Mahesh Swaminathan, MD¹, Philip A. Thompson, MBBS, FRACP, FRCPA^2,3,4, Jan A. Burger, MD, PhD ², Musa Yilmaz, MD^1*, Nitin Jain, MD¹, Tapan M. Kadia, MD¹, Lucia Masarova, MD¹, Yesid Alvarado Valero, MD¹, Prithviraj Bose, MD⁵, Alessandra Ferrajoli, MD¹, Ghayas C. Issa, MD¹, Steven M. Kornblau, MD¹, Farhad Ravandi, MBBS⁶, Koji Sasaki, MD¹, Gautam Borthakur, MD⁷, Kelly S. Chien, MD⁸, Courtney D. DiNardo, MD, MSc⁹, Danielle Hammond, MD¹, Elias Jabbour, MD¹⁰, Guillermo Montalban-Bravo, MD¹, Naveen Pemmaraju, MD¹¹, Nicholas J. Short, MD¹, Koichi Takahashi, MD, PhD¹, Francesco Paolo Tambaro, MD, PhD¹², Wei Qiao, PhD^13*, Naveen Garg, MD^14*, Michael J. Keating, MBBS¹ and William G. Wierda¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston, TX
³Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia
⁴Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁷Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Leukemia, MD Anderson, Houston, TX
⁹Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
¹¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Bellaire, TX
¹²Stem Cell Transplantation and Cell Therapy Unit, AORN Santobono Pausilipon, Napoli, Italy
¹³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX

Paul J. Hampel, MD¹, Kari G. Rabe, MS^2*, Romain Guieze, MD, PhD^3*, Yucai Wang, MD, PhD¹, Emmanuelle Ferrant^4*, Saad S. Kenderian, MD¹, Marie Sarah Dilhuydy, MD^5*, Eli Muchtar, MD¹, Anne-Sophie Michallet, MD, PhD^6*, Jose F. Leis, MD, PhD⁷, Luca Inchiappa^8*, Mazie Tsang, MD⁹, Aline Clavert, MD^10*, Talal Hilal, MD¹¹, Stephane Lepretre, MD^12*, Ricardo D. Parrondo, MD¹³, Emmanuelle Tchernonog^14*, Amber Koehler, PA-C^15*, Lin Wang^16*, Susan M. Schwager^1*, Susan L. Slager, PhD¹, Neil E. Kay, MD¹⁷, Luc-Matthieu Fornecker, MD, PhD^18*, Sameer A. Parikh, MBBS¹ and Loic Ysebaert, MD, PhD^19*

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN
³CHU Estaing, Clermont Ferrand, FRA
⁴Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’Hématologie Clinique, Pierre-Bénite, France
⁵CHU Bordeaux, PESSAC, FRA
⁶Centre Leon Berard, LYON, France
⁷Mayo Clinic, Phoenix, AZ
⁸Hematology Department, Institut Paoli-Calmettes, MARSEILLE CEDEX 09, France
⁹Division of Hematology and Oncology, Department of Medicine, Mayo Clinic, Phoenix, AZ
¹⁰CHU Angers, Angers, FRA
¹¹Division of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ
¹²Centre Henri Becquerel, Rouen, FRA
¹³Division of Hematology-Oncology, Mayo Clinic-Florida, Jacksonville, FL
¹⁴Hematology Department, CHU Montpellier, Montpellier Cedex 5, France
¹⁵Mayo Clinic, Rochester, MN
¹⁶BMS, Lawrence Township, NJ
¹⁷Department of Immunology, Mayo Clinic, Rochester, MN
¹⁸Institut De Cancérologie Strasbourg Europe, Hematology Department, Strasbourg, France
¹⁹Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France

Ingrid Glimelius, MD, PhD^1,2, Love Tätting^3*, Jonatan Freilich^4,5*, Marta Natalia Stelmaszuk^4*, Qian Yang^4*, Anna Deleskog^6* and Sigurdur Y Kristinsson⁷

