Zhe Wang, MD, PhD^1*, Anna Skwarska, PhD², Gowri Poigailwar^2*, Sovira Chaudhry, MSc^2*, Alba Rodriguez-Meira, PhD^3,4*, Pinpin Sui, PhD^5*, Emmanuel Olivier, PhD^6,7*, Yannan Jia^1,8*, Cassandra L. Ramage^1*, Guangrong Zheng, PhD^9*, Alexandra Schurer, MS², Kira Gritsman, MD, PhD¹⁰, Eirini Papapetrou, MD, PhD^6,7, Kapil N. Bhalla, MD¹, Daohong Zhou, MD^11*, Adam J Mead, PhD, MRCP, FRCPath¹², Raajit Rampal, MD, PhD¹³, Jeffrey W Tyner, PhD^14*, Hussein A. Abbas, MD, PhD¹, Naveen Pemmaraju, MD¹, Qi Zhang Tatarata, MD, PhD^1,15* and Marina Konopleva^1,2

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA
⁵Department of Cell Systems & Anatomy, The University of Texas Health Science Center at San Antonio, San Antonio, TX
⁶Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Center for the Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁸Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁹Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL
¹⁰Albert Einstein College of Medicine, Bronx, NY
¹¹Department of Biochemistry and Structural Biology and Center for Innovative Drug Discovery, University of Texas Health Science Center at San Antonio, San Antonio, TX
¹²Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
¹³Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
¹⁵NYC Health + Hospital/ Kings County Hospital, SUNY Downstate Health Sciences University, Brooklyn, NY

Frances M. Cole^1*, George S. Laszlo, PhD^2*, Margaret C. Lunn-Halbert^1*, Allie R. Kehret^1*, Patrick A. Zweidler-McKay, MD, PhD³, Eduardo Rodríguez-Arbolí, MD, MPhil^1,4*, David Wu, MD, PhD^5*, Kyle E. Nyberg^1*, Junyang Li^1*, Sheryl Y. T. Lim, DPhil^1*, Sribalaji Lakshmikanthan, PhD^3* and Roland B. Walter, MD, PhD, MS^6,7,8

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
²1100 Fairview Avenue North, Fred Hutchinson Cancer Center, Seattle, WA
³ImmunoGen, Inc., Waltham, MA
⁴Department of Hematology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, University of Seville, Seville, Spain
⁵Hematopathology, University of Washington, Seattle, WA
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, WA
⁸Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA

Manuela Albuquerque De Melo, MSc^1*, Diego A. Pereira-Martins, Ph.D.^2*, Brunno Gilberto Santos Macedo, MSc^1*, Livia Bassani Lins de Miranda, Bsc^3*, Priscila Santos Scheucher, PhD^1*, Isabel Weinhäuser, PhD^4*, Gerwin Huls², Jan Jacob Schuringa, Prof. Dr.², João Agostinho Machado-Neto, PhD^3* and Fabiola Traina, MD, PhD¹

¹Department of Medical Images, Hematology, and Oncology, University of São Paulo at Ribeirão Peto Medical School, Ribeirão Preto, Brazil
²Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, Netherlands
³Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
⁴Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands

Vakul Mohanty, PhD^1*, Natalia Baran, MD, PhD^2,3, Yuefan Huang^4*, Cassandra L. Ramage^2*, Laurie Cooper^5*, Sarah Gwen Pelletier, BS^2*, Shan He^4*, Ramiz Iqbal^4*, May Daher, MD, MD⁶, Jeffrey W. Tyner, PhD⁷, Gordon B Mills^8*, Marina Konopleva⁹ and Ken Chen, PhD^1*

¹Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Section of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
⁴Department of Bioinformatics and Computational biology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵The University of Texas MD Anderson Cancer Center, Houston
⁶Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁸Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁹Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY

Xiyang Ren^1*, Haotian Yan^1*, Mei Zhou^1*, Fan Wu^2*, Qing Zhang^1*, Yangyang Ding, MD^3*, Qian Li, MD^4*, Huiping Wang^5*, Caixian Xu^5*, Jiyu Wang^6*, Cong Li^2*, Wanqiu Zhang^2*, Linlin Liu^1*, Ruotong Chen^5*, Yi Dong^1*, Wenjie Dai^5*, Zhimin Zhai, MD⁷ and Qianshan Tao, MD^8*

¹The Second Affiliated Hospital of Anhui Medical University, Hefei, China
²Hematologic Department/Hematologic Diseases Research Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
³Hematologic Department/Hematologic Diseases Research Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⁴Center of Hematology Research, Anhui Medical University, Hefei, China
⁵Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
⁶Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, AL, China
⁷The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
⁸Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China

Yuki Nishida, MD, PhD¹, Hideaki Mizuno, MD, PhD^1*, Edward Ayoub, PhD^1*, Eiji Sugihara, PhD^2*, Lauren B. Ostermann, BSc^1*, Shayaun Khazaei, BS^1*, Darah Scruggs, MS^1*, Po Yee Mak^1*, Baozhen Ke, BS^1*, Bing Z. Carter, PhD¹, Abhishek Maiti, MBBS³, Liandong Ma, PhD^4* and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Fujita Health University, Division of Gene Regulation, Cancer Center and Open Facility Center, Research Promotion Headquarters, Toyoake, JPN
³Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁴Oncobiotherapeutics, Radnor, PA

Daniel J Vail^1*, Jill Durkin^2*, Dongxu Jiang, PhD¹, Thomas Laframboise, PhD^3* and Babal K. Jha, PhD^1,4

¹Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Bay Village, OH
³Case Western Reserve University, Cleveland, OH
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

Ida Vänttinen^1,2*, Joseph Saad, MSc^1,2*, Tanja Ruokoranta, MSc^2*, Sari Kytölä, MD^3*, Pia-Sofia Ettala, MD^4*, Marja Pyörälä, MD, PhD^5*, Johanna Rimpiläinen, MD^6*, Timo Siitonen, MD, PhD^7*, Caroline A. Heckman, PhD^1,2, Heikki Kuusanmäki, PhD^1,2,8* and Mika Kontro, MD, PhD^1,2,3,8

¹iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland
²Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
³Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁴Department of Clinical Hematology, Turku University Hospital, Turku, Finland
⁵Department of Medicine, Kuopio University Hospital, Kuopio, Finland
⁶Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
⁷Department of Hematology, Oulu University Hospital, Oulu, Finland
⁸Foundation for the Finnish Cancer Institute, Helsinki, Finland

Yueming Tang, MD, PhD^1*, Adam Braun, MD^2*, Zachary von Behren^3*, Jieya Wu, MD^4*, Caitlyn Haley^3*, Chunxiao Zhang, PhD^5*, Brenda Loera^5*, Pina M. Cardarelli, Ph.D.⁶, Nina Caculitan, PhD^6*, Sylvia Chien^7*, Jin Dai, PhD^7*, Vivian G. Oehler, MD^8*, Jianying Zhang, PhD^9*, Guido Marcucci¹⁰ and Pamela S. Becker, MD, PhD^11,12

¹Department of Hematologic Malignancies Translational Science, City of Hope, Monrovia, CA
²City of Hope, Duarte, CA
³City of Hope, Monrovia, CA
⁴Department of Hematologic Malignancies Translational Science, City of Hope National Medical Center, Monrovia, CA
⁵Amgen, Thousand Oaks, CA
⁶GPCR Therapeutics, Redwood City, CA
⁷University of Washington, Seattle, WA
⁸Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁹Department of Computational and Quantitative Medicine, Duarte, CA
¹⁰Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
¹¹Department of Hematologic Malignancies Translational Science, City of Hope Beckman Research Institute, Duarte, CA
¹²Hematology/HCT, City of Hope, Duarte, CA

