62nd ASH Annual Meeting and Exposition: 401 Basic Science and Clinical Practice in Blood Transfusion: COVID-19 Convalescent Plasma and Transfusion Immunology I

Oral and Poster Abstracts
Oral

Coronaviruses, antibodies, apheresis, Biological, SARS-CoV-2/COVID-19, Therapies, Combinations, blood banking, blood product storage, Technology and Procedures, Clinically relevant, transfusion

Moderators:

Sean R. Stowell, MD, PhD, Emory University and Marie Alice Hollenhorst, MD, PhD, Stanford University

Disclosures:

No relevant conflicts of interest to declare.

2:00 PM

242

Maternal Red Blood Cell Alloimmunization Managed with Intrauterine Blood Transfusion: Predictors of Poor Outcome

Evangelia Vlachodimtropoulou Koumoutsea, MBBS, PhD, BSc¹, Maciej W. Garbowski²^*, Tim VanMieghem, MD, PhD³^*, Shelley Solomon, Laboratory Medicine⁴^*, Nimrah Abbasi⁵^*, Gareth Seaward, MD⁶^*, Rory Windrim, MD⁷^*, Johannes Keunen⁸^*, Edmond Kelly, MB, BCh, BAO, DCH, FRCPC, FAAP⁹^*, Nadine Shehata, MD, FRCPC, MSc¹⁰ and Greg Ryan, MD¹¹^*

¹Mount Sinai Hospital, Toronto, ON, Canada
²Department of Haematology, University College London, London, United Kingdom
³Fetal Medicine Unit MSH and Ontario Fetal Centre, london, Canada
⁴Transfusion Laboratory, Mount Sinai Hospital, Toronto, Canada
⁵Mount Sinai Hospital, Fetal Medicine, Toronto, ON, Canada
⁶University of Toronto, Fetal Medicine Unit MSH and Ontario Fetal Centre, Toronto, Canada
⁷University of Toronto, Fetal Medicine Unit MSH and Ontario Fetal Centre, Torondo, Canada
⁸Fetal Medicine Unit MSH and Ontario Fetal Centre, Toronto, Canada
⁹The hospital for sick children, Toronto, Canada
¹⁰Medicine and Laboratory Medicine and Pathobiology, Mount Sinai Hospital, Toronto, ON, Canada
¹¹University of Toronto, Fetal Medicine Unit MSH and Ontario Fetal Centre, Toronto, ON, Canada

2:15 PM

243

Genetic Basis of Erythrocyte Alloimmunization Among Children with Sickle Cell Anemia in the Dominican Republic

Kristina Prus, MD¹, Rosa M. Nieves, MD²^*, Thad A. Howard, MS³^*, Susan E. Stuber, MA⁴^*, Rafael Mena, MD⁵^*, Teresa Latham, MA⁴^* and Russell E. Ware, MD, PhD⁴

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Robert Reid Cabral Hospital, Santo Domingo, Dominican Republic
³Division of Hematology, Cincinnati Children's Research Hospital, Cincinnati, OH
⁴Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Centro de Obstetricia y Ginecología, Santo Domingo, Dominican Republic

2:30 PM

244

Impact of Blood Group Type on Severity of Disease in COVID-19 Patients

Shivani Rao¹^*, Surbhi Warrior, MD MPH²^*, Sefer Gezer, MD^3,4, Parameswaran Venugopal, MD^3,4 and Shivi Jain, MD, MBBS^3,4

¹Rush University Medical Center, Chicago, IL
²Department of Internal Medicine, Rush University Medical Center, Chicago, IL
³Division of Hematology Oncology, Rush University Medical Center, Chicago, IL
⁴Rush University Cancer Center, Chicago, IL

2:45 PM

245

Efficacy of COVID-19 Pathogen Inactivated Convalescent Plasma for Patients with Moderate to Severe Acute COVID-19: A Case Matched Control Study

Nina Khanna, MD¹^*, Maja Weisser, MD²^*, Anemone Hedstueck, MD²^*, Sarah Tschudin Sutter, MD, MS²^*, Sandra Roesch, MD²^*, Manuel Battegay, MD³^*, Laura Infanti, MD⁴^*, Andreas Holbro, MD⁴, Michael Paul Busch, MD, PhD⁵, Graham Simmons, MD⁵^*, Philip Felgner, PhD⁶^*, Mars Stone, phD⁵^*, Melissa von Goetz, BS⁷^*, Rafael de Assis, PhD⁸^*, Saahir Khan, PhD⁸^*, Jason Tsai, PhD⁹^*, Peter Robinson, PhD⁹^*, David Seftel, MD, MBA⁹^*, Anil Bagri, MD, PhD¹⁰^*, Laurence Corash, MD¹¹ and Andreas S. Buser, MD¹²^*

¹University Hospital of Basel, Basel, CHE
²University of Basel, Basel, Switzerland
³University of Basel, Division of Infectious Diseases & Hospital Epidemiology, Basel, CHE
⁴Regional Blood Transfusion Service, Swiss Red Cross, Basel, Basel, Switzerland
⁵Vitalant Research Institute, San Francisco, CA
⁶Vaccine Research and Development Laboratory, University of California, Irvine, Irvine, CA
⁷Cerus Corporation, Concord, CA
⁸University of California, Irvine, Irvine, CA
⁹Enable Biosciences, San Francisco, CA
¹⁰Research, Cerus Corporation, San Francisco, CA
¹¹Chief Scientific Office, Cerus Corporation, Concord, CA
¹²Blood Transfusion Ctr., Swiss Red Cross, Basel, Switzerland

3:00 PM

246

Phase I and Preliminary Results of a Phase II Study (TERAPLASCoV2) of Convalescent Plasma in Patients with Severe and Life-Threatening Pneumonia Caused By Sars-Cov-2

Fernando Pérez-Jacobo, MD¹, Luis Villela Villela, MD, MC²^*, Edgar Velásquez-Vega²^*, Jesús Hernández³^*, Melani Otañez, MD⁴^*, Mónica Arellano-Mendoza, MD⁵^*, Rosa Sosa-Camas²^*, Víctor Manríquez-Bonillas²^*, Rubén Bejar-Cornejo²^*, Fausto Pérez²^*, Joanna Chávez-Ochoa²^*, Bernardo Ramos-Vadillo²^*, Mabel Limón-Palafox²^*, Karen Jacobo-López²^*, Alondra Vázquez Hernández²^*, Ofelia Rosales Del Real, MD⁶^*, Lidia Mondragón-Posadas, MD⁷^*, Alma Pérez De la O, MD⁶^*, Pablo Rodríguez-Morales, MD⁷^*, Ma. Luisa Millán Cureño⁸^*, Martha Gómez Meza⁹^*, Cecilia Padilla-Ibarra²^*, Alan Soto-Gaxiola²^*, Edgar Melgoza-Gonzáles³^*, Diana Hinojosa-Trujillo³^*, Emilio Reyes-Jiménez, MD⁵^*, Marcos Serrato-Félix²^*, Hilario Martínez Arredondo¹⁰^* and Rodolfo Lehmann Mendoza¹⁰^*

¹Hematology Department, Hospital Central Norte Petróleos Mexicanos, Ciudad DE Mexico, Cdmx, Mexico
²Hospital General del Estado de Sonora, Hermosillo, Mexico
³Immunology Laboratory, Centro de Investigación en Alimentación y Desarrollo, Hermosillo, Mexico
⁴Hospital General del Estado de Sonora, Hermosillo, Son., Mexico
⁵Hospital Central Norte Pemex, Mexico City, Mexico
⁶Department of Internal Medicine, Hospital Central Norte Pemex, Mexico City, Mexico
⁷Department of Geriatric Medicine, Hospital Central Norte Pemex, Mexico City, Mexico
⁸Hematology Department, Blood Bank Department, Hospital Central Norte Pemex, Mexico City, Mexico
⁹Department of Laboratory Medicine, Hospital Central Norte Pemex, Mexico City, Mexico
¹⁰Subdirección de Servicios de Salud, Petróleos Mexicanos, Mexico City, Mexico

3:15 PM

247

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Moritz Stolla, MD^1,2, Yi Wang, PhD¹^*, Jeffrey Miles¹^*, Barbara Osborne, RN¹^*, Yu Shen¹^*, Lydia Fang, M.S.¹^*, Shawn Lawrence Bailey, BS¹^*, Warren Osborn¹^*, Junmei Chen, PhD¹, Jose A. Lopez, MD, BS^2,3 and Xiaoyun Fu, PhD¹

¹Bloodworks Northwest Research Institute, Seattle, WA
²Department of Medicine, University of Washington, Seattle, WA
³BloodworksNW Research Institute, Seattle, WA

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^*signifies non-member of ASH

401.O1.6 401 Basic Science and Clinical Practice in Blood Transfusion: COVID-19 Convalescent Plasma and Transfusion Immunology I