-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

604.P1.45 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Poster I

Symposia: Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms Program: Oral and Poster Abstracts
Type: Poster
Saturday, December 7, 2024: 5:30 PM-7:30 PM
Halls G-H (San Diego Convention Center)

Kristyna Pimkova1*, Michaela Mysakova1*, Juraj Kokavec1*, Lubomir Minarik1*, Lukas Cermak2* and Tomas Stopka, MD, PhD1

1BIOCEV, Charles University, First faculty of Medicine, Vestec, Czech Republic
2Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic

Warren C. Fiskus, BSc, PhD1, Christopher Peter Mill, PhD, BA2, Jessica Piel, PhD, BA3*, Mike Collins4*, Murphy Hentemann4*, Christine Birdwell, PhD2, Kaberi Das, PhD1*, John A. Davis2*, Hanxi Hou5*, Surbhi Sharma, PhD6, Koji Sasaki, MD7, Sanam Loghavi, MD8, Branko Cuglievan, MD9, Tapan M. Kadia, MD7, Naval Daver, MD2, Courtney D. DiNardo, MD, MSc10 and Kapil N. Bhalla, MD1

1UT MD Anderson Cancer Center, Houston, TX
2MD Anderson Cancer Center, Houston, TX
3Foghorn Therapeutics Inc., Cambridge, MA
4Foghorn Therapeutics, Cambridge, MA
5The University of Texas MD Anderson Cancer Center, Houston, TX
6The UT MD Anderson Cancer Center, Houston, TX
7Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
8Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
9Division of Pediatrics, MD Anderson Cancer Center, Houston, TX
10Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Niklas Kruppa1*, Moritz Kruppa1*, Jana Muschhammer1*, Nadine Felber1*, Franziska Brauneck1*, Franziska Modemann2, Jasmin Wellbrock, Dr.3* and Walter Fiedler, MD1

1Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany, Hamburg, Germany
3University Medical Center Hamburg-Eppendorf, Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hamburg, Germany

Dongchan Kim1,2*, Daehyeon Gwak, M.S.2,3*, Ja Min Byun, MD, PhD2,4, Youngil Koh, MD, PhD2,4, Junshik Hong, M.D., Ph.D.2,3,4, Jung Lim Lee, M.D., Ph.D.5*, Sung-Soo Yoon, M.D., Ph.D.2,3,4 and Dong-Yeop Shin, M.D., Ph.D.2,4*

1Cancer Research Institute, Seoul National University College of Medicine, Seoul, AL, South Korea
2Center for Medical Innovation, Seoul National University Hospital, Seoul, Korea, Republic of (South)
3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
4Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
5Division of Hematology & Medical Oncology, Department of Internal Medicine, Daegu Fatima Hospital Cancer Center, Daegu, Korea, Republic of (South)

Jenna Thibodeau, BS1,2, Jianlei Zhao2,3*, Holly Edwards2,3*, Lisa Polin, PhD2,3*, Juiwanna Kushner2,3*, Sijana H Dzinic2,3*, Kathryn H White2,3*, Maik Hüttemann, PhD4,5*, Tasnim Arroum, PhD4*, Lucynda Pham, PhD4*, Austin C. Boucher, PhD6*, John D. Crispino, PhD7, Jeffrey W. Taub, MD2,8,9 and Yubin Ge, PhD2,3,5

1Cancer Biology Graduate Program, Wayne State University School of Medicine, Warren, MI
2Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
3Department of Oncology, Wayne State University School of Medicine, Detroit, MI
4Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI
5Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI
6Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN
7Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
8Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
9Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI

Min Lu1, MD Babu Mia2*, Lijuan Xia3*, Andrea Ellero, PhD4*, Christopher J. Walker, PhD5 and Ronald Hoffman, MD1

1The Tisch Cancer Institute, Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
2The Tisch Cancer Institute, Division of Hematology&Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
3Tisch Cancer Institute, Department of Medicine, Division of Hematology/Oncology, Myeloproliferative Neoplasm-Research Consortium, Icahn School of Medicine at Mount Sinai, New York, NY
4Karyopharm Therapeutics Inc., Newton, MA
5Karyopharm Therapeutics, Newton, MA

