Weiguo Han^1*, Aisharya Bhattacharya^1*, Wenzhi Ji, PhD^2*, Basel A. Karim^2*, Roman C. Sarott, PhD^2*, Meredith Nix^2*, Sai Gourisankar, PhD^2*, Andrey Krokhotin^3*, Sutapa Sinha, PhD^1*, Zhiquan Wang, PhD¹, Tait D. Shanafelt, MD^4,5*, Sameer A. Parikh, MBBS¹, Nathanael S. Gray, PhD^2*, Gerald R. Crabtree, MD^3,6* and Neil E. Kay, MD^1,7

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Department of Chemical and Systems Biology, Stanford University, Stanford, CA
³Department of Pathology, Stanford University, Stanford, CA
⁴School of Medicine, Stanford University, Stanford, CA
⁵WellMD & WellPhD Center, Stanford University, Stanford, CA
⁶Department of Developmental Biology, Stanford University, Stanford, CA
⁷Department of Immunology, Mayo Clinic, Rochester, MN

Angimar Uriepero Palma, MD, MMSc^1*, Melanie Mediavilla Varela, pH.D^2*, Maria Elena Marquez, Ph.D^3*, Wael Gamal², Mohammad Ammad-ud-din, MD^4*, Pablo Oppezzo, Ph.D^5*, Eva Sahakian, PhD^6* and Javier Pinilla-Ibarz, MD, PhD^7*

¹Department of Internal Medicine, Jefferson Einstein Hospital, Philadelphia, PA
²Immunology/Immune-Oncology, Moffitt Cancer Center, Tampa, FL
³Research Laboratory On Chronic Lymphocytic Leukemia. Institut Pasteur De Montevi, Montevideo, URY
⁴Department of Hematology/Oncology, Moffitt Cancer Center, Tampa, FL
⁵Institut Pasteur De Montevideo, Montevideo, URY
⁶Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁷Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, FL

Malte Knöll^1*, Rashmi Priyadharshini Dheenadayalan, PhD^2*, Deyan Y. Yosifov, PhD^3*, Jialei Qi, MD^4*, Christof Schneider, MD^5*, Felix Seyfried, MD^6*, Lueder Hinrich Meyer, MD^6*, Paula Cramer, MD^7*, Julia Von Tresckow, MD^8*, Michael Hallek, MD^9*, Barbara F. Eichhorst, MD⁹, Eugen Tausch, MD^5*, Stephan Stilgenbauer, MD¹⁰ and Billy Jebaraj, PhD^11*

¹Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, AL, Germany
²University of Ulm, Ulm, Germany
³Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Baden-Württemberg, Germany
⁴University Hospital Ulm, Ulm, Germany
⁵Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
⁶Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
⁷Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
⁸Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁹Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Cologne, Germany
¹⁰Department of Internal Medicine III, Division of CLL, Ulm University, Ulm, Germany
¹¹Department of Internal Medicine III, Division of CLL, University of Ulm, Ulm, Baden Wurttemberg, Germany

Rebecca Svanberg Teglgaard, MD, PhD^1,2*, Rudi Agius, PhD^1*, Caspar da Cunha-Bang, MD, PhD^1*, Tereza Faitova, MSc^1*, Christian Brieghel, MD, PhD^1*, Hans Jakob Hartling, MD, PhD^2*, Hanne Vibeke Marquart, MD, PhD^2*, Robert Schou Pedersen, MD, PhD^3*, Christian Bjørn Poulsen, MD, PhD^4*, Mark-David Levin⁵, Fransien De Boer, MD, PhD^6*, Koen de Heer, MD, PhD^7*, Rikke Kragh Lauridsen, MSc, PhD^8*, Joanne Reekie, PhD^8*, Anders Österborg, MD, PhD^9*, Jeanette Lundin, MD, PhD^9*, Magdalena Kättström, MD^10*, Sisse Rye Ostrowski, MD, PhD, DMSc^2,11* and Carsten Utoft Niemann, MD, PhD^1,12*

¹Department of Hematology, Rigshospitalet, Copenhagen, Denmark
²Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
³Department of Hematology, Gødstrup Hospital, Herning, Denmark
⁴Department of Hematology, Zealand University Hospital, Roskilde, Denmark
⁵Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
⁶Ikazia Hospital, Rotterdam, Netherlands
⁷Department of Internal Medicine, Flevoziekenhuis, Almere, Netherlands
⁸CHIP, Rigshospitalet, Copenhagen, Denmark
⁹Department of Hematology, Karolinska University Hospital, Stockholm, Sweden
¹⁰Section of Hematology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
¹¹Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
¹²Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Ramon Massoni-Badosa, PhD^1,2,3*, Joshua S. Schiffman, PhD^1,2,3*, Barun Pradhan, PhD^1,2,3*, Rebecca M. Murray, BS^2,3,4*, Andrew H. Lipsky, MD⁵, Debra Van Egeren, PhD^1,2,3*, Danny Luan, MD, MPH¹, Shirley Chen, BS^1*, Ronan Chaligne, PhD^6*, Kai Beattie, BS^1,2,3*, Alyssa Indart, PhD^1,2,3*, Nada Chraiki, BS^1,2,3*, Neville Dusaj, MD^1,2,3*, Erica B. Bhavsar, BS^1*, Chelston Ang, BS, MSc⁷, Anna S. Nam, MD⁸, Federico Gaiti, PhD⁹, Paulina Chamely, MSc^1,2,3*, Nathaniel D. Omans, PhD^1,2,3*, Preeti Trisal, MS^10*, Anita K. Gandhi, PhD¹¹, Kyu-Tae Kim, PhD^12*, Rafael Schulman, BS^13*, Franco Izzo, PhD^14*, Gavriel Mullokandov, MD, PhD^1,3*, Chingiz Underbayev, MD, PhD^15*, Jan A. Burger, MD, PhD ¹⁶, Adrian Wiestner, MD¹⁵, Elisa Ten Hacken, PhD¹, John N. Allan, MD¹, Jennifer A. Woyach, MD¹⁷, Richard R. Furman, MD¹⁸ and Dan A. Landau, MD, PhD^2,3,4*

