Jean Fan, BS^1*, Lili Wang, MD, PhD^2,3*, Angela N Brooks, PhD^4,5*, Youzhong Wan, PhD^2,3,6*, Donna S Neuberg, ScD⁷, Laura Z. Rassenti, PhD⁸, Emanuela M. Ghia, PhD⁹, Thomas J. Kipps, M.D., PhD.¹⁰, Jennifer R. Brown, MD, PhD^11,12, Shuqiang Li^13*, Kenneth J Livak^13*, Matthew M. Meyerson, PhD^14*, Peter V. Kharchenko, Ph.D.^1* and Catherine J. Wu, MD^2,3,11

¹Department of Biomedical Informatics, Harvard Medical School, Boston, MA
²Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Broad Institute, Cambridge, MA
⁵University of California, Santa Cruz
⁶School of Life Sciences, Jilin University, Changchun, China
⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁸Moores UCSD Cancer Center, CLL Research Consortium, La Jolla, CA
⁹Moores UCSD Cancer Center, CLL Research Consortium, San Diego, CA
¹⁰Moores Cancer Center, University of California, San Diego, La Jolla, CA
¹¹Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA
¹²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹³Fluidigm Corporation, South San Francisco, CA
¹⁴Broad Institute of MIT and Harvard, Cambridge, MA

Lijian Yu^1,2*, Haesook T. Kim, PhD^3*, Siddha Kasar, PhD^4*, Parul Benien^5*, Wei Du^5*, Kevin Hoang^2*, Reina Improgo, PhD^1,2, Stacey M. Fernandes^4*, Josephine L. Klitgaard, MSc, PhD^1,4*, Charles Lee, PhD^5*, Gady Getz^6*, Sunita R Setlur^7* and Jennifer R. Brown, MD, PhD^1,8

¹Department of Medicine, Harvard Medical School, Boston, MA
²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
³Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Pathology, Brigham and Women’s Hospital, Boston, MA
⁶Broad Institute, Cambridge, MA
⁷Department of Pathology, Brigham and Women's Hospital, Boston, MA
⁸Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Bonnie K. Harrington, DVM^1*, Michael Gulrajani, BS^2*, Todd Covey^2*, Allard Kaptein, PhD^3*, Bart Van Lith^3*, Raquel Izumi, PhD², Ahmed Hamdy, MBBCh², Roger Glenn Ulrich, PhD^2*, John C Byrd, MD⁴, Brian J Lannutti, PhD^2* and Amy J. Johnson, PhD⁴

¹College of Veterinary Medicine, The Ohio State University, Columbus, OH
²Acerta Pharma, Redwood City, CA
³Acerta Pharma, Oss, Netherlands
⁴Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH

Nisar A. Amin^1*, Erlene Kuizon Seymour¹, Peter Ulintz^1*, Kamlai Saiya-Cork^1*, Brian Parkin^1*, Kerby Shedden^2* and Sami N. Malek³

¹University of Michigan, Ann Arbor, MI
²Department of Statistics, University of Michigan, Ann Arbor, MI
³Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

Marco Benkisser-Petersen^1,2*, Maike Buchner^3*, Arlette Dörffel^1*, Marcus Dühren von Minden^4*, Kerstin Leberecht^5*, Kathrin Kläsener^5*, Rainer Claus, MD^6*, Ariane Ott^1*, Christine Dierks^1*, Hassan Jumaa, PhD^4*, Fabio Malavasi^7*, Michael Reth^5*, Hendrik Veelken, MD, PhD⁸ and Katja Zirlik, MD⁹

¹Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
²Albert Ludwigs University, Faculty of Biology, Freiburg, Germany
³Technische Universität München, Institute for Clinical Chemistry and Pathobiochemistry, München, Germany
⁴Department of Immunology, University Medical Center Ulm, Ulm, Germany
⁵BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany
⁶Div. Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
⁷Department of Medical Sciences, University of Torino Medical School, Torino, Italy
⁸Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
⁹Div. Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany

Cecelia R Miller, MS¹, Amy S. Ruppert, MAS^2*, Kevin Coombes, PhD^3*, Amy M. Lehman, MAS^4*, James S. Blachly, MD², David M. Lucas, PhD², Michael R. Grever, MD¹, Martin S Tallman, MD⁵, Ian W. Flinn, MD, PhD⁶, Laura Z. Rassenti, PhD⁷, Thomas J. Kipps, MD, PhD⁷, Deepa Sampath, PhD¹, John C Byrd, MD⁸ and Erin K. Hertlein, PhD¹

¹Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH
²Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
³Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH
⁴Center for Biostatistics, Department of Bioinformatics, The Ohio State University, Columbus, OH
⁵Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Sarah Cannon Research Institute, Nashville, TN
⁷Moores UCSD Cancer Center, CLL Research Consortium, La Jolla, CA
⁸Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH

Mohammad Hojjat-Farsangi, Ph.D¹, Ali Moshfegh, Ph.D^1,2*, Amir Hossein Daneshmanesh, MD, Ph.D^1*, Jan Vågberg^2*, Byström Styrbjörn^2*, Johan Schultz^2*, Elisabeth Olsson^2*, Charlotta Löfberg^2*, Carina Norström^2*, Martin Norin^2*, Thomas Olin, Ph.D^2*, Anders Österborg, MD, PhD^3,4 and Håkan Mellstedt, MD, Ph.D^1*

¹Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden
²Kancera AB, Karolinska Institute Science Park, Stockholm, Sweden
³Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
⁴Department of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

Barbara Kantorova, MSc.^1,2*, Jitka Malcikova, Ph.D.^1,2*, Kamila Brazdilova, MSc.^1,2*, Marek Borsky, MSc.^1*, Karla Plevova, Ph.D.^1,2*, Jana Smardova, Prof.^3*, Martin Trbusek, Ph.D.^1,2*, Yvona Brychtova, Ph.D., MD^1*, Michael Doubek, Prof., MD^1,2, Jiri Mayer^1,2 and Sarka Pospisilova, Prof.^1,2*

¹Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic
²Central European Institute of Technology, Masaryk University, Brno, Czech Republic
³Department of Pathology, University Hospital Brno, Brno, Czech Republic

Iris de Weerdt^1,2*, Sanne Terpstra^1,2*, Tom Hofland^1,2*, Roeland Lameris, MD^3*, Renee C.G. de Bruin^3*, Mark-David Levin, MD PhD⁴, Ester B.M. Remmerswaal, PhD^2,5*, Ineke J.M. ten Berge, MD, PhD^2,5*, Sanne H. Tonino, MD, PhD^1*, Tanja D de Gruijl, PhD^3*, Hans van der Vliet, MD, PhD^3* and Arnon P. Kater, MD, PhD¹

¹Department of Hematology, Academic Medical Center, Amsterdam, Netherlands
²Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands
³Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands
⁴Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
⁵Renal Transplant Unit, Academic Medical Center, Amsterdam, Netherlands

Elisa ten Hacken, PhD^1*, Mariela Sivina, PhD^1*, Li Ping, PhD^1*, Susan O'Brien, MD², William G. Wierda, MD, PhD¹, Alessandra Ferrajoli, MD¹, Zeev Estrov, MD¹, Michael J. Keating, MD¹, Cristina Scielzo^3*, Paolo Ghia, MD, PhD³, Federico Caligaris-Cappio, MD^3* and Jan A. Burger, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of California - Irvine, Orange, CA
³IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy

Slinger Erik, PhD^*, Arnon P. Kater, MD, PhD, Rachel Thijssen, MSc^* and Eric Eldering, PhD^*

Departments of Experimental Immunology and Hematology, Lymphoma and Myeloma Center Amsterdam, Academic Medical Center, Amsterdam, Netherlands

Samantha Drennan, PhD^1*, Annalisa D'Avola, MSc^1*, Yifang Gao, PhD^2*, Eleni Chrysostomou, MSc^1*, Andrew J Steele, PhD^2*, Thorsten Zenz, MD^3,4*, Christoph Plass, PhD^5*, Peter W Johnson, MD⁶, Anthony P Williams, PhD, FRCPath^2*, Graham Packham, PhD^2*, Freda K Stevenson, DPhil², Christopher C. Oakes, PhD^5,7* and Francesco Forconi, MD, DM, PhD, FRCPath^1,8*

¹Cancer Sciences Unit, Haematological Oncology Group, University of Southampton, Southampton, United Kingdom
²Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom
³NCT/DKFZ Heidelberg, Heidelberg, Germany
⁴Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
⁵Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁶Cancer Research UK Clinical Centre, University of Southampton, Southampton, United Kingdom
⁷The Ohio State University, Columbus, OH
⁸Department of Haematology, Southampton University Hospital Trust, Southampton, United Kingdom

Doreen te Raa^1*, Perry Moerland^1*, Alexander Leeksma^1*, Ingrid Derks^1*, Martin Loden^2*, Veronika Navrkalova^3*, Martin Trbusek, Ph.D.^3*, Dieuwertje Luijks^1*, Thorsten Zenz, MD^4*, Anna Skowronska, PhD^5*, Tatjana Stankovic⁵, Mels Hoogendoorn, MD, PhD^6*, Marinus H. J. van Oers⁷, Eric Eldering, PhD^8* and Arnon P. Kater, MD, PhD⁸

¹Academic Medical Center, Amsterdam, Netherlands
²MRC-Holland, Amsterdam, Netherlands
³Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⁴Internal Medicine V, University of Heidelberg, Heidelberg, Germany
⁵School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
⁶Department of Hematology, Medical Center Leeuwarden, Leeuwarden, Netherlands
⁷Department of Hematology, Academic Medical Center Amsterdam, Amsterdam, Netherlands
⁸Departments of Experimental Immunology and Hematology, Lymphoma and Myeloma Center Amsterdam, Academic Medical Center, Amsterdam, Netherlands

Paolo Strati, MD¹, Joon Uhm^1*, Timothy Kaufmann^1*, Sameer A. Parikh, MD², Curtis A. Hanson, MD¹, Kari Chaffee^1*, Sara Achenbach^1*, Timothy G. Call, MD¹ and Tait D. Shanafelt, M.D.¹

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN

Sarah E. M. Herman, PhD^1*, Arnau Montraveta, BS^2*, Carsten U Niemann, MD, PhD¹, Helena Mora-Jensen, PhD^1*, Michael Gulrajani, BS^3*, Fanny Krantz^3*, Bonnie K. Harrington, DVM^4*, Todd Covey^3*, Brian J Lannutti, PhD^3*, Raquel Izumi, PhD³, Roger G Ulrich, PhD^3*, John C. Byrd, MD⁵, Adrian Wiestner, MD, PhD¹, Amy J. Johnson, PhD⁶ and Jennifer A. Woyach, MD⁵

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
³Acerta Pharma, Redwood City, CA
⁴College of Veterinary Medicine, The Ohio State University, Columbus, OH
⁵Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁶Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH

Elisavet Chatzilari^1*, Panagiotis Baliakas^2*, Aliki Xochelli^3,4*, Anastasios Maronidis^1*, Anna Vardi^4,5*, Mattias Mattsson^6*, Karin Larsson^2*, Vassiliki Douka^5*, Michail Iskas, MD^7*, George Karavalakis^8*, Apostolia Papalexandri^5*, Carsten Niemann⁹, Marco Montillo^10*, Achilles Anagnostopoulos⁵, David Oscier¹¹, Sarka Pospisilova^12*, Frederic Davi, MD, PhD^13*, Niki Stavroyianni^5*, Paolo Ghia^14*, Anastasia Hadzidimitriou^4*, Richard Rosenquist², Spiros Nikolopoulos^1*, Kostas Stamatopoulos^2,4* and Yannis Kompatsiaris^1*

¹Information Technologies Institute, CERTH, Thessaloniki, Greece
²Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
³Center for Research and Technology Hellas, Thessaloniki, Greece
⁴Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
⁵Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁶Uppsala University, Uppsala, Sweden
⁷Hematology - BMT Unit, George Papanicolaou General Hospital, Thessaloniki, Greece
⁸Department of Hematology - BMT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
⁹Department of Hematology, Rigshospitalet, Copenhagen, Denmark
¹⁰Molecular Pathology Unit and Haematology Department, Niguarda Cancer Center, Niguarda Ca’ Granda Hospital, Milan, Italy
¹¹Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
¹²Central European Institute of Technology, Masaryk University and University Hospital Brno, Brno, Czech Republic
¹³Department of Biological Hematology, Pitie-Salpetriere Hospital and Pierre et Marie Curie University, Paris, France
¹⁴Division of Experimental Oncology and Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan, Italy

Elisa ten Hacken, PhD^1*, Thomas Oellerich, MD^2*, Maria Gounari, PhD^3*, Julia Hoellenriegel, MS^1*, Kuan-Ting Pan, PhD^4*, Susan O'Brien, MD⁵, William Wierda, MD, PhD⁶, Alessandra Ferrajoli, MD¹, Zeev Estrov, MD¹, Michael J. Keating, MD¹, Henning Urlaub, PhD^4,7*, Paolo Ghia, MD, PhD³ and Jan A. Burger, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematology/Oncology, Goethe-University Hospital, Frankfurt am Main, Germany
³IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milano, Italy
⁴Bioanalytical Mass Spectrometry Group, Max Plank Institute for Biophysical Chemistry, Goettingen, Germany
⁵University of California - Irvine, Orange, CA
⁶Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁷Bioanalytics, Institute for Clinical Chemistry, University Medical Center, Goettingen, Germany

Ana Alicia López-Iglesias^1*, Irena Misiewicz-Krzeminska^1*, Ignacio Criado^2*, Miguel Alcoceba^1*, Susana Hernández-García^1*, Laura San-Segundo^1*, Lorena González-Méndez^1*, Montserrat Martín-Sánchez^1*, Esperanza M Algarín^1*, Teresa Paíno^1*, Mercedes Garayoa^1*, Norma C Gutierrez^1*, Maria-Victoria Mateos¹, Marcos González-Díaz^1* and Enrique M Ocio^1*

¹Complejo Asistencial Universitario de Salamanca (IBSAL) y Centro de Investigación del Cáncer (IBMCC-CSIC). Universidad de Salamanca, Salamanca, Spain
²Complejo Asistencial Universitario de Salamanca (IBSAL) y Centro de Investigación del Cáncer (IBMCC-CSIC). Departamento de Medicina y Citometría. Universidad de Salamanca, Salamanca, Spain

Anke Schilhabel^1*, Henrik Knecht^1*, Anton W. Langerak^2*, Jacques J.M. van Dongen², Michael Kneba¹, Jill Ray^3*, Elizabeth Punnoose^3*, Doris Kim^3*, Thomas Haberberger^3*, Coen Bernaards^3*, Yuda Zhu^3*, Sock-Cheng Lewin-Koh^3* and Matthias Ritgen^1*

¹Hematologic Diagnostic Laboratory, University Clinic Schleswig-Holstein Campus Kiel, Kiel, Germany
²Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands
³Genentech, Inc., South San Francisco, CA

Valentina Griggio, Ms^1*, Candida Vitale, MD^1*, Chiara Riganti, MD^2*, Joanna Kopecka, PhD^2*, Michele Dal Bo^3*, Davide Rossi, MD, PhD⁴, Gabriele Pozzato, MD⁵, Luca Laurenti, MD^6*, Francesco Zallio, MD^7*, Monia Marchetti, MD, PhD^8*, Marina Ruggeri^1*, Paola Omedè^1*, Giovanni Del Poeta, Pr, MD⁹, Valter Gattei, MD³, Gianluca Gaidano, MD, PhD⁴, Mario Boccadoro, MD¹, Massimo Massaia, MD^10* and Marta Coscia, MD, PhD^1*

¹Department of Molecular Biotechnologies and health sciences, Hematology Division, University of Torino, Torino, Italy
²University of Torino, Department of Oncology, Torino, Italy
³Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, Italy
⁴Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
⁵Struttura Complessa Seconda Medicina, Piazza Ospedale 1, Trieste, Italy
⁶Institute of Hematology, Catholic University of the Sacred Heart, Rome, Italy
⁷Divisione di Ematologia, Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
⁸Oncology Unit, Ospedale Cardinal Massaia, ASTI, Italy
⁹Division of Hematology, S. Eugenio Hospital and University of Tor Vergata, Roma, Italy
¹⁰SCDU Ematologia e Terapie Cellulari, Azienda Ospedaliera Ordine Mauriziano di Torino, Torino, Italy

Wei Ding, MD, PhD¹, Sara J Achenbach^2*, Kari G. Chaffee, MS^3*, Timothy G. Call, MD¹, Sameer A. Parikh, MD¹, Susan M. Schwager^4*, Jose F. Leis, MD, PhD⁵, Asher Chanan-Khan, MD⁶, Deborah A. Bowen, APRN, CNP^1*, Michael Conte, PA-C^1*, Susan L. Slager, PhD⁷, Kay Medina, PhD^8*, Neil E. Kay, MD¹ and Tait D. Shanafelt, M.D.¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
³Biomedical Statistics and Infomatics, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁵Department of Hematology, Mayo Clinic, Scottsdale, AZ
⁶Division of Hematology, Mayo Clinic, Jacksonville, FL
⁷Department of Health Sciences Research, Mayo Clinic, Rochester, MN
⁸Division of Immunology, Mayo Clinic, Rochester, MN

Herve Roudot, MD^1,2*, Jennifer Martret^2*, Fanny Baran-Marszak^1,2*, Jean-Francois Collon^1*, Abdemalek Dahmani^1*, Valerie Lefebvre^1*, Xavier Troussard, MD, PhD³, Florence Cymbalista, MD, PhD^1,2, Nadine Varin-Blank, PhD^2* and Remi Letestu, MD, PhD^1,2*

¹Hematology Biology, Hopital Avicenne, AP-HP, Bobigny, France
²INSERM U978, Université Paris 13, Sorbonne Paris Cité, Labex “Inflamex”,, Bobigny, France
³Department of Haematology, C.H.U. de CAEN, Caen, France

Vassiliki Mpakou^1*, Dikea-Eleni Ioannidou, MD^1*, Myrofora Vikentiou^1*, Eugenia Konsta^1*, Aris Spathis^2*, Frieda Kontsioti^1*, Christos Kontos^3*, Diamantina Vasilatou^1*, Anthi Bouchla^1*, Kostas Gontopoulos^1*, Christoforos Roubakis^1*, Georgia Stavroulaki^1*, Nikos Papanikolaou^1*, Maria Atta^1*, Sotiris Papageorgiou^1*, Efi Bazani^1*, Christina Economopoulou^1*, Stela Kokkori^1,4*, Elias Kyriakou^1,4*, George Dimitriadis^1* and Vassiliki Pappa, MD⁵

¹Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Athens, Greece, Athens, Greece
²Department of Cytopathology, School of Medicine, University General Hospital "ATTIKON", University of Athens, Athens, Greece
³Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece, Athens, Greece
⁴Hematology Laboratory, Attikon University General Hospital, Athens, Greece
⁵Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Athens, Greece

Jie Wang, MD^1*, Jennifer J.D. Morrissette, PhD^2*, E. Paul Wileyto, PhD^3*, Stephen J. Schuster, MD¹, Alexandra Vandegrift, BA^4*, Allison Rago, BSN^4*, Colleen Dorsey, BSN^1*, David Porter, MD¹, Daniel J. Landsburg, MD¹, Prioty Islam, MD^1*, Sunita Dwivedy Nasta, MD¹, Jakub Svoboda, MD¹, Alison Loren, MD, MS^1,5, Scott Weber, BS^1*, Edward A. Stadtmauer, MD¹ and Anthony Mato, MD^1*

¹Center for Chronic Lymphocytic Leukemia, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
²Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
⁴Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁵Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA

Massimo Gentile, MD^1*, Tait D. Shanafelt, M.D.², Giovanna Cutrona, PhD^3*, Stefano Molica, MD⁴, Giovanni Tripepi, PhD^5*, Isabel Alvarez^6*, Francesca Romana Mauro, MD, PhD^7*, Nicola Di Renzo^8*, Francesco Di Raimondo⁹, Iolanda D. Vincelli^10*, Katia Todoerti^11*, Serena Matis, PhD^12*, Caterina Musolino^13*, Sonia Fabris, BSc^14*, Ernesto Vigna^15*, Luciano Levato, MD^16*, Simona Zupo^17*, Francesco Angrilli, MD^18*, Ugo Consoli, MD^19*, Gianluca Festini^20*, Giuseppe Longo^21*, Agostino Cortelezzi, MD²², Annalisa Arcari^23*, Massimo Federico²⁴, Donato Mannina, MD^25*, Anna Grazia Recchia, PhD^26*, Neil E. Kay, MD²⁷, Manlio Ferrarini, MD²⁸, Antonino Neri, Pr, MD²⁹ and Fortunato Morabito, MD^30*

¹UOC Ematologia, Ospedale Annunziata, Cosenza, Italy
²Hematology, Mayo Clinic, Rochester, MN
³UO Molecular Patology, IRCCS San Martino-IST, Genoa, Italy
⁴Oncology/Hematology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy
⁵Istituto di Biomedicina ed Immunologia Molecolare,, Consiglio Nazionale delle Ricerche,, Reggio Calabria, Italy
⁶Division of Haematology, Arcispedale S. Maria Nuova/IRCCS, Reggio Emilia, Italy, Reggio Emilia, Italy
⁷Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁸Hematology, Ospedale Vito Fazzi, Lecce, Italy
⁹Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy
¹⁰Hematology Unit, AO di Reggio Calabria, Reggio Calabria, Italy
¹¹Laboratory of Pre-clinical and Translational Research, IRCCS Rionero in Vulture, Rionero in Vulture, Italy
¹²Direzione Scientifica, IRCCS San Martino-IST, Genova, Italy
¹³Section of Hematology, A.O.U. Policlinico, Messina, Italy
¹⁴IRCCS Ca’ Granda Ospedale Maggiore Policlinico and University of Milan, MILAN, Italy
¹⁵Hematology Unit, A.O. of Cosenza, Cosenza, Italy, Cosenza, Italy
¹⁶Section of Hematology, A.O. Pugliese-Ciaccio, Catanzaro, Italy
¹⁷San Martino IST, IRCCS, Genova, Italy
¹⁸Hematology and BMT Center, Spirito Santo Hospital, Pescara, Italy
¹⁹Hematology-Oncology Division,, Garibaldi-Nesima Hospital of Catania, Catania, Italy
²⁰Centro di Riferimento Ematologico-Seconda Medicina, Azianda Ospedaliera Universitaria, Trieste, Italy
²¹Ematologia, Ospedale San Vincenzo, Taormina, Italy
²²Oncohematology Unit, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
²³Department of Oncology and Hematology, G. da Saliceto Hospital, Piacenza, Italy
²⁴Oncologia Medica, Università di Modena e Reggio Emilia, Modena, Italy
²⁵Ospedale Papardo, Messina, Italy
²⁶Unità di Ricerca Biotecnologica, Aprigliano (CS), Italy
²⁷Division of Hematology, Mayo Clinic, Rochester, MN
²⁸Scientific Direction, IRCCS San Martino-IST, Genova, Italy
²⁹Department Medical Sciences, Hematology 1 CTMO, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³⁰Section of Hematology, A.O. L'Annunziata of Cosenza, Cosenza, Italy

Kyle A Udd, BA^1*, Laura Z. Rassenti, PhD², Michael E David, BA^1*, James Wang, MD^1*, Suzie Vardanyan, MS^1*, Julia Linesch^1*, Mingjie Li, BS^1*, Eric Sanchez, BA^1*, Haiming Chen, MD, PhD¹, Tanya M. Spektor, PhD^3*, Thomas J. Kipps, M.D., PhD.² and James Berenson, MD^1,3

¹Institute for Myeloma & Bone Cancer Research, West Hollywood, CA
²University of California San Diego, Moores Cancer Center, La Jolla, CA
³Oncotherapeutics Inc., Los Angeles, CA

Emanuela M. Ghia, PhD¹, Laura Z. Rassenti, PhD², Liguang Chen, MD, PhD^3*, Bing Cui, PhD^3*, Christopher Deboever, BS^4*, Kelly A. Frazer^5* and Thomas J. Kipps, M.D., PhD.⁶

¹Moores UCSD Cancer Center, CLL Research Consortium, San Diego, CA
²Moores UCSD Cancer Center, CLL Research Consortium, La Jolla, CA
³Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁴UCSD, San Diego
⁵Institute of Genomic Medicine, Department of Pediatrics, University of California San Diego, La Jolla, CA
⁶UCSD, Moores Cancer Ctr., La Jolla, CA