Tomoki Ito, MD, PhD¹, Teruhito Takakuwa, MD, PhD^2*, Masayuki Hino, MD, PhD³, Hirohisa Nakamae, MD, PhD^4*, Kazunori Murai, MD, PhD⁵, Yoko Kubuki, M.D.^6*, Kazuya Shimoda, MD, PhD⁷, Yuji Kumagai, MD, PhD^8*, Yukiya Yamamoto, MD, PhD⁹ and Tadashi Matsuura, PhD^10*

¹Kansai Medical University Hospital, Hirakata, JPN
²Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan
³Department of Central Clinical Laboratory, Osaka Metropolitan University Hospital, Osaka, Japan
⁴Department of Hematology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
⁵Department of Hematology, Iwate Prefectural Central Hospital, Morioka, JPN
⁶Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
⁷University of Miyazaki, Miyazaki, Japan
⁸Research department, Kitasato University KItasato Institute Hospital, Tokyo, Japan
⁹College of Life and Health Sciences, Department of Biomedical Sciences,, Chubu University, Kasugai-Shi, AIC, JPN
¹⁰Perseus　Proteomics Inc., Tokyo, Japan

Anneli Enblom Larsson Enblom Larsson, MD^1*, Henrik Renlund^2*, Björn Andreasson, MD, PhD^3*, Henrik Holmberg^4*, Maria Liljeholm, MD, PhD^5* and Anders Själander, MD, PhD^6*

¹Department of Public Health and Clinical Medicine, Umeå University, Södra Sunderbyn, Sweden
²Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
³NU Hospital Group, Uddevalla Hospital, Uddevalla, Sweden
⁴Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden
⁵Department of Diagnostics and Intervention, Umeå University, Umeå, Sweden
⁶Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

Johannes Luebke, MD^1*, Tracy I. George, MD², Daniel J. DeAngelo, MD³, Jason Gotlib, MD, MS⁴, Deepti H. Radia^5*, Michael W. Deininger, MD, PhD⁶, Aaron Zakharyan, PhD^7*, Joana Caetano-Lopes^7*, Sasa Dimitrijevic, PhD^8* and Andreas Reiter, MD¹

¹Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
²ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medicine, Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA
⁵Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
⁶Deininger Lab, Versiti Blood Research Institute, Milwaukee, WI
⁷Blueprint Medicines Corporation, Cambridge, MA
⁸Blueprint Medicines Corporation, Zug, Switzerland

Caroline Norup Bistrup^1*, Morten Kranker Larsen, MSc^2*, Peter Junker^3*, Vibe Skov^4*, Lasse Kjær^4*, Trine Alma Knudsen⁴, Morten Karsdal^1*, Nicholas Willumsen^1* and Hans C. Hasselbalch^4*

¹Nordic Bioscience, Herlev, Denmark
²Department of Hematology, Zealand University Hospital, Roskilde, DNK
³Department of Rheumatology, Odense University Hospital, Odense, Denmark
⁴Department of Hematology, Zealand University Hospital, Roskilde, Denmark

Pankit Vachhani, MD^1*, Jennifer Repp, PharmD^2*, JE Hamer-Maansson, MSPH^2*, Evan M. Braunstein, MD, PhD², Valkal Bhatt, PharmD^2* and Haifa Kathrin Al-Ali, MD; PhD^3*

¹University of Alabama at Birmingham, Birmingham, AL
²Incyte Corporation, Wilmington, DE
³University Hospital Halle, Halle (Saale), Germany

Jasmine Makker^1,2*, Kyaw Htin Thaw^2*, Amna Sheikh^2*, Llywelyn Cadman-Davies^2*, Andrea Duminuco, MD^2*, Elena Torre, MD^2*, Claire Woodley^2*, Susan Asirvatham^2*, Jennifer O' Sullivan, MRCP^2*, Natalia Curto-Garcia^2*, Priya Sriskandarajah, MBBS, MRCP, PhD^2*, Deepti H. Radia, MD^2*, Hugues de Lavallade, MD, PhD^2*, Shahram Kordasti, MD, PhD², Claire Harrison^3,4 and Patrick Harrington^2,4*

¹GKT School of Medical Education, King's College London, London, United Kingdom
²Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
³Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
⁴School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom

Hidehiro Itonaga, MD, PhD¹, Yasushi Miyazaki, MD, PhD^2,3, Takeshi Kondo, M.D., Ph.D.⁴, Yutaka Shimazu^5*, Jun Aoki, MD, PhD^6*, Shuhei Kurosawa, MD, PhD^7*, Takashi Ikeda, MD, PhD^8*, Tetsuya Eto^9*, Naoyuki Uchida¹⁰, Hideyuki Nakazawa, MD, PhD^11*, Koji Kawamura, MD, PhD^12*, Junya Kanda, MD, PhD^13*, Yoshiko Atsuta^14* and Takayoshi Tachibana, MD, PhD^15*

¹Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan
²Nagasaki University, Nagasaki, Japan
³Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
⁴Blood Disorders Center, Aiiku Hospital, Sapporo, Japan
⁵Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁶Department of hematology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan
⁷Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center, Tokyo, Japan
⁸Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Shizuoka, JPN
⁹Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
¹⁰Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations TORANOMON HOSPITAL, Tokyo, Japan
¹¹Department of Hematology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
¹²Division of Hematology and Clinical Laboratory Medicine, Tottori University Hospital, Yonago, Japan
¹³Department of Hematology, Kyoto University Hospital, Kyoto, Japan
¹⁴The Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan
¹⁵Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan

Rodrigo Ortega Pérez Sr.^1*, Valentín García Gutiérrez Sr.², Alberto Alvarez Larran^3*, Maria Angeles Foncillas, MD^4*, Francisca Ferrer Marin, MD⁵, Beatriz Cuevas^6*, Clara Martínez Villaverde Sr.^7*, Patricia Velez, MD^8*, Maria Isabel Mata Vazquez^9*, Adrian Segura Diaz^10*, Maria Laura Fox, MD^11*, Elvira Mora Casterá^12*, Concepcion Ruiz Nuño^13*, Jose Maria Raya Sanchez^14*, Manuel Perez Encinas, MD^15*, Javier Loscertales^16*, María Alicia Senin^17,18*, Maria Soledad Noya Pereira^19*, Mercedes Gasior Kabat, MD^20*, Blanca Xicoy, MD^21*, Concha Alaez, MD^22*, Gonzalo Carreño, PhD^23*, Raul Perez Lopez^24*, Rafael Andrés Del Orbe Barreto^25*, María Angeles Goñi Herranz^26*, Juan Manuel Alonso-Dominguez, MD, PhD^27*, Lucía Guerrero Fernández^28*, Jose María Guerra^29*, Anna Angona^30*, Irene Pastor^31*, Ana Pardo Sanz^32* and Jose Luis Zamorano García^32*

¹Universitary Hospital Ramón y Cajal, Madrid, Spain
²Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
³Hospital Clinic, Barcelona, Spain
⁴Department of Hematology, Hospital Universitario Infanta Leonor, Madrid, ESP
⁵Universitary Hospital Morales-Meseguer., Murcia, Spain
⁶Hospital de Burgos, BURGOS, ESP
⁷Sant Pau Hospital, Barcelona, Spain
⁸Department of Hematology, Hospital del Mar, Barcelona, Spain
⁹Hospital Costa del Sol, Malaga, ESP
¹⁰Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas, AE, Spain
¹¹Vall d'Hebron University Hospital, Barcelona, Spain
¹²Hospital la Paz, Valencia, Spain
¹³Hospital de Málaga, Malaga, Spain
¹⁴Hospital Universitario de Canarias, La Laguna, Spain
¹⁵Department of Hematology, Hospital Unviersitario de Santiago de Compostela, IDIS, Santiago de Compostela, ESP
¹⁶Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain
¹⁷Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona, Barcelona, Spain
¹⁸Hospital del Mar, Barcelona, Spain
¹⁹Hospital a Coruña, La Coruna, ESP
²⁰Hospital La Paz, Madrid, ESP
²¹Hematology Service, ICO-Hospital Germans Trias i Pujol, Institut de Recerca contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain
²²Hospital Moncloa, Madrid, ESP
²³Hospital Universitario 12 de Octubre, Madrid, Spain
²⁴Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
²⁵Hospital Universitario de Cruces, Barakaldo, ESP
²⁶Complejo Hospitalario de Navarra, Pamplona, Spain
²⁷Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
²⁸Complejo Asistencial Universitario de Palencia, Palencia, Spain
²⁹Hospital Son Llatzer, Palma de Mallorca, Spain
³⁰Hospital Universitario Doctor Josep Trueta - ICO, Girona, Spain
³¹Hematology Department. Hospital Clínico, Valencia, Spain, Valencia, Spain
³²Hospital Ramón y Cajal, Madrid, Spain

Daniele Cattaneo^1*, Barbara Mora^2*, Cristina Bucelli, MD^3*, Margherita Maffioli^4*, Elena Maria Elli, MD^5*, Giulia Benevolo, MD^6*, Valentina Bellani, MD^7*, Emilia Scalzulli, MD^8*, Filippo Branzanti, MSc^9*, Paola Bianchi, PhD, BSc¹⁰, Marta Lionetti, PhD^11*, Bruno Martino, MD^12*, Umberto Gianelli, Prof^13*, Niccolò Bolli, MD, PhD^14*, Francesca Palandri, MD, PhD^15*, Massimo Breccia^16*, Dario Consonni^17* and Alessandra Iurlo, MD, PhD^18*

¹Hematology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, AL, Italy
²Fondazione I.R.C.C.S. Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
³FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO, MILANO, Italy
⁴ASST Dei Sette Laghi, Ospedale Di Circolo, Varese, Varese, ITA
⁵Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁶AOU Città della Salute e della Scienza, Turin, Italy
⁷Hematology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
⁸Hematology, Department of Translational and Precision Medicine, Az. Policlinico Umberto I-Sapienza University, Rome, Roma, Italy
⁹IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
¹⁰Hematology Unit, Pathophysiology of Anemias Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy
¹¹Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy
¹²Division of Hematology, Azienda Ospedaliera 'Bianchi Melacrino Morelli', Reggio Calabria, Italy
¹³Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
¹⁴Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
¹⁵IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seràgnoli", Bologna, Italy
¹⁶Department of Translational and Precision Medicine, Az., Hematology-Sapienza University, Rome, Italy
¹⁷Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
¹⁸Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Richard Shao^1*, Hailing Zhang, MD^2*, Lynn C. Moscinski, MD², Mohammad Omar Hussaini, MD^3*, Julie Li, MD^2*, Ahmed Arfa, MD^4*, Le Wang, MD, PhD⁵ and Jinming Song, MD, PhD^2*

¹The University of Central Florida College of Medicine, Orlando
²Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Department of Pathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Pathology, H. Lee Moffitt Cancer Center, Tampa
⁵Guthrie Clinic Cancer Center Robert Packer Hospital, Sayre, PA

Giuseppe Gaetano Loscocco^1,2*, Fnu Aperna, MBBS^1*, Moazah Iftikhar, MBBS^1*, Masooma S Rana, MBBS^1*, Amritpal Singh^1*, Tiziano Barbui, MD^3*, Paola Guglielmelli, MD⁴, Alessandro Maria Vannucchi², Animesh D. Pardanani, MBBS, PhD¹, Naseema Gangat, MBBS⁵ and Ayalew Tefferi, MD⁶

¹Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN
²Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy
³FROM Research Foundation ASST Papa Giovanni XXIII Bergamo, Bergamo, ITA
⁴Department of Experimental and Clinical Medicine, Centro di Ricerca e Innovazione Malattie Mieloproliferative (CRIMM), AOU Careggi, University of Florence, Florence, Italy
⁵Rochester, MN
⁶Division of Hematology, Mayo Clinic, Rochester, MN

Ambroise Le Pogam^1*, Matthias Papo^2*, Pierre Hirsh^3*, Jean-Francois Emile^4*, Pierre Duffau^5*, Jerome Razanamahery^6*, Estibaliz Lazarro, MD PhD^7*, Damiens Roos-Weil^8*, Fleur Cohen-Aubart^9*, Vincent Jachiet^10*, Arsene Mekinian, MD, PhD^10*, Olivier Fain^10*, Zahir Amoura^11*, Jerome Hadjadj, MD, PhD^12,13* and Julien Haroche^14*

¹Saint-Antoine hospital, Paris, France
²Internal medicine, Sorbonne University, Pitié Salpêtrière Hospital, Paris, France
³Saint antoine hospital APHP, Paris, France
⁴Assistance Publique–Hôpitaux de Paris (AP-HP), Ambroise-Paré Hospital, Pathology Department, Boulogne, France
⁵Bordeaux University Hospital, Bordeaux, FRA
⁶Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France
⁷CHU Bordeaux, Pessac, FRA
⁸Pitié-salpêtrièRe, Paris, FRA
⁹Centre National De Reference Maladies Auto-Immunes Systemiques Rares, Institut E, Paris, FRA
¹⁰Saint Antoine Hospital AP-HP, Paris, France
¹¹Pitié-salpêtrièRe Hospital, 47-83 Bld De L'hôPital,, Paris, FRA
¹²INSERM UMR 1163-Institut Imagine, PARIS, FRA
¹³Saint Antoine Hospital, APHP, Paris, France
¹⁴Pitié-Salpêtrière Hospital, Paris, FRA

Jieyu Wang, MD^*, Shixuan Wang, MD^* and Fei Li

Center of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China

Sangam Sangam, MD¹, Marco Bermudez, MD^1*, Tripti Jain, MD^2*, Maria Camila Tole, MD^1*, Manoj Ghimire, MD^3* and Shorabh Sharma, MD^1*

¹Department of Medicine, SBH Health System, Bronx, NY
²Rochester General Hospital, Rochester, NY
³Department of Medicine, SBH Health System, Bronx

Lindsay A.M. Rein, MD¹, Daniel J. DeAngelo, MD, PhD², Brian Modena, MD^3*, Stephen Oh, MD, PhD⁴, Bulai Livideanu Cridtina^5*, Celalettin Ustun, MD⁶, Nathan Boggs^7*, Michael Manning, MD^8*, Anthony M. Hunter, MD⁹, Cem Akin, MD, PhD^10*, Arnold Kirshenbaum, MD^11*, Ingunn Dybedal, MD, PhD¹², Cecilia Y. Arana Yi, MD¹³, Richard Herrscher^14*, Mariana Castells, MD, PhD^15*, Frederick Lansigan, MD^16*, Tracy I. George, MD¹⁷, Jay Patel, MD¹⁸, Lei Sun^19*, Nisha Shah^19*, Jenna Zhang, PhD^19*, Amanda Pilla^19*, Priya Singh^19*, Marcus Carden, MD^19*, Frank Siebenhaar, MD^20* and Prithviraj Bose, MD²¹

¹Division of Hematologic Malignancies and Cellular Therapy, Duke Cancer Institute, Durham, NC
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Modena Allergy & Asthma, San Diego, CA
⁴Washington University School of Medicine, Saint Louis, MO
⁵Department of Dermatology, CEREMAST Toulouse, CHU Toulouse, Toulouse, France
⁶Rush University Medical Center, Chicago, IL
⁷Walter Reed, Bethesda, MD
⁸Allergy, Asthma, & Immunology Associates, Scottsdale
⁹Emory University Internal Medicine Residency, Decatur, GA
¹⁰University of Michigan, Ann Arbor, MI
¹¹Allervie Clinical Research, Glenn Dale, MD
¹²Oslo University Hospital, Oslo, Norway
¹³Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹⁴AirCare, Plano, TX
¹⁵Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, MA
¹⁶Dartmouth-Hitchcock Medical Center, Lebanon
¹⁷University of Utah and ARUP Laboratories, Salt Lake City, UT
¹⁸University of Utah, ARUP Laboratories, Salt Lake City, UT
¹⁹Cogent Biosciences, Waltham, MA
²⁰Charité - UniversitäTsmedizin Berlin, Berlin, DEU
²¹The University of Texas MD Anderson Cancer Center, Houston, TX