Sylvain Garciaz, MD1*, Rémy Castellano, PhD2*, Arnaud Jacquel, PhD3*, Arnaud Guille4*, Maxence Bourgoin5*, Camille Montersino2*, José Adélaïde6*, Patrick Auberger7*, Daniel Birnbaum, PhD8*, Marie Anne Hospital, MD, PhD9*, Yves Collette10* and Norbert Vey, MD11

1Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, France; Centre National de la Recherche Scientifique, UMR7258, Marseille, France; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, Marseille, France, Marseille, France
2Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, INSERM UMR1068, CNRS UMR7258, Aix Marseille Université U105, Marseille, France
3Centre Méditerranéen de Médecine Moléculaire (C3M), Nice Cedex 03, FRA
4Institut Paoli-Calmettes, Centre De Recherche en Cancérologie De Marseille, 13009 Marseille, FRA
5Centre Méditerranéen de Medecine Moléculaire, Nice, France
6Institut Paoli-Calmettes, MARSEILLE, France
7INSERM U1095/C3M, Nice, FRA
8INSERM UMR599, Marseille, FRA
9Department of Hematology, Institut Paoli-Calmettes, Marseille, France
10INSERM, Marseille, FRA
11Department of Hematology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM, Marseille, France

Matthew F Jones, MD, DPhil1, Cheryl A C Peretz, MD2, Vanessa E. Kennedy, MD3, Elaine Tran1*, Andrew Koh1*, Andriana Kotini4*, Malgorzata Olszewska5*, Eirini Papapetrou, MD, PhD6 and Catherine C. Smith, MD7

1Department of Medicine, Division of Hematology/Oncology, UCSF, San Francisco, CA
2Division of Hematology-Oncology, Dept. of Pediatrics, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
3Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
4Department of Oncological Sciences, Icahn School of Medicine At Mount Sinai, New York, NY
5Department of Oncological Sciences and Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
6Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
7Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA

Craig Leach, PhD1*, Laura Bertoldi2*, Sofia Carbajosa2*, Natalia Cavallo2*, Alejandra Garcia2*, Gastón Soria3, Yue Wei, PhD4*, Courtney D. DiNardo, MD, MSc5, Guillermo Montalban-Bravo, MD6 and Brandon Turunen, PhD1*

1Solu Therapeutics, Boston
2OncoPrecision, Córdoba, Argentina
3OncoPrecision, Maplewood, NJ
4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
5Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
6Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Ana-Leticia Maragno1*, Katherine Seiss2*, Rick Newcombe, MS3*, Prakash Mistry, PhD4*, Christian R Schnell, PhD4*, Fabian Von Arx4*, Julie Koenig4*, Anthony S Malamas, PhD5*, Gaetane Le Toumelin-Braizat6*, Laura Bresson, PhD1*, Francesca Rocchetti, PhD6*, Didier Demarles, PharmD7*, Esther Kurth5*, Lorena Renteria5*, Dominik Hainzl, PhD8*, Volker Engelhardt9*, Caroline Liot, PharmD, PhD10*, Vincent Madelain, PhD6*, Vesela Kostova, PhD6*, Jérôme-Benoit Starck, PhD6*, Damien Valour, PhD6*, Georges-Alain Franzetti, PhD6*, Frederic Colland, PhD11*, Helena Vostiarova9*, William R Tschantz, PhD2*, Nicholas Bachmann12*, Sebastian Palacio-Ramirez12*, Matthew T Burger, PhD13*, Jennifer M Campbell, PhD13*, Zhuoliang Chen, PhD14*, Robert Koenig13*, Eric McNeill, PhD13*, Ruowei Mo13*, Katsumasa Nakajima, PhD13*, Mark G Palermo13*, Yiping Shen13*, Bing Yu13*, Mark Zambrowski13*, Alan Zhang, PhD13*, Frederic Zecri, PhD14*, Alberto Broniscer, MD15,16, Olivier Geneste17*, Kristin Horton, PhD18* and Joseph A D’Alessio, PhD19*

1Oncology Research and Development Unit, Institut de Recherches Servier, Gif-sur-Yvette, France
2Novartis Institutes For Biomedical Research, Cambridge, MA
3ONC, Biological chemistry, Novartis, Cambridge, MA
4ONC, Pharmacology, Novartis, Basel, Switzerland
5ONC, Pharmacology, Novartis, Cambridge, MA
6Institut de Recherches Servier, Gif-sur-Yvette, France
7Technologie Servier, Gif-sur-Yvette, France
8PKS (Pharmacokinetic Sciences), Novartis, Cambridge, MA
9PKS (Pharmacokinetic Sciences), Novartis, Basel, Switzerland
10Oncology Research and Development Unit, Institut de Recherches Servier, Gif-sur-Yvette, France
11Pierre Fabre Laboratories, Paris, France
12BRC (Biologics Research Center), Novartis, Cambridge, MA
13GDC (Global Discovery Chemistry), Novartis, Cambridge, MA
14Novartis, Cambridge, MA
15Bio-Innovation, Servier Pharmaceuticals, Boston, MA
16Therapeutic Area Oncology, Servier, Arlington, MA
17Institut de Recherches International Servier, Gif-sur-Yvette, FRA
18Bio-Innovation, Servier, Boston, MA
19ONC, Biotherapeutics, Novartis, Cambridge, MA

Sudipta Biswas, PhD1*, Zeinab Albadry M. Zahran, MD2,3*, Xiaorong Gu, PhD2*, Lisa Cardone, BSc1*, Akriti G. Jain, MD4, Kateryna Fedorov, MD5, Ben K. Tomlinson, MD6,7, Mendel Goldfinger8,9*, Amit Verma, MD10,11 and Yogenthiran Saunthararajah, MD12

1Cancer Institute, Cleveland Clinic, Cleveland, OH
2Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
3Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
4Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
5Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN
6Department of Hematology and Stem Cell Transplant, University Hospitals Seidman Cancer Center, Cleveland, OH
7Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
8Hematology/Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
9Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
10Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY
11Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Health System, Inc., Bronx, NY
12Department of Translational Hematology and Oncology Research, Cleveland Clinic Case Western Reserve Univ., Cleveland, OH

Ilias Sinanidis, MD1*, Panagiotis Tsakiroglou, PhD1*, Rebecca Foertsch1*, Julia Gondek1*, Benjamin Dubner1*, InYoung Choi, PhD1*, Bogdan Paun, MD1*, Liang Zhao, PhD2*, Everett Stone, PhD3*, George Georgiou, PhD4*, Gabriel Ghiaur, MD, PhD5 and William Brian Dalton, MD, PhD1

1Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD
2Metabolomics, Complete Omics, Baltimore, MD
3Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX
4Department of Chemical Engineering, The University of Texas at Austin, Austin, TX
5Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, John's Hopkins Hospital, Baltimore, MD

Jessica Atkins1*, Anna-Mariya Kukuyan, PhD1*, Malgorzata Drzewiecka2*, Tomasz Sliwinski2*, Monika Toma, PhD1*, Umeshkumar Vekariya, PhD1*, Adam Karami1* and Tomasz Skorski, MD, PhD1

1Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
2University of Lodz, Lodz, Poland

Larissa Balaian, PhD1*, Jessica Pham, BS2*, Anna Kulidjian, MD3*, Edward D. Ball, MD4, Thomas Whisenant, PhD5*, Michael Burkart, Ph.D6* and Catriona Jamieson, MD, PhD7

1Division of Regenerative Medicine, Department of Medicine, and Sanford Stem Cell Institute, UCSD, La Jolla, CA
2University of California San Diego, La Jolla, CA
3Scripps Health Clinic, La Jolla, CA
4Division of Bone and Marrow Transplantation, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
5Center for Computational Biology and Bioinformatics, UCSD, La Jolla, CA
6Department of Chemistry and Biochemistry, UCSD, La Jolla, CA
7Sanford Stem Cell Institute, CIRM UC San Diego Alpha Stem Cell Clinic, La Jolla, CA

