Junhua Lyu^1*, Yuxuan Liu, PhD^1*, Hui Cao, MS^1*, Mingyi Chen, MD, PhD^2*, Yazan F. Madanat, MD³, Yuannyu Zhang, PhD^1*, Zhimin Gu, PhD¹, Pranita Kaphle, MS^1*, Kathryn E. Dickerson, MD⁴, Paul Yenerall, PhD^5*, Rahul Kollipara, PhD^5*, Ralf Kittler, PhD^5*, John Minna, MD^6*, Weina Chen, MD, PhD^2*, Stephen Chung, MD⁷, Robert H. Collins, MD⁷, Xin Liu, PhD^8* and Jian Xu, PhD¹

¹Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX
²Department of Pathology, UT Southwestern Medical Center, Dallas, TX
³UT Southwestern Medical Center, Dallas, TX
⁴Children's Medical Center/Ut Southwestern, Dallas, TX
⁵Hamon Center for Therapeutic Oncology, Department of Internal Medicine and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX
⁶McDermott Center for Human Growth and Development, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX
⁷Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
⁸Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX

Sunil K Joshi, BA^1,2, Tamilla Nechiporuk, PhD^3*, Daniel Bottomly^4*, Paul Piehowski, Paul.Piehowski@pnnl.gov^5*, Julie Reisz, PhD^6*, Janét Pittsenbarger, BA^7*, Sara J Gosline^5*, Andy Kaempf, MS^8*, Yi-Ting Wang^5*, Jamie Moon^5*, Özgün Babur^7*, Kevin M Watanabe-Smith, Ph.D.⁹, Emek Demir^7*, Liu Tao, BS, PhD^5*, Cristina E. Tognon, PhD¹⁰, Angelo D’Alessandro, PhD^11*, Jeffrey W. Tyner, PhD¹², Shannon K. McWeeney, PhD^4*, Karin Rodland, rodland@ohsu.edu^5,7*, Brian J. Druker, MD¹² and Elie Traer¹³

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR
³Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
⁴Division of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
⁵Pacific Northwest National Laboratory, Richland, WA
⁶Biochemistry, University of Colorado, Aurora, CO
⁷Oregon Health & Science University, Portland, OR
⁸Biostatistics Shared Resource, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁹Oregon Health and Science University, Portland, OR
¹⁰Knight Cancer Institute, Division of Hematology & Medical Oncology, OHSU, Portland, OR
¹¹Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO
¹²Knight Cancer Institute, Division of Hematology & Medical Oncology, Oregon Health & Science University, Portland, OR
¹³Division of Hematology and Medical Oncology, Oregon Health & Sciences University, Portland, OR

Yazan Numan, MD^1*, Zaid Abdel Rahman, MD², Justin Grenet, MD^3*, Stephanie Boisclair, MD⁴, Jan Philipp Bewersdorf, MD^5*, Dylan Barth, PharmD, BCPS^6*, Amer M. Zeidan, MBBS, MHS⁷, Musa Yilmaz, MD⁸, Shira Dinner, MD⁹, Yehuda E. Deutsch, MD¹⁰, Olga Frankfurt, MD^11*, Mark Litzow, MD¹², Aref Al-Kali, MD¹², James M. Foran, MD², Lisa Z. Sproat, MD¹³, Borko Jovanovic, PhD^14*, Naval Daver, MD¹⁵, Alexander E. Perl, MD¹⁶ and Jessica K. Altman, MD^9,17

¹Hematology Oncology, Northwestern University, Chicago, IL
²Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
³the Perelman School of Medicine, Philadelphia, PA
⁴Internal Medicine Residency, Memorial Healthcare System, Pembroke Pines, FL
⁵Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT
⁶Department of Pharmacy, Northwestern University Feinberg School of Medicine, Chicago, IL
⁷Yale University School of Medicine and Yale Cancer Center, New Haven, CT
⁸Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁹Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
¹⁰Department of Malignant Hematology and Cellular Therapy at Memorial Health System, Moffitt Cancer Center, Pembroke Pines, FL
¹¹Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
¹²Division of Hematology, Mayo Clinic, Rochester, MN
¹³Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
¹⁴Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
¹⁵Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX
¹⁶Division of Hematology-Oncology/Department of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁷Northwestern University, Chicago, IL

Donia M Moujalled, PhD^1,2*, Fiona C Brown, PhD^1,2*, Giovanna Pomilio^1*, Natasha S Anstee, PhD^3*, Veronique Litalien^2*, Ella R Thompson, PhD, BSc^4,5*, Thomas Morley^1*, Sarah MacRaild^2*, Chong C Chua, MBBS, BMedSc¹, SéBastien Banquet, PhD^6*, Maia Chanrion^7*, Ana-Leticia Maragno, PhD^7*, Marie Schoumacher^6*, Marco J Herold, PhD^8,9*, Guillaume Lessene, PhD^8,9*, Olivier Geneste, PhD^10*, David C.S. Huang, MBBS MRCP PhD^9*, Andrew W Roberts, MBBS^5,9,11, Piers Blombery, MBBS^11,12* and Andrew Wei, MBBS, PhD^1,2

¹Department of Clinical Haematology, The Alfred Hospital, Melbourne, Australia
²Monash University, Australian Centre for Blood Diseases, Melbourne, Australia
³The Alfred Hospital, Melbourne, Australia
⁴Peter MacCallum Cancer Centre, Melbourne, Australia
⁵The University of Melbourne, Melbourne, Australia
⁶Institut de Recherches Internationales Servier, Oncology R&D Unit, Suresnes, France
⁷Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine, France
⁸Department of Medical Biology, The University of Melbourne, Melbourne, Australia
⁹The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
¹⁰Institut de Recherches Internationales Servier, Oncology R&D Unit, Croissy-sur-Seine, France
¹¹Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
¹²Department of Pathology, Peter MacCallum Cancer Center, East Melbourne, Australia

Piers Blombery, MBBS^1,2*, Ella R Thompson, PhD, BSc^2,3*, Xiangting Chen, PhD^3*, Tamia Nguyen^3*, Mary Ann Anderson, MBBS, PhD, FRACP, FRCPA^1,2,4, David Alan Westerman, MBBS, FRCPA, FRACP^1,2, John F. Seymour, MBBS^1,2, Constantine S. Tam, MBBS, MD^1,2*, Michael A Dengler, PhD^4*, David C.S. Huang, MBBS MRCP PhD^2,4*, Andrew Wei, MBBS, PhD⁵ and Andrew W Roberts, MBBS^1,2,4

¹Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
²University of Melbourne, Melbourne, Australia
³Peter MacCallum Cancer Centre, Melbourne, Australia
⁴The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
⁵Alfred Hospital, Melbourne, Australia

Kyung Hee Chang, PhD^1*, Muharrem Muftuoglu², Weiguo Zhang, MD, PhD³, Mahesh Basyal, BSc^4*, Lauren B Ostermann, BS^1*, William E. Fogler, PhD⁵, John L. Magnani, PhD⁵ and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, MD Anderson Cancer Center , Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, U.T.M.D. Anderson Cancer Center, Houston, TX
⁴Leukemia department, UT MD Anderson Cancer center, Houston, TX
⁵Glycomimetics, Inc., Rockville, MD