Yoseph Elala, MD^1*, Terra L. Lasho, PhD^2*, Naseema Gangat, MBBS², Christy Finke, BS^3*, A Kamel Abou Hussein, MD⁴, Curtis A. Hanson, MD⁵, Rhett P. Ketterling, MD^6*, Animesh Pardanani, MBBS, PhD⁷ and Ayalew Tefferi, MD²

¹Mayo Clinic, Rochester
²Division of Hematology, Mayo Clinic, Rochester, MN
³Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Mayo Clinic, Rochester, MN
⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Vikas Gupta, MD, FRCP, FRCPath¹, Ruben A. Mesa², Michael W Deininger, MD, PhD³, Candido E. Rivera, MD⁴, Shireen Sirhan, MD, FRCP⁵, Srdan Verstovsek, MD⁶, Yafeng Zhang, PhD^7*, Yuanyuan Xiao, PhD^7*, Helen Collins, MD⁷, Kevin Kwei^7*, Adarsh Joshi, PhD^7* and Carrie Baker Brachmann, PhD^7*

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Mayo Clinic, Scottsdale, AZ
³Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT
⁴Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁵Division of Hematology, Jewish General Hospital, Montreal, QC, Canada
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Gilead Sciences, Foster City, CA

Samah Alimam^1*, Lucy Chappell^2*, Marian Knight^3*, Susan Bewley^4*, Garbriella Gray^2*, Claire N. Harrison⁵ and Susan Robinson^1*

¹Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
²Department of Obstetrics and Gynaecology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
³Perinatal Epidemiology Unit Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
⁴Women's Health Academic Centre, King's College London, London, United Kingdom
⁵Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

Alberto Alvarez-Larrán^1*, Paola Guglielmelli, PhD MD^2*, Eduardo Arellano-Rodrigo^3*, Martin Griesshammer, MD^4*, Chiara Paoli^5*, Ana Kerguelen^6*, Francisca Ferrer-Marin^7*, Juan Carlos Hernández-Boluda^8*, Bjorn Andreasson, MD PhD^9*, Jiri Schwarz^10*, Valentín García-Gutierrez^11*, Rosa M. Ayala, MD, PhD¹², Pere Barba, M.D.^13*, María Teresa Gómez-Casares^14*, Radek C. Skoda, MD¹⁵, Carmen Burgaleta^16*, Stefanie Slot^17*, Jan Samuelsson, MD, PhD¹⁸, Alimam Samah^19*, Yan Beauverd^20*, Claire N. Harrison²¹, Francisco Cervantes²², Alessandro M. Vannucchi²³ and Carlos Besses²⁴

¹Hematology Department, Hospital de Mar, Barcelona, Spain
²CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative,Department of Experimental and Clinical Medicine, Azienda Ospedaliera-Universitaria Careggi, University of Florence, Florence, Italy
³Hemotherapy and Hemostasis Department, Hospital Clínic, Barcelona, Spain
⁴Department of Hematology and Oncology, Johannes-Wesling Clinic Minden, Minden, Germany
⁵CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative and Department of Experimental and Clinical Medicine, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy
⁶Hematology Department, Hospital La Paz, Madrid, Spain
⁷Hematology Department, h, Murcia, Spain
⁸Hematology Department, Hospital Clínico, Valencia, Spain
⁹NU Hospital Organization, Uddavella, Sweden
¹⁰Leukemia PCR Diagnostics Laboratory, Institute of Hematology and Blood Transfusion, Prague, Czech Republic
¹¹Hematology Department, Hospital Ramón y Cajal, Madrid, Spain
¹²Hematology Department, Hospital 12 de Octubre, Madrid, Spain
¹³Hospital Universitario Valld'Hebron, Barcelona, Spain
¹⁴Hematology Department, Hospital Dr Negrín, Las Palmas de Gran Canaria, Spain
¹⁵Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland
¹⁶Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain
¹⁷Hematology Department, VU University Medical Center, Amsterdam, Netherlands
¹⁸Department of Internal Medicin, Section of Hematology, Stockholm South Hospital, Stockholm, Sweden
¹⁹Guys' and St Thomas' Hospital, London, United Kingdom
²⁰Hematology Department, Guys' and St Thomas' Hospital, London, United Kingdom
²¹Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
²²Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
²³CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
²⁴Hematology Department, Hospital del Mar, Barcelona, Spain

Veronika Buxhofer-Ausch^1*, Heinz Gisslinger, MD², Josef Thaler, MD^3*, Ernst Schlögl, MD^4*, Gunther Gastl, MD, Prof,⁵, Dominik Wolf, MD^6*, Robert Kralovics, PhD⁷, Bettina Gisslinger^2*, Sarita Ban, MD^8*, Alexander Egle, MD⁹, Thomas Melchardt, MD^10*, Sonja Burgstaller, MD^3*, Ella Willenbacher, MD^11*, Martin Schalling, MSc^2*, Maria Theresa Krauth, MD^2*, Nicole C.C. Them^7*, Michael Zörer^12*, Oliver Ammann-Mwathi^12*, Pavla Kadlecova^13*, Oleh Zagrijtschuk^12*, Christoph Klade^12* and Richard Greil, MD¹⁴

¹Hospital Elisabethinen, Linz, Austria
²Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria
³Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Wels, Austria
⁴Hanusch Hospital, Vienna, Austria
⁵Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
⁶Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany
⁷CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
⁸Sozialmedizinisches Zentrum Ost - Donauspital, Vienaa, Austria
⁹Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria
¹⁰Hospital Salzburg, Salzburg, Austria
¹¹Innsbruck Medical University, Innsbruck, Austria
¹²AOP Orphan Pharmaceuticals AG, Vienna, Austria
¹³Aprova CRO, Brno, Czech Republic
¹⁴3rd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Laboratory for Immunological and Molecular Cancer Research, Oncologic Center, Paracelsus Medical University Hospital Salzburg, and Center for Clinical Cancer and Immunology Trials at Salzburg Cancer Research Institute, Salzburg, Austria

Vikas Gupta, MD, FRCP, FRCPath¹, Claire N. Harrison², Elizabeth O. Hexner, MD³, Haifa Kathrin Al-Ali, MD^4*, Lynda Foltz, MD, FRCP⁵, Michael Montgomery, MD^6*, Wei Peng, PhD^6*, Prashanth Gopalakrishna, MBBS, MRCS^7*, Hagop Kantarjian, MD⁸ and Srdan Verstovsek, MD, PhD^9*

¹Princess Margaret Cancer Centre, Toronto, Canada
²Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
³Abramson Cancer Center, Department of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
⁴University of Leipzig, Leipzig, Germany
⁵St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
⁶Incyte Corporation, Wilmington, DE
⁷Novartis Pharma AG, Basel, Switzerland
⁸Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁹The University of Texas MD Anderson Cancer Center, Houston, TX

Malin Hultcrantz, MD PhD¹, Therese M-L Andersson, MSc PhD^2*, Ola Landgren, MD, PhD^3,4, Paul W Dickman, MSc PhD^5*, Bjorn Andreasson, MD PhD^6*, Magnus Bjorkholm, MD, PhD¹ and Sigurdur Y Kristinsson, MD, PhD^1,7

¹Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
²Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
³Department of Medicine, Myeloma Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Medicine, Weill Cornell Medical College, New York, NY
⁵Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
⁶NU Hospital Organization, Uddavella, Sweden
⁷University of Iceland, Faculty of Medicine, Reykjavik, Iceland

Nicola Polverelli, MD^1*, Massimo Breccia, MD^2*, Giulia Benevolo, MD^3*, Bruno Martino, MD^4*, Alessia Tieghi, MD^5*, Roberto Latagliata, MD^6*, Lucia Catani, Ph.D.^1*, Maura Nicolosi, MD^7*, Margherita Perricone^8*, Marco Romano^1*, Gioia Colafigli^9*, Anna Campana^10*, Francesco Merli, MD^11*, Umberto Vitolo¹², Giuliana Alimena, MD¹³, Giovanni Martinelli¹⁴, Michele Cavo, MD^15*, Nicola Vianelli, MD^1* and Francesca Palandri, MD, PhD^16*

