Xue Chen, MD^1*, Lili Yuan, MD^2*, Xiaoli Ma, MD^1*, Fang Wang, MD^1*, Yang Zhang, MD^1*, Panxiang Cao, MD^2*, Jiancheng Fang, MD^3*, Tong Wang, MD^2*, Jiaqi Chen, PhD^2*, Xiaosu Zhou, PhD^4* and Hongxing Liu, MD^2,5

¹Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
³Department of Clinical Laboratory, Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, China
⁴Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, AL, China
⁵Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China

Kathryn Kimi Shimamoto^1,2*, Arda Arda Karaoglu^1,2*, Zachary Chan^3*, Giorgia Giordano, BE^4*, Bartholomew Eisfelder, PhD^4*, Jason Xiaojun Cheng, MD, PhD⁵, Hamed Youshanlouei^4*, Syed Shah^4*, Anand Ashwin Patel, MD⁶, Adam S. Duvall, MD⁶, Francis Burrows, PhD^7*, Linda Kessler, BA^7*, Michael W Drazer, MD, PhD⁸, Olatoyosi Odenike, MD⁶, Michael J. Thirman, MD⁴, Wendy Stock, MD⁶ and Caner Saygin, MD⁶

¹Section of Hematology/Oncology, The University of Chicago, Chicago, IL, Chicago, IL
²Contributed equally, Chicago
³Cornell University, Ithaca
⁴Section of Hematology/Oncology, The University of Chicago, Chicago, IL, Chicago
⁵Department of Pathology, The University of Chicago, Chicago, IL, Chicago
⁶Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL
⁷Kura Oncology, Carlsbad
⁸Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL

Ryo Nakagawa^1,2*, Yosuke Isobe^3*, Ari Itoh-Nakadai^4*, Haruki Uchino^3*, Minggao Liang^5*, Akiko Kaneko^4*, Kaori Sato^4*, Mariko Tomizawa-Murasawa^4*, Saera Fujiki^4*, Emi Kanamaru^4*, Hanae Amitani^6*, Mikiko Endo^6*, Shinsuke Takagi, MD, PhD^7*, Naoyuki Uchida⁷, Shuichi Taniguchi, MD^7*, Yukihide Momozawa^6*, Yoriko Saito⁴, Makoto Arita^3*, Hideo Harigae, MD, PhD¹ and Fumihiko Ishikawa⁴

¹Department of Hematology, Tohoku University Graduate School of Medicine, Sendai, Japan
²Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Kawasaki, KAN, Japan
³Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁴Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁵Laboratory for Applied Computational Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁶Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁷Department of Hematology, Toranomon Hospital, Tokyo, Japan

Hermione E Allen^1*, Andrew McIntyre, PhD^2*, Jesus Gutierrez-Abril, PhD^3*, Amy A Kirkwood, MSc^4*, Daniel Leongamornlert, PhD^5*, Rodothea Amerikanou, MBBChir^1*, Emily A Cutler, MSc^1*, Aditi Dey, PhD^1*, Richard Burt, PhD, FRCPath, MRCP^6,7*, Ronjon Chakraverty^2* and Adele Kay Fielding, MBBS, PhD^1,8

¹Cancer Institute, University College London, London, United Kingdom
²Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
³Memorial Sloan Kettering Cancer Centre, New York City
⁴Cancer Research UK & UCL Cancer Trials Centre, UCL Cancer Institute, University College London, London, United Kingdom
⁵Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, United Kingdom
⁶Imperial College London, London, United Kingdom
⁷The Francis Crick Institute, London, United Kingdom
⁸Hull York Medical School, University of York, York, United Kingdom

Venkata Sesha Sai Abhinav Ayyadevara, PhD, MS^1*, Gerald Wertheim, MD, PhD^2*, John Chukinas^3*, Joseph Loftus^3*, Sung June Lee^4*, Anil Kumar, PhD^5*, Srividya Swaminathan, PhD⁶, Rahul S Bhansali, MD⁷, Wayne Childers^8*, Huimin Geng, PhD^9*, Thomas A Milne¹⁰, Xianxin Hua, MD, PhD^11*, Kathrin M. Bernt, MD³, Thierry Besson^12*, Junwei Shi, PhD^13*, John D. Crispino, PhD¹⁴, Martin P Carroll, MD², Sarah K Tasian, MD¹⁵ and Christian Hurtz, PhD¹⁶