Hongfei Zhu1*, Yongzhen Lin1*, Luxia Tang1*, Lihan Dai1*, Meiru Su1*, Ruohan Weng1*, Minghu Liao1*, Lingxi Chen1*, Muzi Wen1*, Qifa Liu, MD2 and Qianli Jiang2*

1Southern Medical University, Guangzhou, China
2Nanfang Hospital, Southern Medical University, Guangzhou, China

Yanxia Shi, PhD1*, Fengli He1*, Li Hu1*, Nannan Yu1*, Linxin Li, DPhil1*, Cuifang Zheng1*, Shuzhen Jiang1*, Tingting Yan1*, Shuo Zhang1*, Yinghui Li1*, Xiangyu Hong1*, Yun Liu, PhD2*, Yixin Ai3*, Jiuyang Zhao, PhD4*, Jingrong Cao, PhD5 and Yihan Wang, PhD5*

1Department of Biological and Translational Research, Shenzhen TargetRx, Inc., Shenzhen, China
2Department of Preclinical Management, Shenzhen TargetRx, Inc., Shenzhen, China
3Department of Computational Chemistry, Shenzhen TargetRx, Inc., Shenzhen, China
4Department of Synthetic Chemistry, Shenzhen TargetRx, Inc., Shenzhen, China
5Shenzhen TargetRx, Inc., Shenzhen, China

Simone Frascolla1*, Sara Milovanovic2*, Giulia Perticari3*, Andrea Cossa1*, Yinxiu Zhan4*, Thalia Vlachou5*, Franco Locatelli, MD6,7,8,9,10,11,12,13 and Pier Giuseppe Pelicci, MD, PhD14,15*

1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
2Dom zdravlja, Belgrade, Serbia
3Princess Maxima Center, Utrecht, Netherlands
4DIMA Laboratory, IEO, European Institute of Oncology IRCCS, Milan, Italy
5Purposeful, Athens, Greece
6Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
7Bambino Gesù Children's Hospital, Rome, Italy
8Catholic University of the Sacred Heart, Rome, Italy
9IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
10IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
11Department of Hematology-Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy
12IRCCS, Ospedale Pediatrico Bambino Gesù Rome, Catholic University of the Sacred Heart, Rome, Italy
13Department of Pediatric Hematology and Oncology, Sapienza University of Rome, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
14Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy
15Università degli Studi di Milano, Milan, Italy

Kotoko Yamatani, MD1*, Kaori Saito1*, Abhishek Maiti, MBBS2, Abdullah Khasawneh1*, Faith Jessica Paran, PhD3*, Tastuya Suzuki, PhD4*, Toru Okamoto, PhD4*, Kala Hayes, PhD5*, Zhihong Zeng, MD5, Courtney D. DiNardo, MD, MSc5, Michael Andreeff, MD, PhD6, Marina Konopleva7 and Yoko Tabe, MD, PhD1,5*

1Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
2Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
3Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
4Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan
5Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
6Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
7Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY

Anya L Levinson, MD1, Nicolas Bland2*, Benjamin J Huang, MD1, Karensa Tjoa2*, Steven P. Angus, PhD3*, Yunlong Liu, PhD4*, Luca Gerosa5*, Darlene Dela Cruz6*, Elisabeth A. Lasater, PhD7*, Udi Segal6*, Scott Foster8* and Kevin Shannon, MD1*

1Department of Pediatrics, University of California, San Francisco, San Francisco, CA
2University of California, San Francisco, San Francisco, CA
3Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis
4Indiana University, Indianapolis, IN
5Department of Oncology Bioinformatics, Genentech, Inc, South San Francisco
6Department of Translational Oncology, Genentech, Inc., South San Francisco
7UCSF, South San Francisco, CA
8Department of Discovery Oncology, Genentech, Inc., South San Francisco