¹Division of Hematology and Medical Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medicine, New York, NY
²Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY
³New York Genome Center, New York, NY
⁴Division of Hematology and Medical Oncology and Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY
⁵Herbert Irving Comprehensive Cancer Center, New York-Presbyterian/Columbia University Medical Center, New York, NY
⁶Single Cell Analytics and Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, NY
⁷University of North Carolina School of Medicine, Chapel Hill, NC
⁸Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
⁹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
¹⁰Bristol Myers Squibb, Summit, NJ
¹¹Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
¹²Department of Physiology, Ajou University School of Medicine, Suwon, Korea, Republic of (South)
¹³SUNY-Upstate Medical College, New York, NY
¹⁴Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
¹⁵Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
¹⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁷Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH
¹⁸Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY

Saurabh Yadav, PhD^1,2, Sumbul Jawed Khan, PhD^1*, Binu Kandathilparambil Sasi, PhD^1,2, Elizabeth F. Cohen, MRes^3*, Kiyomi Mashima, MD, PhD^1,2, Hannah Cormier, BS^1*, Stacey M. Fernandes, BS^1*, Samantha J. Shupe, BS^1*, Roberta Santos Azevedo^4,5*, Mariia Mikhaleva, MD^1*, Philippe Armand, MD, PhD^1,2, David C. Fisher, MD^1,2, Matthew S. Davids, MD, MMSc^2,6, Inhye E. Ahn, MD^1,2, Michael Y. Tolstorukov, PhD^3*, Mark A. Murakami, MD^1,2 and Jennifer R. Brown, MD, PhD^1,2

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Medicine, Harvard Medical School, Boston, MA
³Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Sao Paulo, AC, Brazil
⁵Department of Hematology, Hospital Nove de Julho, São Paulo, Brazil
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

Xiao Lu, MD^1*, Yeqin Sha, MD^2*, Xinyu Song, MD^3*, Luomengjia Dai, MD^2*, Ziyuan Zhou, MD^2*, Hanning Tang, MD^2*, Yi Miao, MD^1*, Shuchao Qin, MD PHD^1*, Yi Xia, MD, PhD^2*, Tonglu Qiu, MD^1*, Lei Fan^4*, Jianyong Li, MD⁵ and Huayuan Zhu^6*

¹Lymphoma Center, Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
²Lymphoma Center, Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
³School of Basic Medical Sciences of Nanjing Medical University, Nanjing, Jiangsu Province, China
⁴Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁵First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
⁶Pukou CLL Center, Pukou Division of Jiangsu Province Hospital, Nanjing, Jiangsu, China

Othman Al-Sawaf, MD¹, Benjamin N. Locher^2*, Friederike Christen^2*, Sandra Robrecht, PhD^3*, Can Zhang, PhD^4*, Anna Maria Fink, MD^4*, Eugen Tausch, MD^5*, Christof Schneider, MD^5*, Matthias Ritgen^6*, Karl Anton Kreuzer^7*, Coral Fustero^2*, Raphael Hablesreiter^8*, John F. Seymour, MBBS, PhD⁹, Piers Blombery, MBBS¹⁰, Lars Bullinger², Brenda Chyla¹¹, Hyun Yong Jin, PhD^12*, Yanwen Jiang^12*, Stephan Stilgenbauer, MD¹³, Barbara F. Eichhorst, MD¹⁴, Michael J. Hallek, MD¹⁵, Kirsten Fischer, MD^3* and Frederik Damm^2*

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany, Cologne, Germany
²Department of Hematology, Oncology, and Cancer Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
³Department I of Internal Medicine, Faculty of Medicine and Cologne University Hospital, Cologne, Germany
⁴Faculty of Medicine and Cologne University Hospital, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Cologne, Germany, Cologne, Germany, Cologne, Germany
⁵Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
⁶Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
⁷Department I of Internal Medicine, University of Cologne, Cologne, Germany
⁸Department of Hematology, Oncology, and Cancer Immunology, Charité ? Universitätsmedizin Berlin, Berlin, Germany
⁹Peter MacCallum Cancer Center, Melbourne, Australia
¹⁰Peter Maccallum Cancer Centre, East Melbourne, VIC, Australia
¹¹AbbVie Inc, North Chicago, IL
¹²Genentech, Inc., South San Francisco, CA
¹³Comprehensive Cancer Center Ulm, University of Ulm, Ulm, Germany
¹⁴University Hospital Cologne, Cologne, Germany
¹⁵Department 1 of Internal Medicine, University Hospital Cologne, Cologne, Germany