z. Sproat, MD13, Borko Jovanovic, PhD14*, Naval Daver, MD15, Alexander E. Perl, MD16 and Jessica K. Altman, MD9,17

1Hematology Oncology, Northwestern University, Chicago, IL
2Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
3the Perelman School of Medicine, Philadelphia, PA
4Internal Medicine Residency, Memorial Healthcare System, Pembroke Pines, FL
5Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT
6Department of Pharmacy, Northwestern University Feinberg School of Medicine, Chicago, IL
7Yale University School of Medicine and Yale Cancer Center, New Haven, CT
8Department of Leukemia, MD Anderson Cancer Center, Houston, TX
9Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
10Department of Malignant Hematology and Cellular Therapy at Memorial Health System, Moffitt Cancer Center, Pembroke Pines, FL
11Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
12Division of Hematology, Mayo Clinic, Rochester, MN
13Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
14Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
15Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
16Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA
17Northwestern University, Chicago, IL

2:45 PM

Donia M Moujalled, PhD1,2*, Fiona C Brown, PhD1,2*, Giovanna Pomilio1*, Natasha S Anstee, PhD3*, Veronique Litalien2*, Ella R Thompson, PhD, BSc4,5*, Thomas Morley1*, Sarah MacRaild2*, Chong C Chua, MBBS, BMedSc1, SéBastien Banquet, PhD6*, Maia Chanrion7*, Ana-Leticia Maragno, PhD7*, Marie Schoumacher6*, Marco J Herold, PhD8,9*, Guillaume Lessene, PhD8,9*, Olivier Geneste, PhD10*, David C.S. Huang, MBBS MRCP PhD9*, Andrew W Roberts, MBBS5,9,11, Piers Blombery, MBBS11,12* and Andrew Wei, MBBS, PhD1,2

1Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia
2Monash University, Australian Centre for Blood Diseases, Melbourne, Australia
3The Alfred Hospital, Melbourne, Australia
4Peter MacCallum Cancer Centre, Melbourne, Australia
5The University of Melbourne, Melbourne, Australia
6Institut de Recherches Internationales Servier, Oncology R&D Unit, Suresnes, France
7Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine, France
8Department of Medical Biology, The University of Melbourne, Melbourne, Australia
9The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
10Institut de Recherches Internationales Servier, Oncology R&D Unit, Croissy-sur-Seine, France
11Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
12Department of Pathology, Peter MacCallum Cancer Center, East Melbourne, Australia

3:00 PM

Piers Blombery, MBBS1,2*, Ella R Thompson, PhD, BSc2,3*, Xiangting Chen, PhD3*, Tamia Nguyen3*, Mary Ann Anderson, MBBS, PhD, FRACP, FRCPA1,2,4, David Alan Westerman, MBBS, FRCPA, FRACP1,2, John F. Seymour, MBBS1,2, Constantine S. Tam, MBBS, MD1,2*, Michael A Dengler, PhD4*, David C.S. Huang, MBBS MRCP PhD2,4*, Andrew Wei, MBBS, PhD5 and Andrew W Roberts, MBBS1,2,4

1Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
2University of Melbourne, Melbourne, Australia
3Peter MacCallum Cancer Centre, Melbourne, Australia
4The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
5Alfred Hospital, Melbourne, Australia

3:15 PM

Kyung Hee Chang, PhD1*, Muharrem Muftuoglu2, Weiguo Zhang, MD, PhD3, Mahesh Basyal, BSc4*, Lauren B Ostermann, BS1*, William E. Fogler, PhD5, John L. Magnani, PhD5 and Michael Andreeff, MD, PhD1

1Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Section of Molecular Hematology and Therapy, Department of Leukemia, MD Anderson Cancer Center , Houston, TX
3Section of Molecular Hematology and Therapy, Department of Leukemia, U.T.M.D. Anderson Cancer Center, Houston, TX
4Leukemia department, UT MD Anderson Cancer center, Houston, TX
5Glycomimetics, Inc., Rockville, MD

*signifies non-member of ASH