¹Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Unit, Uppsala University, Uppsala, Sweden., Uppsala University, Uppsala, Sweden
²Blood, Oncology and Tumor department, Akademiska sjukhuset, Uppsala University Hospital, Uppsala, Sweden
³Department of Haematology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University Hospital, Linköping, Sweden
⁴Access Consulting – RWE, Parexel Sweden AB, Stockholm, Sweden
⁵Department of Public Health and Clinical Medicine, Dermatology, Umeå University, Umeå, Sweden
⁶Takeda Pharma AB, Stockholm, Sweden
⁷Department of Hematology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

April Chiu, MD^1*, Jansen N Seheult, M.D.^1*, Min Shi, MD, PhD^2*, Dragan Jevremovic, M.D., Ph.D^3*, Matthew J Weybright^1*, Michael M Timm^1*, Gregory E Otteson^1*, Horatiu Olteanu, M.D., Ph.D.¹ and Pedro Horna, MD¹

¹Division of Hematopathology, Mayo Clinic, Rochester, MN
²Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Rochester, MN
³Mayo Clinic, Rochester, MN

Ellinor Goergen, MD^1*, Sandra Robrecht, PhD^1*, Adam Giza^1*, Can Zhang, PhD^1*, Pascal Nieper, MD^1*, Florian Simon, MD^1*, Paula Cramer, MD^1*, Moritz Fürstenau, MD^1*, Othman Al-Sawaf, MD¹, Nadine Kutsch, MD^1*, Anna Maria Fink, MD^1*, Ursula Vehling-Kaiser, MD^2*, Lothar Müller, MD^3*, Michael J. Eckart, MD^4*, Rudolf Schlag, MD^5*, Werner Freier, MD^6*, Tobias Gaska, MD⁷, Christina Balser, MD^8*, Marcel Reiser, MD^9*, Martina Beate Stauch, MD^10*, Clemens-Martin Wendtner, MD^11*, Eugen Tausch, MD^12*, Christof Schneider, MD^12*, Kirsten Fischer, MD^1*, Stephan Stilgenbauer, MD^12,13, Barbara F. Eichhorst, MD¹, Michael Hallek, MD^1* and Petra Langerbeins^1*

¹Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany
²Outpatient Clinic, Landshut, Germany
³Study Centrum Unter Ems, Practice for Oncology and Hematology, Leer, Germany
⁴Onkologische Schwerpunktpraxis Erlangen, Erlangen, Germany
⁵Practice for Hematology and Oncology Wuerzburg, Wuerzburg, Germany
⁶Medicinum, Hildesheim, Germany
⁷Brüderkrankenhaus St. Josef, Paderborn, Germany
⁸Oncological Practise Marburg, Marburg, He, DEU
⁹Praxis für internistische Onkologie und Hämatologie (PIOH), Frechen, Germany
¹⁰Praxis (Private Practice) Dr, Stauch, Kronach, Germany
¹¹Medical Clinic III, Ludwig-Maximilians University (LMU), Munich, Germany, Munich, Germany
¹²Department of Internal Medicine III, Division of CLL, University Hospital Ulm, Ulm, Germany
¹³Comprehensive Cancer Center Ulm, University of Ulm, Ulm, Germany

Andreas Katsimigas, MD^1*, Lone Bredo Pedersen^2*, Thure Haunstrup, MD^3*, Thor Hoeyer, MD^4*, Rikke Olsen^5*, Michael Boe Møller^6*, Emelie Curovic Rotbain, MD, PhD^7*, Caspar Da Cunha-Bang, MD, PhD^7*, Carsten Utoft Niemann, MD, PhD^8,9* and Christian Brieghel, MD, PhD^2*

¹Department of hematology, Rigshospitalet, Copenhagen, Denmark
²Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
³Department of Clinical Immunology, aalboorg university, Aalborg, Denmark
⁴Aalborg University Hospital, Aalborg, Denmark
⁵Department of pathology, Odense university hospital, Odense, Denmark
⁶Pathology, Odense University Hospital, Odense, Denmark
⁷Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
⁸Department of Clinical Medicine, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
⁹Department of Hematology, Rigshospitalet, Copenhagen, Denmark

Yuting Yan, MD^1*, Bolin Yuan^2*, Tingyu Wang^1*, Ying Yu^1*, Weihao Chen^3*, Dandan Shan^4*, Xiong Wenjie, MD^1*, Gang An^5*, Dehui Zou^5*, Lu-Gui Qiu⁵, Qiong Wang^6* and Shuhua Yi^7*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²School of Clinical Medicine, Shandong Second Medical University, Weifang, China, Shandong, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjjn, China
⁴Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶Shengli Oilfield Central Hospital, Dongying, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Tamar Tadmor, MD^1,2*, Ohad Benjamini, MD^3,4*, Neta Goldschmidt^5,6*, Natalia Kreiniz, MD^7,8*, Osnat Bairey^9,10*, Reut Harel, MD^11*, Nadav Sarid^12,13*, Tsofia Levi, MD^14*, Ofir Wolach, MD^15,16* and Yair Herishanu, MD^17,18*

¹Technion, Ruth and Bruce Rappaport Faculty of Medicine,, Haifa,, Israel
²Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
⁴Hematology and BMT, Sheba Medical Center–Tel HaShomer, Ramat Gan, Israel
⁵Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
⁶Department of Hematology, Hadassah Medical Center, Jerusalem, Israel
⁷Hematology, Bnai Zion Medical Center, Haifa, Israel
⁸Ruth and Bruce Rappaport Faculty of Medicine, Technion,, Haifa, Israel
⁹Davidoff Cancer Center, Rabin Medical Center,, Petach Tikva, ISR
¹⁰School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University,, Tel Aviv,, Israel
¹¹Department of Hematology, Emek Medical Center, Afula, Ein-Dor, Israel
¹²Faculty of Medicine, Tel Aviv University, Tel Aviv, Tel Aviv, Israel
¹³Department of Hematology, Edith Wolfson Medical Center, Holon, Holon, Israel
¹⁴Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
¹⁵Tel Aviv University, The Faculty of Medicine & Health Sciences, Tel Aviv, Israel
¹⁶Rabin Medical Center, Petah Tikva, Israel
¹⁷School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv,, Israel
¹⁸Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel

Bharat Ramakrishna^1*, Gabriela Espinoza^1*, Xiang Zhang^1*, Fidelia Ida^1*, Lara Yoon^2*, John Shen^2*, David Gardiner^1* and Quazi Ataher^1*

¹CSL Behring LLC, King of Prussia, PA
²Aetion, Inc., New York, NY

Daniel A. Ermann, MD¹, Victoria A. Vardell, MD², Allison M. Bock, MD¹, Joshua J. Horns, PhD^3*, Harsh R. Shah, DO¹, Lindsey Fitzgerald, MD¹, Boyu Hu, MD¹, Adam S Kittai, MD⁴ and Deborah M. Stephens, DO⁵

¹Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²Huntsman Cancer Institute, Division of Hematology and Hematological Malignancies, University of Utah, Salt Lake City, UT
³Department of Surgery, University of Utah, Salt Lake City, UT
⁴Icahn School of Medicine at Mount Sinai, New York, NY
⁵University of North Carolina Chapel Hill, Chapel Hill, NC

Matthew S. Davids, MD, MMSc¹, Christine E. Ryan, MD¹, Yue Ren, MS^1*, Liam Hackett^1*, Jeremy Zhang^1*, Svitlana Tyekucheva, PhD^2*, Stacey M. Fernandes, BS^1*, Jennifer L. Crombie, MD², Austin I. Kim, MD³, Matthew Weinstock^4*, Josie Montegaard, NP^1*, Heather A. Walker, MPH^1*, Claire Greenman, BA^1*, Victoria Patterson, BSN, RN^1*, Caron A. Jacobson, MD, MMSc¹, Ann S. LaCasce, MD, MMSc², Philippe Armand, MD, PhD¹, David C. Fisher, MD¹, Steve Lo, MD^5*, Adam J. Olszewski, MD⁶, Jon E. Arnason, MD⁷, Inhye E. Ahn, MD¹ and Jennifer R. Brown, MD, PhD⁸

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Newton Center, MA
⁴Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA
⁵Stamford Hospital, Stamford, CT
⁶Brown University, Providence, RI
⁷Beth Israel Deaconess Medical Center, Boston, MA
⁸Department of Medical Oncology, Dana-Farber Cancer Institute, Newton, MA

Nitin Jain, MD¹, Catherine C. Coombs, MD², James D'Olimpio, MD^3*, Nirav N. Shah, MD⁴, Jacqueline C. Barrientos, MD⁵, Seung Tae Lee, MD, PhD⁶, Andrew Gillis-Smith, MD⁷, Shuo Ma, MD, PhD⁸, Shirou Kirita^9*, Masaaki Sawa, PhD^10*, Kyoko Miyamoto, MD, PhD^11*, Akinori Arimura^11*, William G. Wierda¹, Varsha Gandhi, PhD¹² and Javier Pinilla-Ibarz, MD, PhD¹³

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of California Irvine, Irvine, CA
³Clinical Research Alliance, Westbury, NY
⁴Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁵Mount Sinai Medical Center, Miami Beach, FL
⁶University of Maryland, Greenebaum Comprehensive Cancer Center, Baltimore, MD
⁷Division of Hematology/Oncology, Department of Medicine, University of Massachusetts Memorial Medical Center, Worcester, MA
⁸Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL
⁹Carna Biosciences, Inc, Kobe, Japan
¹⁰Carna Biosciences, Inc., Kobe, Japan
¹¹CarnaBio USA, Inc., South San Francisco, CA
¹²Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
¹³Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Jacob D. Soumerai, MD¹, Ahmet Dogan, MD, PhD², Venkatraman Seshan^2*, Kelsey Leigh Flaherty, BS^2*, Natalie Slupe^2*, Jason Carter, MPH, PA-C^3*, Ephraim Hochberg, MD^4*, Jeffrey A. Barnes, MD, PhD¹, Jeremy S. Abramson, MD⁵, Audrey Hamilton, MD^6*, Ariela Noy, MD⁷, Colette Owens, MD⁷, Maria Lia Palomba, MD⁷, Anita Kumar, MD⁸, Lindsey Roeker, MD⁹, Meghan C. Thompson, MD¹⁰, Ronald W. Takvorian^5*, Zachary D. Epstein-Peterson, MD⁷, Mark Blaine Geyer, MD¹⁰, Gilles Salles, MD, PhD¹¹, Robert Stuver, MD⁷, Philip Caron, MD⁷, Prioty Islam, MD^10*, Tamanna Haque, MD^2*, Paola Ghione, MD, MSEpi², Raphael E. Steiner, MD², Pallawi Torka, MD², Kevin A. David, MD^7*, Jennifer Kimberly Lue, MD⁷, Paul A. Hamlin, MD⁷, Alison Moskowitz, MD⁷, Lorenzo Falchi, MD², Julie Haydu, MD, PhD¹², Patrick Connor Johnson, MD⁵, Joanna Mi^2*, Jessica Pendleton^2*, Alyssa Labarre^2*, Rosalba Martignetti^5*, Sean F. Plummer^5*, Maria Chabowska, BSc^2*, Walter Ramos Amador, MPH, MS^2*, Neena Mahajan^2*, Morgan Choma^2*, Clare Grieve, MPH^2*, Rayna N. Garcia^5*, Hailey E. Kelly^5*, Ella Mallinger^5*, James O'Grady^5*, Bernadette Beatty^5*, Michelle Adams^5*, Athina Apazidis^5*, Aileen Cleary Cohen, MD, PhD¹³, Mina Shahkarami^14*, Allison P. Jacob, MSc¹⁵, Omar Abdel-Wahab, MD¹⁰ and Andrew D. Zelenetz, MD, PhD⁷

¹Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA
²Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York City, NY
⁴Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA
⁵Massachusetts General Hospital Cancer Center, Boston, MA
⁶Memorial Sloan-Kettering, Basking Ridge, Basking Ridge, NJ
⁷Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Short Hills, NJ
⁹Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
¹¹Lymphoma Service Chief, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Massachusetts General Hopsital Cancer Center, Boston, MA
¹³BeiGene USA, Inc, San Mateo, CA
¹⁴Genentech, Inc., South San Francisco, CA
¹⁵Adaptive Biotechnologies, Seattle, WA

Jan A. Burger, MD, PhD ¹, Ekaterina Kim, PhD, MS^1*, Gitanjali Jayachandran, PhD^2*, Wanda Lopez, RN^1*, Ghayas C. Issa, MD¹, Musa Yilmaz, MD^1*, Mahesh Swaminathan, MD¹, Jo Ishizawa, MD, PhD¹, Alexandre Bazinet, MD^1*, Yesid Alvarado Valero, MD¹, Nitin Jain, MD¹, William G. Wierda¹ and Alessandra Ferrajoli, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston

William G. Wierda¹, Ryan Jacobs², Paul M Barr, MD³, John N. Allan, MD⁴, Tanya Siddiqi, MD⁵, Alessandra Tedeschi, MD^6*, Thomas J. Kipps, MD⁷, Susan M. O'Brien⁸, Xavier C. Badoux, MBBS, FRACP, FRCPA⁹, Andrea Visentin, MD, PhD^10*, Masa Lasica, MBBS, BMedSci, FRACP, FRCPA^11*, Dennis A. Carney, MBBS, FRACP, FRCPA, PhD^12*, Anna Elinder Cambrun, MBBS, FRACP, FRCPA^13*, Javier De la Serna, MD¹⁴, Edith Szafer Glusman, PhD^15*, Cathy Zhou, MS^16*, Jutta K. Neuenburg, MD, PhD¹⁶, Lynne Neumayr, MD^16*, Anita Szoke, MD^16*, James P. Dean, MD, PhD^16*, Paolo Ghia, MD, PhD^17,18 and Constantine S. Tam, MBBS, MD¹⁹

¹The University of Texas MD Anderson Cancer Center, Houston, TX
²Levine Cancer Institute, Charlotte, NC
³University of Rochester, Rochester, NY
⁴Division of Hematology and Oncology, Weill Cornell Medicine, Long Island City, NY
⁵City of Hope National Medical Center, Duarte, CA
⁶Niguarda Ca' Granda Hospital, Milano, ITA
⁷Moores Cancer Center, University of Californi, San Diego, La Jolla, CA
⁸UC Irvine, Chao Family Comprehensive Cancer Center, Orange, CA
⁹Ministry of Health, Kogarah, NSW, Australia
¹⁰University of Padova, Padova, Italy
¹¹St Vincent’s Hospital, Melbourne, Australia
¹²Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
¹³North Shore Hospital, Auckland, New Zealand
¹⁴Hospital Universitario 12 de Octubre, Madrid, Spain
¹⁵AbbVie Inc, North Chicago, IL
¹⁶AbbVie, North Chicago, IL
¹⁷Università Vita-Salute San Raffaele, Milano, Italy
¹⁸IRCCS Ospedale San Raffaele, Milan, Italy
¹⁹Alfred Hospital and Monash University, Melbourne, VIC, Australia

Meghan C. Thompson, MD¹, Seema A. Bhat, MD^2*, Wojciech Jurczak, MD, PhD³, Krish Patel, MD⁴, Nirav N. Shah, MD⁵, Jennifer A. Woyach, MD⁶, Catherine C. Coombs, MD⁷, Toby A. Eyre^8*, Michal Danecki^3*, Monika Dlugosz-Danecka, MD, PhD^3*, Neil Bailey, MSc⁴, Joanna M. Rhodes, MD, MSCE^9*, Nicole Lamanna, MD¹⁰, Andrew H. Lipsky, MD¹⁰, Jeffrey Jensen, MD, PhD¹¹, Adam Kidwell, MD^5*, Eytan M. Stein, MD¹, Monica Shah, BA^1*, Jennifer R. Brown, MD, PhD¹², Andriy Derkach, PhD^13*, Anthony R. Mato, MD^14,15* and Lindsey Roeker, MD¹

¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Division of Hematolopgy, The Ohio State University, Columbus, OH
³MSC National Research Institute of Oncology, Kraków, Poland
⁴Swedish Cancer Institute, Seattle, WA
⁵Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, WI
⁶The Ohio State University, Columbus, OH
⁷University of California, Irvine, Irvine, CA
⁸Department of Clinical Haematology, Oxford University Hospitals NHS Trust, Old Road, United Kingdom
⁹Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
¹⁰Herbert Irving Comprehensive Cancer Center, New York-Presbyterian/Columbia University Medical Center, New York, NY
¹¹University of North Carolina, Chapel Hill, NC
¹²Department of Medical Oncology, Dana-Farber Cancer Institute, Newton, MA
¹³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁴Hematology & Oncology, Cayuga Medical Center, Ithaca, NY
¹⁵Research and Development, Contracted Consultant, AstraZeneca, New York, NY

Carsten Utoft Niemann, MD, PhD^1*, Talha Munir, MBBS, PhD², Carolyn Owen, MD, FRCPC³, George Follows, MA, BM, BCh, PhD, FRCP, FRCPath^4*, Jose-Angel Hernandez Rivas, MD, PhD^5*, Ohad Benjamini, MD^6*, Ann Janssens, MD, PhD^7*, Mark-David Levin⁸, Tadeusz Robak^9*, Martin Simkovic, M.D., Ph.D.^10*, Sergey Voloshin, MD, PhD^11*, Vladimir I. Vorobyev, PhD^12*, Loic Ysebaert, MD, PhD^13*, Natasha Schuier, MD, MSc^14*, Kurt Baeten, PhD^15*, Ping Xu^16*, Nguyet Tran, MPH, MBA^16*, Bennett S. Levitan, MD, PhD^16*, Claire Kavanagh^17* and Arnon P. Kater, MD, PhD¹⁸

¹Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
²Department of Haematology, St. James's University Hospital, Leeds, United Kingdom
³Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada
⁴Addenbrookes Hospital, Cambridge, United Kingdom
⁵Hospital Universitario Infanta Leonor, Universidad Complutense, Madrid, Spain
⁶Hematology and BMT, Sheba Medical Center–Tel HaShomer, Ramat Gan, Israel
⁷UZ Leuven Gasthuisberg, Leuven, Belgium
⁸Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands
⁹Department of Hematology, Medical University of Lodz, Lodz, Poland
¹⁰University Hospital and Medical School Hradec Kralove, Hradec Kralove, CZE
¹¹FMBA, Russian Scientific and Research Institute of Hematology and Transfusiology, St Petersburg, Russian Federation
¹²S.P. Botkin Moscow City Clinical Hospital, Moscow, Russian Federation
¹³Hematology Department, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
¹⁴Janssen Research & Development, Bridgewater, NJ
¹⁵Janssen Research & Development, Beerse, Belgium
¹⁶Janssen Research & Development, Titusville, NJ
¹⁷Janssen-Cilag, Dublin, Ireland
¹⁸Amsterdam University Medical Center, Amsterdam, on behalf of HOVON, Netherlands

Gian Matteo Rigolin^1*, Antonio Urso^2*, Stefano Soddu^3*, Riccardo Moia, MD^4*, Riccardo Dondolin, MD^5*, Attilio Olivieri^6*, Ilaria Scortechini^7*, Annamaria Frustaci^8*, Marina Deodato, MD^8*, Giulia Daghia^2*, Francesca Romana Mauro, MD^9*, Sara Pepe, MD, PhD^10*, Marina Motta, MD^11*, Antonella Anastasia^12*, Lydia Scarfo, MD¹³, Emanuela Sant'Antonio^13*, Pellegrino Musto^14*, Annamaria Giordano, MD^15*, Andrea Mengarelli^16*, Martina Tomassi^17*, Sara Martinelli^18*, Caterina Patti, MD^19*, Marika Porrazzo, MD^19*, Alessandro Sanna, MD^20*, Rossella Riccioni^21*, Clara Virginia Vigano'^22*, Francesca Paola Paoloni^3*, Alfonso Piciocchi, MS^3*, Paola Fazi^3*, Guido Gini, MD²³, Andrés José María Ferreri, MD²⁴, Paolo Ghia, MD, PhD¹³ and Antonio Cuneo, MD^2*

¹Hematology Section, St. Anna University Hospital, Ferrara, Italy
²Ematologia, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy
³GIMEMA Foundation, Rome, Italy
⁴Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
⁵Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, ITA
⁶Hematology Unit, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy
⁷Clinica di Ematologia ospedali riuniti diAncona, Università Politecnica delle Marche, Ancona, Italy
⁸Dipartimento di Ematologia, ASST Grande Ospedale Metropolitano Niguarda, Niguarda Cancer Center, Milan, Italy, Milano, Italy
⁹Hematology, Department of Translational and Precision Medicine, Sapienza University, Roma, Italy
¹⁰Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy
¹¹Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
¹²S.C. Ematologia, ASST Spedali Civili di Brescia, Brescia, Italy
¹³Laboratory of B-cell Neoplasia Strategic Research Program on CLL Division of Experimental Oncology IRCCS Ospedale San Raffaele, Milan, Italy
¹⁴Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine,and Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari, Bari, Italy
¹⁵Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico,  and Department of Precision and Regenerative Medicine and  Ionian Area, "Aldo Moro" University School of Medicine, Bari, Italy, Bari, Italy
¹⁶Hematology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Roma, ITA
¹⁷Hematology and Stem Cell Transplant Unit, IRCCS - Regina Elena National Cancer Institute, Istituti Fisioterapici Ospitalieri (I.F.O.), Rome, Italy
¹⁸Struttura Semplice Dipartimentale di Ematologia Ospedale S. Chiara Trento, Trento, ITA
¹⁹U.O.C. di Oncoematologia, "Ospedali Riuniti Villa Sofia - Cervello (Presidio V. Cervello), Palermo, Italy
²⁰Hematology, AOU Careggi, Florence, Italy
²¹UOC Ematologia ATNO, Ospedale di Livorno, Livorno, ITA
²²Dipartimento Oncologico, ASST Lecco Ospedale Manzoni, Unità semplice di Oncoematologia, Lecco, Italy
²³Hematology Unit, AOU delle Marche-Università Politecnica delle Marche, Ancona, Italy
²⁴Unit of Lymphoid Malignancies, Department of Onco-Haematology, IRCCS San Raffaele Scientific Institute, Milano, Italy

Paolo Sportoletti^1*, Luca Laurenti, MD^2*, Emmanuelle Ferrant^3*, Luis Felipe Casado Montero^4*, Stephen P Mulligan^5*, Rosemary Harrup^6*, Stephen Opat^7*, Adalberto Ibatici^8*, Roberto Marasca⁹, Marcus Lefebure^10*, Michelle Boyer^11*, Yanwen Jiang^11*, Simona Barlera^12*, Oscar Cazares^11*, Franck Morschhauser, MD, PhD¹³ and Jeff P. Sharman, MD¹⁴

¹Department of Medicine and Surgery, Institute of Hematology, Centro di Ricerca Emato-Oncologica, University of Perugia, Perugia, Italy
²Department of Diagnostic Imaging, Oncological Radiotherapy and Hematology, Agostino Gemelli University Hospital Foundation IRCCS, Rome, Italy
³Department of Hematology, Lyon Sud Hospital, Pierre Benite, France
⁴Hematology, Hospital General Universitario de Toledo, Toledo, Spain
⁵Royal North Shore Hospital, Sydney, AUS
⁶Royal Hobart Hospital and University of Tasmania, Tasmania, Australia
⁷Monash Health, Clayton, VIC, Australia
⁸Division of Hematology and Bone Marrow Transplant, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
⁹University of Modena and Reggio Emilia, Modena, Italy
¹⁰Roche Products Ltd, Welwyn Garden City, United Kingdom
¹¹Genentech, Inc., South San Francisco, CA
¹²Parexel International, Milan, Italy
¹³Centre Hospitalier Régional Universitaire de Lille, Lille, France
¹⁴Willamette Valley Cancer Institute and Research Center, US Oncology Research, Eugene, OR

Inhye E. Ahn, MD¹, Yue Ren, MS^2*, David C. Fisher, MD², Austin I. Kim, MD², Nancy E. Kaddis, MD, MPH^3*, Jon E. Arnason, MD⁴, John P. Winters III, MD^5*, Sobana Balasubramanian, BS^1*, Heather A. Walker, MPH^2*, Victoria Patterson, BSN, RN^2*, Stacey M. Fernandes, BS^2*, Svitlana Tyekucheva, PhD^1*, Matthew S. Davids, MD, MMSc⁶ and Jennifer R. Brown, MD, PhD¹

¹Dana-Farber Cancer Institute, Boston, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Dana-Farber Cancer Institute at South Shore Health, Weymouth, MA
⁴Beth Israel Deaconess Medical Center, Boston, MA
⁵New England Cancer Specialists, Scarborough, ME
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Inc., Boston, MA

Zulfa Omer, MD¹, Max Yano, MD, PhD^2*, Jayesh Rai^3*, Joyce Chen^4*, Jennifer A. Woyach, MD⁵, Seema A. Bhat, MD^6*, Michael R. Grever, MD⁵, Dan Jones, MD⁷, Kerry A. Rogers, MD⁵ and John C. Byrd, MD⁸

¹Division of Hematology, University of Cincinnati, Cincinnati, OH
²College of Medicine, The Ohio State University, Columbus, OH
³Biostatistics and informatics shared resources, University of Cincinnati, Cincinnati, OH
⁴Biostatistics and Informatics Shared Resource, University of Cincinnati, Cincinnati, OH
⁵Division of Hematology, The Ohio State University, Columbus, OH
⁶Division of Hematolopgy, The Ohio State University, Columbus, OH
⁷The Ohio State University Comprehensive Cancer Center, The Ohio state University, Columbus, OH
⁸Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

Shuhua Yi^1,2*, Tingyu Wang^2,3*, Fei Li⁴, Jingdong Zhang^5*, Xingli Zou^6*, Yanping Ma^7* and Lugui Qiu^2,8

¹State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical, Tianjin, China
²Tianjin Institutes of Health Science, Tianjin, China
³State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sci, Tian Jin, China
⁴Department of Hematology, Jiangxi Clinical Research Center for Hematologic Disease, Jiangxi Provincial Key Laboratory of Hematological Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang, Jiangxi Province, China
⁵Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, China
⁶Affiliated Hospital of North Sichuan Medical college, Nanchong, China
⁷Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, China
⁸State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Tamar Tadmor, MD^1*, Toby A. Eyre^2*, Ohad Benjamini, MD^3*, Arvind Chaudhry, MD, PhD^4*, Juan Shen^5*, Siyang Leng, MD, MS⁵, Mohammed Z. H. Farooqui, DO⁵ and David Lavie^6*

¹Bnai Zion, Haifa, Israel
²Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom
³Hematology and BMT, Sheba Medical Center–Tel HaShomer, Ramat Gan, Israel
⁴Summit Cancer Centers, Spokane, WA
⁵Merck & Co., Inc., Rahway, NJ
⁶Hadassah Medical Center, Jerusalem, Israel