Gobind S Chugh, BS^1*, Vahagn Makaryan, MD², Merideth Kelley, MS^1* and David C. Dale, MD¹

¹University of Washington, Seattle, WA
²Department of Medicine, University of Washington, Seattle, WA

Yvonne Veltman^1*, Anton Langerak^2*, Berna Beverloo, PhD^3*, Roel Fiets^4*, Henk-Jan Boiten, MD, PhD, MSc^5* and Pim Mutsaers, MD^6*

¹Erasmus University Medical Center, Rotterdam, Netherlands
²Erasmus MC, Rotterdam, NLD
³Erasmus MC, University Medical Center Rotterdam, Department of Clinical Genetics, Rotterdam, Netherlands
⁴Amphia Hospital, Breda, NLD
⁵Department of Hematology, Sint Franciscus Gasthuis, Rotterdam, NLD
⁶Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands

Nao Takasugi^1*, Ryota Shirai, MD, PhD^2*, Tomoo Osumi, MD^3*, Kenichi Sakamoto, MD, PhD^4*, Ko Kudo, MD, PhD^5*, Mariko Tanaka, MD, PhD^6*, Toru Uchiyama, MD, PhD^7*, Daisuke Tomizawa, MD, PhD⁸, Tetsuo Ushiku, MD, PhD^6*, Takako Yoshioka, MD, PhD^9*, Yoko Shioda, MD, PhD^8* and Motohiro Kato, MD, PhD¹

¹Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
²Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan
³Children’s Cancer Center, National Center For Child Health and Development, Tokyo, Japan
⁴Department of Pediatrics, Shinshu University of Medical Science, Nagano, Japan
⁵Department of Pediatrics, Hirosaki University, Graduate School of Medicine, Aomori, Japan
⁶Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⁷Department of Human Genetics, National Research Institute for Child Health and Development, Tokyo, Japan
⁸Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
⁹Department of Pathology, National Center for Child Health and Development, Tokyo, Japan

Linda Beneforti^1,2*, Paul Milne^3*, Aurora Chinnici^1,2*, Maria Luisa Coniglio^1*, Sébastien Héritier^4*, Astrid Van Halteren^5,6*, Caroline Hutter^7*, Irene Trambusti^1*, Francesco Pegoraro^8,9*, Zofia Hélias-Rodzewicz^4*, Raphaela Schwentner^7*, Natasja Roozeboom^10*, Michele Tanturli^11*, Jean-Francois Emile^12*, Cor Van Den Bos^6*, Milen Minkov^7*, Jean Donadieu⁴, Matthew Collin, MD, PhD³ and Elena Sieni, MD^13*

¹Pediatric Hematology Oncology, Meyer Children’s Hospital IRCCS, Florence, Italy
²Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy
³Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, United Kingdom
⁴French Reference Center for Histiocytosis, Department of Pediatric Hematology and Oncology, Trousseau Hospital, AP-HP, Sorbonne Université, Paris, France
⁵Erasmus University Medical Center, Rotterdam, Netherlands
⁶Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷LCH Study group, CCRI, St. Anna Kinderkrebsforschung, Vienna, Austria
⁸Department of Health Sciences, University of Florence, Florence, Italy
⁹Department of Hematology and Oncology, Meyer Children’s Hospital IRCCS, Florence, Italy
¹⁰Sanquin, Amsterdam, Netherlands
¹¹Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
¹²Paris-Saclay University, Versailles SQY University, EA4340-BECCOH, Versailles, France
¹³Meyer Children's Hospital, Florence, Italy

Oussama Abla¹, Jennifer Picarsic^2*, Jean-Francois Emile^3,4*, Laura Galluzzo^5*, Arnelle Lardizabal^6*, Faten Abla^6*, Jorge Braier^7*, Guido Felizzia^7*, Elena Sieni, MD^8*, Francesco Pegoraro^8*, Cor van den Bos^9*, Barbara Degar, MD¹⁰, Faisal Razzaqi, MD^11*, David Samuel^11*, Zdenka Krenova^12*, Olga Gryniewicz-Kwiatowska^13*, Steven W. Allen^14*, Rima Jubran^15*, Itziar Astigarraga^16*, Maria Kondyli^17*, Michael Girschikofsky^18*, Carl Friedrich Classen^19*, Sheila Weitzman^20*, Eli L. Diamond^21* and James A. Whitlock²⁰

