62nd ASH Annual Meeting and Exposition: 311. Disorders of Platelet Number or Function: Thrombotic Thrombocytopenic Purpura and Platelet Dysfunction

Oral and Poster Abstracts
Oral

Adult, antibodies, anticoagulant drugs, Biological, Coronaviruses, SARS-CoV-2/COVID-19, Diseases, Bleeding and Clotting, Non-Biological, platelets, Therapies, Pediatric, Biological Processes, Platelet Disorders, Immune Disorders, Cell Lineage, immunotherapy, Study Population, Clinically relevant, Thrombocytopenias, Thrombotic Disorders, TTP, inflammation

Moderators:

Elizabeth E. Gardiner, PhD, Australian National University and Aric D. Parnes, MD, Brigham and Women's Hospital

Disclosures:

Parnes: I-Mab: Consultancy; Sigilon: Consultancy; UniQure: Consultancy; Shire/Takeda: Consultancy, Research Funding; Bayer: Consultancy; Sunovion: Consultancy; Genentech: Research Funding.

12:00 PM

376

Thrombotic Microangiopathy Variants Are Independently Associated with Critical Disease in COVID-19 Patients

Eleni Gavriilaki, MD¹, Panagiotis G Asteris²^*, Styliani Kokoris, MD PhD³^*, Tasoula Touloumenidou¹^*, Evdoxia Koravou⁴^*, Maria Koutra⁵^*, Vassiliki Karali⁶^*, Lila Papalexandri, MD⁷^*, Fani Chatzopoulou⁸^*, Maria Chatzidimitriou⁹^*, Dimitrios Chatzidimitriou⁸^*, Anastasia Veleni¹⁰^*, Savvas Grigoriadis¹¹^*, Eulampia Konstantinidou¹²^*, Diamantis Chloros¹³^*, Ioannis Kioumis, MD PhD¹⁴^*, Evaggelos Kaimakamis¹⁵^*, Milly Bitzani¹⁶^*, Dimitrios Boumpas, MD PhD¹⁷^*, Argyrios Tsantes, MD PhD¹⁸^*, Damianos Sotiropoulos, MD¹⁹, Ioanna Sakellari, MD PhD¹^* and Achilles Anagnostopoulos¹

¹Hematology Department and HCT Unit, George Papanikolaou General Hospital, Thessaloniki, Greece
²Computational Mechanics Laboratory, School of Pedagogical and Technological Education, Athens, Greece
³Laboratory of Hematology and Hospital Blood Transfusion Department, University General Hospital “Attikon”, National and Kapodistrian University of Athens, Medical School; Greece, Athens, Greece
⁴Hematology Department & HCT Unit, G. Papanikolaou Hospital, Thessaloniki, Greece
⁵Hematology Department - BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁶Rheumatology and Clinical Immunology Unit, "Attikon" University Hospital, Athens, GRC
⁷Hematology Department - HCT Unit, George Papanikolaou Hospital, Thessaloniki, Greece
⁸Microbiology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece
⁹Biomedical Sciences Alexander Campus International Hellenic University, Thessaloniki, Greece
¹⁰Infectious Disease Committee, G Papanicolaou Hospital, Thessaloniki, Greece
¹¹Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
¹²Laboratory of Hematology and Hospital Blood Transfusion Department, University General Hospital “Attikon”, Athens, Greece
¹³Pneumonology Department, G Papanicolaou Hospital, Thessaloniki, Greece
¹⁴Respiratory Failure Department, G Papanicolaou Hospital-Aristotle University of Thessaloniki, Thessaloniki, Greece
¹⁵G Papanicolaou Hospital, 1st Intensive Care Unit, Thessaloniki, Greece
¹⁶1st Intensive Care Unit, G Papanicolaou Hospital, Thessaloniki, Greece
¹⁷Attikon" University Hospital, Rheumatology and Clinical Immunology Unit, Athens, Greece
¹⁸Attiko Hospital, Athens, Greece
¹⁹Heamatology Clinic, General Hospital of Thessaloniki G Papanikolaou, Thessaloniki, Greece

12:15 PM

377

Cardiovascular Disease Is a Leading Cause of Death in Thrombotic Thrombocytopenic Purpura (TTP) Survivors

Senthil Sukumar, MD¹, Max Brodsky, MD², Sarah Hussain³^*, Spero Cataland¹ and Shruti Chaturvedi, MBBS, MS⁴

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Department of Medicine, Johns Hopkins University, Baltimore, MD
³Johns Hopkins University, Baltimore
⁴Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

12:30 PM

378

Increased Activated Circulating T Follicular Helper Cells and Changes in B Cell Subsets in Immune TTP (iTTP) and in Response to Rituximab Treatment

Jin-Sup Shin¹^*, Geraldine Cambridge, PhD²^*, Yanping Guo, DPhil³^*, Marie Scully, MD⁴ and Mari Thomas⁵^*

¹Department of Haematology, University College London Hopsital, London, United Kingdom
²Centre for Rheumatology, University College London, London, United Kingdom
³Cancer Institute, UCL, LONDON, GBR
⁴Department of Haematology, University College London Hospitals, Cardiometabolic Program, National Institute for Health Research UCLH/UCL Biomedical Research Centre, London, United Kingdom
⁵Department of Haematology, University College London Hospitals, Cardiometabolic Program, National Institute for Health Research UCLH/UCL Biomedical Research Centre, London, ENG, United Kingdom

12:45 PM

379

Outcomes of a Clinician-Directed Protocol for Discontinuation of Complement Inhibition Therapy in Atypical Hemolytic Uremic Syndrome

Noor Dhaliwal¹^*, Sarah Hussain²^*, Harshvardhan Upreti¹^*, Evan M Braunstein, MD, PhD³, Xuan Yuan, MD, MSc⁴, Alison R. Moliterno, MD³, Robert Brodsky, MD⁵ and Shruti Chaturvedi, MBBS, MS³

¹University of Delhi, New Delhi, India
²Division of Hematology, Johns Hopkins University, Baltimore, MD
³Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Hematology/Medicine, Johns Hopkins University School Medicine, Baltimore, MD
⁵Johns Hopkins University, Baltimore, MD

1:00 PM

380

Transcription Factor RUNX1 Regulates Factor FXIIIA Subunit (F13A1) Expression in Megakaryocytic Cells and Platelet F13A1 Expression is Downregulated in RUNX1 Haplodeficiency

Natthapol Songdej, MD, MPH^1,2^*, Fabiola Del carpio-cano, MS¹^*, Guangfen Mao, MD¹^*, Jeremy Wurtzel³^*, Lawrence Goldfinger, PhD⁴^*, Michele P. Lambert, MD, MSTR⁵ and Angara Koneti Rao, MBBS⁶

¹Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
²Penn State College of Medicine, Hershey, PA
³Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA
⁴Cardeza Foundation for Hematologic Research, Thomas Jefferson Unversity, Philadelphia, PA
⁵Department of Pediatrics, Division of Hematology, Children's Hosp. of Phila., Philadelphia, PA
⁶Sol Sherry Thrombosis Research Center and Hematology Section, Lewis Katz School of Medicine at Temple University, Philadelphia, PA

1:15 PM

381

Platelet Dysfunction and Persistent Fibrinolysis in Pediatric Scoliosis Surgery Patients Receiving Tranexamic Acid

Matthew Duvernay, PhD¹^*, Breanne HY Gibson, BSc², Lydia Joy Mckeithan¹^*, Alexandra J. Borst, MD^3,4 and Jonathan Schoenecker, MD DPhil³^*

¹Vanderbilt University, Nashville, TN
²Department of Pharmacology, Vanderbilt University, Nashville, TN
³Vanderbilt University Medical Center, Nashville, TN
⁴Pediatric Hematology Oncology, Nashville, TN

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

311.O2.6 311. Disorders of Platelet Number or Function: Thrombotic Thrombocytopenic Purpura and Platelet Dysfunction