Alexandra Schurer, MS^1,2, Lindsay Gurska, PhD^1,2*, Yuxuan Wang^1*, Allison Montoya^1*, Swati Goel, MD³ and Kira Gritsman, MD, PhD^1,4

¹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
²The Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY
³Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
⁴Albert Einstein College of Medicine, Bronx, NY

Julia Xu^*, Brian MacDonald, MD^*, John Quisel, PhD^* and Min Wu, PhD

Disc Medicine Inc., Watertown, MA

Nikita Vantsev, BS^1*, Liang Zhao, PhD^1*, Charles S. Abrams, MD¹ and Wei Tong, PhD^2,3

¹Department of Medicine, University of Pennsylvania, Philadelphia, PA
²Children's Hospital of Philadelphia, Philadelphia, PA
³Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Ghazal Narimanfar, MSc^1*, Dorian Forte, PhD^1*, Roberto Maria Pellegrino^2*, Francesca Perut, PhD^3*, Filippo Maltoni, BSc^1*, Martina Barone, PhD^4*, Alessia Brancolini^5*, Filippo Branzanti, MSc^4*, Virginia Pucci^6*, Elisabetta Lugli, MD^6*, Alessia Tieghi, MD^6*, Carla Emiliani, PhD^2*, Regina Grillari, PhD^5*, Pier Luigi Zinzani, MD^1,4, Francesca Palandri, MD, PhD^4* and Lucia Catani, PhD^1,4*

¹Institute of Hematology “L. e A. Seràgnoli”, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
²Department of Chemistry, Biology and Biotechnology, Biochemistry and Molecular Biology Section, University of Perugia, Perugia, Italy
³Biomedical Sciences and Technologies (BST), Biomedical Sciences and Technologies Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy
⁵Evercyte GmbH, Vienna, Austria
⁶Department of Hematology, Azienda USL - IRCCS di Reggio Emilia, Reggio Emilia, Italy

Sarah Awan-Toor^1*, Jimena Castorena^2*, Denis Clay^3*, Juliette Soret-Dulphy^4,5*, Rafael Daltro De Oliveira^5*, Ludovic Drouet^6*, Hélène Pasquer, M.D.^7*, Damien Luque-Paz, PharmD, PhD^8*, Valerie Ugo^9*, Emmanuelle Verger^10*, Nabih Maslah, PharmD, PhD^11,12*, Lina Benajiba, MD, PhD^5,13, Stephane Giraudier^1,12*, Jean-Jacques Kiladjian, MD, PhD^1,4, Bruno Cassinat^14,15 and Laura Velazquez, PhD^2*

¹INSERM UMR 1131, Institut de Recherche Saint-Louis, Paris, France
²INSERM UMRS-MD1197, Hôpital Paul Brousse, Villejuif, France
³INSERM UMS44, Hôpital Paul Brousse, Villejuif, France
⁴Clinical Investigation Center, Saint-Louis Hospital, Paris, France
⁵Hôpital Saint-Louis, Service d’Hématologie seniors, Centre d’Investigation Clinique, 14-27 Saint-Louis, France
⁶Hopital Lariboisière, PARIS, FRA
⁷INSERM UMR944, Institut de Recherche Saint-Louis, PARIS, FRA
⁸Université Angers, Nantes Université, CHU Angers, INSERM, CNRS, CRI2NA, Angers, France
⁹Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, CRCI2NA, Angers, France
¹⁰Laboratoire de Biologie Cellulaire, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, FRA
¹¹INSERM UMR 1131, Institut de Recherche Saint-Louis, Paris, FRA
¹²Laboratoire de Biologie Cellulaire, Université Paris Cité, APHP, Hôpital Saint-Louis, Paris, France
¹³INSERM UMR944, Institut de Recherche Saint-Louis, Paris, France
¹⁴INSERM UMR 1131, Saint-Louis Research Institut, Paris, France
¹⁵Cellular biology departement, Saint-Louis Hospital, Paris, France

Camila Araújo Bernardino Garcia, PhD^1*, Larissa Sarri Binelli^2*, Leonardo Carvalho Palma^3,4, Leticia Olops Marani^5*, Mariana Medeiros^1,2*, Allana Guimarães de Carvalho^2,5*, Priscila Santos Scheucher^6*, Josiane Lillian Schiavinato^1*, Pedro Manoel Marques Garibaldi^5*, Robert Welner, PhD^7,8, Fabíola Attié de Castro^9*, Katia B Pagnano, MD, PhD^10,11 and Lorena Lobo Figueiredo-Pontes, MD, PhD^12,13

¹Division of Hematology, Hemotherapy, and Cellular Therapy, Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, SP, Brazil., Ribeirão Preto, Brazil
²Ribeirão Preto Blood Center Foundation - University of São Paulo, Ribeirão Preto, Brazil
³Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil
⁴Department of Medical Images, Hematology and Clinical Oncology, Hematology division, Ribeirao Preto, Brazil
⁵Hematology Division, Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirao Preto Medical School at University of Sao Paulo, Ribeirao Preto, Brazil, Ribeirão Preto, Brazil
⁶Division of Hematology, Hemotherapy, and Cellular Therapy, Department of Medical Imaging, Hematology, and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, SP, Brazil., Ribeirao Preto, BRA
⁷Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA, Birmingham, AL
⁸Division of Hematology and Oncology, Department of Medicine, UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL
⁹Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil, Ribeirão Preto, Brazil
¹⁰Centro de Hematologia e Hemoterapia (HEMOCENTRO), Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil
¹¹Hematology and Transfusion Medicine Center - University of Campinas/Hemocentro- Unicamp, Campinas, Sao Paulo, Brazil, Campinas, Brazil
¹²Hematology Division, Department of Medical Images, Hematology, and Clinical Oncology, University of Sao Paulo at Ribeirao Preto Medical School, Ribeirao Preto, Sao Paulo, Brazil
¹³Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil, Ribeirão Preto, Brazil

Hongzhe Li, PhD^1*, Alba Sierras, BS^1*, Anne Hultquist, MD, PhD^1,2* and Stefan Scheding, MD^1,3

¹Division of Molecular Hematology and Stem Cell Center, Lund University, Lund, Sweden
²Laboratory Medicine Skane, Department of Clinical Pathology, Lund, Sweden
³Hematology, Skane University Hospital, Lund, Sweden

Jihyun Song, PhD, Soo Jin Kim, MS^*, Grace Min^*, Yewon Lim^* and Josef T. Prchal, MD

Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Eli M Soyfer, MS¹, Jianhong C Heidmann, BS^2*, Helen Huang^3*, Yeowon Jung^2*, Eshika Arora^2*, Lauren Chen^2*, Aanya Amin^2*, Anaya Qamar^4* and Angela G. Fleischman, MD, PhD⁵

¹Medicine, Biological Chemistry, University of California, Irvine, Irvine, CA
²University of California, Irvine, Irvine, CA
³Division of Hematology/Oncology, University of California, Irvine, New Taipei, Taiwan
⁴University of California, Irvine, Irvine
⁵Division of Hematology/Oncology, University of California, Irvine, Irvine, CA

Ivo Veletic, MD^1*, Taghi Manshouri, PhD^1*, C. Cameron Yin, MD, PhD², Christopher D. Pacheco, BS^1*, Christopher P. Ly, MS^1*, Enes Dasdemir^1*, Evan N. Cohen, PhD^3*, Lucia Masarova, MD¹, Naveen Pemmaraju, MD¹, Prithviraj Bose, MD¹, Hagop M. Kantarjian, MD¹, Zeev Estrov, MD¹, Patrick K. Reville, MD, MPH¹, Andrew Dunbar, MD⁴ and Hussein A. Abbas, MD, PhD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX

Franco Castillo Tokumori, MD^1,2, Daniel C Choi, MD^3,4, Ghaith Abu-Zeinah, MD^3,4, Nassima Messali, PhD⁴, Maria Mia Yabut, MS^4* and Joseph M. Scandura, MD, PhD³

