Emmanuela Eusebio Ambrose, MD^1,2, George A. Tomlinson, PhD^3*, Patrick S. Ngoya, MD^2*, Susan E. Stuber, MA^4,5*, Teresa S. Latham, MA^4*, Abel Nkono Makubi, PhD, MD, MSc^6*, Russell E. Ware^4,5,7 and Luke R. Smart, MD^4,5,7,8

¹Bungando Medical Centre, Mwanza, Tanzania, United Republic of
²Catholic University of Health and Allied Sciences, Mwanza, Tanzania, United Republic of
³University Health Network, Toronto, ON, CAN
⁴Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Department of Hematology, Benjamin Mkapa Hospital, Dodoma, Tanzania, United Republic of
⁷Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
⁸Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

Julia Z Xu, MD, MS^1,2, Enrico M Novelli, MD, MS^1,2, Jean-Antoine Ribeil, MD, PhD^3*, Andreas Glenthøj, MD, PhD^4*, Srila Gopal, MD⁵, Hanny Al-Samkari, MD⁶, Modupe Idowu, MD⁷, Jenny Despotovic, DO^8*, Spurthi Patil^8*, Xiaoshu Dai, PhD^8*, Abdullah Al Masud^8*, Michael Callaghan^8* and Fuad El Rassi^9,10*

¹Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
²Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, and Division of Classical Hematology, University of Pittsburgh, Pittsburgh, PA
³Boston Medical Center, Center of Excellence in Sickle Cell Disease, Section of Hematology and Medical Oncology, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, MA
⁴Danish Red Blood Cell Center, Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
⁵Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, CA
⁶Division of Hematology, Massachusetts General Hospital, Cambridge, MA
⁷Department of Internal Medicine, Division of Hematology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX
⁸Agios Pharmaceuticals, Inc., Cambridge, MA
⁹Emory University School of Medicine, Atlanta, GA
¹⁰Georgia Comprehensive Sickle Cell Center and Grady Health System, Atlanta, GA

Aushna Rasool, MBBS^1*, Sinju Thomas^2*, Asad Luqmani^1*, Mamta Sohal^1*, Steven Okoli^1*, Simona Deplano^1*, Christine Ademokun^1*, Catriona Mactier, MD^1*, Nichola Cooper, MD^1,3* and D. Mark Layton, MBBS^1,4*

¹Imperial College Healthcare NHS Trust, London, United Kingdom
²Hammersmith Hospital, London, United Kingdom
³Imperial College London, Centre for Haematology, Department of Immunology and Inflammation, London, United Kingdom
⁴Imperial College London, London, United Kingdom

Aditya Sanjeevi, MD, MBBS¹, Aniket Vijay Rao, MD^2*, Samikchhya Keshary Bhandari^3*, Daniel Idoate Jose Domench^4* and Himal Kharel, MD^1*

¹Department of Internal Medicine, Rochester General Hospital, Rochester, NY
²Rochester General Hospital, Rochester, NY
³Tribhuvan University teaching hospital, Kathmandu, Nepal
⁴Rochester General Hospital, Rochester

Duah Dwomoh, PhD^1*, Daniel Nana Yaw Abankwah, MPH^2*, Amma Benneh-Akwasi Kuma, MBChB, FWACP, GCPS^3*, Jonathan Spector, MD, MPH^4*, Jonathan Quartey, PhD^5*, Olufolake A. Egbujo, MD, MSc^6,7*, Kwaku Marfo^8*, Solomon Fiifi Ofori-Acquah, PhD⁹ and Justice Nonvignon, PhD^10*

¹Department of Biostatistics, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana
²Research, Innovation and Development, College of Health Sciences, University of Ghana, Accra, Ghana
³Department of Hematology, University of Ghana Medical School, Ghana, Accra, Ghana
⁴Department of Global Health, Novartis Biomedical Research,, Cambridge, MA
⁵Department of Physiotherapy, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana
⁶Novartis, Baltimore, MD
⁷In-market Brands and Global Health Development Unit, Novartis Pharmaceutical Corporation, East Hanover, NJ
⁸Novartis Pharmaceuticals Corporation, New Jersey
⁹Department of Medicine, University of Pittsburgh, Pittsburgh, PA
¹⁰University of Ghana, 9 University of Ghana School of Public Health, Health Policy Planning and Management, Accra, Ghana

Gonzalo De Luna, MD^1*, Laura Bencheikh, PhD^2*, Philippe Connes, MD, PhD^3*, Thomas D'Humieres, MD^4,5*, Philippe Le Corvoiser, MD^6*, Sihem Alouni, MD^1*, Jamila Alhamrouni, MD^1*, Raphaelle Arrouasse, MD^6*, Dalila Bitari^6*, Anoosha Habibi, MD¹, Fatima Bensiradj, MD^1*, Etienne Audureau, MD, PhD^7*, Vincent Malcor Deydier De Pierrefeu, PhD^7*, PA Natella, MD^7*, Meghan Perkins, PhD^2*, Laura Matabishi-Bibi, PhD^2*, Caroline Barau, PhD^8*, Marie Cambot, PhD^2* and Pablo Bartolucci, MD, PhD^1,9*

¹Sickle Cell Referral Center, UMGGR, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
²INNOVHEM, Créteil, France
³Laboratory CRIS EA647, Team "Vascular Biology and Red Blood Cell", University of Lyon, Lyon, France; Institut Universitaire de France, Paris, France, Villeurbanne, FRA
⁴CHU Henri Mondor. UPEC. AP-HP, CréTeil, France
⁵Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
⁶INSERM, Centre d’Investigation Clinique 1430, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁷Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁸Plateforme de Ressources Biologiques, Henri Mondor Hospital, AP-HP, Creteil, France
⁹Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Richard J Benjamin, MD PhD¹, John Pitman, PhD^2*, Christopher Karim, PhD^2*, Anna Erickson, PhD^2*, Laurence Corash, MD², Nina Mufti, PhD^2*, Patricia Elizabeth Zerra, MD³, Ross M. Fasano, MD^4* and Marianne Yee, MD, MSc⁵

¹CERUS corp, Concord, CA
²Cerus Corporation, Concord, CA
³CHOA, Atlanta, GA
⁴Emory University, Atlanta, GA
⁵Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA

Austin Wesevich, MD, MPH, MS¹, Megan Woelkers, BA^2*, Ayodeji Adegunsoye, MD, PhD^3*, Adam J. Wesevich, BS^4*, Mark J. Ratain, MD¹ and Gabrielle Lapping-Carr, MD⁵

¹Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
²University of Chicago, Chicago, IL
³Section of Pulmonary/Critical Care, Department of Medicine, University of Chicago, Chicago, IL
⁴University of Texas at Austin, Austin, TX
⁵Section of Pediatric Hematology/Oncology, Department of Pediatrics, University of Chicago, Chicago, IL

Rochelle Fayngor, MD^1*, Franklin Njoku, MD^2*, Insia Rizvi, MBBS³, Marwah Farooqui, DO⁴ and Santosh L. Saraf, MD⁵

¹University of Illinois Chicago, Chicago
²University of Illinois at Chicago, Chicago, IL
³Division of Hematology and Oncology, University of Illinois Chicago, Chicago, IL
⁴Hematology Oncology, University of Illinois, Burr Ridge, IL
⁵Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL

Aleksandra S Dain, MD¹, Yimei Li, PhD^2,3*, Sahal Master, MPH^4*, Leslie Raffini, MD^1,5, Kelly D. Getz, PhD^6,7 and Janet L. Kwiatkowski, MD^1,5

¹Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
³Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
⁴Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁶Division of Oncology, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA
⁷Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Abril Carrillo, md¹, Natalia Michel Carrillo-López^2*, Arantza Lizbeth García-Loera^3*, Yenny Viviana Pinzón-Ramírez^4* and Luis Chinea, MD^1*

¹UT Southwestern Medical Center, Dallas, TX
²Universidad Nacional Autónoma de México, Mexico City, Mexico
³Instituto Politécnico Nacional, Mexico City, Mexico
⁴Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia

Thomas Stehle, MD^1*, Vincent Audard, MD, PhD^1*, Philippe Le Corvoiser, MD^2*, Sihem Alouni, MD^3*, Jamila Alhamrouni, MD^3*, Raphaelle Arrouasse, MD^2*, Thomas D'Humieres, MD^4,5*, Anoosha Habibi, MD³, Fatima Bensiradj, MD^3*, Dalila Bitari^2*, Etienne Audureau, MD, PhD^6*, Vincent Malcor Deydier De Pierrefeu, PhD^6*, Caroline Barau, PhD^7*, PA Natella, MD^6*, Laura Bencheikh, PhD^8*, Pablo Bartolucci, MD, PhD^3,9* and Gonzalo De Luna, MD^3*

¹Nephrology and Renal Transplantation Department, Henri Mondor University-Hospital, Université Paris-Est Créteil, INSERM, Créteil, France
²INSERM, Centre d’Investigation Clinique 1430, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
³Sickle Cell Referral Center, UMGGR, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁴Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
⁵Physiology Department, FHU SENEC, INSERM IMRB U955, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁶Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁷Plateforme de Ressources Biologiques, Henri Mondor Hospital, AP-HP, Creteil, France
⁸INNOVHEM, Créteil, France
⁹Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Sanjay R. Thakoerdin^1*, Chanel C. de Ruiter^1*, Aafke Gaartman, MD^2*, Nick Van Es, MD^3*, Bart J. Biemond, MD, PhD⁴ and Erfan Nur, MD, PhD⁵

¹Amsterdam UMC, Amsterdam, Netherlands
²Amsterdam UMC, Amsterdam, NLD
³Pulmonary Hypertension & Thrombosis, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands
⁴Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁵Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands

Thomas D'Humieres, MD^1,2*, Gonzalo De Luna, MD^3*, Laura Bencheikh, PhD^4*, Philippe Le Corvoiser, MD^5*, Sihem Alouni, MD^3*, Lara Alassaad, MD^1*, Chloe Gerrer, MD^1*, Jamila Alhamrouni, MD^3*, Raphaelle Arrouasse, MD^5*, Anoosha Habibi, MD³, Fatima Bensiradj, MD^3*, Etienne Audureau, MD, PhD^6*, Meghan Perkins, PhD^4*, Laura Matabishi-Bibi, PhD^4*, PA Natella, MD^6*, Laurent Messonier, MD, PhD^7*, Vincent Malcor Deydier De Pierrefeu, PhD^6* and Pablo Bartolucci, MD, PhD^3,8*

¹Physiology Department, FHU SENEC, INSERM IMRB U955, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
²Paris Cardiovascular Research Center - PARCC, Inserm team 8, Paris, France
³Sickle Cell Referral Center, UMGGR, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁴INNOVHEM, Créteil, France
⁵INSERM, Centre d’Investigation Clinique 1430, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
⁶Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁷Inter-university Laboratory of Human Movement Sciences EA 7424, Université Savoie Mont Blanc, Chambéry, France
⁸Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Vanessa Shao^1*, Claire Jones, MD, FRCPC^2*, A. Kinga Malinowski, MD, MSc, FRCSC³, Kevin H.M. Kuo, MD, MSc, FRCPC⁴, Richard Ward, MBBS, MRCP, FRCPath^5*, John Chinawaeze Aneke, MBBS^6*, Andrew Binding, MD, MSc, FRCPC^7* and Nadine Shehata, MD, FRCPC, MSc⁸

