-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

605. Molecular Pharmacology and Drug Resistance: Lymphoid Neoplasms: Poster II

Symposia: Molecular Pharmacology and Drug Resistance: Lymphoid Neoplasms Program: Oral and Poster Abstracts
Type: Poster
Sunday, December 8, 2024: 6:00 PM-8:00 PM
Halls G-H (San Diego Convention Center)

Liemei Lv1*, Ran Kong1*, Yu Zhang2*, Cong Wang3*, Guangcai Zhong2*, Yujie Jiang, MD4*, Kang Lu5*, Tiange Lu2* and Xiangxiang Zhou, MD2

1Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, China
2Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
3Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, AL, China
4Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
5Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Ailin Bai, PhD*, Maija Garnaas*, Zhen Zhang, PhD*, Rebecca L Riding, PhD*, Ankita Mishra, MS*, Kristen Cowens*, Haley BrinJones*, Khushbu Bhatt, PhD*, John Zielinski*, Matthew Sullivan*, Anu Yammanuru, PhD*, Graham MacLean*, Sam Farlow*, Russell Karp*, John Eldredge*, Maiko Obana, PhD*, Darren Potz*, Neeraj Kaushal, PhD*, Christopher Rowbottom, PhD*, Kenneth Drombosky, PhD*, Linh Van, PhD*, Graham Farrington, PhD*, Brendan M. Weiss, MD, Joshua P Frederick, PhD* and Sushma Gurumurthy, PhD*

Moderna, Inc., Cambridge, MA

Olivia Barbara Lightfuss, BS1*, Preet Kumar, BS1*, Austin Daniel Newsam, BS1*, Lingxiao Li, PhD1*, Pierre A. Younes2*, Toral Shastri, DO3*, Abdessamad Youssfi Alaoui, PhD4*, Diego E. Hernandez Parets2*, Paola Manara, MS1, Daniel Bilbao, PhD5, Stephan Schürer, PhD6*, Vance P. Lemmon, PhD7*, Francesco Maura, MD8, Yangbo Feng, PhD6*, Hassan A. Ali, PhD, MSM9* and Jonathan H. Schatz, MD10

1Sylvester Comprehensive Cancer Center, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
2University of Miami, Miami, FL
3Sylvester Comprehensive Cancer Center, Department of Medicine, University of Miami, Miami, FL
4Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
5Cancer Modeling Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
6Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL
7Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL
8University of Miami, Coral Gables, FL
9Department of Neurological Surgery, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
10Sylvester Comprehensive Cancer Center, Department of Medicine, Division of Hematology, University of Miami Miller School of Medicine, Miami, FL

Allison Chan, PhD1*, Akshaya Anbuselvan1*, Patrick Jaynes1*, Nayana Prabhu2*, Yuan Ju3*, Jane Jia Hui Lee3*, Tze King Tan1*, Jasmine Goh1*, Marco Foiani1,4,5*, Takaomi Sanda, MD, PhD6, Wai Leong Tam1,3,7,8*, Mark J O'Connor9*, Edward K Chow10* and Anand Devaprasath D. Jeyasekharan, MBBS, MRCP, PhD1,11,12,13*

1Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
2A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore
3Laboratory of Translational Cancer Biology, Genome Institute of Singapore, Singapore, Singapore
4IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy
5University of Milan, Department of Oncology and Hematology-Oncology, Milan, Italy
6Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
7Department of Biochemistry, National University of Singapore, Singapore, Singapore
8School of Biological Science, Nanyang Technological University, Singapore, Singapore
9Oncology R&D, AstraZeneca, Cambridge, United Kingdom
10KYAN Therapeutics, Singapore, Singapore
11NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
12Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore
13Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Sara Elgamal, PhD1, Casie Furby1*, Marissa Long1*, Kaytlynn Fyock1*, Thomas M. Sesterhenn1*, Megan E. Johnstone, PhD1, Jianmin Pan, PhD2*, Shesh N. Rai, PhD2*, Alexander Khvat, PhD3*, Ruben Karapetian, PhD3*, Alexey Ryakhovskiy, PhD3*, Elena Bulanova, PhD3*, Vladislav Parchinsky, PhD3*, Nikolay Savchuk, PhD4*, Iain Dukes, DPhil4*, Amy Burd, PhD4*, Erin K. Hertlein, PhD1 and John C. Byrd, MD1

1Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
2Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH
3ChemDiv Inc, San Diego, CA
4Eilean Therapeutics, Philadelphia, PA

Simone Rauch, Ph.D.1*, Stefan Reber, Ph.D.1*, Montserrat Perez-Salvia, Ph.D.1*, Marco Pregnolato, Ph.D.1*, Botao Liu, Ph.D.2*, Loren Berry, Ph.D.2*, Olesia Buiakova, Ph.D.2*, Hasane Ratni, Ph.D.1*, Brian Gudenas, Ph.D.1*, Carlo Cusulin, Ph.D.1*, Lauren Shanahan, Ph.D.1*, Douglas V Faller, M.D., Ph.D.2, Veronica Costa, Ph.D.1* and Sergey Paushkin, M.D., Ph.D.2*

1Skyhawk Therapeutics, Basel, Switzerland
2Skyhawk Therapeutics, Waltham, MA

Wei Yang1*, Colleen Burns1*, Kevin Lindquist2*, Julie Dobkin1*, Hee Rae Shin1*, Cindy Nguyen1*, Xiaodong Huang1*, Whitney Helms3*, Nicholas Arce2*, Yvonne Mak2*, Audrey Au1*, Abraham Abouzeid4*, Marta Witek4*, Ching Ching Leow1*, Xueqian Gong4*, Mohan Srinivasan2*, Joshua I. Park2*, Kyla Driscoll1*, Andrew Hass4*, Rikke Holmgaard1*, Omar Duramad2* and Kristin Bedard2*

1Loxo@Lilly, New York, NY
2Loxo@Lilly, South San Francisco, CA
3Loxo@Lilly, Silver Spring, MD
4Eli Lilly and Company, Indianapolis, IN

Daisy Y. Diaz Rohena, BS1, Andrew D. Mitchell, MS2*, Jing Wang, PhD3*, Stephanie Chamberlain3*, Chaomei Liu1*, John R. Sanchez II, BSc1, Charmelle D. Williams, MSc, BSc1, Trisha K. Wathan, BS1*, Bailey Slawin, BS1*, Kevin Bowman, BS1*, Yaxia Yuan4*, Peiyi Zhang5*, Wanyi Hu5*, Guangrong Zheng, PhD5*, William G. Wierda6, Nitin Jain, MD6, Matthew S. Davids, MD, MMSc7, Daohong Zhou, MD4,8*, Jennifer A. Woyach, MD2 and Deepa Sampath, PhD9

1Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX
2Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
4Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX
5Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL
6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
7Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA
8Center for Innovative Drug Discovery, University of Texas Health Science Center at San Antonio, San Antonio, TX
9Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX

Meng Li, PhD1*, Noel Park, PhD2*, Coraline Mlynarczyk, PhD3, Christopher Chin, PhD4*, Shawn Davidson, PhD5* and Ari M Melnick, MD6

1Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
2Department of Molecular Biology, Princeton University, Princeton
3Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York
4Department of Medicine, Weill Cornell Medicine, New York, NY
5Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ
6Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY

Yan Wang1*, Fei Wang2*, Haoan Wu2*, Qi Han1*, Yu Zhang2*, Chunhua Song, M.D., Ph.D.3 and Zheng Ge, M.D., Ph.D.1

1Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China
2State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China
3The Division of Hematology, The Ohio State University Wexner Medical Center, the James Cancer Hospital, Columbus, OH

Muneera Alhaddad, MBChB1,2*, Roberta Buono, PhD1*, Van Thu Huynh2, Sarah K Tasian, MD3 and David A Fruman, PhD1

1Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA
2Division of Oncology, Children's Hospital of Orange County, Orange, CA
3Division of Oncology & Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA

Xingyue An1*, Mohosin Sarkar2*, Guixian Jin2*, Tiffany Liang2*, Tracy Lichter2*, Danielle Klaskin2*, Afsana Sabrin2*, Evelyn Teran2*, Abliz Abdukadir2*, Hayden Karp2*, Julio Rodriguez2*, Hemachander Capiralla2*, Zengzu Lai2*, Martin Preyer2*, Louis Matis2*, Stella Martomo2*, Agnes Meade2*, Jay S. Fine2* and Jeremy S. Myers2*

1EvolveImmune Therapeutics, Inc., BRANFORD, CT
2EvolveImmune Therapeutics, Inc., Branford, CT

Ankit Tanwar, PhD1, Emma Cordover2*, Shikhar Sharma3*, Zixuan Tong4*, Kith Pradhan, PhD5*, Latoya S Townsend, DNP4*, Ioannis Mantzaris, MD6, Mendel Goldfinger7*, Nishi Shah, MBBS, MPH8, Aditi Shastri, MD8, Noah Kornblum, MD8, Dennis L Cooper, MD7, Ridhi Gupta, MD9*, Simon Zhen10*, Nechama Dreyfus, MD11*, Julie Nguyen4, Lauren Shapiro, MD8, Eric J. Feldman, MD8*, Ira Braunschweig, MD9*, Beth McLellan, MD4*, Alyssa de Castro, PharmD12*, Xingxing Zang13*, Ali Bazarbachi, MD, PhD14, Murali Janakiram, MBBS15, Erik Guillen, MSc1*, Gregoire Lauvau, PhD4*, Eric Liu16*, Kira Gritsman, MD, PhD8, B. Hilda Ye4*, Amit Verma, MD17, Marina Konopleva18 and R. Alejandro Sica, MD7

1Albert Einstein College of Medicine, Bronx, NY
2Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY
3Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
4Albert Einstein Collge of Medicine, Bronx, NY
5Department of Oncology, Blood Cancer Institute, Albert Einstein College of Medicine, Bronx, NY
6Montefiore Einstein Comprehensive Cancer Center, Bronx, NY
7Hematology/Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
8Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
9Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
10Columbia Medical Center, New York
11Montefiore Medical Center, Albert Einstein Collge of Medicine, New York, NY
12Montefiore Medical Center, Albert Einstein Collge of Medicine, New York
13Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY
14American University of Beirut Dept. of Medicine, Beirut, Lebanon
15Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA
16Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
17Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
18Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY

Emiri Omori Takaki* and Naoto Ohi, PhD*

Osaka Research Center for Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan

Amira Marouf, MD, PhD1, Raphaël Liévin, MD2*, Mathilde Bonnet des Claustres3*, Matthias Titeux, PhD3*, Mathieu Simonin4*, Manon Vavasseur5*, Amandine Mainreck6*, Mehdi Latiri7*, Aurore Touzart, MD, PhD8*, Marie Bouillié9*, Olivier Pellé10*, Nicolas Gaidot11*, Mathieu Rocquet12*, Didier Bouscary, MD, PhD13*, Arnaud Jaccard, MD, PhD14*, Vahid Asnafi, MD, PhD8*, Olivier Hermine, MD, PhD15,16*, Guillaume P Andrieu, PhD17,18* and Lucile Couronné, MD, PhD19*

1INSERM U1163 Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Université Paris Cité, PARIS, France
2INSERM U1163 Laboratory of molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Université Paris Cité, Paris, France
3INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France
4INSERM UMR_S 1151, Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, Paris, France
5INSERM U1163 Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Paris, France
6LEAT platform – Animal Facility, Imagine Institute-SFR Necker, Paris Cite University, France., Imagine Institute-SFR Necker, Paris, France
7INSERM UMR_S 1151, Necker Enfants Malades Institute (INEM), Laboratory of Onco-Hematology, Assistance Publique-Hopitaux De Paris (AP-HP), Paris, France
8Laboratory of Onco-Hematology, Necker Enfants-Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France
9INSERM 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Paris, France
10Plateforme de Cytométrie en Flux, Structure Fédérative de Recherche Necker, INSERM US24-CNRS UMS3633, Paris, France
11INSERM UMR_S 1151, Necker Enfants Malades Institute (INEM), Laboratory of Onco-Hematology, Assistance Publique-Hopitaux De Paris (AP-HP), Université Paris Cité, paris, France
12Department on Hematology, Necker Enfants Malades, Paris, France
13Hematology, Cochin Hospital, Greater Paris University Hospitals (AP-HP), Paris, France
14Hématologie Clinique, CHU de Limoges, Limoges, France
15INSERM U1163 Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Université Paris Cité, Paris, France
16Hopital Necker, Paris, France
17Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
18INSERM UMR_S 1151, Laboratory of Onco-Hematology, Institut Necker Enfants Malades (INEM), Assistance Publique-Hopitaux De Paris (AP-HP), Université Paris Cité, Paris, France
19INSERM 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, Institut IMAGINE, Université Paris Cité, Paris, France

Xu (Sue) Zhu1*, Damilola Olabode1*, Massimo Lai2*, Cesar Pichardo-Almarza2*, Kevin Smart2*, Denise Brennan1*, David Sermer3* and Robin Lesley, PhD4*

1AstraZeneca, Waltham, MA
2AstraZeneca, Cambridge, United Kingdom
3AstraZeneca, New York, NY
4AstraZeneca, South San Francisco, CA

Praveen Kumar Tiwari, PhD1,2*, Drew A Harrison1*, Samuel Ojeda1*, Ajinkya S Kawale, PhD1,2*, Sai Reddy Doda, PhD1,2*, Raghu Vannam, PhD1,2*, Barbara Karakyriakou1*, Ann-Sophie Koglin1*, Sarah Rizvi1* and Christopher J Ott, PhD2,3

1Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA
2Harvard Medical School, Boston, MA
3Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA

Sara Majocchi*, Valéry Moine*, Giovanni Magistrelli*, Franck Gueneau*, Nicolas Fischer, PhD*, Limin Shang, PhD*, Krzysztof Masternak, PhD* and Walter Giovanni Ferlin, PhD*

Light Chain Bioscience - Novimmune SA, Plan-Les-Ouates - Geneva, Switzerland

*signifies non-member of ASH