Samuel Cutler, BS, MSc¹, Amy Trottier, MD, MSc, FRCPC², Daniel Gaston, PhD^3*, Nicholas Allen Forward, MD⁴, Darrell White⁵, Alfredo H. De La Torre, MD⁶ and Manal Elnenaei, MD, PhD, MSc^3,7*

¹Department of Medicine, Dalhousie University, Wellington, NS, Canada
²Division of Hematology, Department of Medicine, Nova Scotia Health, Halifax, NS, Canada
³Pathology, Dalhousie University, Halifax, NS, Canada
⁴Queen Elizabeth II Health Sciences Centre, Halifax, Canada
⁵Dalhousie University and QEII Health Sciences Centre, Halifax, NS, CAN
⁶QEII Health Sciences Centre, Halifax, NS, CAN
⁷Clinical Chemistry, Nova Scotia Health Authority, Halifax, NS, CAN

David Fandrei, MSc^1,2*, Michael Rade, PhD^1*, Markus Kreuz, PhD^1*, Luise Fischer, PhD^3*, Patrick Born^4*, Sabine Seiffert^5*, Andreas Boldt, MD^5*, Jonathan Scolnick, PhD^6*, Lakshmi Venkatraman^7*, Stacy Xu, PhD^8*, Ronny Baber, PhD^9,10*, Song Yau Wang, MD^2*, Enrica Bach, PhD^2*, Sandra Hoffmann^4*, Klaus H Metzeler, MD², Marco Herling, MD^2*, Madlen Jentzsch, MD^11*, Georg-Nikolaus Franke, MD^4*, Ulrike Köhl, MD, PhD^1,5*, Uwe Platzbecker, MD², Vladan Vucinic, MD^12*, Kristin Reiche, PhD^1,5,13* and Maximilian Merz, MD²

¹Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
²Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
³Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Saxony, Germany
⁴Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Leipzig Medical Center, Leipzig, Germany
⁵Institute of Clinical Immunology, University of Leipzig Medical Center, Leipzig, Germany
⁶Singleron Biothechnologies Pte Ltd, Singapore, Singapore
⁷Singleron Biotechnologies, Singapore, Singapore
⁸Singleron Biotechnologies Pte LtD, Singapore, Singapore
⁹Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig Medical Center, Leipzig, Germany
¹⁰Medical Biobank, University of Leipzig Medical Center, Leipzig, Germany
¹¹Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Sachsen, Germany
¹²Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig, Leipzig, Saxony, Germany
¹³Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI), Dresden, Leipzig, Germany

Erin Flynt, PhD^1*, Chad A. Lewis, PhD^2*, Benjamin Winograd, MD, PhD^2*, Terry Connolly, PhD^2*, Lan Xu, PhD^2* and Anil Menon, PhD^2*

¹K36 Therapeutics, Summit, NJ
²K36 Therapeutics, Cambridge, MA

Carmen Gonzalez, MSc^1*, Camila Guerrero, PhD^1*, Juan-José Garcés, PhD^1*, Alejandro Medina, PhD^2*, Noemi Puig, PhD², Maria Teresa Cedena Romero, MD, PhD^3*, Diego Alignani, PhD^1*, Sarai Sarvide^1*, Paula Aguirre-Ruiz, MSc^1*, Jose Maria Lamo-Espinosa, MD^1*, Felipe Prosper, MD, PhD¹, Paula Rodríguez-Otero, MD, PhD^1*, Jose A. Martinez-Climent, MD, PhD¹, Aldo Roccaro, MD, PhD⁴, Antonio Sacco, MSc^4*, Mario Nuvolone, MD, PhD^5*, Giovanni O. Palladini, MD, PhD⁵, Laura Rosiñol Dachs, MD PhD^6*, Ramon García-Sanz, MD, PhD², Joaquín Martínez-Lopez^3*, Juan-Jose Lahuerta Palacios, MD, PhD^3*, Maria-Victoria Mateos, MD, PhD², Joan Bladé, MD, PhD^6*, Jesús F. San-Miguel, MD, PhD¹ and Bruno Paiva, PhD^1*