¹Western University, London, Canada
²Department of Obstetrics and Gynecology, University of Toronto/Mount Sinai Hospital/, Toronto, Canada
³Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, Toronto, ON, CAN
⁴Division of Medical Oncology and Hematology, Department of Medicine, University Health Network, Toronto, Canada
⁵Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁶Nnamdi Azikiwe University Teaching Hospital, Nnewi, NGA
⁷University Health Network, Toronto, Canada
⁸Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada

Amber Brown, DO, MS, Derrick L. Goubeaux, DO^* and Jennifer Belsky, DO, MS

Riley Hospital for Children, Indianapolis, IN

Anoosha Habibi, MD^1,2,3, ALA Covali, MD^4*, Emilie Bequignon, MD/PhD^5,6*, Vincent Malcor Deydier De Pierrefeu, PhD^7,8*, Laurent Boyer, MD, PhD^9,10*, Vincent Latournerie, MD^11*, Bernard Maitre, MD/PhD^12*, Gonzalo De Luna, MD^7*, Thomas D'Humieres, MD^13*, Pablo Bartolucci, MD, PhD^14* and Serge Adnot, MD/PhD^15*

¹Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital, APHP, Creteil Cedex, France
²UPEC, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de le Recherche Médicale (INSERM) U955, DHU A-TVB, Créteil, France;, Creteil Cedex, FRA
³1 avenue Claude Vellefaux, ERN-EuroBloodNet, PARIS, France
⁴Physiological and functional exploration unit, University Henri Mondor Hospital, Creteil, France
⁵Services d’ORL et de Pneumologie, Henri Mondor University Hospital, Creteil, France
⁶IMRB – Inserm U955, Biomécanique et appareil respiratoire (Equipe B. Louis), UPEC, Creteil, France
⁷Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁸ERN-EuroBloodNet, Paris, France
⁹Physiology Departement, Henri Mondor University Hospitals, APHP,, Créteil, France
¹⁰Institut Mondor de Recherche Biomédicale, équipe 08,, Université Paris Est Créteil (UPEC), Creteil, France
¹¹Henri Mondor University Hospitals, APHP,, Creteil, France
¹²Pneumology departement, Centre Hospitalier Intercommunal de Creteil, Creteil, FRA
¹³Physiology Department, FHU SENEC; INSERM IMRB U955, CHU Henri Mondor. UPEC. AP-HP, CréTeil, France
¹⁴University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
¹⁵IMRB – Inserm U955, Université Paris Est Créteil (UPEC), Creteil, France

Caterina P. Minniti, MD¹, Gregory J. Kato², Melanie E. Garrett, MS^3*, Allison E. Ashley-Koch, PhD^3* and Marilyn J. Telen, MD⁴

¹Department of Hematology, Einstein College of Medicine, Chevy Chase, MD
²Blood Science Consulting, Tilghman, MD
³Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC
⁴Duke University Medical Center, Durham, NC

Eileen Ryan, MBBCHBAO^1*, Xunde Wang, PhD^1*, Haiou Li^2*, Anna Conrey, NP^1* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath³

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Arlington, VA
³Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Charleen Jacobs, MSN, ANP^1*, Brittany McCrary, MS, AGPCNP-BC, RN^2*, Mikayla Gordon Wexler^3*, Angela Liu, MD³, Elizabeth Stidham, MPH^4*, Sarah McCuskee, MD, MPhil^4*, Jeffrey A. Glassberg, MD⁵, Susanna Curtis, MD, PhD³ and Bin Zhang, PhD^6*

¹Mount Sinai Center for Sickle Cell Disease, Mount Sinai Hospital, New York, NY
²Mount Sinai Hospital, New York, NY
³Icahn School of Medicine at Mount Sinai, New York, NY
⁴Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York

