Lesley Mitchell, MD^1*, Daniel Röshammar, PhD^2*, Fenglei Huang, PhD^3*, Manuela Albisetti, MD^4*, Leonardo R. Brandao, MD⁵, Lisa Bomgaars, MD^6*, Elizabeth Chalmers, MD^7*, Jacqueline Halton, MD^8*, Matteo Luciani, MD^9*, David Joseph, PhD^3*, Igor Tartakovsky, MD^10*, Savion Gropper, MD^11*, Martina Brueckmann, MD^10,12* and Joachim Stangier, PhD^13*

¹University of Alberta, Edmonton, Canada
²Pharmetheus AB, Uppsala, Sweden
³Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT
⁴Hematology Department, University Children's Hospital, Zurich, Switzerland
⁵Paediatric Haemotology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
⁶Department of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX
⁷Royal Hospital for Children, Glasgow, United Kingdom
⁸University of Ottawa, Children’s Hospital of Eastern Ontario, Ottawa, Canada
⁹Pediatric Hematology/Oncology Department, Pediatric Hospital Bambino Gesù, Rome, Italy
¹⁰Therapeutic Area Cardiovascular Medicine, Boehringer Ingelheim International GmbH, Ingelheim, Germany
¹¹Therapeutic Area Inflammation Medicine, Boehringer Ingelheim International GmbH, Ingelheim, Germany
¹²Faculty of Medicine Mannheim of the University of Heidelberg, Mannheim, Germany
¹³Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

Christina U Lorentz, PhD^1,2*, Norah G Verbout, PhD^1,2*, Joseph J Shatzel, MD^1,3, Michael Wallisch, PhD^1,2*, Brandon D Markway, PhD^2*, Monica T Hinds, PhD^1*, Owen J T McCarty, PhD^1*, David Gailani, MD⁴, Jeffrey I. Weitz, MD, FRCPC^5,6,7,8, Erik I Tucker, PhD^1,2 and András Gruber, MD^2*

¹Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR
²Aronora, Inc., Portland, OR
³Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁴Vanderbilt University, Nashville, TN
⁵Thrombosis & Atherosclerosis Research Institute, Hamilton, Canada
⁶Department of Medicine, Hematology and Thromboembolism, McMaster University, Hamilton, Canada
⁷McMaster University, and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Canada
⁸McMaster University, Hamilton, ON, Canada

Jack Ansell, MD¹, Bryan Laulicht, PhD^2*, Sasha Bakhru, PhD^3*, Xiaohui Luo, PhD^4* and Stephen Villano, MD^4*

¹Hofstra Northwell school of medicine, Hempstead, NY
²Landsdowne Laboratories, Inc., Fairfield, CT
³Perosphere Technologies Inc., Danbury, CT
⁴Amag Pharmaceuticals, Inc., Waltham, MA

Jacqueline Halton, MD^1*, Leonardo R. Brandao, MD², Matteo Luciani, MD^3*, Lisa Bomgaars, MD^4*, Elizabeth Chalmers, MD^5*, Lesley Mitchell, MD^6*, Ildar Nurmeev, MD^7*, Anjali Sharathkumar, MD⁸, Pavel Svirin, MD^9*, Kirill Gorbatikov, MD^10*, Igor Tartakovsky, MD^11*, Monika Simetzberger, DI^12*, Fenglei Huang, PhD^13*, Zhichao Sun, PhD^14*, Jörg Kreuzer, MD^15*, Savion Gropper, MD^16*, Martina Brueckmann, MD^11,17* and Manuela Albisetti, MD^18*

¹University of Ottawa, Children’s Hospital of Eastern Ontario, Ottawa, Canada
²Paediatric Haemotology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
³Pediatric Hematology/Oncology Department, Pediatric Hospital Bambino Gesù, Rome, Italy
⁴Department of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX
⁵Royal Hospital for Children, Glasgow, United Kingdom
⁶University of Alberta, Edmonton, Canada
⁷Pediatric Hospital, Kazan, Republic of Tatarstan, Russian Federation
⁸Stead Family Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA
⁹Pediatric Hematology Department, Municipal Children’s Hospital ‘Morozovskaya’, Moscow, Russian Federation
¹⁰Pediatric Cardiovascular Surgery, Regional hospital #1, Tyumen region, Russian Federation
¹¹Therapeutic Area Cardiovascular Medicine, Boehringer Ingelheim International GmbH, Ingelheim, Germany
¹²Department of Clinical Development, Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria
¹³Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT
¹⁴Biostatistics and Data Sciences, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT
¹⁵Regional Operating Unit South East Asia and South Korea, Boehringer Ingelheim Singapore Pte. Ltd, The Concourse, Singapore
¹⁶Therapeutic Area Inflammation Medicine, Boehringer Ingelheim International GmbH, Ingelheim, Germany
¹⁷Faculty of Medicine Mannheim of the University of Heidelberg, Mannheim, Germany
¹⁸Hematology Department, University Children’s Hospital, Zürich, Switzerland

Amanda P. Waller, PhD^1*, Katelyn J Wolfgang^1*, Tasha K Wilkie, PhD^1*, Sagar Bhayana, PhD^1* and Bryce A. Kerlin, MD^2,3

¹The Research Institute at Nationwide Children's Hospital, Columbus, OH
²Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, Columbus, OH
³Center for Clinical and Translational Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, Division of Hematology/Oncology/BMT, The Ohio State University College of Medicine, Nationwide Children’s Hospital, Columbus, OH

Kristen M. Sanfilippo, MD^1,2, Mark A Fiala, MSW^3*, Harsha Tathireddy, MD^4*, Dan Feinberg^3*, Ravi Vij, MD, MBA⁵ and Brian F. Gage, MD, MSc^6*

¹Department of Medicine, Division of Hematology, Washington University School of Medicine, Chesterfield, MO
²St. Louis Veterans Affairs Medical Center Research Service, Saint Louis, MO
³Washington University School of Medicine, Saint Louis, MO
⁴St Joseph Memorial Hospital, Southern Illinois Healthcare, Murphysboro, IL
⁵Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO
⁶Washington University in School of Medicine, St. Louis, MO