Alyssa L. Kennedy, MD, PhD¹, Kasiani C. Myers, MD², James Bowman, PhD^3*, Christopher J. Gibson, MD⁴, Gwen M. Muscato^5*, Robert Klein^1*, Kaitlyn Ballotti^5*, Nicholas Camarda^1*, Elissa M. Furutani, MD⁶, Chad E. Harris, MS^5*, Shanshan Liu, PhD^7*, Ashley Galvin^5*, Maggie Malsch, MSN, RN^5*, David C. Dale, MD⁸, John M Gansner, MD, PhD⁹, Taizo A. Nakano, MD¹⁰, Alison A. Bertuch, MD¹¹, Adrianna Vlachos, MD¹², Jeff H. Lipton, MD, PhD¹³, Paul Castillo, MD^14*, James Connelly^15*, John Edwards, MD^16*, Nobuko Hijiya, MD¹⁷, Richard Ho, MD^18*, Inga Hofmann, MD¹⁹, James N Huang, MD²⁰, Sioban B. Keel, MD²¹, Adam J. Lamble, MD²², Bonnie W Lau, MD, PhD²³, Kelly J. Walkovich, MD²⁴, Maxim Norkin, MD²⁵, Wendy Stock, MD²⁶, Steffen Boettcher^27*, Christian Brendel, PhD^28*, Elliot Stieglitz, MD²⁹, Mark D. Fleming, MD, DPhil³⁰, Stella M. Davies, PhD, MBBS, MRCP³¹, Edie A. Weller^32*, Chris Bahl, PhD^3*, Scott L. Carter, PhD^33*, Akiko Shimamura, MD, PhD^34* and R. Coleman Lindsley, MD, PhD³⁵

¹Dana-Farber Cancer Institute, Boston, MA
²Department of Pediatrics, Division of Bone Marrow Transplantation and Immune Deficieny, Cincinnati Children's Hospital, Cincinnati, OH
³Institute for Protein Innovation, Boston, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Chestnut Hill, MA
⁵Boston Children's Hospital, Boston, MA
⁶Boston Children's Cancer and Blood Disorders Center, Boston Children’s Hospital, Boston, MA
⁷Division of Hematology and Oncology and Biostatistics and Research Design Center, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA
⁸Department of Medicine, University of Washington, Seattle, WA
⁹Hematology Division, Brigham and Women's Hospital, Newton, MA
¹⁰Children's Hospital Colorado, University of Colorado School of Medicine, Denver, CO
¹¹Baylor College of Medicine, Houston, TX
¹²Feinstein Institute of Medical Research, Cohen Children's Medical Center, Manhasset, NY
¹³Blood and Marrow Transplant Program, Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁴Shand's Children's Hospital, Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Florida, Gainesville, FL
¹⁵Department of Pediatrics, Division of Pediatric Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN
¹⁶Indiana Blood and Marrow Transplantation, Indianapolis, IN
¹⁷Pediatric Hematology Oncology Transplant, Columbia University Irving Medical Center, New York, NY
¹⁸Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
¹⁹Department of Pediatrics, Division of Hematology/Oncology and Bone Marrow Transplantation, University of Wisconsin, Madison, WI
²⁰Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, Benioff Children's Hospital, San Francisco, CA
²¹Department of Medicine, Division of Hematology, Seattle, WA
²²Division of Hematology-Oncology, Seattle Children's Hospital, Seattle, WA
²³Johns Hopkins University, Grafton, NH
²⁴University of Michigan, Ann Arbor, MI
²⁵University of Florida, Gainesville, FL
²⁶Department of Medicine, University of Chicago, Chicago, IL
²⁷Medical Oncology and Hematology, University and University Hospital Zurich, Zurich, Switzerland
²⁸Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston
²⁹Department of Pediatrics, Division of Hematology-Oncology, UCSF, San Francisco, CA
³⁰Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA
³¹Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
³²Institutional Centers for Clinical and Translational Research, Biostatistics, Boston Children’s Hospital, Boston, MA
³³Dana Farber Cancer Institute, Boston, MA
³⁴Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA
³⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Richa Sharma, MD¹, Sushree Sangita Sahoo, PhD^2*, Masayoshi Honda^3*, Charnise Goodings-Harris, PhD¹, Victor Pastor, PhD^1*, Hauke Busch, PhD^4,5*, Melanie Börries, PhD^6*, Fabian Beier, MD^7,8,9*, Miriam Erlacher, MD, PhD^10,11*, Melchior Lauten^12*, Marc Wold, PhD^13*, Maria Spies, PhD^14*, Charlotte M. Niemeyer, MD^11,15,16,17 and Marcin Wlodarski, MD, PhD^18,19

¹St Jude Children's Research Hospital, Memphis, TN
²Hematology, St. Jude Children's Research Hospital, Memphis, TN
³Department of Biochemistry, University of Iowa, Iowa City, IA
⁴Lübeck Institute of Experimental Dermatology, Lübeck, Germany
⁵Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, Germany
⁶Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, German Cancer Consortium (DKTK), partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany, Freiburg, Germany
⁷Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Hospital Aachen, Aachen, Germany
⁸Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, University Hospital Aachen, Aachen, Germany
⁹Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, University Hospital Aachen, Aachen, NRW, Germany
¹⁰University Medical Center Freiburg, Freiburg, Germany
¹¹German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, Germany
¹²Pediatrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
¹³Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA
¹⁴University of Iowa, Iowa City, IA
¹⁵University Children's Hospital, Freiburg, Germany
¹⁶Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹⁷Department of Pediatrics and Adolescent Medicine, Freiburg University Hospital, Freiburg, Germany
¹⁸Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
¹⁹Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany

Richard N Armstrong, PhD, BSc^1*, Mariana Benicio, PhD^1*, Houtan Moshiri, Ph.D^1*, Hongbing Li, PhD^1*, Bozana Zlateska, MD, MSc^1*, Olga I. Gan, PhD^2*, Eric R Lechman, Ph.D.^3*, John E. Dick, PhD, FRS² and Yigal Dror, MD, FRCPC^1,4

¹Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada

Misam Zawit, MBBS^1*, Jibran Durrani, MD^1*, Wenyi Shen, MD^2*, Vera Adema, PhD^3*, Cassandra M Kerr, MS^1*, Hassan Awada, MD¹, Sunisa Kongkiatkamon, MD^1*, Carmelo Gurnari, MD^4*, Simona Pagliuca, MD¹, Laila Terkawi^1*, Bhumika J. Patel, MD^3,5, Valeria Visconte, PhD¹, Hetty E. Carraway, MD, MBA^1,6, Thomas LaFramboise, Ph.D.^7*, Seth J. Corey, MD⁸, Torsten Haferlach, MD⁹ and Jaroslaw P. Maciejewski, MD, PhD³

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Department of Translational Hematology and Oncology Research,Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
⁵Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁶Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁷Department of Genetics and Genome Sciences Case Western Reserve University School of Medicine, Cleveland, OH
⁸Departments of Pediatrics, Cancer Biology, THOR, Cleveland Clinic, Cleveland, OH
⁹MLL Munchner Leukamie Labor Gmbh, Munchen, Germany

Kohei Hosokawa, MD, PhD ¹, Hiroki Mizumaki, MD^1*, Takeshi Yoroidaka, MD^1*, Hiroyuki Maruyama, MD, PhD^1*, Tatsuya Imi, MD, PhD^1*, Noriaki Tsuji, MD^1*, Ryota Urushihara, MD^1*, Mikoto Tanabe, MD^1*, Yoshitaka Zaimoku, MD, PhD^1*, Mai Anh Thi Nguyen, MD^1*, Dung Cao Tran, MD^1*, Ken Ishiyama, MD, PhD¹, Hirohito Yamazaki, MD, PhD^2*, Takamasa Katagiri, PhD^3*, Kazuyoshi Hosomichi, PhD^4*, Atsushi Tajima, PhD^4*, Fumihiro Azuma^5*, Seishi Ogawa, MD, PhD⁶ and Shinji Nakao, MD, PhD¹

¹Department of Hematology, Kanazawa University, Kanazawa, Japan
²Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan
³Clinical Laboratory Sciences, Kanazawa University Graduate School, Kanazawa, Japan
⁴Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan
⁵HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Kotoku, Japan
⁶Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Simona Pagliuca, MD^1,2, Carmelo Gurnari, MD^2,3*, Diego Chowell, PhD^4*, Chirag Krishna^5*, Bhumika J. Patel, MD⁶, Hassan Awada, MD², Cassandra M Kerr, MS^2*, Sunisa Kongkiatkamon, MD^2,7*, Ashwin Kishtagari, MBBS², Thomas Laframboise, PhD^8*, Yogenthiran Saunthararajah, MD², Babal K. Jha, PhD^2*, Valeria Visconte, PhD², Timothy Chan, MD, PhD^9* and Jaroslaw Maciejewski, PhD^2*

¹Université de Paris, Paris, France
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
³Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁴Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York
⁵Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York
⁶Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH
⁷Department of hematology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
⁸Genetics and Genome Sciences Department, Case Western Reserve University, Cleveland, OH
⁹Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland