Yihan Mei^1*, Yu Liu^1*, Wenbing Liu^1*, Manling Chen^1*, Qing Rao^1*, Min Wang^1*, Shaowei Qiu, MD^1*, Runxia Gu, MD^1* and Jianxiang Wang, MD²

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China

Saurabh Kusurkar, MD^1*, Aarti Ramesh Achrekar, MSc^1*, Priyanka Rajesh Ugale, MSc^1*, Swapnali Joshi, MSc^1*, Vishram Terse, PhD, MSc^1*, Dhanlaxmi Lalit Shetty, PhD, MSc^2,3,4*, Nishant Jindal, MD, MBBS^5,6,7,8*, Prashant Tembhare, MD^6,9*, Sumeet Mirgh, MD, DM^{5,6,8,10,11,12*}, Alok Shetty, MD, DM^13*, Anant Gokarn, MD, DM^6,8,11,13*, Sachin Punatar, MD, DM^6,8,11,13*, Lingaraj Nayak, MBBS, MD, DM^{6,8,11,13,14*}, Hasmukh Jain, MD, DM^15*, Manju Sengar, MD, DM¹⁵, Navin Khattry, MD, DM^5,6,11,13*, Bhausaheb Bagal, MD, DM^6,8,11,13*, Sweta Rajpal, MD, DM^1,6,16*, Gaurav Chatterjee, MD, MSc^1,6*, Papagudi Ganesan Subramanian, MD^1,6,17*, Sumeet Gujral, MD^18* and Nikhil Patkar, MD^1,6,19,20*

¹Department of Hematopathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
²Cancer Cytogenetics, ACTREC, Tata Memorial Centre, Navi Mumbai, India
³Tata Memorial Hospital, Mumbai, India
⁴Tata Memorial Hospital, Mumbai, IND
⁵Department of Medical Oncology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
⁶Homi Bhabha National Institute, Mumbai, India
⁷Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Chandigarh, India, India
⁸BMT unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India
⁹Department of Hemato Pathology, Tata Memorial Centre, Mumbai, India
¹⁰Department of Medical Oncology, ACTREC, Tata Memorial Centre, Mumbai, India
¹¹Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India
¹²Medicine, Mumbai, India
¹³Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
¹⁴Department of Medical Oncology, Tata Memorial Centre, MUMBAI, India
¹⁵Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
¹⁶Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai, India
¹⁷Department of Hematopathology, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India
¹⁸Department of Pathology, Tata Memorial Centre, Mumbai, India
¹⁹Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India
²⁰Department of Hematopathology, Tata Memorial Centre, Mumbai, India

Li Chen^1*, Yongmei Zhu, PhD^2*, Lingling Zhao^2*, Jianfeng Li, PhD^2*, Ran An^3*, Zhiyin Liu^1*, Xiaoqian Xu^1* and Sujiang Zhang, MD¹

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, SHANGHAI, AL, China

Rose Ann Padua, PhD^1,2, Satyananda Patel, PhD^1*, James Smith, PhD^3*, Dr Omidvar, BSc, MSc, PhD^4*, Nilgun Tekin, PhD^1*, Fabien Guidez, PhD^1*, Mathieu Chiquet, MSc^1*, Niclas Setterblad, PhD^5*, Ken I Mills, PhD, FRCPath³, Marika PLA, PhD^1*, Patricia Krief, PhD^1*, Thierry Huet, PhD^2*, Christine Chomienne, MD, PhD^1* and Pierre Fenaux, MD^6,7

¹INSERM UMR-S1131 Institut de la Recherche Saint Louis, Univeristy Paris Cité, Paris, France
²VivAdju SAS, Paris, France
³Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom
⁴Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, GBR
⁵Institut de la Recherche Saint-Louis, University Paris Cité, Imagery Department, Paris, France
⁶Service Hématologie Seniors, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France
⁷Institut de Recherche Saint-Louis, INSERM UMR 944, Paris, France

Naszrin Arani, MD¹, Wei-Ying Jen, MD, FRCPath, MA^2*, Alex Bataller, MD, PhD^2*, Alexandre Bazinet, MD^2*, Farhad Ravandi, MBBS³, Naval Daver, MD⁴, Koichi Takahashi, MD, PhD⁵, Sanam Loghavi, MD⁶, Hussein A. Abbas, MD, PhD², Emmanuel Almanza, MD^2*, Guillermo Montalban-Bravo, MD², Guillermo Garcia-Manero, MD², Courtney D. DiNardo, MD, MSc⁷, Hagop M. Kantarjian, MD² and Tapan M. Kadia, MD²

¹Internal Medicine, Baylor College of Medicine, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁴MD Anderson Cancer Center, Houston, TX
⁵Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Ela Cerovska^1,2*, David Kundrat^3*, Zdenek Krejcik^3*, Cyril Salek^2,3, Jan Musil^3*, Michaela Dostalova Merkerova, PhD, MSc^3*, Monika Belickova^3* and Hana Remesova^3*

¹Institute of Hematology and Blood Transfusion, Praha, Czech Republic
²Charles University in Prague, Prague, Czech Republic
³Institute of Hematology and Blood Transfusion, Prague, Czech Republic

Maher Albitar, MD¹, Sally Agersborg, MD, PhD^1*, Ahmad Charifa, MD^1*, Hong Zhang, MD^1*, Andrew Ip, MD, MSc², Katherine Linder, MD^3*, Andrew L Pecora, MD³, Jamie Koprivnikar, MD^4*, Andre Goy, MD, MS² and James McCloskey, MD⁵

¹Genomic Testing Cooperative, Lake Forest, CA
²Lymphoma Division, John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ
³Hackensack University Medical Center, Hackensack, NJ
⁴Department of Leukemia, John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
⁵John Thuerer Cancer Center, Hackensack Medical Center, Hackensack, NJ

Jae-Sook Ahn, M.D., Ph.D.^1,2, Joo Heon Park, MD^3*, Ik Chan Song, MD, PhD⁴, ChangSun Lee^5*, Sang Kyun Sohn, MD, PhD^6*, Ho-Young Yhim, MD^7*, Yong Park, MD, PhD⁸, Inho Kim, MD, PhD^9*, Ho-Jin Shin, MD^10*, Seong Kyu Park, MD^11*, Sung-Hyun Kim, MD^12*, June-Won Cheong, MD, PhD¹³, Ho Sup Lee, MD, PhD^14*, Hyewon Lee, MD^15*, Sung Hwa Bae, MD^16*, Yunsuk Choi, MD, PhD¹⁷, Hong-Ghi Lee^18*, Young Rok Do, MD, PhD¹⁹, Jae-Joon Han^20*, Min Kyoung Kim^21*, Silvia Park, MD, PhD^22*, Hee-Je Kim, MD, PhD²² and Hyeoung-Joon Kim, MD, PhD^2,23

¹Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
²Genomic Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
³Department of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)
⁴Department of Internal Medicine, College of Medicine, Chungnam National University Hospital, Daejeon, South Korea
⁵BI team, NGeneBio, Seoul, Korea, Republic of (South)
⁶Kyungpook National University Hospital, Daegu, Korea, Republic of (South)
⁷Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea, Republic of (South)
⁸Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea, Republic of (South)
⁹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
¹⁰Department of Hematology-Oncology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea, Republic of (South)
¹¹Department of Hematology/Oncology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea, Republic of (South)
¹²Department of Internal Medicine, Dong-A University Medical Center, Busan, Korea, Republic of (South)
¹³Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea, Republic of (South)
¹⁴Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Korea, Republic of (South)
¹⁵National Cancer Center, Goyang, KOR
¹⁶Department of Internal Medicine, Daegu Catholic, University Hospital, Daegu Catholic University School of Medicine, Daegu, KOR
¹⁷Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of (South)
¹⁸Internal medicine, Konkuk University, Konkuk University Medical Center, Seoul, Korea, Republic of (South)
¹⁹Department of Hemato-Oncology, Dongsan Medical Center, Keimyung University, Daegu, Korea, Republic of (South)
²⁰Internal Medicine, Kyung Hee University,Kyung Hee University Medical Center, Seoul, Korea, Republic of (South)
²¹Yeungnam University College of Medicine, Daegu, Korea, Daegu, Korea, Republic of (South)
²²Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²³Chonnam National University Hwasun Hospital, Hwasun, Korea, Republic of (South)

Hasan Abuamsha^1*, Daniel P. Nurse, DO^1*, Jessica El-Asmar, MD, MPH², Ameed Bawwab, MD^3*, Yomna Abu-Farsakh, MD^4*, Heya Batah, MD^1*, Moath Albliwi, MD^1*, John Hanna, MD¹, Asad Rauf^1*, Emily C. Zabor, DrPH^5*, Yohana B. Bedelu^5*, Mark Jinan Chen, PhD^6*, Joy Nakitandwe, PhD^6*, Akriti G. Jain, MD², John C. Molina, MD, MEd², Sophia Balderman, MD^2*, Abhay Singh, MD, MPH², Aaron T. Gerds, MD, MS², Sudipto Mukherjee, MD, PhD, MPH², Anjali S. Advani, MD², Hetty E. Carraway, MD, MBA² and Moaath K. Mustafa Ali, MD, MPH²

¹Department of Internal Medicine, Cleveland Clinic, Cleveland, OH
²Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
³Department of Internal Medicine, Cleveland Clinic, Akron, OH
⁴Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, North Canton, OH
⁵Department of Quantitative Health Sciences, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁶Department of Pathology and Laboratory Medicine, Cleveland Clinic Diagnostics Institute, Cleveland, OH

Somadri Ghosh, PhD^1*, Katrin Reinbach^2*, Pablo Peña-Martínez, PhD^1*, Ramprasad Ramakrishnan, PhD^2*, Oscar André^3*, Maria Rodriguez Zabala, PhD^4*, Pontus Nordenfelt, PhD^5* and Marcus Järås, PhD^2*

¹Division of Clinical Genetics, Lund University, Lund, Sweden
²Division of Clinical Genetics, Lund University, Lund, Skåne, Sweden
³Lund University, Lund, SWE
⁴Clinical Genetics, Lund Universitet, Lund, Sweden
⁵Lund University, Division of Infectious Medicine, Lund, Sweden

Fanyuan Zeng¹, Kiranj Chaudagar, PhD^1*, Yuou Wang, PhD^1*, Jian-Ming Li, PhD^1* and Edmund K. Waller, MD, PhD²

¹Winship Cancer Institute, Emory University, Atlanta, GA
²Emory University, Winship Cancer Institute, Atlanta, GA

Roger Mulet-Lazaro, PhD^1*, Aniko Sijs-Szabó, MD^1,2*, Remco Hoogenboezem, MSc^1*, Stanley Van Herk^1*, Patricia G. Hoogeveen^3*, Francois Kavelaars^1*, Anita Schelen^1*, Willemijn van den Ancker, MD, PhD^4*, Arjan A. van de Loosdrecht, MD, PhD^4*, Berna Beverloo, PhD^5*, Vincent H.J. Van Der Velden, PhD^3*, Jan J. Cornelissen, MD, PhD^1*, Peter J. M. Valk, PhD¹, Anita W. Rijneveld, MD, PhD¹ and Mathijs Arnoud Sanders, PhD^1*

¹Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
²Department of Hematology, Leiden University Medical Center, Leiden, Netherlands
³Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
⁴Department of Hematology, Amsterdam University Medical Center, Free University, Amsterdam, Netherlands
⁵Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Xunyi Jiao^1*, Xue Liang, PhD^2*, Jinli Zhu^1*, Ji Zhou^3*, Meng Xiao^1*, Hao Xiao^4*, Qianshan Tao, MD^5*, Yingwei Li^2*, Fan Wu^2*, Huiping Wang^2* and Zhimin Zhai, MD^2,6,7

¹Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, hefei, China
²Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
³Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei, China
⁴Hematologic Department/Hematologic Diseases Research Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁵Department of Hematology/Hematological Lab, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁶Center of Hematology Research, Anhui Medical University, Hefei, China
⁷Institute of Hematology and Clinical Immunology，the Second Affiliated Hospital of Anhui Medical University, Hefei, China

Hope L Mumme, MSc¹, Siddhartha Mantrala, BTech^1*, Chenbin Huang, MSc^1*, Denis Ohlstrom, MSc^2,3*, Sarthak Satpathy, MSc^1*, Swati Bhasin, PhD^4,5, Sunil S Raikar, M.D.^5,6 and Manoj Bhasin, PhD^1,4,5

¹Department of Biomedical Informatics, Emory University, Atlanta, GA
²Emory University Medical School, Atlanta, GA
³Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
⁴Department of Pediatrics, Emory University, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
⁶Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, GA

Daniel J Vail^1*, Valeria Visconte, PhD², Babal K. Jha, PhD^1,3, Jill Durkin^4*, Jaroslaw Maciejewski⁵ and Thomas Laframboise, PhD^6*

¹Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Taussig Cancer Institute, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Bay Village, OH
⁵Taussig Cancer Center, Cleveland, OH
⁶Case Western Reserve University, Cleveland, OH

Maria Velegraki, MD, PhD¹, Cankun Wang^2*, Deedra Nicolet, MS^3*, Krzysztof Mrózek, MD, PhD³, Payton Weltge^2*, Ethan Hamp^4*, Jill Buss, BS⁵, Andrea Laganson, BS^5*, Christopher C. Oakes, PhD⁶, Jordan Krull, PhD^2*, John C. Byrd, MD⁷, Richard M. Stone, MD⁸, Qin Ma^2*, Ann-Kathrin Eisfeld, MD³ and Zihai Li, MD, PhD¹

¹Pelotonia Institute for Immunology-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
³The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴The Ohio State University Comprehensive Cancer Center, Columbus
⁵Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁶Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁷Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
⁸Dana-Farber Cancer Institute, Boston, MA

Prasad Iyer, MD^1,2*, Shaista Shabbir Jasdanwala^3*, Xiao Xian Lin^4,5*, Karanpreet Singh Bhatia⁶, Germaine Shimin Liew^7*, Si Ting Tai^8*, Jameelah Sheik Mohamed^9*, Wei-Ying Jen^10*, Melissa Gaik-Ming Ooi^9*, Allen Eng Juh Yeoh^11* and Shruti Bhatt, PhD³

¹Duke- NUS Medical School, Singapore, Singapore
²KK Women and Children's Hospital, Singapore, Singapore
³Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore
⁴Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore, Singapore
⁵Department of Pharmacy, National University of Singapore, Singapore, SGP
⁶Winship Cancer Institute, Emory University, Atlanta, GA
⁷Children’s Blood and Cancer Centre, KK Women’s and Children’s Hospital, Singapore, Singapore, Singapore
⁸National University of Singapore, Singapore, Singapore
⁹Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore
¹⁰Department of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore, Singapore
¹¹5VIVA-University Children’s Cancer Centre, National University of Singapore, Singapore, Singapore

Jayastu Senapati, MD, DM, MBBS¹, Courtney D. DiNardo, MD, MSc², Tapan M. Kadia, MD¹, Niranjan Shiwaji Khaire, MBBS^1*, Fadi G. Haddad, MD¹, Sanam Loghavi, MD³, Guilin Tang, MD, PhD^3*, Indraneel Deshmukh, MBBS, MPH^4*, Joseph E. Jabbour^5*, Ghayas C. Issa, MD¹, Nicholas J. Short, MD¹, Musa Yilmaz, MD^1*, Danielle Hammond, MD¹, Gautam Borthakur, MD⁶, Hussein A. Abbas, MD, PhD¹, Alexandre Bazinet, MD^1*, Sherry Pierce, BSN, BA^1*, Kapil N. Bhalla, MD¹, Guillermo Garcia-Manero, MD¹, Farhad Ravandi, MBBS⁷, Hagop M. Kantarjian, MD¹ and Naval Daver, MD⁸

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴UT MD Anderson Cancer Center, Houston, TX
⁵Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁸MD Anderson Cancer Center, Houston, TX

Marco Roncador^1,2,3*, Fritz Bayer, PhD^2,4*, Jeremy W. Deuel, MD, PhD^3*, Jack Kuipers, PhD^2*, Markus G. Manz, MD³, Steffen Boettcher, MD^3*, Niko Beerenwinkel, PhD^2,4* and Stefan Balabanov, MD, PhD^3*

¹Department of Biosystems Science and Engineering, ETH Zurich, Zurich, Switzerland
²SIB Swiss Institute of Bioinformatics, Basel, Switzerland
³Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
⁴Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

Katayoon Shirneshan^1*, Hannes Treiber^1*, Katharina Rittscher^1*, Ulrich Germing, MD^2*, Barbara Hildebrandt^3*, Corinna Strupp, MD^2*, Julie Schanz, Prof. Dr. med.^1*, Ute Windolph^1*, Christina Ganster¹ and Detlef Haase, Prof. Dr. med.^1*

¹Clinics of Hematology and Medical Oncology, INDIGHO laboratory, University Medical Center Göttingen (UMG), Göttingen, Germany
²Department of Hematology, Oncology and Clinical Immunology, Universitatsklinik Düsseldorf Heinrich Heine University Düsseldorf, Düsseldorf, Germany
³Institute of Human Genetics, Universitatsklinik Düsseldorf Heinrich Heine University Düsseldorf, Düesseldorf, Germany

Vivian M. Liu, MD^1,2, Megan Othus, PhD^3,4, Rhonda E. Ries, MA^5*, Jasmine Naru, PhD^6*, Era L. Pogosova-Agadjanyan, BS^6*, Frederick R. Appelbaum, MD^7,8, Lan W. Beppu^6*, Thomas R. Chauncey, MD, PhD^2,9,10*, Harry P. Erba, MD, PhD¹¹, John E. Godwin, MD^12*, Matthew Fitzgibbon^13*, Min Fang, MD, PhD^10,14, Stanley C. Lee, PhD⁶, Anna B. Moseley, MS^3,4*, Jerald P. Radich, MD^2,6, Cheryl L. Willman, MD^15*, Feinan Wu^13*, Soheil Meshinchi, MD, PhD^5,16 and Derek L. Stirewalt, MD^2,6

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Bellevue, WA
²Division of Hematology & Oncology, University of Washington, Seattle, WA
³SWOG Statistics and Data Management Center, Seattle, WA
⁴Public Health Science Division, Fred Hutchinson Cancer Center, Seattle, WA
⁵Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁶Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
⁷Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁸Division of Hematology & Oncology, University of Washington School of Medicine, Seattle, WA
⁹Seattle VA Medical Center (111 Onc.), Seattle, WA
¹⁰Fred Hutchinson Cancer Center, Seattle, WA
¹¹Duke University Cancer Institute, Durham, NC
¹²Providence Portland Medical Center, Portland, OR
¹³Genomics & Bioinformatics Shared Resource, Fred Hutchinson Cancer Center, Seattle, WA
¹⁴University of Washington, Seattle, WA
¹⁵Mayo Clinic, Rochester, MN
¹⁶Department of Pediatrics, University of Washington, Seattle, WA

Seema Biswas, MD^1*, Aarti Ramesh Achrekar, MSc^1*, Priyanka Rajesh Ugale, MSc^1*, Swapnali Joshi, MSc^1*, Vishram Terse, PhD, MSc^1*, Dhanlaxmi Lalit Shetty, PhD, MSc^2,3*, Nishant Jindal, MD, MBBS^4,5*, Prashant Tembhare, MD^1,5,6*, Sumeet Mirgh, MD, DM^{5,7,8,9,10,11*}, Alok Shetty, MD, DM^12*, Anant Gokarn, MD, DM^5,9,11,12*, Sachin Punatar, MD, DM^5,9,11,12*, Lingaraj Nayak, MBBS, MD, DM^{5,9,11,12,13*}, Hasmukh Jain, MD, DM^14*, Manju Sengar, MD, DM¹⁴, Navin Khattry, MD, DM^5,7,9,12*, Bhausaheb Bagal, MD, DM^5,9,11,12*, Sweta Rajpal, MD, DM^1,5,15*, Gaurav Chatterjee, MD, MSc^1,5*, PG Subramanian, MD^1*, Sumeet Gujral, MD^16* and Nikhil Patkar, MD^1,5,17,18*

¹Department of Hematopathology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
²Cancer Cytogenetics, ACTREC, Tata Memorial Centre, Navi Mumbai, India
³Tata Memorial Hospital, Mumbai, India
⁴Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Chandigarh, India, India
⁵Homi Bhabha National Institute, Mumbai, India
⁶Department of Hemato Pathology, Tata Memorial Centre, Mumbai, India
⁷Department of Medical Oncology, ACTREC, Tata Memorial Centre, Navi Mumbai, India
⁸Department of Medical Oncology, ACTREC, Tata Memorial Centre, Mumbai, India
⁹Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India
¹⁰Medicine, Mumbai, India
¹¹BMT unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India
¹²Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
¹³Department of Medical Oncology, Tata Memorial Centre, MUMBAI, India
¹⁴Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
¹⁵Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Navi Mumbai, India
¹⁶Department of Pathology, Tata Memorial Centre, Mumbai, India
¹⁷Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India
¹⁸Department of Hematopathology, Tata Memorial Centre, Mumbai, India

Mohamad Sabbah, MD^1*, Morgane Fontaine^2*, Kim Pacchiardi^3*, Alexis Delabrière^4*, Stephane De Botton, MD, PhD^5*, Catherine Lonchamp^2*, Renaud Buffet, MD^6*, Laure Farnault, MD^7*, Jean-Baptiste Micol, MD⁸, Typhaine Dumas-Rivero, PharmD^9*, Emmanuel Raffoux, MD^10,11*, Lionel Ades, MD, PhD¹, Nicolas Boissel, MD, PhD¹², Juliette Lambert, MD, PhD^13*, Kevin-James Wattebled, MD^14*, Matthieu Duchmann, MD, PhD^15*, Karine Celli-Lebras, RN^16,17*, Alexandra Coelho^18*, Hervé Dombret, MD, PhD¹⁹, Edouard De Dreuzy, PhD^20*, Marina Deschamps, PhD^21,22*, Christophe Ferrand, PhD^22,23, Jens Hasskarl, MD, PhD²⁴, Richard Sainson^20* and Raphael Itzykson^25,26,27

¹Hopital Saint Louis, Paris, France
²Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, Paris, FRA
³St Louis Hospital, INSERM U944, Paris, France
⁴Advesya, paris, France
⁵Department of Hematology, Institut Gustave Roussy, Villejuif, France
⁶Hospital Saint-Louis, Boulogne, FRA
⁷APHM Hopital La Conception, Marseille, FRA
⁸Hematology Department, Gustave Roussy Institute, Villejuif, France
⁹Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, Paris, France., Paris, France
¹⁰Hematology Department, Saint Louis University Hospital, AP-HP, Paris, France
¹¹Hematology Department, Saint Louis Hospital, Paris, France
¹²Hematology Adolescents and Young Adult Unit, Saint-Louis Hospital, APHP, Paris, France, Paris Cedex 10, Paris, France
¹³Clinical Hematology Department, Versailles Hospital, Le Chesnay-Rocquencourt, France
¹⁴CH Dunkerque, Dunkerque, FRA
¹⁵INSERM U944, Paris, FRA
¹⁶Hopital Saint-Louis, Paris, FRA
¹⁷ALFA Coordination, Hôpital Saint-Louis, Paris, France
¹⁸ALFA Project Manager, Paris, France
¹⁹Hôpital Saint-Louis, Hematology Department, AP-HP, Paris, France
²⁰Advesya, Paris, France
²¹Hopital Jean Minjoz, Besancon, FRA
²²ADVESYA, Paris, France
²³University/INSERM UMR1098 RIGHT, Besancon Cedex, France
²⁴ADVESYA, Paris, Cedex, FRA
²⁵Unité 944/7212-GenCellDi, Saint-Louis Research Institute, INSERM, CNRS, Université Paris Cité, Paris, France
²⁶Service Hématologie Adulte, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France, Paris, France
²⁷Université de Paris, Unité 944/7212-GenCellDi, INSERM and Centre National de la Recherche Scientifique (CNRS), Paris, France, Paris, France

Vishvaas I Ravikumar¹, Jessica T. Leonard, MD², Laura F. Newell, MD³, Arpita Gandhi, MD³, Gabrielle Meyers, MD^3*, Brandon Hayes-Lattin, MD³, Richard T. Maziarz, MD², Rachel J. Cook, MD, MS⁴, Elie Traer, MD, PhD³, Ronan T. Swords, MD, PhD, FRCP, FRCPath³, Jennifer N. Saultz, DO³, Jeffrey W. Tyner, PhD³, Mael Heiblig^5*, Joshua F. Zeidner, MD⁶, Daniel A Pollyea, MD⁷ and Curtis A Lachowiez, MD³

¹OHSU, Portland, OR
²Knight Cancer Institute, Oregon Health and Science University, Portland, OR
³Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁴Oregon Health & Science University, Portland, OR
⁵Centre Hospitalier Lyon Sud, Centre Hospitalier Lyon Sud, Service Hématologie, Centre d’Investigation des thérapeutiques en oncologie et hématologie de Lyon (CITHOL), Vourles, Rhône Alpes, France
⁶Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
⁷Division of Hematology, University of Colorado, Denver, CO

Shih-Hsiang Chen, MD^1,2, Ting-Chi Yeh, MD^3*, Tang-Her Jaing, MD^4*, Shih-Chung Wang, MD^5*, Hsi-Che Liu, MD⁶, Fang-Liang Huang, MD^7*, Yu-Chieh Chen, MD^8*, Jen-Yin Hou, MD^9*, Jiunn-Ming Sheen, MD, PhD^8*, Pei-Chin Lin, MD, PhD^10*, Chih-Ying Lee, MD^11*, Tsung-Yen Chang, MD^12*, Shang-Hsien Yang, MD^13*, Wei-Hao Wang, MD^14*, Shu-Huey Chen, MD^15*, Hsiao-Wen Kao, MD^1*, Shyh-Shin Chiou, MD, PhD^16*, Chih-Cheng Hsiao, MD^17*, Ming-Chung Kuo^18,19*, Chao-Ping Yang, MD^12* and Lee-Yung Shih, MD^18,20

¹Chang Gung Memorial Hospital, Taoyuan, Taiwan
²Chang Gung University, School of Medicine, Taoyuan, Taiwan, Taoyuan, Taiwan
³Mackay Children's Hospital and Mackay Medical College, Taipei, TWN
⁴CHENG GUNG MEMORIAL HOSPITAL, Taoyuan, TWN
⁵Changhua Christian Hospital, Changhua, Taiwan
⁶Mackay Children's Hospital and Mackay Medical College, Taipei, Taiwan
⁷Taichung Veterans General Hospital, Taichung City, TWN
⁸Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan, Kaohsiung, Taiwan
⁹Division of Pediatric Hematology-Oncology, Department of Pediatrics, MacKay Children's Hospital and Mackay Medical College, Taipei, TWN
¹⁰Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Kaohsiung, TWN
¹¹Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, Taipei City, AL, TWN
¹²Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan, Taoyuan, Taiwan
¹³Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
¹⁴Changhua Christian Children’s Hospital, Changhua, Taiwan, Changhua, TWN
¹⁵Taipei Medical University–Shuang Ho Hospital, Taipei, Taiwan
¹⁶Kaohsiung Medical University Hospital, Kaohsiung City, AL, TWN
¹⁷Chang Gung Memorial Hospital At Kaohsiung, Kaohsiung City, TWN
¹⁸Chang Gung University, School of Medicine, Taoyuan, Taiwan
¹⁹Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan
²⁰Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Curtis A Lachowiez, MD¹, Daniel T Peters, MD², Jacob Fang, MD^3*, Andy Kaempf, MS^4*, Jessica T. Leonard, MD⁵, Laura F. Newell, MD¹, Arpita Gandhi, MD¹, Gabrielle Meyers, MD^1*, Brandon Hayes-Lattin, MD¹, Richard T. Maziarz, MD⁵, Rachel J. Cook, MD, MS⁶, Elie Traer, MD, PhD¹, Ronan T. Swords, MD, PhD, FRCP, FRCPath¹, Jeffrey W. Tyner, PhD¹, Joshua F. Zeidner, MD⁷, Daniel A Pollyea, MD^8,9 and Jennifer N. Saultz, DO¹

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Division of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC
³University of Colorado, Denver, CO
⁴Knight Cancer Institute, Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR
⁵Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁶Oregon Health & Science University, Portland, OR
⁷Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
⁸Division of Hematology, University of Colorado, Denver, CO
⁹Division of Hematology, University of Colorado School of Medicine, Aurora, CO

Iman Abou Dalle, MD^1*, Jacques-Emmanuel Galimard, PhD^2*, Xavier Poiré, MD, PhD^3*, Jaime Sanz^4*, Anne Huynh, MD^5*, Nicolaus Kröger, MD^6*, Eva-Maria Wagner Drouet^7*, David Burns, MD, PhD^8*, Matthias Eder, MD^9*, Bruno Lioure^10*, Depei Wu, MD, PhD¹¹, Jiri Mayer, MD¹², Kristina Carlson¹³, Matthias Stelljes, MD¹⁴, Matthew Collin, MD, PhD¹⁵, Mahmoud Aljurf^16*, Arnon Nagler, MD¹⁷, Jordi Esteve, MD, PhD¹⁸, Fabio Ciceri, MD^19*, Ali Bazarbachi, MD, PhD²⁰ and Mohamad Mohty, MD, PhD²¹

¹Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut medical center, Beirut, Lebanon
²EBMT Paris Study Unit, Saint Antoine Hospital, INSERM UMR-S 938, Sorbonne University, Paris, France
³Section of Hematology, Institut Roi Albert II, Cliniques Universitaires St-Luc, Brussels, Belgium
⁴Hematology Department, Hospital Universitari i Politècnic La Fe, Departament de Medicina Universitat de Valencia, CIBERONC, Instituto Carlos III, Spain, VALENCIA, Spain
⁵Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France
⁶German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST), Ulm, Germany
⁷University medical center Mainz, Dept of Hematology and Oncology, Mainz, Germany
⁸University Hospital Birmingham NHS Trust, Stoke, United Kingdom
⁹Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁰Hematology, Department of Hematology, University Hospital of Strasbourg Institut De Canc, Strasbourg, France
¹¹Department of Hematology, The first Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center of Hematologic Diseases, Suzhou, China
¹²Internal Medicine Hematology and Oncology, University Hospital Brno and Masaryk University, Brno, Czech Republic
¹³University Hospital Uppsala, Uppsala, Sweden
¹⁴Department of Medicine A (Hematology, Hemostaseology, Oncology, Pneumology), University of Muenster, Muenster, Germany
¹⁵Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom
¹⁶Department of Hematology, Stem Cell Transplantation, and Cellular Therapy, Cancer Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
¹⁷Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel Aviv, Israel
¹⁸Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
¹⁹Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
²⁰American University of Beirut Dept. of Medicine, Beirut, Lebanon
²¹Sorbonne University, Hôpital Saint-Antoine, and INSERM UMRs938, Paris, France

Lin Pierre Zhao, MD, PhD^1,2*, Typhaine Dumas-Rivero, PharmD^3*, Lauren Barette, MD^1*, Lorea Aguinaga, MD^1*, Arij Cheffai, MD^1*, Pierre Lemaire, MD^3*, Stéphanie Mathis, PharmD^4*, Clémentine Chauvel, PharmD^3*, Reinaldo Dal Bello, MD, PhD^5*, Emmanuelle Clappier, Pharm.D., Ph.D.^6*, Matthieu Duchmann, MD, PhD^3,7*, Pierre Fenaux, MD⁸, Marie Sebert, MD, PhD^7,9*, Lionel Ades, MD, PhD^7,10 and Raphael Itzykson^5,7

¹Service Hématologie Seniors, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France, Paris, France
²Université Paris Cité, INSERM UMR 1160, Institut de Recherche Saint-Louis, Paris, France Service Hématologie Adultes, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France., Paris, France
³Université Paris Cité, Assistance Publique des Hôpitaux de Paris (APHP) Nord, Hôpital Saint-Louis, Laboratoire d’Hématologie, Paris, France, Paris, France
⁴Laboratory of Hematology and Flow cytometry, Saint Louis Hospital, APHP, Paris, France
⁵Service Hématologie Adulte, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France, Paris, France
⁶Saint Louis Hospital, Paris, France
⁷Université de Paris, Unité 944/7212-GenCellDi, INSERM and Centre National de la Recherche Scientifique (CNRS), Paris, France, Paris, France
⁸Service Hématologie Seniors, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France
⁹Service Hématologie Seniors, Assistance Publique des Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France, Paris, FRA
¹⁰Hopital Saint Louis, Paris, France

Macarena Oporto Espuelas^1*, Sina Kanannejad^2*, Ilaria Marina Michelozzi^1*, Eduardo Gomez Castaneda^1*, Theodoros Xenakis^3*, Efstratios Kirtsios^1*, Hannah Macpherson^3*, Jack Bartram^4,5*, Rebecca Thomas^6*, Edoardo Giacopuzzi^2*, Soumick Chatterjee^2*, Filippo Martignano^2*, Sergi Castellano^3*, Persis Jal Amrolia^1,7* and Alice Giustacchini^1,2*

¹Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
²Genomics Research Centre, Human Technopole, Milan, Italy
³Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
⁴Great Ormond Street Hospital for Children, London, United Kingdom
⁵North Thames Genomic Laboratory Hub, Londom, United Kingdom
⁶Department of Haematology, Great Ormond Street Hospital, London, United Kingdom
⁷Bone Marrow Transplant Department, Great Ormond Street Hospital, London, United Kingdom

Anetta Marcinek, PhD^1*, Constance Regina Baer, PhD¹, Stephan Hutter, PhD^1*, Manja Meggendorfer, PhD², Torsten Haferlach, MD¹, Wolfgang Kern, MD¹ and Claudia Haferlach, MD¹

¹MLL Munich Leukemia Laboratory, Munich, Germany
²MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany

Xiaoxiao Chen^1*, Bowen Cui^2*, Shuang Zhao^2*, Kefei Wu^3*, Yangyang Xie^1*, Hui Liu^1*, Jiaoyang Cai¹, Xiang Wang^1*, Yixiao Mo^4*, Wenting Hu^3*, Changcheng Chen^1*, Han Wang^2*, Ronghua Wang^2*, Huiying Sun, Master^2*, Jianan Rao^2*, Wenyan Wu^2*, Yu Liu, PhD^2* and Shuhong Shen⁵

¹Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
²Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
³Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
⁴Key Laboratory of Pediatric Hematology & Oncology of the Ministry of Health of China, Department of Hematology & Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, shanghai, China
⁵Department of Hematology , Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Henri Sundquist^1*, Mikael Tatun, MSc^1*, Mikko Purhonen, MSc^1*, Laura Toivanen, BSc^1*, Johanna Rimpiläinen, MD^2*, Samuli Rounioja, MD, PhD^3*, Timo Siitonen, MD, PhD^4*, Marja Pyörälä, MD, PhD^5*, Pentti Mäntymaa, MD, PhD^6*, Sari Kytölä, MD^7*, Kimmo Porkka, MD, PhD^1,7,8,9, Sanna Siitonen, MD, PhD^1,10*, Heikki Kuusanmäki, PhD^11,12,13*, Mika Kontro, MD, PhD^7,11,12 and Oscar E. Brück, MD, PhD^1*

¹Hematoscope Lab, Comprehensive Cancer Center & Center of Diagnostics, Helsinki University Hospital, Helsinki, Finland & Department of Oncology, University of Helsinki, Helsinki, Finland
²Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
³Fimlab Laboratories, Department of Haematology, Tampere University Hospital, Tampere, Finland
⁴Department of Hematology, Oulu University Hospital, Oulu, Finland
⁵Department of Medicine, Kuopio University Hospital, Kuopio, Finland
⁶Eastern Finland Laboratory Centre, Kuopio, Finland
⁷Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁸Hematology Research Unit Helsinki, Department of Hematology, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁹ICAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹⁰Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
¹¹Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
¹²Foundation for the Finnish Cancer Institute, Helsinki, Finland
¹³Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark

Diego A. Pereira-Martins, Ph.D.^1,2*, Vincent Van Den Boom, Ph.D.^2*, Isabel Weinhaeuser, PhD^1,2*, Nisha van der Meer, MD, MSc^2*, Prodromos Chatzikyriakou, Ph.D.^1*, Noortje van Dijk, BSc^2*, Xuesen Zheng, PhD^3*, Lucio H Pinheiro, BSc, MSc^4,5*, Douglas RA Silveira, MD, PhD^1*, Thiago Mantello Bianco, Ph.D.^6*, César Alexander Ortiz Rojas, Ph.D.^7*, Eduardo M. Rego, MD, PhD⁸, Stuart A Rushworth, PhD⁹, Antonio R. Lucena-Araujo, Prof.^10*, Lynn Quek, MD, Ph.D.^1*, Gerwin Huls² and Jan Jacob Schuringa, Prof. Dr.²

¹Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
²Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
³Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, ENG, United Kingdom
⁴Norwich Medical School, University of East Anglia, Norwich, United Kingdom
⁵LIM31, University of São Paulo Medical School, Sao Paulo, Brazil
⁶Department of Medical Images, Haematology, and Clinical Oncology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Brazil
⁷Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, University of São Paulo Medical School, Sao Paulo, Brazil
⁸Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, University of São Paulo Medical School, São Paulo, São Paulo, Brazil
⁹The University of East Anglia, Norwich, United Kingdom
¹⁰Department of Genetics, Federal University of Pernambuco, Recife, BRA

Stephanie Sendker, MD^*, Jens Gehlen^*, Tabea Ziedrich^*, Evangelia Antoniou, MD, Markus Schneider, PhD^*, Nils Von Neuhoff, PhD^*, Dirk Reinhardt, MD and Lina Marie Hoffmeister^*

University Children’s Hospital Essen. Department of Pediatric Hematology and Oncology, Essen, Germany

Xiaosu Zhou, PhD^1*, Jiancheng Fang, MD^2*, Xiaoli Ma, MD^2*, Fang Wang, MD^2*, Panxiang Cao^2*, Yang Zhang, MD^2*, Xue Chen, MD^2*, Jiaqi Chen, PhD^2*, Ming Liu, MD^2*, Mingyue Liu^2* and Hongxing Liu, MD^2,3

¹Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
²Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China

Uma Borate, MD¹, Ying Huang, MS, MA², Rina Li Welkie, MPH³, Ronan T. Swords, MD, PhD, FRCP, FRCPath⁴, Elie Traer, MD, PhD⁴, Eytan M. Stein, MD⁵, Tara L. Lin, MD⁶, Yazan F Madanat, MD⁷, Prapti A. Patel, MD⁸, Robert H. Collins, MD⁹, Maria R. Baer, MD¹⁰, Vu H. Duong, MD, MS¹¹, William Blum, MD¹², Martha L. Arellano, MD¹³, Wendy Stock, MD¹⁴, Olatoyosi Odenike, MD¹⁴, Robert L. Redner, MD¹⁵, Tibor J. Kovacsovics, MD¹⁶, Michael W. Deininger, MD, PhD¹⁷, Joshua F. Zeidner, MD¹⁸, Rebecca Olin, MD¹⁹, Catherine C. Smith, MD²⁰, James M. Foran, MD²¹, Gary J. Schiller, MD²², Emily K Curran, MD²³, Kristin L Koenig, MD²⁴, Nyla A. Heerema, PhD^25*, Timothy Chen, PhD¹, Molly Martycz^1*, Mona Stefanos, MD²⁶, Sonja Gullen Marcus, MPH^27*, Leonard Rosenberg^27*, Brian J. Druker, MD⁴, Ross L Levine, MD²⁸, Amy Burd, PhD²⁹, Ashley Owen Yocum, PhD²⁷, Alice Mims, MD³⁰ and John C. Byrd, MD³¹