¹Division of Cancer Sciences, Loma Linda University, Philadelphia, PA
²Division of Hematology/Oncology, Department of Medicine, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA
³Children's Hospital of Philadelphia, Philadelphia, PA
⁴City of Hope Beckman Research Institute, Duarte, CA
⁵City of Hope, Duarte, CA
⁶City of Hope - BRC, Duarte, CA
⁷Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁸Temple University, Philadelphia, PA
⁹Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
¹⁰Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
¹¹University of Pennsylvania, Philadelphia, PA
¹²Normandie University, Rouen, FRA
¹³Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹⁴Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
¹⁵Division of Oncology & Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁶Division of Cancer Sciences, Loma Linda University, Loma Linda, CA

Ting Zhou, MD, PhD^1*, Nicholas J. Short, MD², Nitin Jain, MD², Keyur P. Patel, MD, PhD^3*, Elias Jabbour, MD², Hagop M. Kantarjian, MD², L. Jeffrey Medeiros, MD³ and Bryan Iorgulescu, MD, MPH, FCAP^4*

¹Memorial Sloan Kettering Cancer Center, New York
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Molecular Diagnostics Laboratory, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX

Cheng Wang, MAS^1*, Jianfeng Li, PhD^2*, Weiyang Liu, MD^3*, Han Yan^2*, Yuchen Yan^2*, Lingling Zhao^2*, Jiayi Ren, MD^2*, Lijun Peng^2*, Jiaojiao Zhang^2*, Yuanfang Liu, MD, PhD^2*, Xiangqin Weng, Master^2*, Yongmei Zhu, PhD^2*, Weiping Zhang, MD, PhD^2*, Jie Xu, MD, PhD², Duohui Jing^2*, Jian-Qing Mi^2* and Jin Wang, MD, PhD^2*

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, TX, China
²Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, AL, China

Björn-Thore Hansen^1,2,3*, Thomas Beder^2,3,4*, Sören Döhle^2*, Wencke Walter, PhD⁵, Malwine J Barz, PhD^2,3,4*, Cecilia Bozzetti, MD^2*, Johanna Horns^2,3*, Axel Künstner^6,7*, Alina M. Hartmann^3,4,8*, Sören Franzenburg^9*, Michael Wittig^10*, Barbara Ritter^11*, Stefan Schwartz, MD^12*, Hauke Busch, PhD^6,13*, Nikos Darzentas, PhD^3,14*, Claudia Haferlach, MD¹⁵, Nicola Goekbuget, MD¹⁶, Monika Brüggemann, MD^3,4,14*, Claudia D Baldus, MD^3,4,14* and Lorenz Bastian^2,3,4*

¹(DFG, German Research Foundation): 413490537, Clinician Scientist Program in Evolutionary Medicine funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
²Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
³University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
⁴Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
⁵Munich Leukemia Laboratory, Munich, Germany
⁶Medical Systems Biology Group, University of Lübeck, Lübeck, Germany
⁷University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Lübeck, Germany
⁸Department of Internal Medicine II (Hematology/Oncology), University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁹Institute for Clinical Molecular Biology, Kiel University, Kiel, DEU
¹⁰Institute for Clinical Molecular Biology, Kiel University, Kiel, Germany
¹¹Department of Hematology, Oncology and Immunology, Klinikum Kassel, Kassel, Germany
¹²Department of Hematology, Oncology and Cancer Immunology (Campus Benjamin Franklin), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany
¹³University Cancer Center Schleswig-Holstein, Lübeck, Germany
¹⁴Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
¹⁵MLL Munich Leukemia Laboratory, Munich, Germany
¹⁶Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany

Judith M. Boer, PhD¹, Marco J. Koudijs, PhD^2*, Lennart A. Kester, PhD^2*, Edwin Sonneveld, PhD^2*, Jayne Y. Hehir-Kwa, PhD^1*, Simone Snijder, PhD^3*, Esmé Waanders, PhD^3*, Arjan Buijs, PhD^4*, Valerie de Haas, PhD, MD^1*, Inge M. van der Sluis, MD, PhD¹, Rob Pieters, MD, PhD¹, Monique L. den Boer, PhD¹ and Bastiaan B.J. Tops^1*

¹Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
²Princess Maxima Center for pediatric oncology, Utrecht, Netherlands
³Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands
⁴Genome Diagnostics, University Medical Center Groningen, Groningen, Netherlands

Stefan Habringer^1,2*, Iva Todorova^2*, Frederik Herzberg, MD^2*, Daniel Steiert^2*, Arik Horne, PhD^3*, Thomas Burmeister, MD, PhD^4*, Simon Haas, PhD^3*, Ulrich Keller^1,2,5*, Monika Brüggemann, MD^6,7*, Michaela Kotrova, MD, PhD^6,8*, Claudia D Baldus, MD^6,8*, Nicola Goekbuget, MD^9,10, Martin Neumann, MD^6,8* and Stefan Schwartz, MD^1,2*

¹German Cancer Consortium (DKTK) partner site Berlin, a partnership between DKFZ and Charité – Universitätsmedizin Berlin, Berlin, Germany
²Department of Hematology, Oncology and Cancer Immunology (Campus Benjamin Franklin), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany
³Berlin Institute of Health (BIH), Berlin, Germany
⁴Department of Hematology, Oncology and Cancer Immunology (Campus Virchow Klinikum), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin, Berlin, Germany
⁵Max-Delbrück-Center, Berlin, Germany
⁶University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany
⁷Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
⁸Department of Medicine II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany
⁹Department of Medicine II, Hematology/Oncology, Goethe University, University Hospital, Frankfurt/Main, Germany
¹⁰German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and Goethe University, Frankfurt/Main, Germany

Jayastu Senapati, MD, DM, MBBS¹, Hagop M. Kantarjian, MD¹, Clark Robinson, MD^2*, Koichi Takahashi, MD, PhD³, Nitin Jain, MD¹, Fadi G. Haddad, MD¹, Courtney D. DiNardo, MD, MSc⁴, Sanam Loghavi, MD⁵, Guilin Tang, MD, PhD^5*, Guillermo Montalban-Bravo, MD¹, Tapan M. Kadia, MD¹, Naval Daver, MD⁶, Koji Sasaki, MD¹, Zena Komrokji^7*, Rebecca Garris^1*, Guillermo Garcia-Manero, MD¹, Farhad Ravandi, MBBS⁸, Nicholas J. Short, MD¹ and Elias Jabbour, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, MD Anderson, Saint Paul, MN
³Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶MD Anderson Cancer Center, Houston, TX
⁷Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
⁸Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX

Zuzanna Urbanska^1,2*, Karolina Miarka-Walczyk, M.Sc.^1*, Kamila Wypyszczak, M.Sc.^1*, Borys Styka, M.Sc.^3*, Monika Lejman, Ph.D.^3*, Kinga Ostrowska, Ph.D.^2*, Joanna Taha, Ph.D.^2*, Zuzanna Nowicka, M.D.^4*, Klaudia Starosz^1*, Bartosz Urbanski, M.D.^2*, Katarzyna Adamczewska-Wawrzynowicz, M.D., Ph.D.^5*, Katarzyna Derwich, Prof., M.D., Ph.D.^5*, Wojciech Fendler^4*, Monika Mielcarek-Siedziuk, M.D., Ph.D.^6*, Tomasz Szczepanski, Prof., M.D., Ph.D.⁷, Wojciech Mlynarski, Prof., M.D., Ph.D.^2* and Agata Pastorczak, M.D., Ph.D.^1,2*

¹Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland
²Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland
³Laboratory of Genetic Diagnostics, Medical University of Lublin, Lublin, Poland
⁴Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
⁵Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland
⁶Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, Wroclaw, Poland
⁷Department of Pediatric Hematology and Oncology, Medical University of Silesia, Zabrze, Poland

Heye Yu^1*, Wenbing Liu^2*, Junping Zhang^1*, Leling Xie^1*, Anli Lai^1*, Zheng Tian^1*, Kejing Tang^1*, Haiyan Xing^1*, Wang Ying, M.D.^1*, Hui Wei, MD^3*, Qing Rao^1*, Runxia Gu, MD^1*, Min Wang^1*, Huijun Wang^3*, Jianxiang Wang, MD¹ and Shaowei Qiu, MD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Jason Xu^1,2, Jonathan Sussman^3*, Austin Yang^4*, Satoshi Yoshimura, MD^5*, Changya Chen², Omar Elghawy, MD^6*, Tiffaney Vincent, BS^7*, Caroline Diorio, MD², Shovik Bandyopadyay^4*, Jianzhong Hu, BS^8*, Alexander Lai Li^9*, Gregory M. Chen, MD, PhD^10*, Chia-Hui Chen^11*, Rawan Shraim, PhD^2*, Haley Newman, MD², Yang Ding¹¹, Elizabeth Li, MD^12*, Wenbao Yu^11*, Anusha Thadi^9*, Kyung Jin Ahn^4*, Petri Pölönen, PhD¹³, Abdelrahman Elsayed^8*, David Frank, MD, PhD^14*, Elizabeth A. Raetz, MD¹⁵, Mignon L. Loh, MD, PhD¹⁶, Brent L. Wood, MD, PhD¹⁷, Stuart S. Winter, MD¹⁸, Kimberly P. Dunsmore, MD^19*, Meenakshi Devidas, PhD, MBA²⁰, Chunxu Qu^13*, Stanley Pounds, PhD^21*, Stephen P. Hunger, MD²², Charles G. Mullighan, MBBS, MSc, MD¹³, Jun J. Yang, PhD⁵, Kai Tan, PhD²³ and David T. Teachey, MD²⁴

¹Perelman School of Medicine, Philadelphia, PA
²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
³Perelman School of Medicine, Philadelphia
⁴Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
⁶Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁷The Children's Hospital of Philadelphia, Philadelphia, PA
⁸St. Jude Children's Research Hospital, Memphis, TN
⁹Children's Hospital of Philadelphia, Philadelphia
¹⁰Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
¹¹Children's Hospital of Philadelphia, Philadelphia, PA
¹²Children’s Hospital of Philadelphia, Philadelphia, PA
¹³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
¹⁴Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
¹⁵Department of Pediatrics, NYU Langone Health, New York, NY
¹⁶Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
¹⁷Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA
¹⁸Cancer and Blood Disorders, Children's Minnesota, Eagan, MN
¹⁹University of Virginia Health Sciences Center, Charlottesville, VA
²⁰St Jude Children's Research Hospital, Memphis, TN
²¹Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
²²Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
²³Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
²⁴Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA

Daniel Nguyen, MD, PhD¹, Elias Jabbour, MD², Nitin Jain, MD³, Omer Karrar^4*, Cedric Nasnas, MD^3*, Fadi G. Haddad, MD³, Jayastu Senapati, MD, DM, MBBS³, Tapan M. Kadia, MD³, Rebecca Garris^3*, Hagop M. Kantarjian, MD¹ and Nicholas J. Short, MD³

¹University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas M.D. Anderson Cancer Ctr., Houston, TX
³Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The University of Texas MD Anderson Cancer Center, Houston, TX

Sudeepthi Bandikatla, MBBS, Moazzam Shahzad, MD, Bijal D Shah, MD and Todd C Knepper, PharmD^*

H Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Yang Zhang, MD^1,2*, Ming Liu, MD^1*, Xiaoli Ma, MD^1*, Jiancheng Fang, MD^1*, Fang Wang, MD^1*, Xue Chen, MD^1* and Hongxing Liu, MD^1,2

¹Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Langfang, China
²Precision Medicine Center, Beijing Lu Daopei Institute of Hematology, Beijing, China

Jin Jung, PhD^1,2*, Jae-Ho Yoon, MD, PhD³, Seok Lee, MD³, Ari Ahn, MD^2*, Jong-Mi Lee, MD^1,2*, Yonggoo Kim, MD^1,2* and Myungshin Kim, MD^1,2*

¹Catholic Genetic Laboratory Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)