¹Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²Dipartimento di Ematologia e Biotecnologie, Università La Sapienza, Rome, Italy
³Città della Salute e della Scienza di, Torino, Italy
⁴Az.Osp. Bianchi-Melacrino’-Morelli, Reggio Calabria, Italy
⁵Division of Hematology, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
⁶Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University La Sapienza of Rome, Rome, Italy
⁷SC Hematology, Città della Salute e della Scienza Hospital and University, Turin, Italy
⁸Institute of Hematology, Bologna, Italy
⁹Cellular Biotechnologies and Hematology, University La Sapienza, Rome, Italy
¹⁰Città della Salute e della Scienza Hospital, Turin, Italy
¹¹Hematology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy
¹²SC Ematologia, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, Torino, Italy
¹³Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
¹⁴"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
¹⁵"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
¹⁶University of Bologna, Bologna, Italy

Jie Bai, MD, PhD^1*, Yuan Zhou, PhD^1*, Lei Zhang, MD^1*, Mengyao Sheng^1*, Rong Li^1*, Hui Shi^1,2*, Yanping Xue, MD^1*, Mingjiang Xu, MD, PhD² and Feng-Chun Yang, MD, PhD²

¹State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²Department of Biochemistry and Molecular Biology & Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL

Georg Jeryczynski, MD^*, Bettina Gisslinger^*, Maria Theresa Krauth, MD^*, Martin Schalling, MSc^* and Heinz Gisslinger, MD

Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria

Ruben A. Mesa¹, Claire N. Harrison², Francisco Cervantes³, James P. Dean⁴, Lixia Wang^4*, Tanya Granston^4*, Yoojung Yang^5*, Alessandro M. Vannucchi⁶ and Adam Mead^7*

¹Mayo Clinic, Scottsdale, AZ
²Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
³Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
⁴CTI BioPharma Corp., Seattle, WA
⁵Baxalta Inc., Cambridge, MA
⁶University of Florence, Florence, Italy
⁷Oxford University Hospitals, Oxford, United Kingdom

Yu-Cheng Chang, MD^1*, Ken-Hong Lim, MD¹, Huan-Chau Lin, MD^1*, Yi-Hao Chiang, MD^1*, Ling Huang, MSc^2*, Chen-Wei Kao^2*, Chiao-Yi Chang, MSc^2*, Ching-Sung Lin, MSc^2*, Nai-Wen Su, MD^1*, Johnson Lin, MD, MPH^1*, Ruey-Kuen Hsieh, MD^3*, Ming-Chih Chang, MD^1*, Yi-Fang Chang, MD, PhD^1*, Caleb Gon-Shen Chen, MD, PhD^1*, Yuan-Yeh Kuo, PhD^4* and Wen-Chien Chou, MD, PhD⁵

¹Mackay Memorial Hospital, Taipei City, Taiwan
²Mackay Memorial Hospital, New Taipei City, Taiwan
³Department of Internal Medicine, Division of Hematology and Oncology, and Department of Medical Research Good Clinical Research Center Laboratory, Mackay Memorial Hospital, Taipei, Taiwan
⁴Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei City, Taiwan
⁵Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

A Kamel Abou Hussein, MD¹, Naseema Gangat, MBBS², Yoseph Elala, MD^3*, Curtis A. Hanson, MD⁴, Animesh Pardanani, MBBS, PhD⁵, Tiziano Barbui, MD^6* and Ayalew Tefferi, MD⁵

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Mayo Clinic, Rochester
⁴Division of Hematopathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁶Hospital Papa Giovanni XXIII and Research Foundation, Bergamo, Italy

Christopher R Reilly, M.D.^1*, Daria V. Babushok, MD, PhD², Ranjeeta Bahirwani, M.D.^3*, Jeffery Mondschein, M.D.^4* and Elizabeth O. Hexner, MD²

¹Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
²Abramson Cancer Center, Department of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
³Department of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, PA
⁴Department of Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA

Yan Beauverd^1*, Arvind Pillai, MBBS, MRCP, FRCPath^2*, Steven Knapper, DM BMBCh FRCPath MRCP³, Catherine Cargo, MB MRCP FRCPath^4*, Claire N. Harrison⁵ and Susan Robinson^1*

¹Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
²Department of Haematology, Countess of Chester Hospital, Chester, United Kingdom
³Cardiff, Department of Haematology, Institute of Cancer and Genetics, School of Medicine, Cardiff, United Kingdom
⁴Haematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, United Kingdom
⁵Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

Nicola Polverelli, MD^1*, Roberto Latagliata, MD^2*, Giuseppe A. Palumbo, MD^3*, Alessia Tieghi, MD^4*, Margherita Perricone^1*, Massimo Breccia, MD^5*, Lucia Catani, Ph.D.^1*, Francesco Merli, MD^6*, Emanuela Ottaviani^7*, Giuliana Alimena, MD⁸, Giovanni Martinelli⁹, Michele Cavo, MD^10*, Nicola Vianelli, MD^1* and Francesca Palandri, MD, PhD^7*

¹Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²Division of Hematology-Dept. of Cellular Biotechnologies and Hematology, University La Sapienza of Rome, Rome, Italy
³Division of Hematology, Ospedale Ferrarotto, University of Catania, Catania, Italy
⁴Division of Hematology, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
⁵Dipartimento di Ematologia e Biotecnologie, Università La Sapienza, Rome, Italy
⁶Hematology Unit, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy
⁷University of Bologna, Bologna, Italy
⁸Department of Cellular Biotechnologies and Hematology, Hematology, Sapienza University, Rome, Italy
⁹"Seràgnoli" Institute of Hematology, University of Bologna, Bologna, Italy
¹⁰"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy

Lisa Pieri, MD, PhD^1,2*, Emanuela Sant'Antonio, MD^1,2*, Elisa Rumi, MD^3*, Paola Guglielmelli, MD, PhD^1,2*, Rajmonda Fjerza, MD^1,2*, Chiara Paoli, BS^1,2*, Lucia Merli, BSN^1,2*, Mario Cazzola, MD³ and Alessandro M. Vannucchi^1,2

¹Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
²CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
³Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Frauke Bellos, MD^1*, Karl Sotlar, MD^2*, Susanne Schnittger, PhD¹, Claudia Haferlach, MD¹, Torsten Haferlach¹ and Wolfgang Kern, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²Ludwig-Maximilians-University Munich, Munich, Germany

Chun Qiao^1*, Yuan Ouyang^2* and Sujiang Zhang^2,3*

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
²Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
³Department of Hematology, Ruijin Hospital North Affiliated with Shanghai Jiao Tong University School of Medicine, shanghai, China

Krisstina L. Gowin, DO^1*, Heidi E. Kosiorek, MS^2*, Amylou Constance Dueck, PhD^3*, John Mascarenhas⁴, Ronald Hoffman, M.D.⁵, Craig B. Reeder, MD², John Camoriano, MD¹, Veena Fauble, MD⁶, Raoul Tibes, MD¹, Katherine Gano, MS^1*, Vineta Ghurye^1*, Patricia Koenig^1* and Ruben A. Mesa²

¹Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, AZ
²Mayo Clinic, Scottsdale, AZ
³Division of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ
⁴Hematology, Mount Sinai School of Medicine, New York, NY
⁵Tish Cancer Institute, Mount Sinai School of Medicine, New York, NY
⁶Hematology Oncology/ Blood and Marrow Transplant, Mayo Clinic Arizona, Phoenix, AZ

Maria Coakley, MD^1*, Krisstina L. Gowin, DO^2*, Heidi E. Kosiorek, MS^3* and Ruben A. Mesa³

¹Cork University Hospital, Wilton, Cork, Ireland
²Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, AZ
³Mayo Clinic, Scottsdale, AZ

Lesley A. Anderson, PhD, MPH^1*, Glen J. Titmarsh, BSc^2*, Amylou C. Dueck, PhD³, Andrew Duncombe, MD, PhD^4*, Ruben A. Mesa, MD³, Robyn M. Scherber, MD, MPH⁵, Heidi E. Kosiorek, MS^3*, Frank de Vocht, PhD^6*, Mike Clarke, PhD^1* and Mary Frances McMullin, MD, FRCPath, FRCP⁷

¹Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
²Centre for Public Health, Queen's University Belfast, Belfast, Antrim, United Kingdom
³Mayo Clinic, Scottsdale, AZ
⁴Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⁵Hematology and Oncology, Oregon Health and Sciences University, Portland, OR
⁶School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⁷Queen's University Belfast, Belfast, United Kingdom

Mary Frances McMullin, MD, FRCPath, FRCP^1,2, Andrew Duncombe, MD, PhD^3*, Glen J. Titmarsh, BSc^4*, Frank de Vocht, PhD^5*, Lin Fritschi, PhD^6*, Ruben A. Mesa⁷, Mike Clarke, PhD^8* and Lesley A. Anderson, PhD, MPH^8*

¹Queen's University Belfast, Belfast, United Kingdom
²Queens University of Belfast Belfast City Hospital, Belfast, United Kingdom
³Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⁴Centre for Public Health, Queen's University Belfast, Belfast, Antrim, United Kingdom
⁵School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⁶4Curtin University, Perth, Australia
⁷Mayo Clinic, Scottsdale, AZ
⁸Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom

Shijia Zhang, MD, PhD¹, Yucai Wang, MD, PhD¹, Larysa Sanchez, MD¹, Narjust Duma, MD^1* and Victor Chang, MD^1,2*

¹Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ
²Section of Hematology/Oncology, VA New Jersey Health Care System, East Orange, NJ

Daniel P McMahon, MD^1*, Amanda Lance, BS^2*, Andrea E. Price, BS^2*, Jonathan M. Gerber, MD², Sarah A Baxter, PhD^2*, Lawrence J Druhan, PhD², Nury M Steuerwald, PhD^3* and Belinda R Avalos, MD²

¹Pediatric Hematology/Oncology, Levine Children's Hospital, Carolinas HealthCare System, Charlotte, NC
²Department of Hematologic Oncology and Blood Disorders, The Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC
³Molecular Biology Core Facility, Carolinas HealthCare System, Charlotte, NC

Amanda Bell Grimes, MD¹, Daniel Zinn, MD², Olive S. Eckstein, MD³, Carl Allen, MD, PhD⁴ and Kenneth McClain, MD, PhD⁵

¹Texas Children's Hospital, Baylor College of Medicine, Houston, TX
²Texas Childrens Cancer Center, Texas Childrens Hospital, Houston, TX
³Cancer and Hematology Centers, Texas Children's Hospital/Baylor College of Medicine, Houston, TX
⁴Texas Children’s Cancer and Hematology Centers, Texas Children`s Hospital, Houston, TX
⁵Texas Childrens Cancer and Hematology Centers, Houston, TX

Keita Kirito, MD¹, Norio Komatsu, MD, PhD², Kazuya Shimoda, MD, PhD³, Hikaru Okada, MD, PhD^4*, Taro Amagasaki, PhD^4*, Toshio Yonezu, MSc^4* and Koichi Akashi, MD, PhD⁵

¹Department of Hematology and Oncology, University of Yamanashi, Yamanashi, Japan
²Department of Hematology, Juntendo University Faculty of Medicine, Tokyo, Japan
³University of Miyazaki, Miyazaki, Japan
⁴Novartis Pharma KK, Tokyo, Japan
⁵Kyushu University Hospital, Fukuoka, Japan