Roberto Avellino^1*, Marije Havermans^1*, Claudia Erpelinck^1*, Mathijs Sanders^1*, Stefan Groeschel^2*, Harmen Vandewerken^3*, Remco M. Hoogenboezem, M.Sc.^4*, Elwin Rombouts^1*, Kirsten Van Lom^1*, Paulette Van Strien^1*, Hans De Looper^1*, Claudia Christine Gebhard^5*, Michael Rehli^6*, Dominik Beck, PhD^7*, Julie A.I. Thoms, Ph.D.^7*, Stefan Erkeland^1*, Ivo Touw^1*, John E. Pimanda, MD Ph.D.⁷, Eric JM Bindels^1* and Ruud Delwel¹

¹Hematology, Erasmus Medical Centre, Rotterdam, Netherlands
²NCT Heidelberg, Heidelberg, Germany
³Cell Biology, Erasmus Medical Centre, Rotterdam, Netherlands
⁴Department of Hematology, Erasmus Medical Centre, Rotterdam, Netherlands
⁵Uniklinik, Regensburg, Germany
⁶UniKlinik, Regensburg, Germany
⁷Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia

Jean-Baptiste Micol, MD^1*, Nicolas Duployez^2*, Alessandro Pastore, MD^3*, Robert Williams^4*, Eunhee Kim, PhD^3*, Stanley Lee^3*, Benjamin Durham, MD, PhD^3*, Young Rock Chung, MS^5*, Hana Cho^3*, Claude Preudhomme⁶ and Omar Abdel-Wahab³

¹MSKCC, New York, NY
²Centre Hospitalier Régional Universitaire of Lille, Lille, France
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Cornell University, New York, NY
⁵Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Hematology Laboratory, CHRU Lille, Lille, France

Yoshihiro Hayashi, MD, PhD¹, Yue Zhang, MD^2*, Xiaomei Yan, MD, PhD^1*, Kwangmin Choi, PhD^1*, Goro Sashida, MD, PhD³, Yunzhu Dong^1*, Zefeng Xu, MD^1,2, Lingyun Wu, MD, PhD^1,4*, Aili Chen, PhD^5*, Xiujuan Sun, MD^2*, Andre Olsson, Ph.D.^6*, Hironori Harada, MD, PhD⁷, Lee-Yung Shih, MD⁸, William Tse, MD, FACP⁹, James Bridges, PhD^10*, David P Witte, MD^11*, Qianfei Wang⁵, Michael A. Caligiuri, MD¹², H. Leighton Grimes, PhD⁶, Stephen D. Nimer, MD¹³, Zhijian Xiao, MD^2* and Gang Huang, PhD¹

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
²State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan
⁴Department of Hematology, The Sixth Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China
⁵Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
⁶Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
⁸Division of Hematology, Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taipei, Taiwan
⁹James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY
¹⁰Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
¹¹Division of Pathology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
¹²The Ohio State University Comprehensive Cancer Center, Columbus, OH
¹³Sylvester Comprehensive Cancer Center, Department of Biochemistry and Molecular Biology, and Department of Medicine, University of Miami Miller School of Medicine, Miami, FL

Kazutsune Yamagata, PhD^*, Yukiko Aikawa^*, Mika Shino^* and Issay Kitabayashi, PhD

Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan

Britta Will, PhD¹, Thomas O. Vogler^1*, Swathi-rao Narayanagari^2*, Boris Bartholdy^1*, Tihomira I. Todorova, MSc^3*, Jiahao Chen^1*, Yiting Yu^4*, Jillian Mayer^1*, Mariana da Silva Ferreira^1*, Laura Barreyro, PhD¹, Luis Carvajal^1*, Michael Roth, MD^1*, Johanna van Oers^1*, Sonja Schaetzlein^1*, Christine McMahon, MD^5*, Winifried Edelmann^1*, Amit Verma, MD⁴ and Ulrich Steidl, MD PhD¹

¹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
²Albert Einstein College of Medicine, Bronx
³Department of Cell Biology, Albert Einstein College of Medicine, New York, NY
⁴Department of Medicine-Oncology, Albert Einstein College of Medicine, Bronx, NY
⁵Department of Pathology, Albert Einstein College of Medicine, Bronx, NY

Francine E. Garrett-Bakelman, MD, PhD¹, Sheng Li, PhD^2*, Stephen S. Chung, MD³, Todd Hricik^4*, Rapaport Franck^5*, Jay Patel^5*, Richard Dillon, MA, MRCP, FRCPath^6*, Priyanka Vijay^7*, Anna L Brown, PhD⁸, Alexander E. Perl, MD⁹, B. Joy Cannon^10*, Mathijs A. Sanders, PhD^11*, Peter J M Valk, PhD¹², Lars Bullinger, MD¹³, Selina Luger, MD¹⁴, Michael W. Becker, MD¹⁵, Ian D. Lewis, MBBS PhD FRACP FRCPA¹⁶, L. Bik To, MD¹⁷, Richard J D'Andrea, PhD¹⁸, David Grimwade, MD, PhD¹⁹, Ruud Delwel, PhD²⁰, Bob Lowenberg, MD, PhD²¹, Hartmut Dohner, MD²², Konstanze Dohner, MD²³, Duane C Hassane, PhD²⁴, Monica L. Guzman, PhD²⁵, Gail J Roboz, MD²⁶, Martin Carroll, MD²⁷, Christopher Y. Park, M.D., Ph.D.²⁸, Donna S. Neuberg, Sc.D.²⁹, Ross L. Levine, MD⁵, Christopher Mason, PhD^30* and Ari Melnick, MD³¹

¹Department of Medicine/Hematology-Oncology, Weill Cornell Medical College, New York, NY
²Department of Neurological Surgery, Weill Cornell Medical College, New York, NY
³Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering Cancer Center (Currently at Desca Consulting), New York, NY
⁵Memorial Sloan Kettering Cancer Center, New York, NY
⁶Medical and Molecular Genetics, King's College, London, London, United Kingdom
⁷Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY
⁸School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
⁹University of Pennsylvania-Abramson Comprehensive Cancer Center, Philadelphia, PA
¹⁰University of Pennsylvania, Philadelphia, PA
¹¹Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
¹²Department of Hematology, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands
¹³Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹⁴Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
¹⁵James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
¹⁶Dept of Haematology, Royal Adelaide Hospital, Adelaide, Australia
¹⁷Division of Haematology and Centre for Cancer Biology, SA Pathology, Adelaide, Australia
¹⁸Centre for Cancer Biology, SA Pathology, Adelaide, Australia
¹⁹King's College London, London, United Kingdom
²⁰Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
²¹Erasmus University Medical Center, Rotterdam, Netherlands
²²University Hospital of Ulm, Ulm, Germany
²³Department of Internal Medicine III,, University of Ulm, Ulm, Germany
²⁴Division of Hematology / Oncology, Weill Cornell Medical College, Institute for Computational Biomedicine, New York, NY
²⁵Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
²⁶Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY
²⁷Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
²⁸Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY
²⁹Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
³⁰Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY
³¹Department of Medicine, Weill Cornell Medical College, New York, NY