Harish Kumar, PhD1, Mostafa Mohamed2*, Aditi Dhir, MD3*, George M Burslem4*, Xinyang Zhao, PhD1, Rui Lu, PhD5, Erin Ahn, PhD2 and Ravi Bhatia, MD6

1University of Alabama At Birmingham, Birmingham, AL
2Department of Pathology, University of Alabama at Birmingham, Birmingham, AL
3University of Alabama at Birmingham, Birmingham, AL
4Department of Biochemistry and Biophysics, University of Pennsylvania, Pennsylvania, PA
5Department of Medicine, Division of Hematology/Oncology, University of Alabama At Birmingham, Birmingham, AL
6Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL

Marina Able1*, Marc-André Kasper2,3,4*, Binje Vick, PhD5,6*, Jonathan Schwach7*, Xiang Gao, MD8*, Saskia Schmitt2*, Belay Tizazu1*, Amrei Fischer1,5,9*, Sarah Künzl1*, Marit Leilich, MD10*, Isabelle Mai2*, Philipp Ochtrop2,3*, Andreas Stengl7*, Mark A.R. de Geus3*, Michael von Bergwelt-Baildon, MD, PhD11,12,13*, Dominik Schumacher2,3,4*, Jonas Helma2,7*, Katharina S. S. Götze, MD5,10,14, Irmela Jeremias, MD6,15,16, Michaela Feuring, md17* and Karsten Spiekermann, MD1,5,14*

1Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
2Tubulis GmbH, Munich, Germany
3Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany
4Department of Chemistry, Humboldt Universität zu Berlin, Berlin, Germany
5German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany
6Research Unit Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany
7Faculty of Biology, Human Biology and BioImaging, LMU Munich, Planegg-Martinsried, Germany
8Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
9German Cancer Research Center (DKFZ), Heidelberg, Germany
10Department of Medicine III, Hematology and Oncology, Technical University of Munich School of Medicine, Munich, Germany
11Bavarian Cancer Research Center (BZKF), Munich, Germany
12Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
13German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
14Bavarian Cancer Research Center (BZKF), partner site Munich, Munich, Germany
15Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Munich, Germany
16German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and the Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
17Ulm University Hospital, Ulm, Germany

Dominique Sternadt1*, Diego A. Pereira-Martins, Ph.D.1,2*, Douglas RA Silveira, MD, PhD3*, Isabel Weinhaeuser, PhD1,3*, Ming Yang, PhD4*, Prodromos Chatzikyriakou, Ph.D.3*, Pilar Casares Alaez5*, Ayşegül Erdem, Ph.D.6*, Lieve Oudejans, MSc1*, Shanna Hogeling1*, Emanuele Ammatuna, MD, PhD1*, Gerwin Huls1, Christian Frezza, PhD4*, Lynn Quek, MD, Ph.D.3* and Jan Jacob Schuringa, Prof. Dr.1

1Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
2Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
3Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
4University of Cologne, Cologne Excellence Cluster on Stress Responses in Ageing-Associated Diseases, Cologne, Germany
5Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
6Cellular Metabolism and Microenvironment Laboratory, de Duve Institute, UCLouvain, Brussels, Belgium

Vivek M. Shastri, PhD1, Srideshikan Sargur Madabushi, PhD2, Susanta Hui, PhD2* and Jatinder K. Lamba, PhD1,3

1Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
2Radiation Oncology, City of Hope National Medical Center, Duarte, CA
3UF Health Cancer Center, University of Florida, Gainesville, FL

Carmen Jimenez1*, Jose Francisco Lopez2*, Estela Garcia, PhD3*, Laura Diaz Regalado2*, Alejandro Panjkovich2*, Sophie Peng4*, Rama Krishna Narla4*, Noelia Purroy5*, Mark Rolfe4, Daniel W. Pierce6* and Soraya Carrancio, PhD4*

1Bristol Myers Squibb, Seville, CA
2Bristol Myers Squibb, Seville, Spain
3CITRE, Bristol Myers Squibb, Sevilla, Spain
4Research and Development, Bristol Myers Squibb, San Diego, CA
5Bristol Myers Squibb, San Francisco, CA
6Research and Development, Bristol Myers Squibb, Brisbane, CA

John C. Byrd, MD1, Amy Burd, PhD2*, Brian Ledwith, PhD2*, Fraser Pickersgill2*, Kate Dokukina, MD, PhD2*, Ruben Karapetian, PhD3*, Megan E. Johnstone, PhD1, Erin K. Hertlein, PhD1, Ola A. Elgamal, PhD1, Alexei Pushechnikov, PhD2*, Nikolay Savchuk, PhD2* and Iain Dukes, DPhil2*

1Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
2Eilean Therapeutics, Philadelphia, PA
3ChemDiv Inc, San Diego, CA

Franziska Brauneck1*, Stefan Menzel2*, Niklas Kruppa3*, Fritz Koch-Nolte4*, Walter Fiedler, MD3 and Jasmin Wellbrock, Dr.5*

1Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hubertus Wald Tumor Center - University Cancer Center Hamburg Department of Oncology, Hematology and Bone Marrow Transplantatio, Hamburg, Germany
2Department of Immunology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
3Hubertus Wald Tumor Center - University Cancer Center Hamburg Department of Oncology, Hematology and Bone Marrow Transplantatio, Hamburg, Germany
4University Medical Center Hamburg-Eppendorf, Hamburg, Germany
5University Medical Center Hamburg-Eppendorf, Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hamburg, Germany

Lianjun Zhang, PhD1*, Yu-Hsuan Fu, MS1, Wei-Kai Hua2*, Le Xuan Truong Nguyen3*, Xin He, MD4*, Wancheng Guo, MD5*, Yinghui Zhu6*, Ying-Chieh Chen, PhD1*, Zhenhua Chen, PhD7*, Haojie Dong, PhD4*, Lei Zhang, PhD, MD4*, Bin Zhang8, Jeremy Stark9*, Ling Li, PhD4, Guido Marcucci10 and Ya-Huei Kuo, PhD11

1Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
2GenomeFrontier Therapeutics, New Taipei City, Taiwan
3Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, South El Monte, CA
4Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
5City of Hope Medical Center, Duarte, CA
6State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, Shanghai, China
7Department of Systems Biology, City of Hope, Arcadia, CA
8Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
9Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
10Department of Hematologic Malignancies Translational Science, Duarte, CA
11Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope Natl. Medical Center, Duarte, CA

Wing Lam1,2*, Koon C. Chan2,3*, Kwui-Wa Tong2,3*, Ka-Lam Ng, PhD2,3*, Mark R Bray, PhD4,5*, Tak-Wah Mak, PhD2,4,5,6*, Cheuk-Him Man, PhD3* and Anskar Y. H. Leung, MD, PhD2,3,7

1Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
2Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China
3Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
4Treadwell Therapeutics Canada Inc, Toronto, Canada
5Princess Margaret Cancer Centre, The Campbell Family Institute for Breast Cancer Research, Toronto, Canada
6Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
7The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Liang Zhang, PhD1*, Ran Zhao, MSc1*, Hiroki Akiyama, MD, PhD1,2, Jalen Nguyen1*, Kazuharu Kamachi, MD, PhD1*, Saurabh Kumar Gupta, PhD1*, Valeria Impedovo3*, G. Lavender Hackman3*, Michael Andreeff, MD, PhD1, Alessia Lodi, PhD3* and Jo Ishizawa, MD, PhD1

1Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan
3Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX

Shiyuan Zhang1*, Mengyuan Li1,2*, Xiaojian Zhu1*, Hao Zhou3*, Bin Xu1*, Xiwen Tong1*, Su Shuai1*, Yi Zhu1*, Yi Xiao1*, Liang Huang4, Dengju Li1*, Wei Huang1*, Jia Wei1, Mei Huang1* and Donghua Zhang1*

1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of hematology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
3Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
4Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China

*signifies non-member of ASH