66th ASH Annual Meeting: 636. Myelodysplastic Syndromes: Basic and Translational: Poster III

Symposia: Myelodysplastic Syndromes: Basic and Translational Oral and Poster Abstracts
Poster

Research, Acute Myeloid Malignancies, Combination therapy, AML, MDS, Fundamental Science, Adult, Drug development, MPN, Translational Research, Elderly, Genomics, Clinical Research, Hematopoiesis, Chronic Myeloid Malignancies, CMML, Diseases, Treatment Considerations, Lymphoid Malignancies, Computational biology, Biological Processes, Myeloid Malignancies, Technology and Procedures, Gene editing, Molecular biology, Study Population, Profiling, Human, Pathogenesis, Animal model, Omics technologies

Halls G-H (San Diego Convention Center)

4570

HMGB3 As a Cargo Protein for XPO1: Implications for Myelodysplastic Syndromes Prognosis and Treatment

Hongyan Tong, PhD^1,2,3,4, Wenli Yang³^*, Liya Ma⁵^*, Yudi Zhang³^*, Wei Wang⁶^*, Kongfei Li³^*, Wei Lang³^*, Lu Wang³^*, Wenbin Yang⁶^* and Hua Huang³^*

¹Zhejiang University Cancer Center, Hangzhou, China
²Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, PR China;, Hangzhou, China
³Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁴Zhejiang Provincial Clinical Research Center for Hematological disorders, Hangzhou, China
⁵Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
⁶Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

4571

Dysregulation of Transposable Elements and Piwi-Interacting RNAs in Myelodysplastic Neoplasms

Zdenek Krejcik¹^*, David Kundrat¹^*, Monika Belickova¹^*, Jiri Klema²^*, Andrea Hrustincova¹^*, Iva Trsova^1,3^*, Jaroslav Cermak¹, Anna Jonasova⁴^* and Michaela Dostalova Merkerova, PhD, MSc¹^*

¹Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²Czech Technical University, Prague, Czech Republic
³Faculty of Science, Charles University, Prague, Czech Republic
⁴General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic

4572

The Zymogen Form of Caspase-1 Is Required to Finetune Excessive Cell-Intrinsic Inflammation in Myelodysplastic Syndromes

Emma E. Uible, BS^1,2, Kathleen Hueneman, MBA³^*, Lyndsey C. Bolanos, MBA, BSc³^*, Kwangmin Choi, PhD⁴^*, William Seibel⁵^* and Daniel Starczynowski, PhD^3,6

¹Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH
²Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Cincinnati, OH
³Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
⁵Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶University of Cincinnati College of Medicine, Cincinnati, OH

4573

Elucidating the Somatic Genetic Rescue Underlying Del(20q) Myeloid Neoplasms

Mark Orland, MD^1,2, Arda Durmaz, PhD¹^*, Carlos Bravo-Perez, MD^1,3^*, Carmelo Gurnari, MD, PhD^1,4, Luca Guarnera, MD^1,4^*, Matteo D'Addona^1,5^*, Aashray Mandala, BS¹^*, Christopher Haddad, BS¹^*, Kartik Lakhotiya, MS¹^*, Valeria Visconte, PhD¹^* and Jaroslaw Maciejewski¹

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Internal Medicine, Cleveland Clinic, South Euclid, OH
³Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
⁴Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁵Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Ercolano, Italy

4574

CBL Loss or Mutations Upregulates AXL to Promote Cytokine-Independent Growth in Myeloid Malignancies: AXL Upregulation Promotes Cytokine-Independent Growth in CBL-Mutant CMML

Rouxing Wang, PhD^1,2, Shiwei Chen, MD^1,2^*, Mohammed Alhusayan³^*, Bowen Xing^1,2^*, Yan Liu, PhD⁴, Hamid Band, MD, PhD⁵^*, Irfan Asangani³^*, Junwei Shi, PhD³^* and Wei Tong, PhD^2,6

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
³Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁴Northwestern University, Chicago, IL
⁵Nebraska Medicine, University of Nebraska Medical Center, Omaha, NE
⁶Children's Hospital of Philadelphia, Philadelphia, PA

4575

Single-Cell Transcriptomic Analysis Reveals Distinct Hematopoietic Landscapes and Immune Dysregulation in Der(1;7)(q10;p10) Myelodysplastic Syndromes

Hongyan Tong, PhD^1,2, Wei Wang^1,2^*, Yingwan Luo^1,2^*, Wei Lang^1,2^*, Wenbin Yang^1,2^*, Wenli Yang^1,3^*, Wenxia Li^1,2^* and Hua Huang^1,2^*

¹Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, China
²Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
³Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

4576

Heterozygous ddx41 Mutation Drive Age-Dependent Hematopoietic Stem and Progenitor Cell Dysfunction

Maria Feliz Norberto, MS^1,2, Yanhua Wang, MD³^*, Qing Wang, MD³^*, Anastasia Nizhnik, MS¹^*, Bianca A Ulloa, MD/PhD¹, Sofia De Oliveira, PhD¹^* and Teresa V. Bowman, PhD⁴

¹Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY
²Comprehensive Cancer Center, Montefiore Medical Center, Bronx
³Department of Pathology, Montefiore Medical Center, Bronx
⁴Department of Oncology, Department of Molecular and Developmental Biology, Albert Einstein College of Medicine, New York, NY

4577

Bone Marrow Spatial Multi-Omics Identifies Reduced Interactions between Hematopoietic Stem Cells and Myeloid Cells in Myelodysplastic Syndrome

Alyssa C. Parker, BS¹^*, Joseph C. Van Amburg, MS²^*, Tianzi Zhang³^*, Diane C. Saunders, PhD⁴^*, Thomas J. Gracie, MD⁵^*, Pawan Bhat, BSc⁶, J. Brett Heimlich, MD, PhD⁶^*, John W. Hickey, PhD⁷^*, Emily F. Mason, MD, PhD⁸^*, Ashwin Kishtagari, MBBS⁹, Brent Ferrell Jr., MD¹⁰ and Alexander G. Bick, MD, PhD¹¹^*

¹Vanderbilt University, Nashville, TN
²School of Medicine, Human Genetics Program, Vanderbilt University, Nashville, TN
³Department of Computer Science, Vanderbilt University, Nashville, TN
⁴Department of Medicine, Vanderbilt University, Nashville, TN
⁵Internal Medicine Residency, Vanderbilt University Medical Center, Nashville, TN
⁶Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
⁷Duke University, Durham, NC
⁸Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN
⁹Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN
¹⁰Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN
¹¹Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN

4578

Synchronous Dual Hematologic Neoplasms of Myeloid and Lymphoid Lineage Are of Common Clonal Origin

Somedeb Ball, MD¹, Surendra Neupane²^*, Hannah Newman²^*, Joshua A Traina²^*, Najla H. Al Ali, Ms³^*, Abhishek Dhawan, PhD²^*, Praneeth Reddy R Sudalagunta, PhD⁴^*, Ariosto Siqueira Silva, PhD²^*, Danny DeAvila²^*, Mohammad Omar Hussaini, MD⁵^*, Jinming Song, MD, PhD⁶^*, Zhuoer Xie, MD, MS⁷, Onyee Chan, MD⁸, Alison R. Walker, MD, MBA, MPH⁹, Christopher Ryder²^*, Andrew T. Kuykendall, MD³, Jeffrey E Lancet, MD³, Lubomir Sokol, MD, PhD³, Brent Ferrell Jr., MD¹⁰, Ling Zhang, MD¹¹^*, Michael R. Savona, MD¹⁰^*, David Sallman, MD³, Javier Pinilla-Ibarz, MD, PhD³, Rami S. Komrokji, MD¹², Kenneth H. Shain, MD, PhD² and Eric Padron, MD¹³

¹Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN
²H. Lee Moffitt Cancer Center, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵Department of Pathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁶Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁷Department of Malignant Hematology, Moffitt Cancer Center, Lutz, FL
⁸H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁹Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Wesley Chapel, FL
¹⁰Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN
¹¹Hematopathology and Laboratory Medicine, Moffitt Cancer Center & Research Institute, Tampa, FL
¹²Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹³Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL

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