66th ASH Annual Meeting: 201. Granulocytes, Monocytes, and Macrophages: Poster II

Symposia: Granulocytes, Monocytes, and Macrophages Oral and Poster Abstracts
Poster

Research, Fundamental Science, Clinical trials, Apoptosis, Adult, Bone Marrow Failure Syndromes, Inherited Marrow Failure Syndromes, Bacterial, Translational Research, Epidemiology, Genetic Disorders, Genomics, Bioinformatics, Clinical Research, Diversity, Equity, and Inclusion (DEI), Hematopoiesis, Health disparities research, Diseases, Immune Disorders, Immune mechanism, Cell expansion, Immunodeficiency, Treatment Considerations, Infectious Diseases, Immunology, Real-world evidence, Neutropenia, Adverse Events, Computational biology, White blood cell disorders, Biological Processes, Microbiome, Technology and Procedures, Gene editing, Molecular biology, Study Population, Profiling, Human, Pathogenesis, Imaging, Machine learning, Omics technologies

Halls G-H (San Diego Convention Center)

2523

Degradation of Ikaros Induces Neutropenia through Altered Transcriptional Programming across Multiple Stages of Neutrophil Development and Maturation

Ajit Dhadve, PhD¹^*, Neelam Kumari¹^*, Swati Mahapatra²^*, Amrutha Y¹^*, Riddhita Deb¹^*, Gobinathan Rengarasu¹^*, Vakkil Mariyappan²^*, Ramya V¹^*, Swetha Muralidhar¹^*, Preethi Kulothungan²^*, Gaurav Jain³^*, Anita K. Gandhi, PhD⁴, Patrick R. Hagner, PhD⁵^* and Sambuddho Mukherjee, Ph.D.³^*

¹Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India
²BMS Biocon Research Center, Bangalore, India
³Bristol Myers Squibb, Bangalore, India
⁴Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
⁵Bristol Myers Squibb, Summit, NJ

2524

Illuminating the Functional Architecture of iPSC-Derived Neutrophil Granulocytes with Split Fluorescent Proteins

Daniel Petersheim¹^*, Monika I Linder, PhD¹^*, Mehmet T Kiziltug¹^*, Johanna Schmid^2,3^*, Almke Bader, PhD^2,3^*, Daniela Maier-Begandt, PhD^2,3^*, Barbara Walzog, PhD^2,3^*, Jörg Renkawitz, PhD^2,3^* and Christoph Klein, MD^4,5

¹Department of Pediatrics, Dr. von Hauner Children’s Hospital, LMU Hospital, LMU Munich, Munich, Germany
²Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, LMU Munich, Planegg-Martinsried, Germany
³Walter Brendel Center of Experimental Medicine, LMU Hospital, LMU Munich, Munich, Germany
⁴Gene Center and Department of Biochemistry, LMU Munich, Munich, Germany
⁵Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Munich, Germany

2525

Constructing a Computational Workflow for the Identification of Novel Cellular and Molecular Drivers of Human Granulopoiesis

Simone G Riva^1,2^*, Christina Simoglou Karali, PhD, MRes, BSc³^*, E. Ravza Gür, PhD, MSc, BSc^2,4^*, Martin Sergeant, PhD^2,4^*, Edward Sanders, PhD^2,4^*, Sally-Ann Clark, PhD, BSc⁵^*, Nicholas Denny, FRCPath, BMBCh⁴^*, Roman Doll, MSc, BSc⁴^*, Anastasia Kosmidou, MD³^*, Assunta Adamo, PhD, MSc, BSc³^*, Shady Adnan Awad, PhD, MBBCh³, Srinivasa Adusumalli, PhD, MSc⁶^*, Jiangpeikun Song, PhD⁶^*, Sean Wen³^*, Nikolaos Sousos, DPhil, MSc, MD³, Eleni Louka, PhD, MD³^*, Nawshad Hayder, MSc, BSc³^*, Kim Sharp, PhD⁷^*, William E. Pierceall, PhD⁸^*, Anjan Thakurta, PhD⁹, Anita K. Gandhi, PhD¹⁰, Patrick R. Hagner, PhD¹⁰^*, James Oliver Davies, MRCP, FRCPath⁴^*, Kilian Huber, PhD⁶^*, Adam J Mead, MBBChir³ and Jim Hughes, PhD, BSc^2,4^*

¹Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, ENG, United Kingdom
²Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
³Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁴Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁵Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁶Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⁷Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁸Formerly Bristol Myers Squibb, Summit, NJ
⁹Oxford Translational Myeloma Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom
¹⁰Translational Medicine, Bristol Myers Squibb, Summit, NJ

2526

Investigating Neutropenia in FNIP1 Deficiency: A CRISPR/Cas9 Model in HL-60 Cells

Francesco Saettini, MD¹^*, Fabiola Guerra^2,3^*, Benedetta Elena Di Majo²^*, Mario Mauri, PhD⁴^*, Federica Malighetti, MS⁴^*, Angela Maria Savino⁵^*, Stefano Rebellato²^*, Arnalda Lanfranchi⁶^*, Cristina Bugarin, MSc⁷^*, Cecilia Poli^8,9^*, Elma Nievas¹⁰^*, Tim Niehues¹¹^*, Peter McNaughton¹²^*, Selami Ulaş¹³^*, Sven Kracker¹⁴^*, Rocco Piazza, MD, PhD^15,16^*, Grazia Fazio, PhD^7,17^* and Andrea Biondi^17,18,19

¹Centro Tettamanti, IRCCS San Gerardo dei Tintori, Monza, Italy
²Dipartimento di Medicina e Chirurgia, Università degli Studi Milano-Bicocca, Monza, Italy
³Pediatria, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁴Department of Medicine and Surgery, University of Milano-Bicocca, Monza, ITA
⁵Università Degli Studi di Milano-Bicocca, Department of Medicine, Milano, Italy
⁶Laboratorio Cellule Staminali, Laboratorio Centrale di Chimica Clinica, Spedali Civili, Brescia, Italy
⁷Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
⁸Facultad de Medicina, Universidad del Desarrollo-Clínica Alemana, Santiago, Chile
⁹Unidad de Inmunología y Reumatología, Hospital Roberto del Río, Santiago, Chile
¹⁰Alexander Fleming Hospital, Mendoza, Argentina
¹¹Department of Pediatrics, Helios Klinik Krefeld, Krefeld, Germany
¹²Queensland Children's Hospital, Queensland, Australia
¹³Department of Pediatric Allergy and Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey
¹⁴Rene Descartes University of Paris and Necker Children's Hospital, Paris, FRA
¹⁵Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
¹⁶Hematology Division and Bone Marrow Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁷School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
¹⁸Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy
¹⁹Centro Tettamanti, Fondazione IRCCS San Gerardo dei Tintori,, Monza, Italy

2527

KLF5 Is a Key Regulator of IMiD-Induced Neutropenia

Christina Simoglou Karali, PhD, MRes, BSc¹^*, Simone G Riva^2,3^*, Sally-Ann Clark, PhD, BSc⁴^*, E. Ravza Gür, PhD, MSc, BSc^3,5^*, Nicholas Denny, FRCPath, BMBCh⁶^*, Roman Doll, MSc, BSc⁶^*, Anastasia Kosmidou, MD¹^*, Assunta Adamo, PhD, MSc, BSc¹^*, Shady Adnan Awad, PhD, MBBCh¹, Srinivasa Adusumalli, PhD, MSc⁷^*, Jiangpeikun Song, PhD⁷^*, Sean Wen¹^*, Nikolaos Sousos, DPhil, MSc, MD¹, Eleni Louka, PhD, MD¹^*, Nawshad Hayder, MSc, BSc¹^*, Kim Sharp, PhD⁶^*, William E. Pierceall, PhD⁸^*, Anjan Thakurta, PhD⁹, Anita K. Gandhi, PhD¹⁰, Patrick R. Hagner, PhD¹⁰^*, James Oliver Davies, MRCP, FRCPath⁶^*, Kilian Huber, PhD⁷^*, Jim Hughes, PhD, BSc^3,5^* and Adam J Mead, MBBChir¹

¹Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
²Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, ENG, United Kingdom
³Centre for Computational Biology, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁴Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
⁵Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁶Medical Research Council (MRC) Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
⁷Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⁸Formerly Bristol Myers Squibb, Summit, NJ
⁹Oxford Translational Myeloma Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom
¹⁰Translational Medicine, Bristol Myers Squibb, Summit, NJ

2528

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Veronica Bochenek, BA¹^*, Abigail E Skidmore, BS¹^*, Anh T.P. Ngo, PhD², Samir Maarouf¹^*, Weiming Hu³^*, Santosh K Yadav, PhD¹^*, Ethan Mack, MD, PhD⁴^*, M. Anna Kowalska, PhD¹^*, Mortimer Poncz, MD^1,5 and Kandace Gollomp, MD^1,5

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, San Diego, CA
³Division of gastroenterology, hepatology, and nutrition, The Children’s Hospital of Philadelphia, Philadelphia, PA
⁴Division of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
⁵Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

2529

Malignant Transformation in Relationship to Clonal Hematopoiesis in CIN

Grigorios Tsaknakis¹^*, Erasmia Boutakoglou¹^*, Stavros Papadakis, MD¹^*, Irene Mavroudi¹^*, Anna Maria Perantonaki¹^*, Peggy Kanellou²^* and Helen A Papadaki, MD¹

¹Hemopoiesis Research Laboratory, School of Medicine, University of Crete & Department of Hematology, University Hospital of Heraklion, Heraklion, Greece
²Department of Hematology, Venizeleio-Pananeio General Hospital of Heraklion, Heraklion, Crete, Greece

2530

Genotype-Phenotype Correlations in Patients with Severe Chronic Neutropenia Harboring ELANE Mutations: A Long-Term Study of the Severe Chronic Neutropenia International Registry

Ivan Tesakov, MD¹^*, Vahagn Makaryan, MD², Audrey Anna Bolyard²^*, Maksim Klimiankou, PhD¹^*, Yasmine El Chazli, MD, PhD³^*, Khoshoua Mohamed⁴^*, Sabine Mellor-Heineke, MD¹^*, Stefanida Shliaga, MD⁵^*, Akiko Shimamura, MD, PhD⁶, Peter E. Newburger, MD⁷, Julia Skokowa, MD, PhD¹, Karl Welte, MD, PhD^1,8, David C. Dale, MD² and Cornelia Zeidler, MD^5,8^*

¹Department of Oncology, Hematology, Immunology, Rheumatology and Clinical Immunology, University Hospital Tübingen, Tübingen, Germany
²Department of Medicine, University of Washington, Seattle, WA
³Hematology and Oncology Unit, Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
⁴Department of Human Genetics, Medical Research Institute, Alexandria University, Alexandria, Egypt
⁵Severe Chronic Neutropenia International Registry, Hannover Medical School, Hannover, Germany
⁶Boston Children's Hospital, Boston, MA
⁷Department of Pediatrics, UMass Chan Medical School, Worcester, MA
⁸University Children’s Hospital Tübingen, Tübingen, Germany

2531

Multinational Assessment of Absolute Neutrophil Counts and White Blood Cell Counts Among Healthy Individuals with the Duffy Null Phenotype or Genotype

Stephen P Hibbs¹^*, Israel Chipare²^*, Amr J Halawani³^*, Sophie E Legge⁴^*, Geoffrey Fell⁵^*, Abdulrahman A. Alhamzi⁶^*, Edwig Shingenge⁷^*, Mohammed J Alabdly⁶^*, Hilary T Charuma²^*, Mohammed A Nushaily⁶^*, Judith M Sinvula²^*, Menelik Russo⁷^*, Sara Paparini¹^*, Nancy Berliner, MD⁸, Vanessa Apea¹^*, Maureen Okam Achebe, MD, MPH⁹ and Lauren E. Merz, MD, MSc^10,11,12

¹Wolfson Institute for Population Health, Queen Mary University of London, London, United Kingdom
²Blood Transfusion Service of Namibia, Windhoek, Namibia
³Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
⁴Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
⁵Data Science, Dana-Farber Cancer Institute, Boston
⁶Department of Blood Bank, King Fahad Central Hospital, Jazan, Saudi Arabia
⁷Namibia University of Science and Technology, Windhoek, Namibia
⁸Brigham and Women's Hospital, Boston, MA
⁹Brigham and Women's Hospital, Harvard Medical School, Boston, MA
¹⁰Division of Hematology/Oncology, Mass General Brigham, Boston, MA
¹¹Department of Medicine, Harvard Medical School, Boston, MA
¹²Department of Medical Oncology, Dana-Farber Cancer Institute, Brookline, MA

2532

Clinical and Laboratory Characteristics of Pediatric Patients with ACKR1/Darc-Associated Neutropenia

Lital Oz-Alcalay, MD^1,2^*, Orna Steinberg-Shemer, MD^3,4^*, Sarah Elitzur, MD^3,4^*, Dafna Brik Simon, MD^5,6^*, Hannah Tamary, MD⁷, Shai Izraeli, MD^5,8, Joanne Yacobovich, MD, MPH^5,9 and Oded Gilad, MD^5,9

¹Department A, Schneider Children's Medical Center of Israel, Petach Tikva, Israel, Petach Tikva, Israel
²School of Medicine, Tel Aviv University,, Tel Aviv, Israel
³The Rina Zaizov Hematology/Oncology Division, Schneider Children's Medical Center of Israel, Petach Tikva, Israel, Petach Tikva, Israel
⁴School of Medicine, Tel Aviv University,, Tel Aviv,, Israel
⁵Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⁶Department of Hematology-Oncology, Schneider Children's Medical Center of Israel, Tel Aviv, Israel
⁷Sheba Medical Center, Tel Aviv University, Ramat Gan, Israel
⁸Department of Pediatric Hematology and Oncology, Schneider Children's Medical Center and Tel Aviv University, Petah Tikva, Israel
⁹Department of Hematology-Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel

2533

Unsupervised Analysis Applied to a Cohort of Likely Acquired Neutropenia: Is It a Unique Entity ?

Francesca Fioredda, MD¹^*, Saba Kainat^2,3^*, Giacomo Cavalca^3,4^*, Mariacarla Giarratana⁵^*, Gianluca Dell'Orso⁵^*, Luca Arcuri⁶^*, Paolo Uva⁷^*, Davide Cangelosi²^* and Carlo Dufour, MD^1,8

¹Hematology Unit-IRCCS Istituto Giannina Gaslini, Genoa, Italy
²Clinical Bioinformatics Unit, IRCCS-Istituto Giannina Gaslini, Genova, Italy
³University of Bologna, Bologna, Italy
⁴Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy, Genoa, Italy
⁵Unit of Hematology, IRCCS-Istituto Giannina Gaslini, Genova, Italy
⁶Hematology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy, Genoa, Italy
⁷Clinical Bioinformatics, IRCCS Istituto Giannina Gaslini, Genova, Italy
⁸Hematology Unit, IRCCS G. Gaslini Children's Hospital, Genova, Italy

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^*signifies non-member of ASH