Aparna Vasanthakumar, BSc, MSc, PhD¹, Stephen Arnovitz^2*, Rafael Marquez^3*, Janet Lepore^3*, George Rafidi^3*, Elizabeth M. Davis, BS^4*, Anase Asom^3*, Madison Weatherly^3*, Barbara Neistadt^3*, Robert Duszynski^3*, James W. Vardiman, MD⁵, Michelle M. Le Beau, PhD⁶, Lucy A. Godley, MD, PhD⁷ and Jane E. Churpek, MD⁷

¹Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
²Department of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL
³The University of Chicago, Chicago, IL
⁴Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
⁵Department of Pathology, University of Chicago, Chicago, IL
⁶SECTION OF HEMATOLOGY/ONCOLOGY, THE UNIVERSITY OF CHICAGO COMPREHENSIVE CANCER CENTER, Chicago, IL
⁷Department of Medicine, Section of Hematology/Oncology, The University of Chicago Medicine, Chicago, IL

Carine Domenech, MD^1*, Alix Rousseau^2*, Laurence Petit^3*, Sandra Sanfilippo^1*, Jean Soulier, MD, PhD² and Michele Souyri, PhD¹

¹IBPS/ Developmental Biology Laboratory, CNRS UMR7622/INSERM U1156/UPMC, PARIS, France
²Institute of hematology, University Paris-Diderot, Paris, France
³IBPS/UMR7622/U1156, CNRS/INSERM/UPMC, Paris, France

Haojian Zhang, PhD^1*, David Kozono, MD, PhD^1*, Kevin O'Connor^1*, Alix Rousseau^2*, Lisa Moreau^1*, Emily Gaudiano, BS^1*, Joel S Greenberger, MD³, Grover C. Bagby Jr., MD, MACP⁴, Jean Soulier, MD, PhD², Markus Grompe, MD^4*, Kalindi Parmar, PhD^1* and Alan D D'Andrea, MD¹

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Institute of hematology, University Paris-Diderot, Paris, France
³Radiation Oncology, University of Pittsburgh, Pittsburgh, PA
⁴Oregon Health & Science University, Portland, OR

Hengjun Chao, MD^* and Johnson M. Liu, MD

Department of Pediatrics, The Feinstein Institute for Medical Research, Manhasset, NY

Victor Bengt Pastor Loyola, MSc^1*, Shinsuke Hirabayashi, MD^1*, Sandra Pohl, PhD^2*, Emilia J Kozyra, MSc^1*, Albert Catala, MD^3*, Barbara De Moerloose, MD, PhD^4*, Michael Dworzak, MD^5*, Henrik Hasle, MD⁶, Riccardo Masetti, MD^7*, Markus Schmugge, MD⁸, Owen Smith⁹, Jan Starý, MD^10*, Marek Ussowicz, MD^11*, Marry M. van den Heuvel-Eibrink, MD, PhD^12,13*, Ester Mejstrikova, MD, PhD^14*, Ulrich Salzer, MD^15*, Michael Lübbert, MD^16*, Daniel Heudobler, MD^2*, David Betts, MD^17*, Jose Cervera, MD^18*, Gudrun Göhring, MD^19*, Oskar A. Haas²⁰, Olga Haus, MD^21*, Kyra Michalova, PhD, DSc^22*, Francesco Pasquali, MD^23*, Joelle Tchinda, MD^24*, Nadine van Roy, MD^25*, Brigitte Schlegelberger, MD, Prof.²⁶, H. Berna Beverloo, PhD^27*, Peter Noellke, MSc^28*, Ayami Yoshimi, MD^1*, Franco Locatelli, Prof, MD, PhD^29*, Brigitte Strahm, MD^1*, Jaroslaw P. Maciejewski, MD, Ph.D.³⁰, Michael Rehli, PhD^31*, Charlotte M Niemeyer, Prof, MD¹ and Marcin W Wlodarski, MD^1*

¹University Children´s Hospital Freiburg, Division of Pediatric Hematology and Oncology, University of Freiburg, Freiburg, Germany
²Department of Internal Medicine 3, University Hospital Regensburg, Regensburg, Germany
³Dep of Hematology, Hospital Sant Joan de Déu, Barcelona, Spain
⁴Department of Pediatrics, Ghent University, Ghent, Belgium
⁵Department of Pediatrics, Medical University of Vienna, St. Anna Children's Hospital and Children’s Cancer Research Institute, Vienna, Austria
⁶Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
⁷Pediatric Oncology and Hematology, University of Bologna, Bologna, Italy
⁸Haematology, University Children's Hospital Zurich, Zurich, Switzerland
⁹Department of Haematology, Our Lady's Children's Hospital, Dublin, Ireland
¹⁰Department of Pediatric Hematology and Oncology, Charles University and Univ Hospital Motol, Prague, Czech Republic
¹¹Dep of Pediatric Hematology/ Oncology, Charles University and Univ Hospital Motol, Prague, Czech Republic
¹²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
¹³Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands
¹⁴CLIP-DPHO, Charles University, Hospital Motol, Prague, Czech Republic
¹⁵Department of Rheumatology and Clinical Immunology, Freiburg University Medical Center, ALU Freiburg, Freiburg, Germany
¹⁶Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
¹⁷Paediatric Oncology and Haematology, Our Lady´s Children´s Hospital Crumlin, Dublin, Ireland
¹⁸Hematology Department, Hospital Universitari i Politecnic La Fe, Valencia, Spain
¹⁹Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
²⁰St. Anna Children's Hospital, Childrens Cancer Research Institute, Vienna, Austria
²¹Department of Hematology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
²²General Teaching Hospital and 1st Faculty of Medicine, Prague, Czech Republic
²³Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
²⁴Dep of Hematology and Oncology, University Children's Hospital Zurich, Zurich, Switzerland
²⁵Center for Medical Genetics, Ghent University, Ghent, Belgium
²⁶Institute of Human Genetics, Hannover Medical School, Hannover, Germany
²⁷Dutch Childhood Oncology Group (DCOG), The Hague, Netherlands
²⁸University Children´s Hospital Freiburg, Division of Pediatric Hematology and Oncology, University Freiburg, Freiburg, Germany
²⁹Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
³⁰Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³¹Internal Medicine III, University Hospital, Regensburg, Germany

Bhumika J. Patel^1*, Bartlomiej Przychodzen, MSc^2*, Michael J. Clemente^3*, Cassandra M. Hirsch^2*, Tomas Radivoyevitch, PhD^4*, Swapna Thota, MD^1*, Aziz Nazha, MD⁵, Hetty E. Carraway, MD, MBA⁶, Mikkael A. Sekeres, MD, MS⁶ and Jaroslaw P. Maciejewski, MD, PhD⁷

¹Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, OH
³Taussig Cancer Institute, Cleveland Clinic, Translational Hematology Oncology Research, Cleveland, OH
⁴Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
⁵Leukemia Program, Department of Hematology and Oncology, Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
⁶Leukemia Program, Cleveland Clinic, Cleveland, OH
⁷Leukemia Program, Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH