-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

613.O2.6 613. Acute Myeloid Leukemia: Molecular Mutations and Their Prognostic Implications

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
AML, Adult, Biological, Diseases, Combinations, Elderly, Therapies, Pediatric, Biological Processes, enzyme inhibitors, Young Adult, Study Population, Myeloid Malignancies, Clinically relevant, hematopoiesis
Sunday, December 6, 2020: 12:00 PM-1:30 PM
Moderators:
Courtney D. DiNardo, MD, MSc, UT MD Anderson Cancer Center and Michael R. Grunwald, MD, Johns Hopkins University
Disclosures:
DiNardo: AbbVie: Consultancy, Honoraria, Research Funding; Takeda: Honoraria; Daiichi Sankyo: Consultancy, Honoraria, Research Funding; ImmuneOnc: Honoraria, Research Funding; Jazz: Honoraria; Agios: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria, Research Funding; Novartis: Consultancy; MedImmune: Honoraria; Calithera: Research Funding; Notable Labs: Membership on an entity's Board of Directors or advisory committees.
12:00 PM

Sara Zarnegar-Lumley, MD1, Todd A. Alonzo, PhD2,3*, Megan Othus, PhD4, Zhuoxin Sun, PhD5*, Rhonda E. Ries, MA6*, Yi-Cheng Wang, MS2*, Amanda R. Leonti, MS7*, Matthew A. Kutny, MD8, Derek Stirewalt, MD6,9*, Jerald P. Radich, MD6, Frederick R. Appelbaum, MD6, Era L Pogosova-Agadjanyan, BS6*, Kristen Marie O'Dwyer, MD10, Harry P. Erba, MD, PhD11, Omar Abdel-Wahab, MD 12,13, Martin S. Tallman, MD 14,15, Mark Litzow, MD16, Ehab L. Atallah, MD17, Selina M. Luger, MD, FRCPC18, Ross L. Levine, MD12,13, Todd M. Cooper, DO19, Alan S. Gamis, MD, MPH20, Richard Aplenc, MD, PhD21, Anders E. Kolb, MD22, Soheil Meshinchi, MD, PhD23 and Katherine Tarlock, MD6,19

1Vanderbilt University Medical Center, Nashville, TN
2Children's Oncology Group, Monrovia, CA
3Department of Preventive Medicine, University of Southern California, Monrovia, CA
4Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA
5Dana Farber Cancer Institute, ECOG-ACRIN Statistical Center, Boston, MA
6Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
7Clinical Research Division, Fred Hutchinson Cancer Research Center, Mountlake Terrace, WA
8Department of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL
9Departments of Oncology and Hematology, University of Washington, Seattle, WA
10University of Rochester Medical Center, Rochester, NY
11Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC
12Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
13Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
14Memorial Sloan-Kettering Cancer Center, New York, NY
15Weill Cornell Medical College, New York, NY
16Division of Hematology, Mayo Clinic, Rochester, MN
17Medical College of Wisconsin, Wauwatosa, WI
18Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
19Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA
20Hematology/Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO
21Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
22Division of Oncology, Nemours/Alfed I. duPont Hospital For Children, Wilmington, DE
23Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA

12:15 PM

Badder Kattih, MD1*, Amir Shirvani2*, Piroska Klement3*, Abel Martin Garrido4*, Razif Gabdoulline3*, Alessandro Liebich3*, Maximilian Brandes3*, Anuhar Chaturvedi, PhD3*, Timon Seeger5*, Felicitas Thol3, Gudrun Gohring, Prof., MD6*, Brigitte Schlegelberger, MD6, Robert Geffers, PhD7*, David John8*, Udo Bavendiek2*, Johann Bauersachs2*, Arnold Ganser3, Joerg Heineke4* and Michael Heuser3

1Department of Cardiology, University Hospital Frankfurt, Frankfurt Am Main, Germany
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
3Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
4Department of Cardiovascular Physiology, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany
5Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
6Department of Human Genetics, Hannover Medical School, Hannover, Germany
7Genome Analytics Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
8Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt am Main, Germany

12:30 PM

Nicholas J. Short, MD1, Guillermo Montalban-Bravo, MD1*, Hyunsoo Hwang2*, Jing Ning, PhD2*, Miguel Franquiz1*, Rashmi Kanagal-Shamanna, MD3, Keyur Patel, MD, PhD4*, Courtney D. Dinardo, MD, MSc1, Farhad Ravandi, MBBS1, Guillermo Garcia-Manero, MD1, Koichi Takahashi, MD, PhD1, Marina Konopleva, MD, PhD1, Naval Daver, MD1, Elias Jabbour, MD1, Musa Yilmaz, MD1, Ghayas C. Issa, MD1, Michael Andreeff, MD, PhD1 and Tapan M. Kadia, MD1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX

12:45 PM

Frank G. Rücker, MD1*, Ling Du, PhD2*, Tamara J. Blätte, PhD3*, Axel Benner4*, Julia Krzykalla, PhD4*, Insa Gathmann5*, Maria Teresa Voso, MD6, Sergio Amadori7, Thomas W. Prior8*, Joseph M Brandwein, MD9, Frederick R. Appelbaum, MD10, Bruno C. Medeiros, MD11, Martin S. Tallman, MD 12, Lynn Savoie, MD13*, Jorge Sierra, MD14, Celine Pallaud, PhD5*, Miguel A. Sanz, MD15, Joop Jansen, PhD16, Dietger Niederwieser, MD, PhD17, Thomas Fischer, MD18, Gerhard Ehninger, MD19, Michael Heuser20, Arnold Ganser20, Lars Bullinger, MD3, Richard A. Larson, MD21, Clara D. Bloomfield, MD8, Richard M. Stone, MD22, Hartmut Döhner1, Christian Thiede, MD19 and Konstanze Dohner, MD1

1Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
2Novartis Pharmaceuticals, Cambridge, MA
3Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Berlin, Germany
4Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
5Novartis Pharmaceuticals, Basel, Switzerland
6University of Rome Tor Vergata, Rome, Italy
7Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
8Comprehensive Cancer Center, The Ohio State University, Columbus, OH
9Division of Hematology, University of Alberta, Edmonton, AB, Canada
10Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
11Division of Hematology, Stanford Comprehensive Cancer Center, Stanford University, Standford, CA
12Memorial Sloan-Kettering Cancer Center, New York, NY
13University of Calgary, Alberta Health Services, Calgary, AB, Canada
14Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
15Hospital Universitario la Fe, Hematology Department, Department of Medicine, University of Valencia, Valencia, Spain
16Radboud Institute Molecular Studies, Radboud University Medical Center, Nijmegen, Netherlands
17Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
18Department of Hematology and Oncology, Otto-von-Guericke University, Medical Center, Magdeburg, Germany
19Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der TU Dresden, Dresden, Germany
20Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
21Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
22Department of Medical Oncology, Dana-Farber Cancer Institute, Boston

1:00 PM

Raffaele Palmieri, MD1*, Francesco Buccisano, MD1, Alfonso Piciocchi, MS2*, Valentina Arena, MS2*, Anna Candoni3*, Lorella MA Melillo, MD4*, Valeria Calafiore5*, Roberto Cairoli, MD6*, Paolo De Fabritiis, MD7*, Gabriella Storti8*, Prassede Salutari, MD9*, Francesco Lanza, MD10*, Giovanni Martinelli, MD11,12, Mario Luppi13*, Saveria Capria, MD14*, Luca Maurillo15*, Maria Ilaria Del Principe1*, Giovangiacinto Paterno1*, Maria Teresa Voso, MD16, Tiziana Ottone1*, Serena Lavorgna1*, Paola Fazi, MD2*, Marco Vignetti, MD17*, William Arcese, MD, PhD1,18 and Adriano Venditti, MD 1

1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
2GIMEMA Foundation, Rome, Italy
3Hematology, Azienda Sanitaria Integrata di Udine, Udine, ITA
4IRCCS CASA SOLLIEVO DELLA SOFFERENZA, San Giovanni Rotondo, ITA
5Division of Hematology, Azienda Policlinico-OVE, University of Catania, Rodolico, Italy
6Department of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
7Department of Hematology S. Eugenio Hospital, Rome, Italy, Roma, Italy
8Azienda Ospedaliera di rilievo Nazionale, S.G. Moscati, Avellino, ITA
9Bone Marrow Transplant Center, Department of Hematology, Transfusion Center and Biotechnology, Presidio Ospedaliero Spirito Santo, Pescara, Italy
10Division of Hematology, Onco-hematologic Department, AUSL della Romagna, Ravenna, Italy
11Institute of Hematology “L. e A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine, Bologna, Italy
12Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST IRCCS, Meldola, Italy
13Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Modena, Italy
14Department of Translational and Precision Medicine, Sapienza University, Division of Hematology, Rome, Italy
15Hematology Department, Tor Vergata University Hospital, Rome, Italy, Rome, Italy
16University of Rome Tor Vergata, Rome, Italy
17GIMEMA Foundation, Roma, ITA
18Tor Vergata University of Rome, Rome Transplant Network, Rome, Italy

1:15 PM

Eline J.M. Bertrums, MD1,2,3*, Jenny L. Smith, MSc, MEd4*, Rhonda E. Ries, MA4*, Todd A. Alonzo, PhD5*, Fabiana Ostronoff, MD4, Gertjan J.L. Kaspers, Prof. MD, PhD1, Henrik Hasle, MD6, Christian M. Zwaan1,2*, Betsy A Hirsch, PhD7*, Susana C. Raimondi, PhD8, Todd M. Cooper, DO9, Richard Aplenc, MD, PhD10, Alan S. Gamis, MD, MPH11, Edward A. Kolb, MD12, Bianca F. Goemans, MD, PhD1 and Soheil Meshinchi, MD, PhD13

1Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
2Department of Pediatric Oncology/Hematology, Erasmus Medical Center, Rotterdam, Netherlands
3Oncode Institute, Utrecht, Netherlands
4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
5University of Southern California, Los Angeles, CA
6Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
7Children's Oncology Group, Monrovia, CA
8Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
9Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, WA
10Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
11Children's Mercy Kansas City, Kansas City, MO
12Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
13Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA

*signifies non-member of ASH