¹Weill Cornell Medical College, New York, NY
²New York Presbyterian Hospital - Weill Cornell Medical College, New York, NY
³Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
⁴Weill Cornell Medicine, New York, NY

Idan Goldberg, MD^1,2,3*, Shirly Partouche, PhD^4*, Erez Halperin, MD^1,2*, Bahaa Atamna, MD^5,6*, Adi Shacham Abulafia, MD^1,2*, Saar Shapira, MMSc^4*, Aladin Samara, BSc, MSc^4*, Ayala Gover-Proaktor, PhD^4*, Avi Leader, MD^7,8, Galia Spectre, MD, PhD^1,2*, Pia Raanani, MD^9,10, Galit Granot, PhD^2,4* and Ofir Wolach, MD^1,2*

¹Rabin Medical Center, Institute of Hematology, Petah Tikva, Israel
²Tel Aviv University, The Faculty of Medicine & Health Sciences, Tel Aviv, Israel
³Beilinson Hospital, Rabin Medical Center, Department of Internal Medicine F – Recanati, Petah Tikva, Israel
⁴Rabin Medical Center, Felsenstein Medical Research Center, Petah Tikva, Israel
⁵Rabin Medical Center, Institute of Hematology, Kfar Qara, Israel
⁶Tel Aviv University, The Faculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, Israel
⁷Hematology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Weill Cornell Medical College, New York, NY
⁹Tel Aviv University, The Faculty of Medicine and Health Sciences, Tel Aviv, Israel
¹⁰Davidoff Cancer Center, Rabin Medical Center, Institute of Hematology, Petah Tikva, Israel

Luca Di Marino^1*, Francesco Ramundo^2*, Tanja Malara, MD^3*, Monica Rossi, MD^4*, Roberto Maggi, MD^5*, Federica Fosso^6*, Silvia Betti^7*, Elena Rossi, MD^8*, Giuseppe Leone, Prof⁹, Simona Sica, MD, PhD^10*, Valerio De Stefano, MD^8* and Patrizia Chiusolo, MD, PhD^11*

¹Dipartimento di Scienze di Laboratorio ed Ematologiche-Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma, Italy
²Institute of Hematology, Catholic University School of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Roma, Italy
³Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
⁴Dipartimento di Scienze di Laboratorio ed Ematologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
⁵Dipartimento di Scienze di Laboratorio ed Ematologiche-Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, AL, ITA
⁶Dipartimento di Scienze di Laboratorio ed Ematologiche-Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, ITA
⁷Ematologia Universita Cattolica Sacro Cuore, Roma, Italy
⁸Fondazione Policlinico Gemelli IRCCS, Section of Hematology, Catholic University, Rome, Roma, Italy
⁹Catholic University of Sacred Heart, Roma, RM, ITA
¹⁰Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
¹¹UOC Ematologia e Trapianto Cellule Staminali Emopoietiche, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Rome, Italy

Daniel C Choi, MD¹, Nassima Messali, PhD², Ghaith Abu-Zeinah, MD^1,2, Pouneh Kermani, PhD^2*, Maria Mia Yabut, MS^2*, Franco Castillo Tokumori, MD^1,3, Katie Erdos^1*, Joseph M. Scandura, MD, PhD^1,2, Narasimha Rao Uda, PhD^4*, Heidi Lischer, PhD^5*, Thomas Lehmann, MD^4*, Marta Sobas, MD^6* and Tata Nageswara Rao, PhD^4,7*

¹Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY
²Weill Cornell Medicine, New York, NY
³New York Presbyterian Hospital - Weill Cornell Medical College, New York, NY
⁴Department of Oncology and Hematology, Medical Research Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
⁵Interfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern,, Switzerland
⁶Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Medical University of Wroclaw, Wroclaw, Poland
⁷Institute for Pharmacology, University of Bern, Bern, Switzerland