66th ASH Annual Meeting: 321. Coagulation and Fibrinolysis: Basic and Translational: Poster II

Symposia: Coagulation and Fibrinolysis: Basic and Translational Oral and Poster Abstracts
Poster

Research, Bleeding and Clotting, Bleeding disorders, Fundamental Science, Hemophilia, Translational Research, Assays, Genetic Disorders, Diseases, Immune mechanism, Immunology, Thrombotic disorders, Biological Processes, Technology and Procedures, Gene editing, Molecular biology, Multi-systemic interactions, Pathogenesis, Imaging

Halls G-H (San Diego Convention Center)

2571

Extracoagulative Role of FVIII: Impact on in Vitro and In Vivo Murine Bone Cell Differentiation and Function

Chiara Borsotti¹^*, Paolo E Di Simone²^*, Vakhtang Kalandadze²^* and Antonia Follenzi¹^*

¹Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
²Department of Health Sciences, Histology laboratory, Università del Piemonte Orientale, Novara, Italy

2572

Inhibitor-Positive Hemophilia a Patients-Derived Humanized Mouse Models Revealed the Connection of PD-1/PD-L1 Interactions to Successful Immune Tolerance Induction (ITI) Therapy

Li-Fu Chen¹^*, Sheng-Chieh Chou²^*, Yen-Ting Chang¹^*, I-Shing Yu³^*, Yu-Chun Liao⁴^*, Chien-Hung Liu⁵^*, Shih-Fan Wu³^*, Te-Hsien Liu³^*, Kuei-Liang Chen³^*, Cheng-Pu Sun⁶^*, Ying-Hui Su, M. Sc.⁷^*, Chin-Yu Cheng⁵^*, Bin-Bin Lin⁵^*, Cheng-An Hsu⁸^*, Mi-Hua Tao⁹^*, Wen-Chien Chou, MD, PhD¹⁰ and Shu-Wha Lin¹¹^*

¹National Taiwan University, Taipei, TWN
²Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
³National Taiwan University College of Medicine, Taipei, Taiwan
⁴Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine,, National Taiwan University, Taipei City, Taiwan
⁵National Taiwan University Hospital, Taipei, Taiwan
⁶Academia Sinica, Taipei, Taiwan
⁷Clinical Laboratory Technician, Childhood Cancer Foundation of R.O.C., Taipei City, Taiwan
⁸National Taiwan University Hospital, Taipei, TWN
⁹Academia Sinica, Taipei, TWN
¹⁰Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
¹¹Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, Department of Clinical Laboratory Sciences and Medical Biotechnology, Taipei, Taiwan

2573

A Novel Hemophilia a Mouse Model Shows Expression of a Fluorescent Reporter Under the Endogenous F8 promoter in Subsets of Liver and Kidney Endothelial Cells

Paige Patterson, DO, Radoslaw Kaczmarek^* and Roland W. Herzog, PhD

Indiana University School of Medicine, Indianapolis, IN

2574

Interaction between Collagen IV and Heparin-Binding Sites in the Activity, Distribution and Clearance of Factor IX(a)

Douglas S. Annis¹^*, Pamela R. Westmark, PhD²^*, Christina E. Amend, MD³^*, Brianna Torres¹^* and John P. Sheehan, MD¹

¹Department of Medicine/Hematology, Oncology and Palliative Care, University of Wisconsin School of Medicine & Public Health, Madison, WI
²Departments of Neurology and Medicine/Hematology, Oncology and Palliative Care, University of Wisconsin School of Medicine & Public Health, Madison, WI
³Department of Pediatrics/Hematology-Oncology, University of Wisconsin School of Medicine & Public Health, Madison, WI

2575

The Gut Microbiome Regulates FVIII Immune Responses

Weiqing Jing, PhD, MD¹^*, Jocelyn Schroeder¹^*, Yuanhua Cai, MD, PhD¹^*, Jennifer Ziegelbauer¹^*, Mary Holtz¹^*, Nita Salzman, MD, PhD²^* and Qizhen Shi, MD, PhD¹

¹Medical College of Wisconsin, Blood Research Institute, Children's Research Institute, Milwaukee, WI
²Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI

2576

Investigating the Impact of FIX Fc Fusion on Its Extravascular Distribution and Hemostatic Properties

Bonnie Chu¹^*, Michela Ronconi, MSc¹^*, Hasam Madarati, PhD¹^*, Colin Kretz, PhD¹^*, Peter L. Gross, MD², Anthony K C Chan³ and Davide Matino, MD, MSc¹^*

¹Thrombosis and Atherosclerosis Research Institute (TaARI), McMaster University, Hamilton, ON, Canada
²University of Toronto, Toronto, ON, Canada
³McMaster Children’s Hospital, McMaster University, Hamilton, ON, Canada

2577

Rebalancing Hemostasis in Hemophilia: Interplay between Antithrombin and Ancillary Thrombin Inhibitors

Allen Ma¹^*, Dougald M. Monroe, PhD² and Maureane Hoffman, MD, PhD³

¹UNC Blood Research Center, University of North Carolina, Chapel Hill, NC
²UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Pathology and Laboratory Medicine Service, Durham VA Medical Center, Durham, NC

2578

Disulfide Bond Heterogeneity in Factor VIII: Implications for Protein Function and Haemophilia a Therapy

Aster E. Pijning, PhD¹, Diego Butera, Ph.D.²^*, Manuela Flórido, Ph.D.²^*, Carmen Coxon, Ph.D.³^*, Clive Metcalfe, Ph.D.³^* and Philip Hogg, Ph.D.²^*

¹University of Technology Sydney, Sydney, Australia
²Centenary Institute, The University of Sydney, Sydney, Australia
³Division of Biotherapeutics, National Institute for Biological Standards and Control, South Mimms, United Kingdom

2579

Low Normal Levels of Factor V Enhance Thrombin Generation in Hemophilia a in a Tissue Factor Pathway Inhibitor Independent Manner

Megan P Jewell, PhD¹^*, Alexandra Bernal¹^*, Christine Baird, MS²^*, Marilyn Manco-Johnson, MD², Dougald M. Monroe, PhD³ and Keith B. Neeves, PhD⁴

¹University of Colorado Denver | Anschutz Medical Campus, Aurora, CO
²Hemophilia & Thrombosis Center, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO
³UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Hemophilia & Thrombosis Center & Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO

2580

A Novel In Vivo Model to Study the Role of Excess FVIII Function in Venous Thrombosis

John Morris, PhD^1,2^*, Robert Davidson, MS²^* and Lindsey A. George, MD^1,3

¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
²Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA
³Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA

2581

Novel Rationally Developed Substrates for Factor IXa Demonstrate Active Site Differentiation between Factor IXa and Factor IXa-Padua

Lei Ke, MS^1,2^*, Lindsey A. George, MD^1,2 and Nabil K. Thalji, MD, PhD¹^*

¹University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
²Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA

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^*signifies non-member of ASH