Priyanka Sharma, PhD¹, Natalia Baran, MD, PhD², Qi Zhang, PhD^2*, M. Anna Zal, M.Sc.^3*, Joanne Munck, PhD^4*, Martin Sims, PhD^4*, Bing Z. Carter, PhD¹, Michael Andreeff, MD, PhD¹ and Gautam Borthakur, MD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Astex Pharmaceuticals, Cambridge, United Kingdom

Zhe Wang, MD, PhD^1*, Cassandra L. Ramage^1*, Helen Ma^1*, Haichao Zhang^2*, Andrew Souers, PhD³, Darren C Phillips, PhD, BSc^2*, Marina Konopleva⁴ and Qi Zhang Tatarata, MD, PhD^1,5*

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Abbvie, North Chicago, IL
³AbbVie Inc., North Chicago, IL
⁴Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁵NYC Health + Hospital/ Kings County Hospital, SUNY Downstate Health Sciences University, Brooklyn, NY

Ebubechukwu Nwarunma, MSc^1*, Katerina Miari, PhD^2*, Athanasia Papadopoulou, MSc^1*, Leandro Martinez, PhD^3*, Victoria Campbell, MD, PhD^4*, Samantha Hurwitz, PhD⁵, Tatiana Fourfouris, MSc⁵, Ki Jun Lee, MSc⁵, Carl Goodyear, PhD^6*, Theodoros Simakou, PhD^6*, Marcus Doohan, BSc^6*, Lucy MacDonald, PhD^6*, Timothy Humpton, PhD^1,7*, Lesley Forrester, PhD^8*, Mariola Kurowska-Stolarska, PhD^6*, Ken I Mills, PhD, FRCPath⁹, Yong-Mi Kim, MD, PhD, MPH⁵, Helen Wheadon, PhD^2*, Monica L Guzman, PhD¹⁰ and Mark T Williams, PhD^1,11*

¹Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
²Paul O’Gorman Leukaemia Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
³Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
⁴Department of Haematology, Western General Hospital, Edinburgh, United Kingdom
⁵Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA
⁶School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom
⁷Cancer Research UK Scotland Institute, Glasgow, United Kingdom
⁸Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom
⁹Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, NI, United Kingdom
¹⁰Weill Cornell Medicine and The New York Presbyterian Hospital in New York City, New York, NY
¹¹School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Yingying Yang, MSc^1*, Ekaterina Parfenova², Nikolina Vrdoljak, BSc^3*, Mark D. Minden, MD, PhD^4,5,6,7,8*, Jessica Luc^9*, Andrew Doxey, Ph.D.^9* and Paul A. Spagnuolo, PhD^10*

¹Food Science, University of Guelph, Guelph, ON, Canada
²Department of Food Science, University of Guelph, Guelph, ON, CAN
³Department of Food Science, University of Guelph, Georgetown, ON, Canada
⁴Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada
⁷Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁸Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁹Department of Biology, University of Waterloo, Waterloo, ON, Canada
¹⁰Department of Food Science, University of Guelph, Guelph, ON, Canada

Xiaoyuan Zeng^1,2*, Kwui-Wa Tong^1,2*, Koon Chuen Chan^1,2*, Li-Chuan Zheng^1,2*, Stephen Lam, PhD, MBBS,^1*, Mark Robert Bray, PhD^3*, Tak-Wah Mak, PhD^2,3,4*, Cheuk-Him Man, PhD^1* and Anskar Y. H. Leung, MD, PhD^1,2

¹Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
²Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China
³Princess Margaret Cancer Centre, The Campbell Family Institute for Breast Cancer Research, Toronto, Canada
⁴Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Emily E Hartung^1,2*, Kanwaldeep Singh, PhD^1,3*, Sarah Coopersmith, BSc^1,2*, Jamie Avrumutsoae^1,2*, Siddaarth Varatharajan^1,2*, Sara Pishyar, MSc^1,2*, Pradhariny Prabagaran, MSc^1,2*, Dina Khalaf, MSc, MBBS³, Alejandro Garcia-Horton, MD³, Ronan Foley, MD, FRCPC^3*, Brian Leber, MD⁴, Irwin Walker, MBBS⁴, Kylie L. Lepic, MD^3*, Maria Kleppe, PhD, RPh^5*, Hugh Young Rienhoff Jr., MD⁵ and Tobias Berg, MD^1,3,6

¹Centre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada
²Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
³Department of Oncology, McMaster University, Hamilton, ON, Canada
⁴Department of Medicine, McMaster University, Hamilton, ON, Canada
⁵Imago BioSciences, Inc., a subsidiary of Merck & Co., Inc., Rahway, NJ
⁶Escarpment Cancer Research Institute, Hamilton Health Sciences / McMaster University, Hamilton, ON, Canada

Kazuharu Kamachi, MD, PhD^1*, Hiroki Akiyama, MD, PhD^1,2, Ran Zhao, MSc^1*, Liang Zhang, PhD^1*, Saurabh Kumar Gupta, PhD^1*, Lauren B. Ostermann, BSc^1*, Yuji Otsuki, MD, PhD^3*, Osamu Nagano, DDS, PhD^3*, Hideyuki Saya, MD, PhD^3*, Ayumu Taguchi, MD, PhD^4*, Michael Andreeff, MD, PhD¹ and Jo Ishizawa, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan
³FerroptoCure, Tokyo, Japan
⁴Division of Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan

Abdullah Khasawneh^1*, Faith Jessica Paran, PhD^2*, Abhishek Maiti, MBBS³, Bofei Wang, PhD⁴, Kala Hayes, PhD^5*, Courtney D. DiNardo, MD, MSc⁶, Michael Andreeff, MD, PhD⁷, Hussein A. Abbas, MD, PhD⁵, Marina Konopleva^5,8 and Yoko Tabe, MD, PhD^9,10*

¹Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo, Japan
²Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
³Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
⁴Department of Leukemia, Division of Cancer Medicine, The University of Texas At MD Anderson Cancer Cent, Houston, TX
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁷Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁹Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
¹⁰Department of Leukemia, The University of Texas MD Anderson Cancer Center, Tokyo, Japan

Kentson Lam, MD, PhD¹, Yoon Joon Kim^2*, Carlo M. Ong^2*, Andrea Z. Liu^2*, Fanny Jiahua Jiahua Zhou, BS, MS³, Bernadette A. Chua, PhD^2*, Silvia Vicenzi, PhD⁴, Pierce W. Ford^5*, Jie-Hua Zhou^6*, Eric Bennett^5*, Leslie A Crews, PhD⁷, Edward D. Ball, MD⁶ and Robert Signer, PhD⁸

¹Division of Regenerative Medicine, Department of Medicine, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, San Diego, CA
²Division of Regenerative Medicine, Department of Medicine, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, CA
³Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California San Diego, San Diego, CA
⁴Moores Cancer Center, UNIVERSITY CALIFORNIA, SAN DIEGO, La Jolla, CA
⁵Department of Cell and Developmental Biology, University of California at San Diego, School of Biological Sciences, La Jolla, CA
⁶Division of Bone and Marrow Transplantation, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁷Division of Regenerative Medicine, UCSD, La Jolla, CA
⁸University of California San Diego, La Jolla, CA

Sandhya Dhiman¹, Md. Hafiz Uddin^2*, Vikram Dhillon, DO, MBA^3,4,5*, Jeff Justin Aguilar, MD, MBA⁶, Amro Aboukameel^2*, Husain Khan^2*, Sahar Bannoura^7*, Jay Yang, MD⁸, Gregory Dyson, PhD^9*, Steven Buck^10*, Asfar Azmi^2*, Lisa Polin, PhD^11,12*, Francis Burrows, PhD^13*, Linda Kessler, BA^13*, Jaroslaw Maciejewski¹⁴ and Suresh Kumar Balasubramanian, MD¹⁵

¹Karmanos Cancer Institute/Wayne State University, Detroit, MI
²Karmanos Cancer Institute/ Department of Oncology, Wayne State University, Detroit, MI
³Department of Hematology/Oncology, Neal Cancer Center/Houston Methodist Hospital, Detroit, MI
⁴Department of Hematology/Oncology, Neal Cancer Center/Houston Methodist Hospital, Houston, TX
⁵Department of Oncology, Karmanos Cancer Center/Wayne State University, Detroit, MI
⁶Department of Internal Medicine, Detroit Medical Center, Detroit, MI
⁷Karmanos Cancer Institute/ Department of Oncology, Detroit, MI
⁸Department of Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI
⁹Karmanos Cancer Institute/Department of Oncology, Wayne State University, Detroit, MI
¹⁰Wayne State University, Detroit, MI
¹¹Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
¹²Department of Oncology, Wayne State University School of Medicine, Detroit, MI
¹³Kura Oncology, Carlsbad
¹⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹⁵Department of Oncology, Karmanos Cancer Institute/ Wayne State University, Detroit, MI

Ton Falques, PhD^*, Mattias Pilheden, PhD^*, Larissa Helena Moura-Castro, PhD^*, Qirui Zhang, PhD^*, Louise Ahlgren, PhD^*, Helena Sturesson, PhD^*, Kajsa Paulsson, PhD, Axel Hyrenius Wittsten, PhD^* and Anna K. Hagstroem-Andersson, PhD

Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden

Bogdan Popescu, MD^1*, Madison Piao^2*, Sydney Abelson^3*, Carolina E. Morales, BS^3*, Khadija Yousuf^3*, Jose M. Rivera^3*, Cheryl A C Peretz, MD³, Elliot Stieglitz, MD, PhD³ and Catherine C. Smith, MD²

¹Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
²Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA
³Division of Hematology-Oncology, Dept. of Pediatrics, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA

Brandon Turunen, PhD^1*, Craig Leach, PhD^1*, Matthew Smith^2*, Terra L. Lasho, PhD², Christy Finke, BS^3*, Abhishek A. Mangaonkar, MBBS², Aref Al-Kali, MD², Yael Kusne, MD, PhD⁴, Talha Badar, MD⁵, James M. Foran, MD⁶, Aisha Margaert^7*, Michelle Baptista^1*, Stephanie Wiltzius^1* and Mrinal M. Patnaik, MD, MBBS²

¹Solu Therapeutics, Boston
²Mayo Clinic, Rochester, MN
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Mayo Clinic, Phoenix, AZ
⁵Department of Hematology/Oncology, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology & Medical Oncology, Mayo Clinic, Jacksonville, FL
⁷Discovery Life Sciences, Seattle

John Pollard^1*, Graham Craggs^1*, Gillian Farnie^2*, Matthew Fawkes^1*, Fenella Gross^1*, Joe Harman^1*, Marta Llorca-Cardenosa^1*, Sarah Major^1*, Alison Maloney, PhD^3*, Thomas A Milne⁴ and Iain Simpson^1*

¹Dark Blue Therapeutics, OXFORD, United Kingdom
²Cancer Research Horizons, The Francis Crick Institute, London, United Kingdom
³Dark Blue Therapeutics, OXFORD,, ENG, United Kingdom
⁴Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

Mattia Vitale, PhD^1*, Hollie B S Griffiths, PhD^2*, Nyle Jones, PhD^2*, Meera Mistry, MSc(Eng)^2*, Jack Sangster, PhD^2*, Chloe Patterson, PhD^2*, Samuel E O'Halloran, PhD^2*, Adrian Blanco-Gomez, PhD^2*, Oliver Schon, PhD^2* and Tiffany Thorn (nee Daniels), MSc^2*

¹Bivictrix Therapeutics Plc, Nether Alderley, United Kingdom
²BiVictriX Therapeutics plc, Nether Alderley, England, United Kingdom