Patrick Harrington^1,2*, Kim Summers, PhD, MSc, BSc^3*, Andrea Preston, MSc, BSc, BPharm^3*, Debbie Street^4*, Mark Taylor^4*, Amna Sheikh^1*, Muna Yusuf, BSc MSc^3*, Rebecca Frewin, FRCPath, MRCP, MBBS, BSc^5*, Louise Wallis^6*, Catherine Loughran, BPharm, MSc^7*, Jennifer O'Sullivan^1*, Claire Woodley^1*, Priya Sriskandarajah^1*, Samah Alimam, MD, PhD^8*, Alesia Khan^9*, Andrea Duminuco, MD^1*, Shahram Kordasti, MD, PhD¹, Orlando Agrippa, BSc MBA^3* and Claire Harrison¹⁰

¹Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
²School of Cancer & Pharmaceutical Sciences, King's College London, London, United Kingdom
³Sanius Health, London, United Kingdom
⁴MPN Voice, London, United Kingdom
⁵Gloucestershire Hospitals NHS Foundation Trust, Gloucester, GBR
⁶Royal Bournemouth Hospital, Bournemouth, GBR
⁷University Hospitals Leicester, Nottingham, GBR
⁸Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
⁹Haematological Malignancy Diagnostic Service, Leeds Teaching Hospital NHS Trust, Leeds, England, United Kingdom
¹⁰Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom

Katie Erdos^1*, Neville Lee Jr.^1*, Yushu Shi, PhD^2*, Ghaith Abu-Zeinah, MD¹ and Joseph M. Scandura, MD, PhD¹

¹Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
²Department of Population Health Sciences, Weill Cornell Medicine, New York, NY

Aaron T. Gerds, MD, MS¹, Andrew T. Kuykendall, MD², Marina Kremyanskaya, MD, PhD³, Ellen K. Ritchie, MD⁴, Jason Gotlib, MD, MS⁵, Jeanne Palmer, MD⁶, Kristen M. Pettit, MD⁷, Victor Priego, MD^8*, Uttam Kumar Nath, MD, DM⁹, Abdulraheem Yacoub, MD^10*, Arkapal Bandyopadhyay, MD, DNB, DM^11*, Suneel Gupta, PhD¹², Sarita Khanna, PhD^13*, Arturo Molina, MD, MS¹³ and Naveen Pemmaraju, MD¹⁴

¹Hematology and Medical Oncology, Cleveland Clinic - Taussig Cancer Institute, Cleveland, OH
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
⁵Department of Medicine, Division of Hematology, Stanford Cancer Institute/Stanford University School of Medicine, Stanford, CA
⁶Mayo Clinic – Mayo Clinic Hospital, Phoenix, AZ
⁷Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
⁸Center for Cancer & Blood Disorders, American Oncology Partners of Maryland PA, Bethesda, MD
⁹Department of Medical Oncology Haematology, All India Institute of Medical Sciences, Rishikesh, India
¹⁰University of Kansas Medical Center, Westwood, KS
¹¹Department of Pharmacology, All India Institute of Medical Sciences, Kalyani, India
¹²Protagonist Therapeutics, Inc., Sunnyvale, CA
¹³Protagonist Therapeutics, Inc., Newark, CA
¹⁴The University of Texas MD Anderson Cancer Center, Houston, TX

Michelle Hyunju Lee, MD¹, Yating Wang, MS^2*, Angel Cronin, MS^2*, Angela C. Tramontano^3*, Lachelle D. Weeks, MD, PhD^4,5 and Gabriela S. Hobbs, MD^6,7

¹Department of Medical Oncology, Massachusetts General Hospital, Winchester, MA
²Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
³Dana-Farber Cancer Institute, Boston, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Medicine, Harvard Medical School, Boston, MA
⁶Harvard Medical School, Boston, MA
⁷Boston, MA

Jeremy V. DiGennaro, DO¹, George Concepcion, MD^2*, Najla H. Al Ali, Ms^3*, Onyee Chan, MD⁴, Alison R. Walker, MD, MBA, MPH⁵, Zhuoer Xie, MD, MS⁶, Eric Padron, MD³, Jeffrey E Lancet, MD⁴, David Sallman, MD³, Ashwin Kishtagari, MBBS⁷, Pankit Vachhani, MD^8*, John O. Mascarenhas, MD⁹, Rami S. Komrokji, MD⁴ and Andrew T. Kuykendall, MD³

¹Department of Internal Medicine, The University of South Florida Morsani College of Medicine, Tampa, FL
²Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL
³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁵Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Wesley Chapel, FL
⁶Department of Malignant Hematology, Moffitt Cancer Center, Lutz, FL
⁷Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Franklin, TN
⁸Division of Hematology/Oncology, O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY

Shanshan Suo, MD^1*, Rongfeng Fu, MD^2*, Albert Qin, MD, PhD^3*, Zonghong Shao^4*, Jie Bai, MD⁵, Hu Zhou, MD^6*, Na Xu^7*, Suning Chen, MD, PhD^8*, Xuelan Zuo^9*, Xin Du^10*, Minghui Duan^11*, Li Wang^12*, Pei Li^13*, Xuhan Zhang^14*, Sujiang Zhang, MD¹⁵, Daoxiang WU, MA^16*, Jingjing Zhang^16*, Weihong Shen^16*, Wei Wang^16*, Lei Zhang², Zhijian Xiao, MD^2* and Jie Jin, M.D.¹⁷

¹Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Medical Research & Clinical Operations, PharmaEssentia Corporation, Taipei, Taiwan
⁴The Second Hospital of Tianjin Medical University, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶Department of Hematology, Henan Cancer Hospital/The Affiliated Cancer Hospital of Zheng Zhou University, Zhengzhou, China
⁷Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁸Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, Suzhou, China
⁹Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China
¹⁰Department of Hematology, Shenzhen Second People's Hospital, Shenzhen, China
¹¹Department of Hematology, Peking Union Medical College Hospital, Beijing, China
¹²The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
¹³Huashan Hospital of Fudan University, Shanghai, China
¹⁴The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
¹⁵Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
¹⁶PharmaEssentia Biotech (Beijing) Limited, Beijing, China
¹⁷Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Alanis Enid Rodriguez-Rosario¹, Aldo Adrian Acosta Medina, MD², N. Nora Bennani, MD³, Gaurav Goyal, MD⁴, Aishwarya Ravindran, M.B.B.S.^5*, Karen L Rech, M.D.^6*, Gordon J Ruan, M.D.³, Mithun V Shah, M.D., Ph.D.³, Dongni Yi, MD^7*, Saurabh Zanwar, MD, MBBS³, Jithma P Abeykoon, MD³ and Ronald S Go, M.D.⁸

¹University of Puerto Rico School of Medicine, Dorado, PR
²Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴University of Birmingham Alabama, Birmingham, AL
⁵Department of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL
⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁸Division of Medical Oncology, Mayo Clinic, Onalaska, WI

Alanis Enid Rodriguez-Rosario¹, Aldo Adrian Acosta Medina, MD², N. Nora Bennani, MD³, Gaurav Goyal, MD⁴, Aishwarya Ravindran, M.B.B.S.^5*, Karen L Rech, M.D.^6*, Gordon J Ruan, M.D.³, Mithun V Shah, M.D., Ph.D.³, Dongni Yi, MD^7*, Saurabh Zanwar, MD, MBBS³, Jithma P Abeykoon, MD³ and Ronald S Go, M.D.⁸

¹University of Puerto Rico School of Medicine, Dorado, PR
²Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴University of Birmingham Alabama, Birmingham, AL
⁵Department of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL
⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁸Division of Medical Oncology, Mayo Clinic, Onalaska, WI

Daiki Yamashita, MD^1*, Hideki Muramatsu, MD, PhD¹, Shintaro Oyama, MD, PhD^2*, Manabu Wakamatsu^3*, Daichi Sajiki, MD^1*, Yusuke Tsumura, MD, PhD^1*, Kotaro Ogawa, MD^1*, Ayako Yamamori, MD, PhD^1*, Kotaro Narita, MD, PhD^1*, Shinsuke Kataoka, MD, PhD^1*, Atsushi Narita, MD, PhD^1*, Asahito Hama, MD, PhD^4* and Yoshiyuki Takahashi¹

¹Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
²Innovative Research Center for Preventive Medical Engineering, Nagoya University, Nagoya, Japan
³Nagoya University, Nagoya, Japan
⁴Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Japan

Nieves Garcia-Gisbert, PhD^1,2*, Lucia Gomez-Perez, MD^3*, Patricia Velez, MD^3*, Lierni Fernández-Ibarrondo, PhD^1*, Raquel Longarón^1,4*, Alicia Senín, MD^3*, Concepción Fernández, PhD^1,4*, Joan Gibert, PhD^1*, Ramón Diez-Feijóo Varela, MD^1,3*, Barbara Tazon, PhD^4*, Laura Camacho^1,4*, Irene Botella^1*, Junjie Ji^1*, Marta Lafuente^1*, Antonio Salar, MD^1*, Carlos Besses, MD^1* and Beatriz Bellosillo, PhD^1,4*

¹Hospital del Mar Research Institute, Barcelona, Spain
²Department of Hematology, Cambridge Stem Cell Institute, Cambridge, United Kingdom
³Department of Hematology, Hospital del Mar, Barcelona, Spain
⁴Department of Pathology, Hospital del Mar, Barcelona, Spain

Junyuan Qi, MD^1*, Bo Jiang, MD^2*, Wei Yang, MD^3*, Xudong Wei, MD, PhD^4*, Hongmei Jing, MD⁵, Yongping Song^6*, Andrea Wang-Gillam, MD, PhD^7*, Yuli Ding^7*, Chao Bi, MD^7* and Ting Zhang, MD/PhD^7*

¹Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences, Tianjin, China
²State Key Laboratory of Experimental Hematology, National clinical Research Center for Blood Diseases, Institute of Hematology, Chinese Academy of Medical Science, Tianjin, China
³Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China
⁴Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China
⁵Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China
⁶Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁷JACOBIO PHARMACEAUTICALS, Beijing, China

Neville Lee Jr.^1*, Katie Erdos^1*, Aqib Abdul Rahman^2*, Richard T. Silver, MD¹, Joseph M. Scandura, MD, PhD¹ and Ghaith Abu-Zeinah, MD¹

¹Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
²Weill Cornell Medicine in Qatar, Doha, Qatar

Yunlong Chen^1*, Xingchen Wang^1*, Chenmeng Liu^1*, Xiaofan Zhu, MD² and Wenyu Yang, MD^1*

¹Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Tianjin, China
²Department of Pediatric Hematology and Oncology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

Isaac Goncalves, MBBS, PhD^1*, Stephen Fuller^2*, Jason Gotlib, MD, MS³, Pankit Vachhani, MD^4*, Vinod Pullarkat, MD⁵, Daniel J. DeAngelo, MD, PhD⁶, Saskia K. Klein, MD, PhD⁷, Wolfgang R. Sperr, MD^8*, Karin Hartmann^9*, Khalid Shoumariyeh, MD^10*, Jens Panse, MD ¹¹, Teng Fong Ng, BSc, MBBS, MRCP, FRACP, FRCPA^12*, Miguel Piris-Villaespesa, MD^13*, Tsewang Tashi, MD¹⁴, Anthony M. Hunter, MD¹⁵, Prithviraj Bose^16*, Cecilia Y. Arana Yi, MD¹⁷, Manish Jain, FRCPath, MBBS^18*, Helena Pomares^19*, Tracy I. George, MD²⁰, Jay Patel, MD²¹, Cristina Papayannidis, MD, PhD²², Minakshi S. Taparia, MBBS²³, Bulai Livideanu Cridtina^24*, Juliana Schwaab, MD^25*, Ingunn Dybedal, MD, PhD²⁶, Jonathan Lambert, PhD, BSc, BMBS, FRCP, FRCPath^27*, Tania Jain, MD²⁸, Ewa Wierzbicka-Hainaut^29*, Olivier Hermine, MD, PhD³⁰, Massimiliano Bonifacio, MD^31*, Gabriela S. Hobbs, MD³², Michael W. Deininger, MD, PhD³³, Amanda Pilla^34*, Marcus Carden, MD^34* and Deepti H. Radia, MD^35*

¹Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Australia
²Sydney Medical School, Nepean Clinical School, University of Sydney, Kingswood, Australia
³Stanford Cancer Institute, Stanford, CA
⁴Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL
⁵City of Hope, La Canada, CA
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Department of Hematology, University Medical Center Groningen, Groningen, Netherlands
⁸Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
⁹University Hospital Basel and University of Basel, Basel, Switzerland
¹⁰Department of Medicine I, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
¹¹Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany
¹²Gold Coast University Hospital, Queensland, Australia
¹³Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
¹⁴Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
¹⁵Emory University Internal Medicine Residency, Decatur, GA
¹⁶MD Anderson Cancer Center, Houston, TX
¹⁷Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
¹⁸Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom
¹⁹Institut Català d’Oncologia , Hospital Duran i Reynals, Barcelona, Spain
²⁰University of Utah and ARUP Laboratories, Salt Lake City, UT
²¹University of Utah, ARUP Laboratories, Salt Lake City, UT
²²IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
²³University of Alberta, Edmonton, AB, CAN
²⁴Department of Dermatology, CEREMAST Toulouse, CHU Toulouse, Toulouse, France
²⁵Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany
²⁶Oslo University Hospital, Oslo, Norway
²⁷Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom
²⁸Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²⁹CHU de Poitiers, Poitiers, France
³⁰CEREMAST Necker Hospital, Paris, France
³¹Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy
³²Boston, MA
³³Deininger Lab, Versiti Blood Research Institute, Milwaukee, WI
³⁴Cogent Biosciences, Waltham, MA
³⁵NHS Foundation Trust, Guy's and St. Thomas' Hospital, London, United Kingdom

Andrew T. Kuykendall, MD¹, Somedeb Ball, MD², Jason Gotlib, MD, MS³, Cecilia Y. Arana Yi, MD⁴, Tsewang Tashi, MD⁵, Raajit Rampal, MD, PhD⁶, Daniel J DeAngelo, MD, PhD⁷, Virginia O. Volpe, MD⁷, Kristen M. Pettit, MD⁸, Gerard Hoehn^9*, Sasa Dimitrijevic, PhD^10*, Rami S. Komrokji, MD¹ and Eric Padron, MD¹

¹Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
²Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, TN
³Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA
⁴Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁵Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
⁶Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁸Rogel Cancer Center, University of Michigan, Ann Arbor, MI
⁹Sobi Inc., Waltham, MA
¹⁰Blueprint Medicines GmbH, Zug, Switzerland

Yuka Sugimoto, MD, PhD¹, Eran Zimran^2*, Yoshimitsu Shimomura, MD, PhD^3*, Hiroki Yamaguchi, MD⁴, Hans Carl Hasselbach^5*, Jean-Jacques Kiladjian, MD, PhD⁶, Steffen Koschmeider^7*, Harinder Gill, MBBS, MD, FRCP (Edin, Glasg, Lond), FRCPath, FHKCP, FHKAM (Medicine)⁸, Kristen Pettit^9*, David M Ross, MD, PhD, FRACP, FRCPA^10*, Claire Harrison¹¹, Alejandro Berkovits, PhD^12*, Ahmet Muzaffer Demir, MD^13*, Tsai-Yun Chen^14*, Stefan Scheding, MD¹⁵, Claudia Barrera Carmona, MD¹⁶, Alessandro Vannuchi^17*, Shiyu Zhang^18*, Uzor C. Ogbu, MBBS, PhD¹⁸ and Keita Kirito, MD¹⁹

¹Mie University Graduate School of Medicine, Tsu, Japan
²Hadassah Medical Center, Jerusalem, Israel
³Kobe City Medical Center General Hospital, Kobe, Japan
⁴Nippon Medical School, Tokyo, Japan
⁵Zealand University Hospital, Roskilde, Denmark
⁶Hôpital Saint-Louis, Université Paris Cité, Paris, France
⁷Faculty of Medicine, RWTH Aachen University, Aachen, Germany
⁸School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong
⁹University of Michigan, Ann Arbor, MI
¹⁰Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
¹¹Guy's and St Thomas' NHS Foundation Trust, London, ENG, United Kingdom
¹²Inmunocel, Santiago, Chile
¹³Trakya University, Edirne, Turkey
¹⁴National Cheng Kung University Hospital Clinical Trial Center, Tainan, Taiwan
¹⁵Skånes Universitetssjukhus Lund, Lund, Sweden
¹⁶Higiea Oncologia, Mexico City, Mexico
¹⁷University of Florence, Florence, Italy
¹⁸Merck & Co., Inc., Rahway, NJ
¹⁹University of Yamanashi, Chuo, Japan