¹Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada, Universidad de Navarra, CCUN, IDISNA, CIBER-ONC, Pamplona, Spain
²Hospital Universitario de Salamanca (HUSAL), IBSAL, IBMCC (USAL-CSIC), CIBER-ONC, Salamanca, Spain
³Hematology Department, Hospital Universitario 12 de Octubre, CIBER-ONC, Instituto de Investigación IMAS12, Madrid, Spain
⁴ASST Spedali Civili di Brescia, Clinical Trial Center, Translational Research and Phase I Unit, Brescia, Italy
⁵Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo Pavia, Pavia, Italy
⁶Amyloidosis and Multiple Myeloma Unit, Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain

Cinnie Soekojo, MD^1,2, Susan M. Geyer, PhD³, Emmanuel Contreras Guzman^1*, Kaitlyn Whitaker, M.S.^1*, Shaji Kumar, MD¹, Vincent Rajkumar, MD^1*, Joselle Cook, MBBS¹, Yogesh Chawla, PhD^1*, Francis Buadi, MD¹, Angela Dispenzieri, MD¹, Moritz Binder, MD¹, Rafael Fonseca, MD⁴, Taro Hitosugi⁵, Dragan Jevremovic, M.D., Ph.D^6*, Wilson I. Gonsalves, MD¹ and Jose C. Villasboas Bisneto, MD¹

¹Division of Hematology, Mayo Clinic, Rochester, MN
²National University Cancer Institute of Singapore, Singapore, Singapore, Singapore
³Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Paradise Valley, AZ
⁵Department of Oncology, Mayo Clinic, Rochester, MN
⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Bo Hu^1*, Hardik Modi^1*, Diana Jankeel^2*, Jacob T. Edwards^3*, Junfei Zhao^4*, Chad C. Bjorklund^4*, Gaurav Jain^5*, Patrick R. Hagner, PhD^4*, Maria Ortiz^6*, Zhongying Mo^1*, Celia Fontanillo^1*, Christoph W. Zapf^2*, Antonia Lopez-Girona^2*, Neil Bence^2*, Kai Wang^1*, Anita K. Gandhi, PhD⁷, Mark Rolfe², Deborah S. Mortensen^2* and Lynda Groocock^2*

¹Bristol Myers Squibb, San Diego, CA
²Research and Development, Bristol Myers Squibb, San Diego, CA
³Bristol Myers Squibb, Redwood City, CA
⁴Bristol Myers Squibb, Summit, NJ
⁵Bristol Myers Squibb, Bangalore, India
⁶Bristol Myers Squibb, Seville, Spain
⁷Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ

Nathan Becker, MS^1*, Enze Liu, PhD^2*, Parvathi Sudha, MS^2*, Riya Sharma, MS^2*, Travis Johnson, PhD³, Aneta Mikulasova, PhD^4*, Rafat Abonour, MD² and Brian A. Walker, PhD²

¹Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Fishers, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN
⁴Centre for Cancer and Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom

Lifang Zou^1* and Fei Li²

¹Department of Hematology，Jiangxi Clinical Research Center for Hematologic Disease，Jiangxi Provincial Key Laboratory of Hematological Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang, China, Nanchang, CA, China
²Department of Hematology, Jiangxi Clinical Research Center for Hematologic Disease, Jiangxi Provincial Key Laboratory of Hematological Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang, China;, Nanchang, China

Takeshi Harada, MD, PhD¹, Yusuke Inoue, PhD^2*, Asuka Oda^1*, Jumpei Teramachi^3*, Yusaku Maeda^1*, Ryohei Sumitani^1*, Masahiro Oura^1*, Kimiko Sogabe^1*, Hikaru Yagi^1*, Shiro Fujii^1*, Shingen Nakamura^4*, Hirokazu Miki^5*, Kumiko Kagawa, MD, PhD^6*, Shuji Ozaki⁶, Ken-ichi Matsuoka, MD, PhD^1* and Masahiro Abe^7*

¹Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
²Department of Medical Technology, Tokushima University Hospital, Tokushima, Japan
³Department of Oral Function and Anatomy, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JPN
⁴Department of Community Medicine and Medical Science, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, Tokushima, Japan
⁵Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, Tokushima, Japan
⁶Department of Hematology, Tokushima Prefectural Central Hospital, Tokushima, Japan
⁷Department of Hematology, Kawashima Hospital, Tokushima, Japan, Tokushima, Japan

Visanu Wanchai, PhD^1*, Hongwei Xu, DDS^2*, Cody Ashby, PhD^1*, Frits van Rhee, MD, PhD², Guido Tricot, MD^2*, John D Shaughnessy, Jr, PhD^2* and Fenghuang Zhan, MD²

¹Department of Bioinformatics, University of Arkansas for Medical Sciences, Little Rock, AR
²Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR

Xiangao Huang, PhD^1*, David S Jayabalan, MSc^1*, Maurizio Di Liberto, PhD^1*, Zhengming Chen, PhD^1*, Scott Ely, MD¹, Roger Pearse, MD, PhD^1*, Joseph Lane, MD^2*, Gang Lin, PhD^1*, Ruben Niesvizky, MD³ and Selina Chen-Kiang, PhD¹

¹Weill Cornell Medicine, New York, NY
²Hospital For Special Surgery, New York, NY
³Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY

David Zihala^1,2*, Anjana Anilkumar Sithara^3,4,5*, Veronika Kapustova^4,5*, Ondrej Venglar^4,5*, Eva Radova^4,5*, Lucie Broskevicova^4,5*, Jan Vrana^4,5*, Serafim Nenarokov^4,5*, Daniel Bilek^3*, Ludmila Muronova^1,2*, Tereza Popkova, MD^1,2*, Jana Mihalyova^4,5*, Hana Plonkova, MD^2*, Sandra Charvatova^4,5*, Kamlesh Bisht^6*, Hongfang Wang, PhD^6*, Helgi Van de Velde, MD, PhD⁶, Michal Simicek^4,5*, Tereza Sevcikova^5,7*, Roman Hajek, MD, PhD^5,8 and Tomas Jelinek^5,9

¹Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
²Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic
³Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
⁴Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic
⁵Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
⁶Sanofi R&D, North America, Cambridge, MA
⁷Department of Hematooncology, University Hospital Ostrava, Ostrava, AL, Czech Republic
⁸University Hospital Ostrava and University of Ostrava, Ostrava, Czech Republic
⁹Department of Hematooncology, University Hospital Ostrava, Ostrava, Ostrava-Mesto, Czech Republic

Rena Feinman, PhD¹, Ariel Aptekmann, PhD^1*, Iriana Colorado, MSc^1*, Reilly Kobbe, BSc^1*, Marta Salas, BSc^1*, Noa Biran, MD², David S. Siegel, MD, PhD^1,3 and Benjamin Tycko, MD, PhD^1*

¹Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ
²Division of Multiple Myeloma, John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
³John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, NJ

Aleksandra Kurowska^1*, Azari Bantan^2*, Raghad Shuwaikan^3*, Itziar Cenzano, PhD^1*, Paula Aguirre-Ruiz, MSc^4*, Estíbaliz Miranda^4*, Leire Garate^4*, Amaia Vilas-Zornoza^4*, Patxi San-Martin^4*, Marta Larrayoz, PhD^4*, Nahia Gómez-Echarte^4*, Beñat Ariceta^4,5*, Daniel Soto Ortiz^1*, Turki Sobahy^2*, José Ignacio Martín-Subero^6,7*, Vincenzo Lagani, PhD^1*, Jesper Tegnér, PhD^1*, Jose A. Martinez-Climent, MD, PhD⁴, Xabier Agirre, PhD^4*, Mikel Hernáez Arrazola, PhD^3,5,8*, Felipe Prosper, MD, PhD^4,5,9 and David Gomez-Cabrero, PhD^1,10*

¹Bioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal, Saudi Arabia
²Bioengineering Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology KAUST, Thuwal, Saudi Arabia
³Computational Biology Program CIMA-Universidad de Navarra, Cancer Center Clinica Universidad de Navarra, IdISNA, Pamplona, Spain
⁴Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain
⁵Centro de Investigación Biomedica en Red de Cancer (CIBERONC), Madrid, Spain
⁶Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
⁷Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
⁸Center for Data Science and Artificial Intelligence Institute (DATAI), Universidad de Navarra, Pamplona, Spain
⁹Hematology and Cell Therapy Department, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain
¹⁰Translational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain

Tim Robin Wagner^1*, Niklas Kehl^1*, Simon Steiger^1*, Tamara Boschert^1*, Michael Kilian, PhD^2*, Kane A Foster, MSc^3*, Hartmut Goldschmidt, MD⁴, Niels Weinhold, PhD^4*, Steven A. Carr, PhD^5*, Kwee Yong, MD, PhD³, Carsten Müller-Tidow, MD^4*, Karsten Rippe, PhD^1*, Marc S. Raab^4*, Michael Platten, MD^1*, Stefan B Eichmüller^1* and Mirco Julian Friedrich, MD, PhD^5*

¹German Cancer Research Center (DKFZ), Heidelberg, Germany
²Brigham and Women's Hospital, Boston
³Cancer Institute, University College London, London, United Kingdom
⁴Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
⁵Broad Institute of MIT and Harvard, Cambridge, MA

James P. Roy, PhD¹, Ee June Chua^1*, Georgina S.F. Anderson, PhD¹, Ben Uttenthal, MD PhD^2,3* and Michael A. Chapman, PhD^1,3,4,5

¹MRC Toxicology Unit, University of Cambridge, Cambridge, United Kingdom
²Cambridge University Hospitals, Cambridge, United Kingdom
³CRUK Cambridge Centre, Cambridge, United Kingdom
⁴Cambridge University Hospitals NHS Foundation, Cambridge, United Kingdom
⁵Department of Haematology, University of Cambridge, Cambridge, United Kingdom

Holly Lee, MD¹, Sungwoo Ahn, PhD^1*, Mansour Poorebrahim, PhD^1*, David Jung, BSc^1*, Sacha Benaoudia, PhD^1*, Noémie Leblay, PhD^1*, Francesco Maura, MD², Lawrence H. Boise, PhD³, Paola Neri, MD, PhD¹ and Nizar J. Bahlis, MD¹

¹Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
²University of Miami, Coral Gables, FL
³Emory University, Atlanta, GA

Dominic James Fowler-Shorten, MRes, BSc^1*, Charlotte Hellmich, PhD, BSc, MBBChir^1,2, Annalisa Altera, PhD^1*, Rebecca S Maynard, MSc^1*, Katherine Hampton, MSc, BSc^1*, Matthew Markham, PhD^1*, Alyssa Nicole Polski-Delve, MSc, BSc^1*, Kristian Bowles, MBBS, PhD^1,2 and Stuart A Rushworth, PhD³

¹Norwich Medical School, University of East Anglia, Norwich, United Kingdom
²Norfolk and Norwich University Hospital, Norwich, United Kingdom
³The University of East Anglia, Norwich, United Kingdom

Jean-Baptiste Alberge, PhD^1,2,3, Ankit K. Dutta, PhD^1,2,3*, Andrea Poletti^1,4,5*, Oliver Priebe^3*, Tim H.H. Coorens, PhD^3*, Elizabeth D. Lightbody, PhD^1,2,3, Rosa Toenges, MD^1,2,3*, Xavi Loinaz^3*, Sofia Wallin^1*, Andrew Dunford^3*, Cody J. Boehner, BSc^1*, Erica M. Horowitz, BA^1*, Nang Kham Su, MSc^1*, Hadley Barr, BSc^1*, Laura Hevenor^1*, Katherine Towle^1*, Rashmika Beesam^1*, Jenna D. Beckwith^1*, Jacqueline Perry^1*, David M. Cordas dos Santos, MD^1,2,3*, Luca Bertamini, MD^1*, Kirsten Kübler, MD^3,6*, Carolina Terragna, PhD^4*, Elena Zamagni, MD^5,7*, Julian Hess^3*, Romanos Sklavenitis-Pistofidis, MD^1,2,3, Chip Stewart, PhD^3*, Gad Getz, PhD^2,3,8,9* and Irene Ghobrial, MD^1,2,3

¹Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁵Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy
⁶Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
⁷Istituto di Ematologia “Seràgnoli”, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
⁸Department of Pathology, Massachusetts General Hospital, Boston, MA
⁹Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA

Romanos Sklavenitis-Pistofidis, MD^1,2,3, Ting Wu, MS^2*, Elizabeth D. Lightbody, PhD^1,2,3, Yoshinobu Konishi, MD, PhD^1,2,4, Mahshid Rahmat, PhD^1,2,3*, Michael P. Agius, PhD^1,2,5*, Junko Tsuji, PhD^2*, Jean-Baptiste Alberge, PhD^1,2,3, Michael Timonian, MD^1,2,3*, Ankit K. Dutta, PhD^1,2,3*, Michelle P. Aranha, PhD^1,2,3*, Nayda Bidikian, MD^1,2,3*, Hadley Barr, BSc^3*, Nicholas J. Haradhvala, PhD^2*, Moshe Sade-Feldman, PhD^2*, Gad Getz, PhD^1,2,6* and Irene Ghobrial, MD^1,2,3

¹Harvard Medical School, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Dana-Farber Cancer Institute, Boston, MA
⁴Dana-Farber Cancer Institute, Brookline, MA
⁵Dana Farber Cancer Institute, Boston, MA
⁶Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA

Xueping Wan, PhD^1*, Yan Song, PhD^1*, Ting Du, PhD^1*, Arghya Ray, PhD¹, Teng Fang, PhD^1*, Minxing Wang, MS^1*, Sindhu C Pillai, PhD^1*, Md. Abu Musa, PhD^1*, Kenneth Wen, BS^1*, Dharminder Chauhan, PhD^1* and Kenneth C. Anderson, MD²

¹The Jerome Lipper Multiple Myeloma Center,Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, The Jerome Lipper Multiple Myeloma Center, Boston, MA

Fengping Peng^*, Zhaoyun Liu, PhD^*, Fengjuan Jiang^* and Rong Fu, MD

Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China

Joanna Blocka, MD^1,2*, Seong Gu Heo, PhD^3,4*, Shonali Midha, MD^3*, Nathaniel G. Tadros^5*, Steffen B. Kulp^3*, Julia Frede, PhD^3,4,6*, Marius Mathies^3,4*, Nikhil C. Munshi, MD³, Andrew J. Yee, MD^7* and Jens G. Lohr, MD, PhD^3,4

¹Division of Hematologic Neoplasia, Department of Medical Oncology, Dana-Farber Cancer Institute, Dana-Farber Cancer Institute / Harvard Medical School, Boston, MA
²Internal Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany
³Division of Hematologic Neoplasia, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁴Broad Institute of MIT and Harvard, Cambridge, MA
⁵Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA
⁶German Cancer Consortium, Ludwig-Maximilian University of Munich, Munich, Germany
⁷Center for Multiple Myeloma, Mass General Cancer Center, Hematology / Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

Marios Papadimitriou, MD^1*, Sungwoo Ahn, PhD^2*, Benjamin Diamond, MD¹, Holly Lee, MD², John McIntyre^3*, Marietta Truger^4*, Michael Durante, MD, PhD^1*, Bachisio Ziccheddu^1*, Ola Landgren¹, Leo Rasche, MD^5*, Nizar J. Bahlis, MD², Paola Neri, MD, PhD² and Francesco Maura, MD⁶

¹Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
³Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, AB, Canada
⁴MLL Munich Leukemia Laboratory, Munich, Germany
⁵Department of Internal Medicine, University Hospital of Würzburg, Würzburg, Germany
⁶University of Miami, Coral Gables, FL

Mariko Ishibashi, PhD^1*, Mika Sunakawa-Kii, MD^2,3*, Yoichi Imai, MD PhD^4*, Hiroki Yamaguchi, MD⁵, Rimpei Morita, MD, PhD^3* and Hideto Tamura, MD, PhD^6*

¹Department of Microbiology and Immunology, Nippon Medical School, Bunkyo-Ku, Japan
²Department of Hematology, Nippon Medical School, Tokyo, Japan
³Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan
⁴Department of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan
⁵Department of Hematology, Nippon Medical School Hospital, Tokyo, Japan
⁶Division of Diabetes, Endocrinology and Hematology, Department of Internal Medicine, Dokkyo Medical University Saitama Medical Center, Saitama, Japan

Thanh Mai Baumhardt^1*, Vadim Sakk^2*, Karin Soller^2*, Miriam Kull, MD^1*, Jan Kronke, MD³, Hartmut Geiger, Prof.^2* and Medhanie Assmelash Mulaw, Jun.-Prof.^4*

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Ulm University, Ulm, Germany
³Charité University Hospital, Berlin, Germany
⁴Unit for single-cell genomics, Medical faculty Ulm, Ulm, Germany

Xiaoyan Qu^*, Yating Li^*, Zhengxu Sun^*, Wanting Ying^*, Hailing Liu^*, Sanmei Wang^*, Miao Zhong^*, Jianyong Li, MD and Lei Fan^*

Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China

Elizabeth D. Lightbody, PhD^1,2,3, D. R. Mani, PhD^2*, Hasmik Keshishian, PhD^2*, Namrata Udeshi, PhD^2*, Romanos Sklavenitis-Pistofidis, MD^1,2,3, Ankit K. Dutta, PhD^1,2,3*, Ting Wu, MS^2*, Junko Tsuji, PhD^2*, Habib El-Khoury, MD^1,4*, Hadley Barr, BSc^1*, Sarah Nersesian, PhD^5*, Nang Kham Su, MSc^1*, Cody J. Boehner, BSc^1*, Michael P. Agius, PhD^2,3,6*, Michelle P. Aranha, PhD^1,2,3*, Laura Hevenor^1*, Katherine Towle^1*, Grace Fleming^1*, Christian Cea-Curry, MSc^1*, Daniel Heilpern-Mallory^1*, Erica M. Horowitz, BA^1*, Jacqueline F Perry^1*, Maya Davis, BA^1*, Kelly Walsh, PA-C^7*, Annie Cowan, BA^1,8*, John E. Ready, MD^3,7*, Catherine R. Marinac, PhD^1,3, Gad Getz, PhD^2,3,9*, Michael Gillette, MD, PhD^2*, Steven A. Carr, PhD^2* and Irene Ghobrial, MD^1,2,3

¹Dana-Farber Cancer Institute, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Harvard Medical School, Boston, MA
⁴University of Chicago Medical Center, Chicago, IL
⁵Dalhousie University, Halifax, NS, Canada
⁶Dana Farber Cancer Institute, Boston, MA
⁷Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA
⁸Mayo Clinic Alix School of Medicine, Rochester, MN
⁹Department of Pathology, Massachusetts General Hospital, Boston, MA

Yihao Zhan, MD^1,2*, Hongling Peng, MD^3*, David E. Mery, PhD⁴, Eric Siegel^5*, Clyde Bailey, BS^4*, Catherine Ma^6*, Hongwei Xu, DDS^4*, Daisy V. Alapat, MD⁷, Samer Al Hadidi, MD, MSc⁸, Carolina Schinke, MD⁴, Maurizio Zangari, MD⁴, Sharmilan Thanendrarajan, MD⁴, Frits van Rhee, MD, PhD⁴, Guido Tricot, MD^4*, John D Shaughnessy, Jr, PhD^4* and Fenghuang Zhan, MD⁴

¹University of Arkansas for Medical, Little Rock, AR
²Department of Hematology, Second Xiang-ya Hospital, Central South University, Changsha, China
³Department of Hematology, The Second XIANGYA Hospital, Changsha, China
⁴Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR
⁵Department of Biostatistics, University of Arkansas For Medical Sciences, Little Rock, AR
⁶Department of Internal Medicine, University of Arkansas for Medical, Little Rock, AR
⁷Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR
⁸University of Arkansas for Medical Sciences, Little Rock, AR

