Keara Little, BSc^1*, Zhenqi Zhu, PhD^2*, Oluwabukola Gbotosho, PhD³ and Punam Malik, MD⁴

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital and Medical Center, Mount Orab, OH
²Cincinnati Children's Hospital and Medical Center, Cincinnati
³University of Cincinnati, Cincinnati, OH
⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Marisa Morakis, BS^1*, Luojie Huang, MS^1*, Gregory N McKay, MD, PhD^1*, Sophie Lanzkron, MD^2,3, Lydia H. Pecker, MD, MS² and Nicholas J Durr, PhD^1*

¹Biomedical Engineering, Johns Hopkins University, Baltimore, MD
²Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
³Thomas Jefferson University, Philadelphia, PA

Ahmed Daak, MD, PhD, MSc, DPM/MFPM¹, David R. Light, PhD², Fuad Abdulla^3*, Chunsheng Chen, PhD^3*, Julia Nguyen, B.S.^4*, Conglin Ruan, B.S.^4*, Michael Storek^5*, Dimitry Ofengeim^6*, Alexandra Hicks^6*, Michelle Lee^5*, Vincent Mikol^6*, Gregory M. Vercellotti, MD³ and John D. Belcher, PhD³

¹Sanofi, Cambridge, MA
²Sanofi Consultant, San Mateo, CA
³Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
⁴Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁵Immunology and Inflammation Research, Sanofi, Cambridge, MA
⁶Research & Development, Sanofi, Vitry-sur-Seine, France

Elisabeth Dovern, MD^1*, Tim R. Mocking^2,3*, Mette D. Hazenberg, MD, PhD^4,5*, Cornelis R van der Torren, MD, PhD⁶, Boukje M. Beuger^7*, Robin Van Bruggen, PhD^7*, Simon Tol^7*, Erik Mul^8*, Marjolein van der Pot^6*, Arjan A. van de Loosdrecht, MD, PhD^3,9*, Myrddin Verheij, PhD^2,10*, Karin Fijnvandraat, MD, PhD^6*, Carlijn Voermans, PhD^2,10*, Bart J. Biemond¹, Costa Bachas, PhD^2,3* and Erfan Nur, MD, PhD^1,11

¹Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
²Department of Hematology, Amsterdam UMC location Vrije Universiteit, Amsterdam, Netherlands
³Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, Netherlands
⁴Department of Experimental Immunology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
⁵Sanquin Research, Amsterdam, Netherlands
⁶Department of Pediatric Hematology, Amsterdam UMC, Emma Children's Hospital, Amsterdam, Netherlands
⁷Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
⁸Department of Research Facilities, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
⁹Department of Hematology, Amsterdam University Medical Center, Free University, Amsterdam, Netherlands
¹⁰Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
¹¹Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands

Guohui Ren, MD, PhD^1*, Maria Armila Ruiz, MS^2*, Suman Setty^3*, Victor R. Gordeuk, MD⁴ and Santosh L. Saraf, MD⁵

¹University of Illinois At Chicago, CHICAGO, IL
²University of Illinois At Chicago, Chicago, IL
³University of Illinois Chicago, Chicago, IL
⁴Department of Medicine, University of Illinois Hospital, Chicago, IL
⁵Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL

Rudra Ray, PhD^1*, Haiou Li^2*, Nancy Asomaning, MS^1*, Kang Le, PhD^1*, Xunde Wang, PhD^1*, Justin Lack^3*, Yuesheng Li^4*, Sayuri Kamimura, MS^5*, Zenaide Quezado, MD^5,6 and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath¹

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Arlington, VA
³Bioinformatics (NCBR)/Integrated Data Sciences Section(IDSS)/ Research Technology Branch/DIR, NIAID, NIH, National Institutes of Health, Bethesda, MD
⁴DNA SEQUENCING & GENOMICS CORE, NHLBI, NIH, National Institutes of Health, Bethesda, MD
⁵Department of Perioperative Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
⁶Sickle Cell Branch, NHLBI, NIH, Bethesda, MD

Thiago Trovati Maciel, PhD^1*, Nabiha Sbeih, MD^1*, Rachel Rignault-Bricard^1*, Isabelle Chevalme^1*, Slimane Allali^1,2*, Camille Brochier, PhD^3*, Anna Kiialainen^4*, Tovo David⁴ and Olivier Hermine, MD, PhD^1,5

¹Institut Imagine - INSERM U1163, Paris, France
²Sickle Cell Center, Pediatrics Department, Necker Hospital for Sick Children, APHP, Paris Cité University, Paris, FRA
³Institut Roche, Boulogne Billancourt, France
⁴F. Hoffmann-La Roche Ltd, Basel, Switzerland
⁵Hematology, Necker Hospital, Greater Paris University Hospitals (AP-HP), Paris, France

Christopher Chambliss, PhD¹, Elizabeth Manci, MD^2*, Elizabeth Eldeiry^3*, Earl Fields Jr., MPH^1*, Jesse Bueno^1*, Satheesh Chonat, MD¹ and David R Archer, PhD¹

¹Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA
²Univ. of S. AL Children's & Women's Hosp., Mobile, AL
³Georgia Institute of Technology, Atlanta, GA

Gang Huang, PhD^1,2, Jie Bai^1*, Mingzhe Pan^1*, Dong Liu, PhD^3*, Min Xiong^3* and Shaojiang Deng, PhD^3*

¹Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX
²Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX
³Kind Pharmaceuticals, LLC, Redwood City, CA

Lucas F.S. Gushiken, PhD^1*, Sarah Liane Linguet, MD^2*, Erica M.F. Gotardo, Ph.D.^1*, Pamela L Brito, PhD^1*, Flavia C. Leonardo, PhD^1*, Laetitia Claer, MSc^3*, Slim Azouzi, PhD^2*, Caroline Le Van Kim, PhD^2*, Fernando Ferreira Costa, MD, PhD¹, Sandrine Laurance, PhD^2*, Berengere Khoel, MD, PhD^2* and Nicola Conran, PhD¹

¹Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil
²Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, F-75015, Paris, France
³Université Paris Cité and Université des Antilles, INSERM, BIGR, F-75015 Paris, F97150 Pointe à Pitre, France, Paris, France

Kang Le, PhD^1*, Zenaide Quezado, MD², Haiou Li^3*, Sayuri Kamimura, MS^2*, Meghann L. Smith^4*, Yuki Tahara^5*, Yujeong Lee^5*, Anna Conrey, NP^1*, Josie Schultz^6*, Thorkell Andresson, PhD^7*, Eric T Kool^5* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁸

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Department of Perioperative Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
³Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Arlington, VA
⁴Clinical Center, National Institutes of Health, Bethesda, MD
⁵Department of Chemistry, Stanford University, Stanford, CA
⁶CCR Protein Characterization Laboratory, National Cancer Institute, NIH, Frederick, MD
⁷CCR Protein Characterization Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD
⁸Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Xunde Wang, PhD^1*, Yechan Cho, BS^1*, Nancy Asomaning, MS^1*, Maureen Lundt, MS^1*, Anna Conrey, NP^1*, Britney Kruah, MS^1*, Amber M Yates, MD^2*, Megan Wind-Rotolo, PhD², Haiou Li^3*, Kang Le, PhD^1* and Swee Lay Thein, MBBS, DSc, FRCP, FRCPath, MRCP, MRCPath⁴

¹Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD
²Agios Pharmaceuticals, Inc., Cambridge, MA
³Sickle Cell Branch, National Heart, Lung, and Blood Institute, NIH, Arlington, VA
⁴Sickle Cell Branch, National Heart, Lung & Blood Institute, Bethesda, MD

Justin J Yoo, MD^1,2, Kennedy N Goldsborough, PhD^3*, Britney Hernandez, BS^3*, Ashwin P. Patel, MD, PhD, MPH⁴ and Vivien Sheehan, MD, PhD⁵

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Avondale Estates, GA
²Georgia Comprehensive Sickle Cell Center at Grady Health System, Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
⁴Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁵Emory University School of Medicine, Atlanta, GA

Rikesh K Dubey, PhD¹, Omika Katoch, PhD^1*, Nicholas Swendrowski, MS^1* and Prithu Sundd, PhD^1,2

¹Thrombosis and Hemostasis Program, VERSITI Blood Research Institute, Milwaukee, WI
²Medical College of Wisconsin, Division of Hematology and Oncology, Milwaukee, WI

Daniel M Sop, MS, BS¹, Yue May Zhang, PhD^2* and Wally R Smith, MD²

¹Sickle Cell Disease program / General Internal Medicine, Virginia Commonwealth University, Glen Allen, VA
²Virginia Commonwealth University, Richmond, VA