Edo Schaefer, MD¹, Morgan Anderson-Crannage, BSc^2*, Yiouli Panayiota Ktena, MD³, Jessica Hochberg, MD^2*, Temima Kanarfogel^2*, John Herrick^2*, Emily Thatcher, PA^2*, Qiuhu Shi, PhD^2*, Bruno Hochberg^2*, Yaya Chu, PhD^1*, Sankaran Krishnan, MD, MPH, FAAP^2*, Erin Morris, RN, BSN^1*, Sandra Fabricatore, RN, MSN, CPNP^2*, John DuFresne, CRA^2*, Kenneth R. Cooke, MD³ and Mitchell S. Cairo, MD^1,4,5,6,7

¹Department of Pediatrics, New York Medical College, Valhalla, NY
²New York Medical College, Valhalla, NY
³The Sidney Kimmel Comp. Cancer Center At Johns Hopkins, Baltimore, MD
⁴Department of Medicine, New York Medical College, Valhalla, NY
⁵Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY
⁶Department of Epidemiology and Community Health, New York Medical College, Valhalla, NY
⁷Department of Pathology/Microbiology and Immunology, New York Medical College, Valhalla, NY

Andrew Q Pucka, BS^1*, Lina Houran^1*, Andrew RW O'Brien, MD², Steven E Harte, PhD^3*, Richard E Harris, PhD^4,5*, Zahra Pakbaz, MD⁶ and Ying Wang, MD, PhD^1,2

¹Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN
²Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN
³Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI
⁴School of Medicine, Susan Samueli Integrative Health Institute, University of California, Irvine, Irvine, CA
⁵Department of Anesthesiology and Perioperative Care, University of California at Irvine, Irvine, CA
⁶Division of Hematology Oncology, University of California Irvine School of Medicine, Orange, CA

Akinyemi O.D. Ofakunrin, MD^1,2*, Rasaq Olaosebikan, MD³, Edache S Okpe, MD^4*, Ijeoma Diaku-Akinwumi^5*, Samah Babiker, MBBS, FRCPath, MRCP^2*, Maryam Shehu, MD^6* and Stephen Oguche, MD^7*

¹Department of Pediatrics, University of Jos / Jos University Teaching Hospital, Jos, CA, Nigeria
²Evelina London Guy’s and St Thomas NHS Foundation Trust, London, United Kingdom
³Department of Pediatrics, Division of Hematology and Oncology, Pennsylvania State Health Children’s Hospital, 500 University Drive, Hershey, PA 17033, USA, Reading, PA
⁴Department of Pediatrics, Federal University of Health Sciences Teaching Hospital, Otukpo, NGA
⁵Pediatric Sickle Cell Center, Lagos State University Teaching Hospital / Lagos State University College of Medicine, Lagos, NGA
⁶Department of Paediatrics, College of Medicine and Health Sciences, Bingham University/Teaching Hospital, Jos, Nigeria
⁷Department of Paediatrics, University of Jos / Jos University Teaching Hospital, Jos, NGA

Giorgi Maziashvili, MD^1*, Dunia Hatabah, MD¹, Rawan Korman, MD¹, Lou Ann Brown, PhD^2*, Frank Harris^2*, Chris A. Rees, MD^3*, Carlton Dampier, MD³ and Claudia R. Morris, MD³

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Emory University School of Medicine, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA

Wei Li, PhD^1*, Andrew Pucka, BS^2*, Candice Debats^2*, Brandon Reyes^2*, Andrew Ross Wickman O'Brien, MD³, Steven E Harte, PhD^4*, Richard E Harris, PhD^5*, Qigui Yu, MD, PhD^1* and Ying Wang, MD, PhD^2,3

¹Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
²Department of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN
³Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
⁴Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI
⁵Susan Samueli Integrative Health Institute, and Department of Anesthesiology and Perioperative Care, University of California at Irvine School of Medicine, Irvine, CA

Gonzalo De Luna, MD^1*, Suella Martino, MD, PhD^1*, Philippe Le Corvoiser, MD^2*, Christophe Ferreira De Matos, MD^1*, Sihem Alouni, MD^1*, Dalila Bitari^2*, Etienne Audureau, MD, PhD^3*, Fatima Bensiradj, MD^1*, Thomas Rupp, MD^4*, Anoosha Habibi, MD¹, Jamila Alhamrouni, MD^1*, PA Natella, MD^3*, David Calvet, MD, PhD^5* and Pablo Bartolucci, MD, PhD^1,6*

¹Sickle Cell Referral Center, UMGGR, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
²INSERM, Centre d’Investigation Clinique 1430, Henri-Mondor University Hospital- UPEC, AP-HP, Créteil, France
³Unité de Recherche Clinique, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
⁴Inter-University Laboratory of Human Movement Sciences EA7424, LIBM University Savoie Mont-Blanc, Chambéry, France
⁵Centre Hospitalier Sainte-Anne, Paris, France
⁶Université Paris-Est Créteil, INSERM U955, IMRB, Laboratory of excellence LABEX GRex, Créteil, France

Kawana Simon, MD^1,2, Alice J. Cohen, MD³ and Frances Ugonne Ogunnaya, MD^4*

¹Hematology/Oncology, Rutgers- Newark Beth Israel Medical Center, Newark, NJ
²Hematology/Oncology, Rutgers- Robert Wood Johnson Medical School, New Brunswick, NJ
³Hematology/Oncology, Newark Beth Israel Med. Ctr, Newark, NJ
⁴Newark Beth Israel Medical Center, Newark, NJ

Jérémy Morel^1*, Charline Oddon, MSc^2*, Lea Kuznicki, MSc^2*, Laetitia Claer, MSc^2*, Berengere Koehl, MD, PhD^2,3*, Jean-Hugues Dalle, MD, PHD⁴, Laurent Holvoet, MD^3*, Florence Missud, MD^3*, Malika Benkerrou, MD^3*, Ghislaine Ithier, MD^3*, Arnaud Bonnard, MD, PhD^5*, Liza Ali, MD^5*, Slim Azouzi, PhD^2,6*, Sandrine Laurance, PhD^2* and Valentine Brousse, MD, PhD^2,3*

¹Université Paris Cité and Université des Antilles, INSERM, BIGR, F-75015 Paris, F97150 Pointe à Pitre, France, Paris, AE, France
²Université Paris Cité and Université des Antilles, INSERM, BIGR, F-75015 Paris, F97150 Pointe à Pitre, France, Paris, France
³Centre de Référence MCGRE, Service d'Hémato-Immunologie, Hôpital Universitaire Robert Debré, APHP, Paris, France, Paris, France
⁴Department of Pediatric Hematology and Immunology, Robert-Debré Academic Hospital ,, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France
⁵Chirurgie Viscérale, Hôpital Universitaire Robert Debré, APHP, Université Paris Cité, Paris, France, Paris, France
⁶CNRGS, EFS, Paris, France

Miguel Brito, PhD^1*, Catarina Ginete, MSc^2*, Tatiana Gomes, MSc^3*, Helena Pitangueira, MSc^3*, Manuela Mendes, MD^4*, Ana Furtado, MD^4*, Ligia Alves, MD^5*, Fernanda Simão, MD^5*, Mauer Gonçalves, MD, PhD^6* and Joana Morais, PhD^7*

¹H&TRC, Escola Superior de Tecnologia da Saude de Lisboa, Lisbon, AL, Portugal
²H&TRC, Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal
³Clincord, EUA, Los Angeles
⁴Hospital Materno Infantil Dr Manuel Pedro Azancot de Menezes, Luanda, Angola
⁵Maternidade Lucrécia Paim, Luanda, Angola
⁶Faculdade de Medicina da Universidade Agostinho Neto, Luanda, Angola
⁷Centro de Investigação em Saúde de Angola, Instituto Nacional de Investigação em Saúde, Luanda, Angola