57th ASH Annual Meeting and Exposition (December 5-8, 2015): 322. Disorders of Coagulation or Fibrinolysis: Inhibitors in Hemophilia

Disorders of Coagulation or Fibrinolysis Oral and Poster Abstracts
Oral

W311ABCD, Level 3 (Orange County Convention Center)

Moderators:

Christine L Kempton, MD, MSc, Emory University and Shannon L. Meeks, MD, Emory University

Disclosures:

Kempton: Baxter: Consultancy ; Biogen: Consultancy ; CSL Behring: Consultancy . Meeks: Bayer: Consultancy ; CSL Behring: Consultancy ; Baxalta: Consultancy ; Grifols: Consultancy ; Biogen: Consultancy ; Pfizer: Research Funding .

4:30 PM

289

Meta-Analysis on Incidence of Inhibitors in 1,945 Previously Untreated Patients Treated with Recombinant Factor VIII Products: Is There a Difference?

Lorenzo G. Mantovani¹^*, Matteo Rota²^*, Paolo Cortesi¹^*, Katharina Steinitz³^*, Armin Reininger³ and Alessandro Gringeri³^*

¹Research Centre on Public Health (CESP), University of Milan-Bicocca, Monza, Italy
²Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, University of Milan-Bicocca, Monza, Italy
³Baxalta Innovations GmbH, Vienna, Austria

4:45 PM

290

Modification of Predicted Inhibitor Risk in Non-Severe Hemophilia-a By in silico Analysis of Human Proteome Homology with Wild-Type, FVIII-Derived Peptides

Adrian Shepherd, PhD¹^*, Stuart Skelton, MSc^1,2^*, David Moss, PhD¹^* and Dan Hart, MBChB, PhD²^*

¹Biological Sciences, Birkbeck, London, United Kingdom
²Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom

5:00 PM

291

Immunosuppressive FVIII-Specific Human Cartregs in Hemophilia a

Jeong Heon Yoon, PhD¹^*, Anja Schmidt, PhD²^*, Yong Chan Kim, PhD¹^*, Christoph Koenigs, MD, PhD³^* and David William Scott, PhD¹

¹Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD
²Department of Pediatrics, University Hospital Frankfurt, Frankfurt am Main, Germany
³Department of Pediatrics, University Hospital Frankfurt, Frankfurt Am Main, Germany

5:15 PM

292

Factor IX Expressed in Lettuce Chloroplasts Induces Oral Tolerance in Hemophilia B Mice

Roland W. Herzog, PhD¹, Jin Su, PhD²^*, Liqing Zhu, BS³^*, Xiaomei Wang, PhD³^*, Shina Lin, BS²^*, Aditya Kamesh, BS²^* and Henry Daniell, PhD²^*

¹Pediatrics, University of Florida, Gainesville, FL
²Dept. Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA
³Department of Pediatrics, University of Florida, Gainesville, FL

5:30 PM

293

Pharmacological Concentrations of Recombinant Factor VIIa Restores Hemostasis in Acquired Hemophilia Primarily Independent of Tissue Factor

Shiva Keshava, Ph.D.^*, Jagan Sundaram, Ph.D.^*, Anuradha Rajulapati, M.S.^*, Usha R Pendurthi, PhD and L. Vijaya Mohan Rao, Ph.D.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX

5:45 PM

294

BAR-CD8 T-Cell Mediated Targeted Killing of Inhibitor Producing FVIII-Specific B Cells

Kalpana Parvathaneni, MS^*, Aihong Zhang, PhD^*, Yong Chan Kim, PhD^* and David William Scott, PhD

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD

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^*signifies non-member of ASH

322.O1.6 322. Disorders of Coagulation or Fibrinolysis: Inhibitors in Hemophilia