¹The Ohio State University, Columbus, OH
²Division of Hematology, Department of Statistics, The Ohio State University Wexner Medical Center, Columbus, OH
³The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁵Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
⁶Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Cancer Center, Westwood, KS
⁷Hematologic Malignancies and Cellular Therapy, Northwestern University, Dallas, TX
⁸Servier Pharmaceuticals LLC, Boston, MA
⁹Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
¹⁰University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD
¹¹University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
¹²Emory University, Winship Cancer Institute, Atlanta, GA
¹³Emory University, Atlanta, GA
¹⁴Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
¹⁵University of Pittsburgh Medical Center, Pittsburgh, PA
¹⁶University of Utah, Salt Lake City, OR
¹⁷Versiti Blood Research Institute, Milwaukee, WI
¹⁸Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹⁹University of California San Francisco, San Francisco, CA
²⁰Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA
²¹Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
²²David Geffen School of Medicine at UCLA, Los Angeles, CA
²³University of Cincinnati, Cincinnati, OH
²⁴Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
²⁵Ohio State University, Columbus, OH
²⁶The Ohio State University, Lewis Center, OH
²⁷Leukemia and Lymphoma Society, Rye Brook, NY
²⁸Memorial Sloan Kettering Cancer Center, New York, NY
²⁹Leukemia and Lymphoma Society, White Plains, NY
³⁰The Ohio State University Comprehensive Cancer Center, Columbus, OH
³¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Fieke W Hoff, MD, PhD^1*, Ying Huang, MS, MA², Rina Li Welkie, MPH³, Ronan T. Swords, MD, PhD, FRCP, FRCPath⁴, Elie Traer, MD, PhD⁴, Eytan M. Stein, MD⁵, Tara L. Lin, MD⁶, Prapti A. Patel, MD⁷, Robert H. Collins, MD⁸, Maria R. Baer, MD⁹, Vu H. Duong, MD, MS¹⁰, William Blum, MD¹¹, Martha L. Arellano, MD¹², Wendy Stock, MD¹³, Olatoyosi Odenike, MD¹³, Robert L. Redner, MD¹⁴, Tibor J. Kovacsovics, MD¹⁵, Michael W. Deininger, MD, PhD¹⁶, Joshua F. Zeidner, MD¹⁷, Rebecca Olin, MD¹⁸, Catherine C. Smith, MD¹⁹, James M. Foran, MD²⁰, Gary J. Schiller, MD²¹, Emily K Curran, MD²², Kristin L Koenig, MD²³, Nyla A. Heerema, PhD^24*, Timothy Chen, PhD²⁵, Molly Martycz^25*, Mona Stefanos, MD²⁶, Sonja Gullen Marcus, MPH^27*, Leonard Rosenberg^27*, Brian J. Druker, MD⁴, Ross L Levine, MD²⁸, Amy Burd, PhD²⁹, Ashley Owen Yocum, PhD²⁷, Uma Borate, MD²⁵, Alice Mims, MD³⁰, John C. Byrd, MD³¹ and Yazan F. Madanat, MD³²

¹National Institutes of Health, Washington, DC
²Division of Hematology, Department of Statistics, The Ohio State University Wexner Medical Center, Columbus, OH
³The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁵Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
⁶Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Cancer Center, Westwood, KS
⁷Servier Pharmaceuticals, LLC, Boston, MA
⁸Division of Hematology/Oncology, Department of Internal Medicine, University of Texas Southwestern, Dallas, TX
⁹University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD
¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
¹¹Emory University, Winship Cancer Institute, Atlanta, GA
¹²Winship Cancer Institute of Emory University School of Medicine, Atlanta, GA
¹³Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
¹⁴University of Pittsburgh Medical Center, Pittsburgh, PA
¹⁵University of Utah, Salt Lake City, OR
¹⁶Division of Hematology and Hematologic Malignancies, University of Wisconsin Milwaukee, Milwaukee, WI
¹⁷Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
¹⁸University of California San Francisco, San Francisco, CA
¹⁹Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA
²⁰Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
²¹David Geffen School of Medicine, University of California, Los Angeles, CA
²²Division of Hematology/Oncology, University of Cincinnati Cancer Center, Cincinnati, OH
²³Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
²⁴Ohio State University, Columbus, OH
²⁵The Ohio State University, Columbus, OH
²⁶The Ohio State University, Lewis Center, OH
²⁷Leukemia and Lymphoma Society, Rye Brook, NY
²⁸Memorial Sloan Kettering Cancer Center, New York, NY
²⁹Leukemia and Lymphoma Society, White Plains, NY
³⁰The Ohio State University Comprehensive Cancer Center, Columbus, OH
³¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
³²Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX

Xue Chen, MD^1*, Lili Yuan, MD^2*, Xiaoli Ma, MD^1*, Fang Wang, MD^1*, Yang Zhang, MD^1*, Panxiang Cao, MD^2*, Jiancheng Fang, MD^3*, Tong Wang, MD^2*, Jiaqi Chen, PhD^2*, Xiaosu Zhou, PhD^4* and Hongxing Liu, MD^2,5

¹Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China
⁴Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
⁵Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China

Richard J Marrero, PharmD¹, Xueyuan Cao, PhD^2*, Huiyun Wu, PhD^3*, Raul C. Ribeiro, MD⁴, Jeffrey E. Rubnitz, MD, PhD⁴, Stanley Pounds, PhD^3* and Jatinder K. Lamba, PhD⁵

¹Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL
²University of Tennessee Health Science Center, Memphis, TN
³Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁵UF Health Cancer Center, University of Florida, Gainesville, FL