Norman Fultang, PhD^1*, Ashley M Schwab^1*, Ian Johnson^1*, Alexander Grego^1*, Emma Filler^1*, Carly Bachner^1*, Jake Karwoski^1*, Andrew Moore^1*, Ashley Bartilomo^1*, Anjana Agarwal^1*, Olusola Peace Osinubi^1*, Koichi Ito^1*, Sarah Aminov, PhD², Srabani Sahu, MS^2*, Amit Verma, MD², Peggy A Scherle, PhD¹, Neha Bhagwat, PhD³ and Diane Heiser, PhD^3*

¹Prelude Therapeutics, Wilmington, DE
²Blood Cancer Institute, Department of Oncology, Albert Einstein College of Medicine, Bronx, NY
³Prelude Therapeutics Incorporated, Wilmington, DE

Lucio Henrique Pinheiro, MSc^1,2*, Isabel Weinhäuser, PhD^3,4*, Diego A. Pereira-Martins, Ph.D.^3,5*, Luise Araujo De Albuquerque Simoes, BS^2,6*, Matthew Markham, PhD^7*, Lynn Quek, MD, Ph.D.^3*, Gerwin Huls⁴, Jan Jacob Schuringa, Prof. Dr.⁴, Stuart A Rushworth, PhD⁸ and Eduardo M. Rego, MD, PhD²

¹Norwich Medical School, University of East Anglia, Norwich, ENG, United Kingdom
²Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, University of São Paulo Medical School, Sao Paulo, Brazil
³Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁴Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
⁵Department of Experimental Hematology, University Medical Centre Groningen, Groningen, Netherlands
⁶Department of Experimental Hematology, University Medical Center Groningen, São Paulo, SP, Brazil
⁷Norwich Medical School, University of East Anglia, Norwich, United Kingdom
⁸University of East Anglia, Norwich, United Kingdom

Heather Betz^1,2* and Xiaoyan Jiang, MD, PhD^1,2

¹Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, BC, Canada
²Department of Medicine, The University of British Columbia, Vancouver, BC, Canada

Dhabya Majid, BS^1*, Zhe WANG, MD^1*, Bin Yuan, PhD^2*, Mhd Yousuf Yassouf, PhD^3*, Amanda Schalk, PhD^4*, Basant T. Gamal, MS^5*, Qi Zhang Tatarata, MD, PhD^1*, Jessica Lynn Root, MS^6*, Araceli Isabella Garza^1*, Annie Hoai Nguyen^7*, Sammy Ferri-Borgogno, PhD^5*, Patrick K. Reville, MD, MPH¹, Arnon Lavie, PhD^4* and Hussein A. Abbas, MD, PhD^1,8

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²The University of Texas at MD Anderson Cancer center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁴University of Illinois, Chicago, IL
⁵University of Texas MD Anderson Cancer Center, Houston
⁶Department of Leukemia, The University of Texas MD Anderson Cancer center, Houston, TX
⁷Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston
⁸Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Matthew Tcheng, BSc^1,2*, Veronique Voisin, PhD^2*, Marcela Gronda^2*, Rose Hurren^3*, Dakai Ling^2*, Yongran Yan^2*, Lan Xin Zhang^4*, Yue Feng^2*, Zaynab Mamai^5*, Yulia Jitkova^2*, Chaitra Sarathy, PhD^2*, Andrea Arruda^6*, Steven M. Kornblau, MD⁷, Mark D. Minden, MD, PhD^6,8,9* and Aaron D Schimmer, MD¹⁰

¹University Health Network, Princess Margaret Cancer Research Tower, Richmond Hill, ON, Canada
²University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada
³UHN, Princess Margaret Cancer Centre, Toronto, ON, Canada
⁴University Health Network, Princess Margaret Cancer Center, Toronto, ON, Canada
⁵University of Toronto, Toronto, ON, Canada
⁶Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁹Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada
¹⁰Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada