66th ASH Annual Meeting: 203. Lymphocytes and Acquired or Congenital Immunodeficiency Disorders: Poster II

Symposia: Lymphocytes and Acquired or Congenital Immunodeficiency Disorders Oral and Poster Abstracts
Poster

Research, Autoimmune disorders, Viral, Fundamental Science, Adult, Bispecific Antibody Therapy, Translational Research, Epidemiology, Autoimmune hemolytic anemia, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Clinical Research, Health outcomes research, Pediatric, Education, Supportive Care, Diseases, Immune Disorders, Immune mechanism, Immunodeficiency, Treatment Considerations, Infectious Diseases, Biological therapies, Immunology, Real-world evidence, Lymphoid Malignancies, Metabolism, White blood cell disorders, Registries, Biological Processes, Myeloid Malignancies, Study Population, Human

Halls G-H (San Diego Convention Center)

2534

RNA Methyltransferase Mettl16 Is Indispensable for the Survival of Naïve CD4⁺ T Cells In Vivo

Daigo Michimata¹^*, Hiroki Kato¹^*, Naoya Morota¹^*, Yuya Tanaka, MD¹^*, Kazuki Sakurai¹^*, Kazuki Hashimoto¹^*, Koichi Onodera, MD¹^*, Shunsuke Hatta¹^*, Yasushi Onishi¹^*, Noriko Fukuhara, MD, PhD² and Hideo Harigae, MD, PhD¹

¹Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
²Department of Hematology, Tohoku University School of Medicine, Sendai, Japan

2535

Memory NKG2C⁺nk Cells Undergo Robust Expansion and Exhibit Strong Effector Functions upon Re-Exposure to the HCMV gpUL40 Antigen Peptide

Mohamed Khalil, BS¹, Scott Terhune, PhD²^* and Subramaniam Malarkannan, PhD^2,3,4

¹Medical College of Wisconsin, Brookfield, WI
²Microbiology & Immunology, Medical College of Wisconsin, Milwaukee, WI
³Department of Medicine, Versiti, Wisconsin, Milwaukee, WI
⁴Department of Medicine, Medical College of Wisconsin, Milwaukee, WI

2536

Deep Cellular and Molecular Characterization Reveal a Distinct Phenotype and Metabolic Signature of Human Senescent CD8⁺ T Cells: Implication for Cancer Cellular Therapy

Kevin Jan Jan Legscha¹^*, Lea Philine Märker¹^*, Najla Abassi, M.Sc.²^*, Abdul Yilmaz, M.Sc.¹^*, Catherine Woelfel, PhD¹^*, Edite Antunes Ferreira¹^*, Annekathrin Nedwed, M.Sc.²^*, Sara Salome Helbich, M.Sc.³^*, Michael Delacher, Prof.³^*, Federico Marini, PhD^3,4^*, Stefan Porubsky, Prof.⁵^*, Matthias Theobald, MD, Prof.^1,3,6 and Hakim Echchannaoui, PhD^1,6^*

¹Department of Hematology and Oncology, University Medical Center (UMC), Mainz, Germany
²Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center (UMC), Mainz, Germany
³Institute of Immunology, Research Center for Immunotherapy (FZI), University Medical Center (UMC), Mainz, Germany
⁴Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center (UMC) Mainz, Mainz, Germany
⁵Institute of Pathology, University Medical Center (UMC), Mainz, Germany
⁶Partner site Frankfurt/Mainz, German Cancer Consortium (DKTK), Mainz, Germany

2537

Immunoglobulin Replacement Therapy (IgRT) for the Treatment of Haematological Malignancy Associated Secondary Immunodeficiency (HM-SID) – a Large UK Tertiary Centre Experience

Zin Aung J Soe¹^*, Ahmed Eldarwi, MBBS¹^*, Ethan Troy-Barnes, MBBchBAO MRCP FRCPath²^*, Rahi Patel³^*, Dario Melotti, MBBS⁴^*, Anish Tailor, PharmD³ and Samah Alimam, MD, PhD⁵^*

¹Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom
²University College London Hospital, London, United Kingdom
³Haematology, University College London Hospitals NHS Foundation Trust, LONDON, United Kingdom
⁴University College London Hospitals NHS Foundation Trust, LONDON, United Kingdom
⁵Department of Haematology, University College Hospital, University College of London Hospitals NHS Foundation Trust, London, United Kingdom

2538

Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype

Pratik Vikhe, PhD¹^*, Silas Ferrao²^* and Lyn Jones, PhD²^*

¹Center for Protein Degradation, Dana Farber Cancer Insitute, Boston, MA
²Center for Protein Degradation, Dana Farber Cancer Institute, Boston, MA

2539

Synergistic Risks: The Impact of HIV on Kaposi Sarcoma and Lymphoma Incidence in Castleman’s Disease

Joseph Elengickal, MD¹^*, Aditya Sood, MD²^*, Michael Pavy, DO¹^*, Lilly Hou, MD³^*, Wint Yan Aung, MD³, Vivek Varughese, MD¹^*, Anish Sangari, MD⁴^*, Cody Cooper, DO¹^* and Suzanne Fanning, DO⁵

¹Prisma Health - University of South Carolina, Columbia, SC
²Zucker School of Medicine at Hofstra/Northwell Residency at NS/LIJ, Manhasset, NY
³Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, NY
⁴Emory University School of Medicine, Atlanta, GA
⁵Greenville Health System Cancer Institute, Greenville, SC

2540

Circulating T Follicular Helper Cells in Pediatric Immune Cytopenias

Emily M Harris, MD^1,2, Sarah Chamseddine, MD^2,3^*, Matthew Nikiciuk, BS³^*, Aleksandra Bourdine, HBSc³^*, Logan Magin, BS³^*, Brenna Labere, MD⁴^*, Rachael F. Grace, MD, MMSc^1,2 and Janet Chou, MD^2,3^*

¹Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA
²Harvard Medical School, Boston, MA
³Division of Immunology, Boston Children's Hospital, Boston, MA
⁴Divison of Immunology, Phoenix Children's Hospital, Phoenix, AZ

2541

The Quiet Defenders: Immunoglobulin Levels As Predictors of Mortality in Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD)

Dawlat Khan, MBBS¹^*, Muhammad Ammar Bin Hamid, MBBS¹^*, Dawood Shehzad, MBBS¹^*, Hammad Chaudhry, MBBS¹^*, Rafia Waheed, MBBS¹^*, Mamoon Ahmed, MBBS¹^* and Hafez Ammar Abdullah, MBBS²

¹Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, SD
²Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE

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^*signifies non-member of ASH