¹Division of Haematology/Oncology, The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada
²Department of Pathology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
³Paris-Saclay University, Versailles SQY University, EA4340-BECCOH, Versailles, France
⁴Assistance Publique–Hôpitaux de Paris (AP-HP), Ambroise-Paré Hospital, Pathology Department, Boulogne, France
⁵Hospital Nacional de Pediatria Garrahan, Beunos Aires, Argentina
⁶Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada
⁷Hospital Nacional de Pediatria Garrahan, Buenos Aires, Argentina
⁸Department of Hematology and Oncology, Meyer Children’s Hospital IRCCS, Florence, Italy
⁹Department of Hemato-Oncology Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands
¹⁰Dana Farber Cancer Institute and Boston Children’s Hospital, Boston, MA
¹¹Valley Children’s Hospital, Madera, CA
¹²Department of Pediatric Oncology, University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
¹³Department of Pediatric Oncology, Children’s Memorial Health Institute, Warsaw, Poland
¹⁴UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
¹⁵Children’s Hospital Los Angeles, Los Angeles, CA
¹⁶Department of Pediatrics, Hospital Universitario Cruces, Osakidetza, IIS, Bizkaia, UPV/EHU, Barakaldo, Spain
¹⁷CHU Saint-Justine, Montreal, QC, Canada
¹⁸Ordensklinikum, Linz Elisabethinen, Austria
¹⁹University Children's Hospital, Rostock, Germany
²⁰Division of Haematology/Oncology, The Hospital for Sick Children/University of Toronto, Toronto, Canada
²¹Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY

Mitali Sen, MD^1*, Gordon J Ruan, M.D.², Samuel B Reynolds, MD, BS³, Haadi Ali, MD³, XI Yang, MD⁴, Diana Morlote, MD^5*, Aishwarya Ravindran, M.B.B.S.^6*, Lauren Kelly Shea, MD, MS⁷, Matthew J Koster, M.D.^8*, Jithma P Abeykoon, MD², Hind Salama, MD^9*, Xinxin Cao, MD^10*, Asra Z. Ahmed, M.D.¹¹, Ronald S Go, M.D.² and Gaurav Goyal, MD¹²

¹rheumatology, university of alabama at birmingham, Birmingham, AL
²Division of Hematology, Mayo Clinic, Rochester, MN
³Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
⁴Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
⁵University of Alabama at Birmingham, Birmingham, AL
⁶Department of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL
⁷O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁸Division of Rheumatology, Mayo Clinic, Rochester, MN
⁹Divison of Hematology & HSCT, Departement of Oncology, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
¹⁰oncology, Peking union medical college hospital, BEIJING, CHN
¹¹Division of Hematology and Medical Oncology, University of Michigan, Ann Arbor, MI
¹²Division of Hematology and Medical Oncology, University of Alabama at Birmingham, Birmingham, AL

Sabrina R Wilcox, MD¹, XI Yang, MD², Asra Z. Ahmed, M.D.^3,4 and Samuel B Reynolds, MD, BS¹

¹Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
³University of Michigan Health System, Ann Arbor, MI
⁴Division of Hematology and Medical Oncology, University of Michigan, Ann Arbor, MI

Ali Abdelhay, MD¹, Basant Eltaher, MD^2*, Mouna Reghis, MD^3*, Aditya Sanjeevi, MD, MBBS², Aniket Vijay Rao, MD^4* and Peter A. Kouides, MD⁵

¹Department of Internal Medicine, Rochester General Hospital, Rochester, NY
²Rochester General Hospital, Rochester, NY
³Rochester General Hospital, Rochester N.Y, NY
⁴Internal Medicine, Rochester General Hospital, Rochester, NY
⁵Department of Hematology, Rochester General Hospital, Rochester, NY

Naval Daver, MD¹, Andrew Danquah^2*, Didier Halimi^2*, Jérôme Wojcik^3* and Emmanuel Monnet^2*

¹MD Anderson Cancer Center, Houston, TX
²Sobi, Basel, Switzerland
³Data2time Sàrl, Froideville, Switzerland

Yi Miao, MD^1*, Xuzhang Lu^2*, Chunling Wang, PhD^3*, Bingzong Li, MD, PhD⁴, Sun Miao^5*, Yun Zhuang^6*, Haiwen Ni, MD, PhD^7*, Xiaoyan Xie^8*, Jingyan Xu, MD^9*, Yunping Zhang^10*, Min Zhao^11*, Min Xu, PhD^12*, Wanchuan Zhuang, MD^13*, Weiying Gu, PhD^14*, Haiying Hua, MD^15*, Jianfeng Zhu^16*, Maozhong Xu^17*, Tao Jia^18*, Ping Liu^19*, Lijia Zhai^20*, Tongtong Zhang^21*, Qiurong Shan^22*, Qiudan Shen^23*, Guoqiang Lin^24*, Jun Qian^25*, Yuqing Miao^26*, Wenyu Shi^27* and Jianyong Li, MD²⁸

¹Lymphoma Center, Department of Hematology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
²Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, China
³Department of Hematology, Huai'an First People's Hospital, Huai'an, China
⁴Department of Hematology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
⁵Department of Hematology, Jingjiang People's Hospital, The Seventh Affiliated Hospital of Yangzhou University,, Jingjiang, China
⁶Department of Hematology, Wu Xi People's Hospital, Wuxi, China
⁷The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China
⁸Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China
⁹Department of Hematology, The Affliated Drum Tower Hospital, Nanjing, China
¹⁰The Affiliated Yixing Hospital of Jiangsu University, Yixing, China
¹¹Department of Hematology, Wuhu Second People's Hospital, Wuhu, China
¹²Zhangjiagang First Affiliated Hospital of Soochow University, Zhangjiagang, China
¹³The Second People's Hospital of Lianyungang, Lianyungang, China
¹⁴Department of Hematology, Changzhou First People's Hospital, Third Affiliated to Soochow University, Changzhou, China
¹⁵Affiliated Hospital of Jiangnan University, Jiangsu, CHN
¹⁶Department of Hematology, the People's Hospital of Taizhou, Taizhou, China
¹⁷The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China
¹⁸The First People's Hospital of Lianyungang, Lianyungang, China
¹⁹The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, CHN
²⁰Department of Hematology, Affiliated Hospital of Yangzhou University, Yangzhou, China
²¹Department of Hematology, Rudong County People's Hospital, Rudong, China
²²Department of Hematology, Shuyang Traditional Chinese Medicine Hospital, Shuyang, China
²³Department of Hematology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China
²⁴Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai'an, China
²⁵Department of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China., Zhenjiang, China, China
²⁶Department of Hematology, The First People’s Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng, China
²⁷Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China
²⁸First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Andrei Pobischan^1*, Alyce Hayes, MBChB, MRCPCH^2*, Catriona Lewis^3*, Asima Chaudhary, MBBS^4*, Anupama Rao^5*, Kimberly Gilmour, Ph.D.^6*, Jayashree Motwani, MBBS, MRCPath^7*, Ben Carpenter, MD^8*, Galina Jigoulina^9*, Zohreh Nademi, MD, PHD^10*, Srividhya Senthil, MBBS^11*, Majid Madni^12*, Sushil Gunaseelan, MD^13*, Beki James, MD^14* and Salah Ali, MRCP^15*

¹Paediatric Haematology and Oncology unit, Leeds Children's Hospital, Leeds, ENG, United Kingdom
²Paediatric Oncology and Haematology, Leeds Children's Hospital, Leeds, United Kingdom
³Leeds Children's Hospital, Leeds, United Kingdom
⁴Paediatric haematology, Great Ormond Street Hospital, London, United Kingdom
⁵Department of Hematology, Great Ormond Street Hospital, London, United Kingdom
⁶Department of Immunology, Great Ormond Street Hospital, London, GBR
⁷Paediatric haematology and oncology, Birmingham Children's Hospital, Birmingham, United Kingdom
⁸University College London Hospitals NHS Foundation Trust, London, United Kingdom
⁹Paediatric haematology and oncology, Southampton CHildren's Hospital, Southampton, United Kingdom
¹⁰Department Paediatric Stem Cell Transplant, Great North Children's Hospital, Newcastle Upon Tyne, GBR
¹¹Blood and Marrow Transplant Unit, Royal Manchester Children's Hospital, Manchester, United Kingdom
¹²Department of paediatric haematology and oncology, Nottingham University Hospitals, Nottingham, United Kingdom
¹³Paediatric Oncology and Haematology, Sheffield Children's Hospital, Sheffield, United Kingdom
¹⁴Leeds Teaching Hospital NHS Trust, Leeds, United Kingdom
¹⁵Department of paediatrics, Cancer Centre Of Southeastern Ontario, Queens University, kingston, ON, Canada

Dan Yoon, MS^1*, Erim Keresteci^1*, Bita Jafarzadeh, MD^1*, Vahid Mehrtash, MD^1*, Hortense Le, MS^1,2*, Nicolas Coudray, PhD^3*, Aristotelis Tsirigos, PhD^1,2,3 and Christopher Y. Park, MD, PhD^1,2

¹Department of Pathology, New York University School of Medicine, New York, NY
²Department of Medicine, Division of Precision Medicine, New York University School of Medicine, New York, NY
³Applied Bioinformatics Laboratories, New York University School of Medicine, New York, NY