Teng Fang, PhD^1,2*, Yan Song, PhD^1*, Ting Du, PhD^1*, Arghya Ray, PhD¹, Xueping Wan, PhD^1*, Minxing Wang, MS^1*, Sindhu C Pillai, PhD^1*, Md. Abu Musa, PhD^1*, Mu Hao, MD^3*, Lugui Qiu², Dharminder Chauhan, PhD^1* and Kenneth C. Anderson, MD⁴

¹The Jerome Lipper Multiple Myeloma Center,Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
²State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Dana-Farber Cancer Institute, The Jerome Lipper Multiple Myeloma Center, Boston, MA

Mark B. Meads, PhD^1*, Xiaohong Zhao, MD, PhD^1*, David R. Noyes, MS^1*, Alexandra Achille^1*, Praneeth Reddy Sudalagunta, PhD^2*, Chaomei H. Zhang^3*, Sonila Toska, MEd^1*, Jongphil Kim, PhD^4*, Samer Sansil^5*, Sean J. Yoder, MS^3*, Ariel Grajales-Cruz, MD⁵, Brandon Blue⁶, Ciara Louise Freeman, PhD, MSc, FRCPC, MRCP⁷, Melissa Alsina, MD⁸, Ariosto Siqueira Silva, PhD^9*, Xiaofei Song, PhD^4*, Rachid Baz, MD¹ and Kenneth H. Shain, MD, PhD¹

¹Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁴Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁶H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁷Department of Blood and Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Moffitt Cancer Center, Tampa, FL
⁹Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Yong Zhang, PhD^1*, David G. Coffey, MD², Elizabeth Hill, MD^3*, Frank Cross Jr.^4*, Reena Philip^5*, Marc R. Theoret, MD^5*, Ola Landgren⁶, Andrea C Baines, MD, PhD^4* and Dickran Kazandjian, MD²

¹Center for Drug Evaluation, US Food and Drug Administration, Silver Spring, MD
²Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
³Lymphoid Malignancies Branch, National Institutes of Health, Bethesda, MD
⁴Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
⁵Center for Drug Evaluation and Research, Oncology Center of Excellence, US Food and Drug Administration, Silver Spring, MD
⁶Sylvester Comprehensive Cancer Center, Miami, FL

Bernice Matusow^1*, Sadegh Saghafinia^2*, Pei Pei Li^2*, Amanda Kohler^2*, Pan-Yu Chen, PhD^3*, Christine Nichols^2*, Parmveer Singh^2*, Kerry Inokuchi^2*, Jackie M. Walling, MCBhB PhD² and Gideon Bollag, PhD²

¹Opna Bio LLC, Hayward, CA
²Opna Bio LLC, South San Francisco, CA
³Opna Bio, LLC, South San Francisco, CA

Naser Ansari-Pour, PhD^1*, Mohammad Kazeroun^1*, Seyed Alireza Hasheminasab, PhD^1*, Emma J Lyon^2*, Bethan Hudson-Lund^2*, Evie Fitzsimons^2*, Gaurav Agarwal, MD^3*, Kara-Louise Royle^4*, Matthew W. Jenner^5*, Martin F Kaiser, MD⁶, Karthik Ramasamy, MD, PhD^7,8, Kwee Yong, MD, PhD², Eileen M Boyle, MBChB, PhD², Sarah Gooding, MD, PhD^1,9,10*, Angela Hamblin, MD, PhD^1,10* and Anjan Thakurta, PhD¹

¹Oxford Translational Myeloma Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, United Kingdom
²UCL Cancer Institute, University College London, London, United Kingdom
³Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cambridge
⁴Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, United Kingdom
⁵University Hospital Southampton, Southampton, United Kingdom
⁶The Institute of Cancer Research, London, ENG, United Kingdom
⁷Oxford Translational Myeloma Centre, NDORMS University of Oxford, Department of Haematology, Oxford University Hospitals, NHS Foundation Trust, Oxford, United Kingdom
⁸Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom, Oxford, United Kingdom
⁹MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, ENG, United Kingdom
¹⁰Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom