Serine Avagyan, MD, PhD¹, Jonathan E Henninger^2*, William P. Mannherz^3*, Meeta Mistry^4*, Song P. Yang, PhD^3*, Margaret Weber^3*, Jessica Moore^3* and Leonard I. Zon, MD⁵

¹Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, MA
²Biological and Biomedical Sciences Program, Harvard University, Cambridge, MA
³Boston Children's Hospital, Boston
⁴Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA
⁵Stem Cell Program and Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA

Taehoon Shin^1*, Shirley Chen, BS^2*, Stefan Cordes, MD, PhD³, Yifan Zhou, MS^2*, Byung-Chul Lee, PhD^2*, Aisha Aljanahi, BS^2*, So Gun Hong, PhD^2*, Robert E. Donahue, VMD^4*, Kyung-Rok Yu, PhD² and Cynthia E. Dunbar, MD²

¹Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, BETHESDA, MD
²Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD
³Translational Stem Cell Biology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD

Juliette Roels^1,2,3*, Morgan Thénoz^1,3*, Bronisława Szarzyńska^4*, Mattias Landfors^5*, Stien De Coninck^1,6*, Lisa Demoen^1,3*, Lien Provez^1,3*, Anna Kuchmiy^6*, Steven Strubbe^6*, Lindy Reunes^1,2,3*, Tim Pieters, PhD^1,2,3*, Filip Matthijssens, PhD^1,3*, Wouter Van Loocke^1,3*, Tim Lammens, PhD^7,8,9*, Barbara De Moerloose, MD, PhD^2,9,10*, Marc R. Mansour, MD, PhD^11*, Utpal Dave, MD^12,13, Steven Goossens, PhD⁶, David J. Curtis, MBBS, PhD¹⁴, Tom Taghon, PhD^6*, Małgorzata Dawidowska, PhD^4*, Sofie Degerman, PhD^5* and Pieter Van Vlierberghe, PhD^1,2,3

¹Center for Medical Genetics, Ghent University, Ghent, Belgium
²Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium
³Department for Biomolecular Medicine, Ghent University, Ghent, Belgium
⁴Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
⁵Department of Medical Biosciences, Medical and Clinical Genetics, Umeå University, Umeå, Sweden
⁶Department of Diagnostic Sciences, Ghent University, Ghent, Belgium
⁷Department of Pediatric Hemato-oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
⁸Cancer Research Institute Ghent (CRIG), Ghent, Belgium
⁹Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
¹⁰Belgium Society of Paediatric Hematology Oncology, Ghent, Belgium
¹¹Cancer Institute, Department of Haematology, University College London, London, United Kingdom
¹²Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN
¹³IU Melvin and Bren Simon Cancer Center; Division of Hematology/Oncology, Vanderbilt University Medical Center, Indianapolis, IN
¹⁴Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia

Ryunosuke Saiki, MD^1*, Tetsuichi Yoshizato, MD, PhD¹, Yasuhito Nannya, MD, PhD¹, Yukihide Momozawa, DVM, Ph.D^2*, Chikashi Terao, MD, PhD^3*, Yuichi Shiraishi, PhD^4*, Kenichi Chiba^5*, Hiroko Tanaka^6*, Atsushi Niida, PhD^7*, Seiya Imoto, PhD^8*, Koichi Matsuda, MD, PhD^9*, Takayuki Morisaki, MD, PhD^10*, Yoshinori Murakami, MD, PhD^10*, Yoichiro Kamatani, MD, Ph.D^3,9*, Michiaki Kubo, MD, Ph.D^11*, Satoru Miyano, PhD^6*, Hideki Makishima, MD, PhD¹ and Seishi Ogawa, MD, PhD^1,12,13

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
³Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁴Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center Research Institute, Tokyo, Japan
⁵Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
⁶Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
⁷Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁸Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
⁹Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, Japan
¹⁰Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹¹RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
¹²Department of Medicine, Center for Haematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
¹³Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan

Teng Gao^1*, Ryan Ptashkin, MS^2*, Kelly L. Bolton, MD, PhD³, Christopher Fong, PhD^4*, Barbara Spitzer, MD⁵, Kamal Menghrajani, MD³, Juan E. Arango Ossa, BS^6*, Yangyu Zhou, BS^6*, Elsa Bernard, PhD^7*, Max Levine, MS^8*, Juan Medina, MS^4*, Yanming Zhang, MD^9,10, Sebastià Franch-Expósito, PhD^11*, Minal A Patel, MPH^6*, Lior Braunstein, MD^12*, Daniel Kelly, MS^13*, Mariko Yabe, MD, PhD¹⁴, Ryma Benayed, PhD^2*, Nicole M Caltabellotta, BA^6*, John Philip, BA, MS^15*, Ederlinda Paraiso^16*, Simon Mantha, MD, MPH¹⁷, David B. Solit, MD^18*, Luis Alberto Diaz, MD^19*, Michael F. Berger, PhD^20*, Virginia M. Klimek, MD²¹, Ross L. Levine, MD⁴, Ahmet Zehir, PhD^2*, Sean Devlin, PhD^22* and Elli Papaemmanuil, PhD^6,23

¹Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Pediatrics, BMT Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Center for Molecular Oncology, Center for Heme Malignancies and Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA, New York, NY
⁸Memorial Sloan Kettering Cancer Institute, New York, NY
⁹Department of Pathology, Memorial Sloan Kettering Cancer Center, Chicago, IL
¹⁰Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Information Systems, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁵Department of Health Informatics, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁶Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁷Department of Medicine, Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁸Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁹Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
²⁰Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
²¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²²Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
²³Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY

Sebastià Franch-Expósito, PhD^1*, Preethi Srinivasan, PhD^1*, Ryan Ptashkin, MS^2*, Chaitanya Bandlamudi, PhD^1*, Kelly L. Bolton, MD, PhD³, Erika Gedvilaite^2*, Kamal Menghrajani, MD³, Diana Mandelker, MD, Ph.D^2*, Elizabeth Comen, MD^3*, Larry Norton, MD^3*, Ryma Benayed, PhD^2*, Teng Gao^4,5*, Elli Papaemmanuil, PhD^6,7, Barry S Taylor, PhD^1,8,9*, Ross L. Levine, MD^3,4,9, Michael F. Berger, PhD^1,2,9* and Ahmet Zehir, PhD^2*

¹Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York
⁷5Computational Oncology Service, Department of Epidemiology & Biostatistics, Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY