Guillermo Garcia-Manero, MD¹, Mikkael A. Sekeres, MD, MS², Miklos Egyed³, Giuliana Alimena, MD⁴, Carlos Graux^5*, Jamie D. Cavenagh, MD⁶, Huda Salman^7*, Arpad Illes, MD, PhD^8*, Pierre Fenaux, MD, PhD⁹, Daniel J. DeAngelo¹⁰, Reinhard Stauder, MD, MSc^11*, Karen Yee, MD¹², Nancy Y Zhu, MD FRCPC^13*, Je-Hwan Lee, MD, PhD¹⁴, David Valcarcel, MD, PhD¹⁵, Alan MacWhannell^16*, Zita Borbenyi, MD, PhD¹⁷, Antje Wegener^18*, Lucien Gazi^19*, Suddhasatta Acharyya, PhD^20*, Florence Binlich^18* and Oliver G. Ottmann, MD^21*

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Houston, TX
²Leukemia Program, Cleveland Clinic, Cleveland, OH
³Kaposi Mór Teaching Hospital, Kaposvár, Hungary
⁴Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁵Mont-Godinne University Hospital, Yvoir, Belgium
⁶Barts Health NHS Trust, London, United Kingdom
⁷Georgia Regents University, Augusta, GA
⁸Department of Hematology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
⁹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁰Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹¹Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
¹²Princess Margaret Hospital, Toronto, Canada
¹³Division of Hematology, University of Alberta, Edmonton, AB, Canada
¹⁴Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
¹⁵Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain
¹⁶The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, United Kingdom
¹⁷2nd Department of Internal Medicine-Hematological Unit, University of Szeged Faculty of Medicine, Szeged, Hungary
¹⁸Novartis Pharma SAS, Rueil-Malmaison, France
¹⁹Novartis Pharma AG, Basel, Switzerland
²⁰Novartis Pharmaceuticals Corporation, East Hanover, NJ
²¹Department of Haematology, Cardiff University, Cardiff, United Kingdom

Uwe Platzbecker, MD¹, Ulrich Germing, MD^2*, Aristoteles Giagounidis, MD, PhD³, Katharina Götze, MD^4*, Philipp Kiewe, MD^5*, Karin Tina Mayer, MD^6*, Oliver Ottmann, MD⁷, Markus Radsak, MD^8*, Thomas Wolff, MD⁹, Detlef Haase, MD^10*, Monty Hankin^11*, Dawn Wilson^11*, Xiaosha Zhang^11*, Abderrahmane Laadem, MD¹², Matthew L. Sherman, MD¹¹ and Kenneth M. Attie, MD¹¹

¹Carl Gustav Carus an der Technischen Universität, Universitätsklinikum, Dresden, Germany
²Universitätsklinikum Düsseldorf, Düsseldorf, Germany
³Marien Hospital Düsseldorf, Düsseldorf, Germany
⁴Technical University of Munich, Munich, Germany
⁵Onkologischer Schwerpunkt am Oskar-Helene-Heim, Berlin, Germany
⁶Department of Internal Medicine III, University Hospital Bonn, Bonn, Germany
⁷Universitätsklinikum Frankfurt, Goethe Universitaet, Frankfurt/Main, Germany
⁸University Medical Center - Johannes Gutenberg-Universität, Mainz, Germany
⁹OncoResearch Lerchenfeld UG, Hamburg, Germany
¹⁰Department of Hematology and Medical Oncology, Universitätsmedizin Göttingen, Göttingen, Germany
¹¹Acceleron Pharma, Cambridge, MA
¹²Celgene Corporation, Summit, NJ

Hagop Kantarjian, MD¹, Ghulam J. Mufti, MD, PhD², Pierre Fenaux, MD, PhD³, Mikkael A. Sekeres, MD, MS⁴, Jeffrey Szer, MB BS FRACP⁵, Uwe Platzbecker, MD⁶, Andrea Kuendgen, MD^7*, Gianluca Gaidano⁸, Wieslaw Wiktor-Jedrzejczak, MD, PhD^9*, Janet Franklin, MD, MPH¹⁰ and Aristoteles Giagounidis, MD¹¹

¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
²Haematological Medicine, King's College London, London, United Kingdom
³Service d'Hématologie Clinique, Hopital Avicenne Université Paris XIII, Bobigny, France
⁴Leukemia Program, Cleveland Clinic, Cleveland, OH
⁵Clinical Haematology, Royal Melbourne Hospital, Melbourne, Australia
⁶Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
⁷Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
⁸Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
⁹Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland
¹⁰Amgen Inc., Thousand Oaks, CA
¹¹Klinik für Onkologie, Hämatologie und Palliativmedizin, Marienhospital Düsseldorf, Düsseldorf, Germany

Mrinal M Patnaik, MBBS¹, Terra L. Lasho, PhD^1*, Pooja Vijayvargiya^1*, Christy Finke, BS^2*, Curtis A. Hanson, MD³, Rhett P. Ketterling, MD^4*, Naseema Gangat, MBBS¹ and Ayalew Tefferi, MD⁵

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Louise De Swart, MD^1*, Chloé Reiniers^2*, Tim Bagguley^3*, David Bowen, MD, PhD⁴, Jaroslav Cermak, MD, PhD,⁵, Eva Hellström-Lindberg, MD, PhD⁶, Aurelia Tatic, MD^7*, Argiris Symeonidis, MD, PhD⁸, Gerwin Huls, MD, PhD^9*, Panagiotis Panagiotidis^10*, Hege Garelius, MD^11*, Dominic Culligan¹², Marta Krejci^13*, Corine van Marrewijk^1*, Jackie Droste, PhD^1*, Alexandra Smith^3*, Dorine W. Swinkels, MD, PhD¹⁴ and Theo de Witte, MD, PhD¹⁵

¹Hematology, Radboudumc, Nijmegen, Netherlands
²Radboudumc, Nijmegen, Netherlands
³Epidemiology and Cancer Statistics Group, University of York, York, United Kingdom
⁴St. James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom
⁵Department of Clinical Hematology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
⁶Division of Hematology, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Stockholm, Stockholm, Sweden
⁷Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
⁸Hematology, University of Patras Medical School, Patras, Greece
⁹Department of Hematology, Radboud university medical center, Nijmegen, Netherlands
¹⁰First Department of Propaedeutic Medicine, University of Athens, Athens, Greece
¹¹Department of Medicine, Sect. of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden
¹²NHS Grampian, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
¹³Dep. of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
¹⁴Dep. of Laboratory Medicine, Radboudumc, Nijmegen, Netherlands
¹⁵Nijmegen Center for Molecular Life Sciences, Dep. of Tumor Immunology, Radboud University of Nijmegen Medical Centre, Nijmegen, Netherlands

Xavier Calvo, MD^1*, Leonor Arenillas, MD^1*, Mar Tormo, MD, PhD², David Valcárcel, MD, PhD³, Elisa Luño, MD, PhD^4*, Esther Alonso, MD^5*, María Díez-Campelo, MD, PhD^6*, Fernando Ramos, MD, PhD, MPH^7*, Carmen Pedro, MD, PhD^8*, Beatriz Arrizabalaga, MD^9*, Alicia Bailén, MD^10*, José María Raya, MD^11*, María Teresa Ardanaz, MD^12*, Guillermo Sanz, MD, PhD¹³ and Lourdes Florensa, MD, PhD^1*

¹Hematological Cytology Laboratory, Hospital del Mar, GRENTHE, IMIM (Hospital del Mar Research Institute), Barcelona, Spain
²Hospital Clínico Universitario de Valencia, Valencia, Spain
³Hospital Vall d'Hebrón, Barcelona, Spain
⁴Hematology, Hospital Universitario Central Asturias, Oviedo, Spain
⁵Hematology, Department of Pathology. Hospital de Bellvitge., Barcelona., Spain
⁶Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
⁷Hospital Universitario de León, León, Spain
⁸Hospital del Mar, Barcelona, Spain
⁹Hospital Universitario Cruces, Spanish MDS Cooperative Group, Bilbao, Spain
¹⁰Hospital Universitario Carlos Haya, Málaga, Spain
¹¹Hospital Universitario de Canarias, Tenerife, Spain
¹²Hospital de Txagorritxu, Vitoria, Spain
¹³Hospital Universitario La Fe, Spanish MDS Cooperative Group, Valencia, Spain

Aaron T. Gerds, MD, MS¹, Alan F. List, MD², Aristoteles Giagounidis, MD, PhD³, Eva Hellström-Lindberg, MD, PhD^4*, Jack Shiansong Li, PhD^5*, Arlene S. Swern, PhD^5*, Mary M. Sugrue, MD, PhD^5*, Pierre Fenaux, MD, PhD⁶ and Mikkael A. Sekeres, MD, MS⁷

¹Leukemia Program, Cleveland Clinic, Cleveland, OH
²Division of Clinical Science, Moffitt Cancer Center and Research Institute, Tampa, FL
³Marien Hospital Düsseldorf, Düsseldorf, Germany
⁴Karolinska University Hospital, Stockholm, Sweden
⁵Celgene Corporation, Summit, NJ
⁶Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
⁷Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH

Takahiro Suzuki, MD, PhD¹, Yasunori Ueda, MD, PhD², Michinori Ogura, MD, PhD^3,4, Toshiki Uchida, MD, PhD^4*, Keiya Ozawa, MD, PhD⁵, Shigesaburo Miyakoshi, MD, PhD^6*, Tomoki Naoe, MD, Ph.D.⁷, Makoto Murata, MD, PhD⁷, Masahiro Kizaki, MD, PhD⁸, Naokuni Uike, MD^9*, Yasunobu Abe, MD, PhD^9*, Michihiro Hidaka, MD, PhD^10*, Shuzo Tagashira^11*, Satoru Tsuchiya^11*, Kazuma Ohyashiki, MD, PhD¹² and Yasushi Miyazaki, MD, Ph.D.¹³

¹Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
²Department of Haematology/Oncology, Kurashiki Central Hospital, Kurashiki City, Okayama, Japan
³Department of Hematology, Tokai Central Hospital, Kakamigahara, Japan
⁴Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
⁵Division of Hematology, Departiment of Medicine, Jichi Medical University, Shimotsuke, Japan
⁶Department of Hematology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
⁷Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁸Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
⁹Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
¹⁰Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
¹¹Sumitomo Dainippon Pharma Co.,Ltd., Tokyo, Japan
¹²Department of Hematology, Tokyo Medical University, Tokyo, Japan
¹³Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

Lionel Ades, MD, PhD¹, Agnes Guerci-Bresler, MD^2*, Pascale Cony-Makhoul, MD^3*, Laurence Legros, MD^4*, Marie Sebert, MD^5*, Thorsten Braun, MD, PhD^6*, Jacques Delaunay, MD^7*, Benedicte Samey^8*, Kristell Desseaux^9*, Sylvie Chevret^10* and Pierre Fenaux, MD, PhD^11,12

¹Service d’Hématologie Séniors, St Louis hospital, University Paris 7, Paris, France
²Hematology department, Hôpital d'Adultes du Brabois, CHU Nancy, Nancy, France
³CHANGE, PRINGY CEDEX, France
⁴Hematology department, Hopital Archet 1, CHU Nice, Nice, France
⁵Hopital Saint Louis, Paris, France
⁶Hematologie Clinique, CHU Avicenne, Bobigny, France
⁷Department of Hematology, Nantes University Hospital, Nantes, France
⁸Groupe Francophone des myélodysplasies, Paris, France
⁹DBIM, Paris, France
¹⁰Biostatistics department, Hôpital Saint-Louis, Paris, France
¹¹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹²Groupe Francais des myélodysplasies (GFM), Paris, France

Mikkael A. Sekeres, MD, MS¹, Arlene S. Swern, PhD^2*, Alan F. List, MD³, Pierre Fenaux, MD, PhD⁴ and Mary M. Sugrue, MD, PhD^2*

¹Leukemia Program, Cleveland Clinic, Cleveland, OH
²Celgene Corporation, Summit, NJ
³Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Carlo Finelli, MD^1*, Cristina Clissa, M.D.^2*, Matilde Follo, PhD^3*, Marta Stanzani, M.D.^1*, Sarah Parisi, M.D.^1*, Sara Mongiorgi, PhD^3*, Paolo Avanzini, MD^4*, Costanza Bosi, M.D.^5*, Barbara Castagnari, M.D.^6*, Anna Candoni, MD^7*, Monica Crugnola, MD^8*, Maria Benedetta Giannini, M.D.^9*, Marco Gobbi, MD^10*, Giovanna Leonardi^11*, Gian Matteo Rigolin^12*, Domenico Russo¹³, Patrizia Tosi^14*, Giuseppe Visani, M.D.^15*, Lucio Cocco, M.D., PhD^3* and Michele Cavo^16*

¹Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
²Hematology and Stem Cell Transplant Center, AORMN Hospital, Pesaro, Italy
³Biomedical Sciences-Human Anatomy, University of Bologna, Bologna, Italy
⁴Hematology, S.Maria Nuova Hospital, Reggio Emilia, Italy
⁵Hematology, Guglielmo da Saliceto Hospital, Piacenza, Italy
⁶Hematology, S. Maria delle Croci Hospital, Ravenna, Italy
⁷Hematology, Santa Maria della Misericordia University Hospital, Udine, Italy
⁸Clinical and Experimental Medicine, University of Parma, Parma, Italy
⁹Oncology, I.R.S.T., Meldola (FC), Italy
¹⁰Chair of Hematology, Department of Internal Medicine (DiMI), IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy
¹¹Hematology, University of Modena, MODENA, Italy
¹²Hematology Section, Azienda Ospedaliero-Universitaria S. Anna, University of Ferrara, Ferrara, Italy
¹³Chair of Hematology, University of Brescia, Brescia, Italy
¹⁴Oncology and Hematology, Infermi Hospital, Rimini, Italy
¹⁵Hematology, S.Salvatore Hospital, Pesaro, Italy
¹⁶Institute of Hematology, Bologna, Italy

Matthieu Duchmann^1*, Thorsten Braun, MD, PhD^2*, Olivier Kosmider, MD, PhD^3*, Aline Renneville^4*, Uwe Platzbecker, MD⁵, Lionel Ades, MD, PhD⁶, Marie Sebert, MD^7*, François Dreyfus, MD^8*, Sophie Park, MD, PhD⁹, Norbert Vey¹⁰, Odile Beyne Rauzy, MD, PhD^11*, Stéphane De Botton, MD, PhD^12*, Jean-Baptiste Micol, MD^13*, Romain Guieze, MD^14*, Jean-Noel M. Bastie, MD, PhD¹⁵, Claude Preudhomme, MD, PhD¹⁶, Michaela Fontenay, MD, PhD^9*, Éric Solary, MD, PhD^17*, Pierre Fenaux, MD, PhD¹⁸ and Raphaël Itzykson, MD, PhD¹⁹

¹Université Paris 7 Diderot, Paris, France
²Clinical Hematology, CHU Avicenne, Bobigny, France
³APHP Laboratoire d'Hématologie, Hôpital Cochin, Paris, France
⁴Hematology Laboratory, CHRU, Lille, France
⁵Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Dresden, Germany
⁶Service d’Hématologie Séniors, St Louis hospital, University Paris 7, Paris, France
⁷Hospital Saint Louis, University Paris 7, Paris, France
⁸Cochin hospital, University Paris 5, Paris, France
⁹Cochin Hospital, University Paris 5, Paris, France
¹⁰Hematology, Institut Paoli-Calmettes, Marseille, France
¹¹IUCT Oncopole, CHU Toulouse, Toulouse, France
¹²Clinical Hematology, Gustave Roussy, Villejuif, France
¹³Gustave Roussy Cancer Center, Villejuif, France
¹⁴Clinical Hematology, CHU Clermont-Ferrand, Clermont Ferrand, France
¹⁵CHU Dijon Bocage, Dijon, France
¹⁶Hôpital Claude Huriez, Lille, France
¹⁷Gustave Roussy, Villejuif, France
¹⁸University Paris 7 Diderot, Hôpital Saint-Louis, Paris, France
¹⁹Hematology Department, Saint-Louis Hospital, University Paris 7, Paris, France

Pragya Srivastava, PhD^1*, Junko Matsuzaki, PhD^2*, Benjamin E. Paluch^3*, Zachary Brumberger^1*, Stephanie Kaufman^2*, Adam R. Karpf, PhD^4*, Kunle Odunsi, MD/PhD^2,5*, Austin Miller, PhD^6*, Justin Kocent^1*, Eunice S. Wang, MD¹, Michael J. Nemeth, PhD^1,5 and Elizabeth A. Griffiths, MD^1,3,5

¹Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
²Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, NY
³Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY
⁴Eppley Institute, Fred & Pamela Buffett Cancer Center, Omaha, NE
⁵Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY
⁶Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY

Bing Li, MD^1*, Jinqin Liu^2*, Shiqiang Qu, MD^1*, Robert Peter Gale, MD, PhD, DSc³, Ruixian Xing^1*, Tiejun Qin^1*, Yue Zhang, MD^2*, Zefeng Xu, MD², Liwei Fang^1*, Hongli Zhang, MD^1*, Lijuan Pan^1*, Naibo Hu^1*, Gang Huang, PhD⁴ and Zhijian Xiao, MD^2*

¹MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Imperial College, London, United Kingdom
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Naseema Gangat, MBBS¹, Mrinal M Patnaik, MBBS¹, Kebede H. Begna, MD², Aref Al-Kali, MD¹, Mark R Litzow, MD¹, Curtis A. Hanson, MD³, Rhett P. Ketterling, MD^4*, Animesh Pardanani, MBBS, PhD⁵ and Ayalew Tefferi, MD²

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Gege Feng, MD^1*, Wen Cui^2*, Wenyu Cai^2*, Tiejun Qin^1*, Yue Zhang, MD^2*, Zefeng Xu, MD², Liwei Fang^1*, Hongli Zhang, MD^1*, Lijuan Pan^1*, Naibo Hu^1*, Bing Li, MD^1* and Zhijian Xiao, MD^2*

¹MDS and MPN Centre, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Guillermo Montalban-Bravo, MD^1*, Guillermo Garcia-Manero, MD², Nicholas J. Short, MD³, Koji Sasaki, MD⁴, Mikkael A. Sekeres, MD, MS⁵, Rami S. Komrokji, MD⁶, David P. Steensma, MD⁷, Amy E. DeZern, MD, MHS⁸, Gail J. Roboz, MD⁹, Tapan Kadia, MD¹⁰, Gautam Borthakur, MD³, Courtney DiNardo, MD³, Darla Miller^3*, Zeev Estrov, MD¹¹, Naveen Pemmaraju, MD³, Naval Daver, MD¹², Marina Konopleva, MD, PhD³, Jorge E. Cortes, MD³, Hagop M. Kantarjian, MD³ and Elias Jabbour³

¹Department of Leukemia, M D Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Leukemia Program, Cleveland Clinic, Cleveland, OH
⁶Malignant Hematology Department, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁷Dana-Farber Cancer Institute, Boston, MA
⁸Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁹Division of Hematology and Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY
¹⁰Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
¹¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
¹²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, Houston, TX

Su Wai Maung, MBBS, MRCP(UK)^1,2*, Niamh Strahan, M.Sc^1*, Philomena O'Byrne, M.Sc^3,4*, Sarah O'Dowd, M.Sc^5*, John O'Loughlin^5*, Ronan Desmond, MD, FRCPath¹, Johnny McHugh, FRCPath^1*, Michael Jeffers, FRCPath^5* and Helen Enright, MD, FRCPI, FRCPath^1,2*

¹Department of Haematology, Tallaght Hospital, Dublin, Ireland
²Department of Haematology, Trinity College Medical School, University of Dublin, Dublin, Ireland
³Department of Pharmacy, Tallaght Hospital, Dublin, Ireland
⁴Trinity College, University of Dublin, Dublin, Ireland
⁵Department of Cellular Pathology, Tallaght Hospital, Dublin, Ireland

Julie Schanz, MD, PhD^1*, Heinz Tüchler^2*, Francesc Sole, PhD³, Guillermo Sanz, MD, PhD⁴, Guillermo Garcia-Manero, MD⁵, Michelle M. Le Beau⁶, John M. Bennett, MD⁷, Marilyn L. Slovak, PhD⁸, Pierre Fenaux, MD, PhD⁹, Luca Malcovati, MD^10*, Mario Cazzola, MD¹⁰, Peter Valent, MD¹¹, Kazuma Ohyashiki, MD, PhD¹², Alessandro Levis¹³, Mikkael A. Sekeres, MD, MS¹⁴, Sudhir Tauro, PhD^15*, Silvia Magalhaes^16*, A. A van de Loosdrecht¹⁷, Jaroslav Cermak, MD, Ph.D.¹⁸, Michael Luebbert, MD^19*, Reinhard Stauder, MD, MSc^20*, Eva Hellstrom-Lindberg, MD, PhD²¹, Tatjana Gindina, MD^22*, Ulrich Germing, MD^23*, Peter Greenberg, MD²⁴ and Detlef Haase, MD^25*

¹Hematology and Medical Oncology, Goettingen, Germany
²Ludwig Boltzmann Institute for Leukemia Resaerch, Vienna, Austria
³MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
⁴Hematology, Hospital Universitario La Fe, Valencia, Spain
⁵Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁶University of Chicago, Chicago, IL
⁷University of Rochester, Rochester, NY
⁸Signature Genomic Laboratories, Spokane, WA
⁹Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁰Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Pavia, Italy
¹¹Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
¹²Department of Hematology, Tokyo Medical University, Tokyo, Japan
¹³Oncology and Hematology, Ospedale Civile, Alessandria, Italy
¹⁴Leukemia Program, Cleveland Clinic, Cleveland, OH
¹⁵Division of Cancer Research, Dundee School of Medicine, Dundee, United Kingdom
¹⁶Federal University of Ceara, Fortaleza, Brazil
¹⁷Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
¹⁸Department of Clinical Hematology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
¹⁹Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
²⁰Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
²¹Dept. of Med., Div. of Hem., Karolinska Institutet, Stockholm, Sweden
²²R.M. Gorbacheva Memorial Institute of Children Hematology and Transplantation, I.P. Pavlov State Medical University, Saint Petersburg, Russia
²³Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
²⁴Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA
²⁵Department of Hematology and Medical Oncology, Georg-August-University Göttingen, Göttingen, Germany

Antonio Almeida, MD, PhD^1*, Valeria Santini, MD², Stefanie Gröpper, MD^3*, Anna Jonasova, MD^4*, Norbert Vey⁵, Aristoteles Giagounidis, MD, PhD³, Eva Hellström-Lindberg, MD, PhD^6*, Ghulam J. Mufti, MD, PhD⁷, Guillermo Sanz, MD, PhD⁸, Barry Skikne, MD⁹, Albert Hoenekopp, MD^10*, Francis Séguy^10*, Jianhua Zhong, PhD^9* and Pierre Fenaux, MD, PhD¹¹

¹Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
²AOU Careggi, University of Florence, Florence, Italy
³Marien Hospital Düsseldorf, Düsseldorf, Germany
⁴1st Department of Medicine, Charles University General Hospital, Prague, Czech Republic
⁵Institut Paoli-Calmettes Centre Régional de Lutte Contre le Cancer, Marseille, France
⁶Karolinska University Hospital, Stockholm, Sweden
⁷King's College Hospital, London, United Kingdom
⁸Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁹Celgene Corporation, Summit, NJ
¹⁰Celgene International, Boudry, Switzerland
¹¹Service d’Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Louis Drevon^1*, Alice Marceau^2*, Virginie Eclache^3*, S. Dominique Raynaud, MD⁴, Valentine Richez^5*, Inès Berkaoui^5*, Odile Maarek^6*, Wendy Cuccuini^6*, Daniel Lusina^7*, Celine Berthon^8*, Sophie Dimicoli-Salazar^9*, Audrey Bidet^10*, Jean-Philippe Vial^10*, Sophie Park, MD, PhD¹¹, Aspasia Stamatoullas, MD^12*, Christina Vieira Dos Santos^13*, Thorsten Braun, MD, PhD^14*, Rosa Sapena^15*, Aline Renneville^16*, Lionel Ades, MD, PhD¹ and Pierre Fenaux, MD, PhD¹

¹Clinical Hematology, CHU Saint-Louis, Paris, France
²Hematology Laboratory, CHRU Lille, Lille, France
³Hematology Laboratory, CHU Avicenne, Bobigny, France
⁴Laboratoire d'Oncohematolgie, Hopital Pasteur, Nice, France
⁵Hematology Laboratory, Hopital Pasteur, Nice, France
⁶Hematology Laboratory, CHU Saint-Louis, Paris, France
⁷Hematology Laboratory, CHU Avicenne, Paris, France
⁸Clinical Hematology, CHRU Lille, Lille, France
⁹Clinical Hematology, CHU Bordeaux, Bordeaux, France
¹⁰Hematology Laboratory, CHU Bordeaux, Bordeaux, France
¹¹CHU de Grenoble, Clinique Universitaire d’Hématologie, Université Joseph Fourier, Grenoble Cedex 9, France
¹²Clinical Hematology, CENTRE HENRI BECQUEREL, Rouen, France
¹³Clinical Hematology, CHU Grenoble, Grenoble, France
¹⁴Clinical Hematology, CHU Avicenne, Bobigny, France
¹⁵Clinical Hematology, CHU Cochin, Paris, France
¹⁶Hematology Laboratory, CHRU, Lille, France

Naseema Gangat, MBBS¹, Terra L. Lasho, PhD^1*, Mrinal M Patnaik, MBBS¹, Christy Finke, BS^2*, Mark R Litzow, MD¹, Curtis A. Hanson, MD³, Rhett P. Ketterling, MD^4*, Animesh Pardanani, MBBS, PhD⁵ and Ayalew Tefferi, MD⁶

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Hematology, Mayo Clinic, Rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
⁶Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Laura Palomo, MSc^1*, Blanca Xicoy, MD, PhD^2*, Montse Arnan, MD^3*, Marta Cabezon^2*, Rosa Coll, MD^4*, Vera Ademà, MSc^1*, Francisco Fuster, MSc^1*, Javier Grau, MD^5*, María José Jiménez^2*, Helena Pomares, MD^6*, Sílvia Marcé, PhD^2*, Maria Pilar Armengol, PhD^7*, Mar Mallo, PhD^1*, Fuensanta Millá, MD, PhD^2*, Evarist Feliu, MD, PhD^2*, Francesc Sole, PhD¹ and Lurdes Zamora, PhD^2*

¹MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
²Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain
³Hematology Service, ICO-Hospital Duran i Reynals, Barcelona, Spain
⁴Hospital Universitario de Girona Dr. Josep Trueta (ICO Girona), Girona, Spain
⁵Hematology Service, Institut Català d'Oncologia. Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain
⁶Hospital Durán i Reynals, Barcelona, Spain
⁷Genomic and Microscopy facilities, Institut Investigació Ciències de la Salut Germans Trias i Pujol, Badalona, Spain

Marie Sebert, MD^1,2*, Aspasia Stamatoullas, MD^3*, Thorsten Braun, MD, PhD^4*, Jacques Delaunay, MD^5*, Benoît de Renzis^6*, Ramzi Jeddi, MD^7*, Balkis Meddeb^8*, Mathilde Hunault Berger^9*, Benedicte Samey^1*, Fatiha Chermat^1*, Sylvie Chevret^10*, Cendrine Chaffaut^11*, Pierre Fenaux, MD, PhD^1,2 and Lionel Ades, MD, PhD^1,12

¹GFM, Hôpital Saint Louis, Paris, France
²Service d’Hématologie Séniors, Hôpital St Louis, Université Paris 7, Paris, France
³Clinical Hematology, CENTRE HENRI BECQUEREL, Rouen, France
⁴Hematologie Clinique, CHU Avicenne, Bobigny, France
⁵Department of Hematology, Nantes University Hospital, Nantes, France
⁶CHU Clermond Ferrand, Clermont Ferrand, France
⁷Aziza Othmana University Hospital, Tunis, Tunisia
⁸Aziza Othmana University Hospital, TUNIS, Tunisia
⁹CHU Angers, Angers, France
¹⁰Statistics St-Louis Hospital, Paris 7, Paris, France
¹¹Departement de biostatistiques, hôpital Saitn-Louis, Paris, France
¹²Service d’Hématologie Séniors, St Louis hospital, University Paris 7, Paris, France

Jenny N Poynter, PhD^1*, Michaela Richardson^1*, Erica Langer^1*, Anthony Hooten^1*, Michelle A. Roesler, BS^1*, Betsy A. Hirsch, PhD^1*, Phuong L. Nguyen, MD², Adina Cioc, MD^3*, Erica Warlick, MD¹ and Julie A Ross, PhD^1*

¹University of Minnesota, Minneapolis, MN
²Hematopathology, Mayo Clinic, Rochester, MN
³Hematopathology, VA Medical Center, Minneapolis, MN

Camille Bigenwald^1*, Stephanie Harel^2*, Florian Chevillon^3*, Damien Roos-Weil^4*, Olivier A. Bernard, PhD^5*, Sandy Amorim, MD^6*, Pauline Brice, MD⁷, Ades Lionel^2*, Anne Marie Nloga^2*, Marie Sébert, MD^8*, Thorsten Braun, MD, PhD^9*, Virginie Eclache^10*, Catherine Thieblemont, MD PhD¹¹ and Pierre Fenaux, MD, PhD¹²

¹Onco-Hematology Department, Hôpital saint Louis/ Paris 7 University, Paris, France
²Hôpital saint Louis/ Paris 7 University, Paris, France
³Hôpital Avicenne / Paris 13 University, paris, France
⁴INSERM U1170, Institut Gustave Roussy, Villejuif, France
⁵Institut Gustave-Roussy, INSERM U985, Villejuif, France
⁶Hospital Saint-Louis, Paris, France
⁷Hematology-Oncology, Hospital Saint Louis, Paris, France
⁸Hospital St Louis, University Paris 7, Paris, France
⁹Clinical Hematology, CHU Avicenne, Bobigny, France
¹⁰Hematology Laboratory, CHU Avicenne, Bobigny, France
¹¹Hemato-Oncology, Hopital Saint-Louis, APHP - INSERM U 728 - Institut Universitaire d'Hematologie, Paris, France
¹²University Paris 7 Diderot, Hôpital Saint-Louis, Paris, France

Wei Shen, PhD^1*, Philippe Szankasi, PhD², Maria Sederberg, MS^2*, Jonathan Schumacher, MS^2*, Kimberly Frizzell, PhD^1*, Elaine P Gee, PhD^3*, Jay L Patel, MD^2,4*, Sarah T. South, PhD^4,5*, Xinjie Xu, PhD^2,4* and Todd W Kelley, MD^2,4

¹Genomics, ARUP Laboratories, Salt Lake City, UT
²ARUP Institute for Clinical and Experimental Pathology®, Salt Lake City, UT
³Clinical Laboratory Informatics and Integration, ARUP Laboratories, Salt Lake City, UT
⁴Department of Pathology, University of Utah, Salt Lake City, UT
⁵ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT

Aziz Nazha, MD¹, Rami S. Komrokji, MD², Guillermo Garcia-Manero, MD³, John Barnard, PhD^4*, Katrina Zell, MA, MS^4*, Cassie Zimmerman, MPH^4*, Najla H. Al Ali, BDS, MSc^5*, Gail J Roboz, MD⁶, David P. Steensma, MD⁷, Amy E. DeZern, MD, MHS⁸, Eric Padron, MD⁵, Elias J. Jabbour, MD³, Molly Dara Greenberg, BS^9*, Alan F. List, MD¹⁰, Hagop M. Kantarjian, MD³, Jaroslaw P. Maciejewski, MD, PhD¹¹ and Mikkael A. Sekeres, MD, MS⁴

¹Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
²H. Lee Moffitt Cancer Center, Tampa, FL
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Leukemia Program, Cleveland Clinic, Cleveland, OH
⁵Malignant Hematology Department, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁶Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
⁷Dana-Farber Cancer Institute, Boston, MA
⁸Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁹Division of Hematology and Oncology, New York Presbyterian Hospital-Weill Cornell Medical College, New York, NY
¹⁰Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
¹¹Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Amy E. DeZern, MD¹, Amer M. Zeidan, MBBS, MHS², John Barnard, PhD^3*, Wesley Hand^4*, Najla Al Ali^5*, Francis Brown^6*, Cassie Zimmerman, MPH^3*, Gail J Roboz, MD⁷, Rami S. Komrokji, MD⁸, Guillermo Garcia-Manero, MD⁹, David P. Steensma, MD⁶ and Mikkael A. Sekeres, MD, MS¹⁰

¹Cancer Research Building 1, Room 3M87, Baltimore, MD
²Yale School of Medicine, New Haven, CT
³Leukemia Program, Cleveland Clinic, Cleveland, OH
⁴Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁵H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁶Dana-Farber Cancer Institute, Boston, MA
⁷Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
⁸Malignant Hematology Department, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰Leukemia Program, Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH

Juan Carlos Caballero, MD^1,2*, Mercedes Sánchez-Barba^3*, Mónica Del Rey^4*, Kamila Janusz^4*, Eva Lumbreras^4*, María Abáigar^4*, Robledo Cristina^4*, Andrés Jerez^5*, Esperanza Such, PhD^6,7*, Guillermo Sanz, MD, PhD^7,8, Cristina Calderon, MD^9*, David Valcarcel, MD, PhD¹⁰, Jesus Maria Hernandez-Rivas, PhD^1,4*, María Consuelo Cañizo, MD, PhD^1,4,7* and María Díez-Campelo, MD, PhD^1,7,11*

¹Hematology, Salamanca Universitary Hospital, Salamanca, Spain
²Servicio de Hematología, Centro de Investigación del Cáncer, IBSAL (Instituto de Biomedicina de Salamanca) y BMCC, Universidad de Salamanca, Salamanca, Salamanca, Spain
³Statistics Department, University of Salamanca, Salamanca, Spain
⁴Servicio de Hematología, Centro de Investigación del Cáncer, IBSAL (Instituto de Biomedicina de Salamanca) y BMCC, Universidad de Salamanca, Salamanca, Spain
⁵Hematology Service, Hospital Universitario Morales Meseguer, Murcia, Spain
⁶Hematology Department, Hospital Universitari i Politecnic La Fe, Valencia, Spain
⁷GESMD, Valencia, Spain
⁸Servicio de Hematologia, Hospital Universitario La Fe, Valencia, Spain
⁹Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS / CSIC), Seville, Spain
¹⁰Hospital Universitario Vall d'Hebron, Spanish MDS Cooperative Group, Barcelona, Spain
¹¹Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain

Johann-Christoph Jann^1*, Daniel Nowak, MD^1*, Florian Nolte^1*, Stephanie Fey^1*, Verena Nowak^1*, Julia Oblaender^1*, Jovita Pressler^1*, Alice Charlotte Fabarius, PhD^1*, Uwe Platzbecker, MD², Aristoteles Giagounidis, MD³, Katharina Goetze, MD^4*, Anne Letsch^5*, Detlef Haase, MD^6*, Richard F. Schlenk, MD⁷, Gesine Bug, MD^8*, Michael Luebbert, MD^9*, Arnold Ganser, M.D.¹⁰, Ulrich Germing, MD^11*, Claudia Haferlach, MD¹², Wolf-Karsten Hofmann, MD¹ and Maximilian Mossner^1*

¹Department of Hematology and Oncology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
²Carl Gustav Carus an der Technischen Universität, Universitätsklinikum, Dresden, Germany
³Medical Clinic II, St. Johannes Hospital, Duisburg, Germany
⁴Technische Universität München, München, Germany
⁵Department of Hematology and Oncology, Charite, Berlin, Germany
⁶Department of Hematology and Medical Oncology, Georg-August-University Göttingen, Göttingen, Germany
⁷University Hospital of Ulm, Ulm, Germany
⁸Department of Medicine, Hematology/Oncology, University of Frankfurt, Frankfurt, Germany
⁹Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany
¹⁰Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹¹Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
¹²MLL Munich Leukemia Laboratory, Munich, Germany

Lionel Ades, MD, PhD¹, Christian Récher, MD PhD², Julie Lejeune^3*, Aspasia Stamatoullas, MD^4*, Marie Sebert, MD^5*, Jacques Delaunay, MD^6*, Benedicte Samey^7*, Krimo Bouabdallah, MD^8*, Thorsten Braun, MD, PhD^9*, Norbert Vey¹⁰, Sophie Park, MD, PhD¹¹, Benoit de Renzis^12*, Sylvie Chevret^13* and Pierre Fenaux, MD, PhD¹⁴

¹Service d’Hématologie Séniors, St Louis hospital, University Paris 7, Paris, France
²Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
³Hôpital Saint Louis, Assistance Publique - Hôpitaux de Paris, Paris, France
⁴Clinical Hematology, CENTRE HENRI BECQUEREL, Rouen, France
⁵Hopital Saint Louis, Paris, France
⁶Department of Hematology, Nantes University Hospital, Nantes, France
⁷Groupe Francophone des myélodysplasies, Paris, France
⁸CHU de Bordeaux, Bordeaux, France
⁹Hematologie Clinique, CHU Avicenne, Bobigny, France
¹⁰Hematology, Institut Paoli-Calmettes, Marseille, France
¹¹CHU de Grenoble, Clinique Universitaire d’Hématologie, Université Joseph Fourier, Grenoble Cedex 9, France
¹²CHU, Clermont-Ferrand, France
¹³Biostatistics department, Hôpital Saint-Louis, Paris, France
¹⁴Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France

Matthieu Duchmann^1*, Thorsten Braun, MD, PhD^2*, Uwe Platzbecker, MD, PhD³, Lionel Adès, MD, PhD^4*, Marie Sébert, MD^5*, François Dreyfus, MD^6*, Sophie Park, MD, PhD⁷, Norbert Vey⁸, Odile Beyne Rauzy, MD, PhD^9*, Stéphane De Botton, MD, PhD^10*, Jean-Baptiste Micol, MD^11*, Céline Berthon, MD, PhD^12*, Romain Guieze, MD^13*, Jean-Noel M. Bastie, MD, PhD¹⁴, Éric Solary, MD, PhD^15*, Pierre Fenaux, MD, PhD¹⁶ and Raphaël Itzykson, MD, PhD¹⁷

¹Université Paris 7 Diderot, Paris, France
²Clinical Hematology, CHU Avicenne, Bobigny, France
³Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
⁴Hospital St Louis, Paris 7 University, Paris, France
⁵Hospital St Louis, University Paris 7, Paris, France
⁶Cochin hospital, University Paris 5, Paris, France
⁷Cochin Hospital, University Paris 5, Paris, France
⁸Hematology, Institut Paoli-Calmettes, Marseille, France
⁹IUCT Oncopole, Toulouse, France
¹⁰Clinical Hematology, Gustave Roussy, Villejuif, France
¹¹Gustave Roussy Cancer Center, Villejuif, France
¹²Hospital Huriez, CHRU de Lille, Lille, France
¹³Clinical Hematology, CHU Clermont-Ferrand, Clermont Ferrand, France
¹⁴CHU Dijon Bocage, Dijon, France
¹⁵Gustave Roussy, Villejuif, France
¹⁶University Paris 7 Diderot, Hôpital Saint-Louis, Paris, France
¹⁷Hematology Department, Saint-Louis Hospital, University Paris 7, Paris, France

Leonor Arenillas, MD^1*, Xavier Calvo, MD^1*, Mar Tormo, MD, PhD², David Valcárcel, MD, PhD³, Elisa Luño, MD, PhD^4*, Esther Alonso, MD^5*, María Consuelo Cañizo, MD, PhD^6*, Fernando Ramos, MD, PhD, MPH^7*, Carmen Pedro, MD, PhD^8*, Beatriz Arrizabalaga, MD^9*, Alicia Bailén, MD^10*, José María Raya, MD^11*, María Teresa Ardanaz, MD^12*, Guillermo Sanz, MD, PhD¹³ and Lourdes Florensa, MD, PhD^1*

¹Hematological Cytology Laboratory, Hospital del Mar, GRENTHE, IMIM (Hospital del Mar Research Institute), Barcelona, Spain
²Hospital Clínico Universitario de Valencia, Valencia, Spain
³Hospital Vall d'Hebrón, Barcelona, Spain
⁴Hematology, Hospital Universitario Central Asturias, Oviedo, Spain
⁵Hematology, Department of Pathology. Hospital de Bellvitge., Barcelona., Spain
⁶Hematology, Salamanca Universitary Hospital, Salamanca, Spain
⁷Hospital Universitario de León, León, Spain
⁸Hospital del Mar, Barcelona, Spain
⁹Hospital Universitario Cruces, Spanish MDS Cooperative Group, Bilbao, Spain
¹⁰Hospital Universitario Carlos Haya, Málaga, Spain
¹¹Hospital Universitario de Canarias, Tenerife, Spain
¹²Hospital de Txagorritxu, Vitoria, Spain
¹³Hospital Universitario La Fe, Spanish MDS Cooperative Group, Valencia, Spain

Alena Moudra^1*, Sona Hubackova, PhD^1*, Jiri Bartek, MD, PhD^1,2*, Zdenek Hodny, MD, PhD^1* and Anna Jonasova, MD, PhD^3*

¹Department of Genome Integrity, Institute of Molecular Genetics, Academy of Sciences of the Czech republic, Prague, Czech Republic
²Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
³Haematology, Charles University and General Hospital in Prague, Prague, Czech Republic

María Díez Campelo, MD, PhD^1*, Julio Davila, MD^1*, Sanchez Barba Mercedes, MD^2*, Maria Lopez-Pavia, MD^3*, Esperanza Such, PhD^1*, Teresa Bernal, MD^1*, Elisa Luño^1*, Fernando Ramos^1*, Marisa Calabuig, MD^1*, Helena Pomares, MD^1*, Bernardo Gonzalez^1*, Brayan Merchan, MD^1*, Edgardo Barranco, MD^1*, Reyes Sancho Tello^1*, Marta Callejas^1*, Maria Jose Requena^1*, María José Jiménez^1*, Maria Pedreño^1*, Angeles Medina, MD^1*, Ana I Vicente, PhD^1*, Andrea Campeny^1*, Montse Cortes Sansa^1*, Carmen Pedro, MD^4*, Jose Falantes, M.D.^1*, Maria Jesus Arilla^1*, Abelardo Bárez, MD^1*, Regina Garcia, MD^1*, Maria Jose Arcos^1*, Valle Gomez^1*, Carolina Muñoz^1*, Carlos Cervero, MD^1*, Javier Casaño^1*, Raquel De Paz^1*, Luz Amigo^1*, Andres Insunza^1*, Juan Antonio Muñoz^1*, Maria Teresa Cedena^1*, Marta Gomez^1*, Patricia Font^1*, Raquel Del Campo^1*, Carlos Fernandez Lago^1*, Jose Antonio Gonzalez Hurtado^1*, Maria Dolores Linares Latorre^1*, Asuncion Mora Casado^1*, Maria Vahi, MD, PhD^1*, Luis Benlloch^3*, Guillermo Sanz, MD, PhD¹ and María Consuelo Cañizo, MD, PhD^1*

¹GESMD, Valencia, Spain
²Departamento de Estadística, Universidad de Salamanca, Salamanca, Spain
³Hospital Universitario La Fe, GESMD, Valencia, Spain
⁴Hospital del Mar, GESMD, Valencia, Spain

Hanadi Ramadan, BA^1*, Vu H. Duong, MD², Najla H. Al Ali, BDS, MSc^1*, Eric Padron, MD¹, Ling Zhang, MD³, Jeffrey E Lancet, MD¹, Alan F. List, MD¹ and Rami S. Komrokji, MD¹

¹Malignant Hematology Department, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
³Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL

Joanna (Asia) Grabska, MD¹, Bijal D. Shah, MD², Najla H. Al Ali, BDS, MSc^1*, Eric Padron, M.D.³, Hanadi Ramadan, BA^1*, Jeffrey E Lancet, MD¹, Alan F. List, MD⁴ and Rami S. Komrokji, MD⁵

¹Malignant Hematology Department, H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁴Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
⁵H. Lee Moffitt Cancer Center, Tampa, FL

Thierry Guillaume, MD, PhD^1*, Virginie Dehame, MSc^2*, Patrice Chevallier, MD, PhD^1*, Pierre Peterlin, MD^1*, Marc Grégoire, PhD^2*, Philippe Moreau^3*, Daniel B Rubinstein, MD⁴, Eddy Pichinuk, PhD^5* and Daniel H Wreschner, MD^5*

¹Department of Hematology, Nantes University Hospital, Nantes, France
²INSERM U892, Cancer Research Center Nantes-Angers, Nantes, France
³University of Nantes, Nantes, France
⁴Biomodifying, LLC, Silver Spring
⁵Departments of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, Israel

Thomas Prebet, MD^1,2, Jacques Delaunay, MD^3*, Eric Wattel, MD PhD⁴, Thorsten Braun, MD, PhD^5*, Pascale Cony-Makhoul, M.D.^6*, Sophie Dimicoli, MD^7*, Stefan Wickenhauser, MD^8*, Julie Lejeune^9*, Sylvie Chevret^10*, Fatiha Chermat^11*, Pierre Fenaux, MD, PhD^12,13,14 and Norbert Vey¹⁵

¹Dept of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT
²Groupe Francophone des Myelodysplasies, Paris, France
³Department of Hematology, Nantes University Hospital, Nantes, France
⁴Lyon I University, Lyon, France
⁵Hematologie Clinique, CHU Avicenne, Bobigny, France
⁶Hematology department, Centre Hospitalier Annecy-Genevois, Site Annecy, Metz-Tessy, France
⁷service d'hematologie, CHU Bordeaux, Pessac, France
⁸CH Nimes, Nimes, France
⁹Hôpital Saint Louis, Assistance Publique - Hôpitaux de Paris, Paris, France
¹⁰Statistics St-Louis Hospital, Paris 7, Paris, France
¹¹GFM, Hôpital Saint Louis, Paris, France
¹²Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹³Service d'Hématologie Clinique, Hopital Avicenne Université Paris XIII, Bobigny, France
¹⁴Groupe Francais des myélodysplasies (GFM), Paris, France
¹⁵Hematology, Institut Paoli-Calmettes, Marseille, France

Amer M. Zeidan, MBBS, MHS¹, B. Douglas Smith², Hetty E. Carraway, MD, MBA³, Ivana Gojo, MD², Sarah Sakoian^4*, Steven D. Gore, MD⁵ and Amy E. DeZern, MD, MHS⁶

¹Yale University School of Medicine, New Haven, CT
²Johns Hopkins University, Baltimore, MD
³Leukemia Program, Cleveland Clinic, Cleveland, OH
⁴Johns Hopkins University School of Medicine, Baltimore, MD
⁵Yale Cancer Center, New Haven, CT
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD

Helena Pomares, MD^1*, Isabel Sánchez-Ortega, MD, PhD^1*, Esther Alonso, MD^2*, Javier Grau, MD^3*, Rafael F. Duarte, MD, PhD⁴, Anna Sureda, MD, PhD^1* and Montserrat Arnan, MD, PhD^1*

¹Institut Català d'Oncologia, Hospital Duran i Reynals, Barcelona, Spain
²Hematology, Department of Pathology. Hospital de Bellvitge., Barcelona., Spain
³Hematology Service, Institut Català d'Oncologia. Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain
⁴Department of Hematology. Hospital Puerta de Hierro, Madrid, Spain

Roman Shapiro, MD¹, Alla Iansavichene, BSc, MLIS^1* and Alejandro Lazo-Langner, MD, MSc²

¹London Health Science Center, London, ON, Canada
²Division of Hematology, London Health Sciences Centre, London, ON, Canada

Ellen K. Ritchie, MD¹, Apurv Agrawal, MD^2*, Kashyap B Patel, MD^3*, Seth Rosen, MD^4*, Amy Law, MD, BA^5*, Jeffrey M Skolnik, MD^6* and Ashkan Lashkari, MD,⁷

¹Division of Hematology / Oncology, Weill Cornell Medical College, New York, NY
²New Jersey Hematology Oncology Associates, Brick, NJ
³Carolina Blood and Cancer Care, Rock Hill, SC
⁴Hem-Onc Associates of Treasure Coast, Port Lucie, FL
⁵Desert Hematology Oncology Medical Group, Inc., Rancho Mirage, CA
⁶TetraLogic Pharmaceuticals, Malvern, PA
⁷Wellness Oncology, Omid S. Shaye Medical Corp., West Hills, CA

Marta Cabezon^1*, Joan Bargay, MD, PhD^2*, Blanca Xicoy, MD, PhD^1*, Laura Palomo, MSc^3*, Sílvia Marcé, PhD^1*, Ramón Guàrdia, MD, PhD^4*, Salut Brunet, MD, PhD^5*, Carmen Pedro, MD, PhD^6*, Mar Tormo, MD, PhD⁷, Vera Ademà, MSc^3*, Victor Marco^8*, Lourdes Escoda, MD, PhD^9*, Llorenç Font, MD, PhD^10*, Elena Rámila, MD, PhD^11*, Josep Maria Martí, MD, PhD^12*, David Valcarcel, MD, PhD¹³, Josep Borras^2*, Evarist Feliu, MD, PhD^1*, Fuensanta Millá, MD, PhD^1* and Lurdes Zamora, PhD^1*

¹Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain
²Hospital Son Llàtzer, Palma de Mallorca, Spain
³MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
⁴ICO Girona- Hospital Josep Trueta, Girona, Spain
⁵Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⁶Hospital del Mar, Barcelona, Spain
⁷Hospital Clínico Universitario de Valencia, Valencia, Spain
⁸Hospital Arnau de Vilanova, Spanish MDS Cooperative Group, Lleida, Spain
⁹ICO-Hospital Joan XXIII, Tarragona, Spain
¹⁰Hospital Verge de la Cinta, Tortosa, Spain
¹¹Hospital Parc Taulí, Sabadell, Spain
¹²Hospital Mútua de Terrassa, Terrassa, Spain
¹³Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain