Kristyna Pimkova^1*, Michaela Mysakova^1*, Juraj Kokavec^1*, Lubomir Minarik^1*, Lukas Cermak^2* and Tomas Stopka, MD, PhD¹

¹BIOCEV, Charles University, First faculty of Medicine, Vestec, Czech Republic
²Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic

Warren C. Fiskus, BSc, PhD¹, Christopher Peter Mill, PhD, BA², Jessica Piel, PhD, BA^3*, Mike Collins^4*, Murphy Hentemann^4*, Christine Birdwell, PhD², Kaberi Das, PhD^1*, John A. Davis^2*, Hanxi Hou^5*, Surbhi Sharma, PhD⁶, Koji Sasaki, MD⁷, Sanam Loghavi, MD⁸, Branko Cuglievan, MD⁹, Tapan M. Kadia, MD⁷, Naval Daver, MD², Courtney D. DiNardo, MD, MSc¹⁰ and Kapil N. Bhalla, MD¹

¹UT MD Anderson Cancer Center, Houston, TX
²MD Anderson Cancer Center, Houston, TX
³Foghorn Therapeutics Inc., Cambridge, MA
⁴Foghorn Therapeutics, Cambridge, MA
⁵The University of Texas MD Anderson Cancer Center, Houston, TX
⁶The UT MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Division of Pediatrics, MD Anderson Cancer Center, Houston, TX
¹⁰Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX

Niklas Kruppa^1*, Moritz Kruppa^1*, Jana Muschhammer^1*, Nadine Felber^1*, Franziska Brauneck^1*, Franziska Modemann², Jasmin Wellbrock, Dr.^3* and Walter Fiedler, MD¹

¹Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
²Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany, Hamburg, Germany
³University Medical Center Hamburg-Eppendorf, Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hamburg, Germany

Dongchan Kim^1,2*, Daehyeon Gwak, M.S.^2,3*, Ja Min Byun, MD, PhD^2,4, Youngil Koh, MD, PhD^2,4, Junshik Hong, M.D., Ph.D.^2,3,4, Jung Lim Lee, M.D., Ph.D.^5*, Sung-Soo Yoon, M.D., Ph.D.^2,3,4 and Dong-Yeop Shin, M.D., Ph.D.^2,4*

¹Cancer Research Institute, Seoul National University College of Medicine, Seoul, AL, South Korea
²Center for Medical Innovation, Seoul National University Hospital, Seoul, Korea, Republic of (South)
³Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South)
⁴Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
⁵Division of Hematology & Medical Oncology, Department of Internal Medicine, Daegu Fatima Hospital Cancer Center, Daegu, Korea, Republic of (South)

Jenna Thibodeau, BS^1,2, Jianlei Zhao^2,3*, Holly Edwards^2,3*, Lisa Polin, PhD^2,3*, Juiwanna Kushner^2,3*, Sijana H Dzinic^2,3*, Kathryn H White^2,3*, Maik Hüttemann, PhD^4,5*, Tasnim Arroum, PhD^4*, Lucynda Pham, PhD^4*, Austin C. Boucher, PhD^6*, John D. Crispino, PhD⁷, Jeffrey W. Taub, MD^2,8,9 and Yubin Ge, PhD^2,3,5

¹Cancer Biology Graduate Program, Wayne State University School of Medicine, Warren, MI
²Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
³Department of Oncology, Wayne State University School of Medicine, Detroit, MI
⁴Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI
⁵Cancer Biology Graduate Program, Wayne State University School of Medicine, Detroit, MI
⁶Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁷Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
⁹Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI

Min Lu¹, MD Babu Mia^2*, Lijuan Xia^3*, Andrea Ellero, PhD^4*, Christopher J. Walker, PhD⁵ and Ronald Hoffman, MD¹

¹The Tisch Cancer Institute, Division of Hematology & Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²The Tisch Cancer Institute, Division of Hematology&Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
³Tisch Cancer Institute, Department of Medicine, Division of Hematology/Oncology, Myeloproliferative Neoplasm-Research Consortium, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Karyopharm Therapeutics Inc., Newton, MA
⁵Karyopharm Therapeutics, Newton, MA

Sylvain Garciaz, MD^1*, Rémy Castellano, PhD^2*, Arnaud Jacquel, PhD^3*, Arnaud Guille^4*, Maxence Bourgoin^5*, Camille Montersino^2*, José Adélaïde^6*, Patrick Auberger^7*, Daniel Birnbaum, PhD^8*, Marie Anne Hospital, MD, PhD^9*, Yves Collette^10* and Norbert Vey, MD¹¹

¹Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, France; Centre National de la Recherche Scientifique, UMR7258, Marseille, France; Centre de Recherche en Cancérologie de Marseille, INSERM U1068, Marseille, France, Marseille, France
²Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, INSERM UMR1068, CNRS UMR7258, Aix Marseille Université U105, Marseille, France
³Centre Méditerranéen de Médecine Moléculaire (C3M), Nice Cedex 03, FRA
⁴Institut Paoli-Calmettes, Centre De Recherche en Cancérologie De Marseille, 13009 Marseille, FRA
⁵Centre Méditerranéen de Medecine Moléculaire, Nice, France
⁶Institut Paoli-Calmettes, MARSEILLE, France
⁷INSERM U1095/C3M, Nice, FRA
⁸INSERM UMR599, Marseille, FRA
⁹Department of Hematology, Institut Paoli-Calmettes, Marseille, France
¹⁰INSERM, Marseille, FRA
¹¹Department of Hematology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM, Marseille, France

Matthew F Jones, MD, DPhil¹, Cheryl A C Peretz, MD², Vanessa E. Kennedy, MD³, Elaine Tran^1*, Andrew Koh^1*, Andriana Kotini^4*, Malgorzata Olszewska^5*, Eirini Papapetrou, MD, PhD⁶ and Catherine C. Smith, MD⁷

¹Department of Medicine, Division of Hematology/Oncology, UCSF, San Francisco, CA
²Division of Hematology-Oncology, Dept. of Pediatrics, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
³Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Palo Alto, CA
⁴Department of Oncological Sciences, Icahn School of Medicine At Mount Sinai, New York, NY
⁵Department of Oncological Sciences and Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
⁷Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA

Craig Leach, PhD^1*, Laura Bertoldi^2*, Sofia Carbajosa^2*, Natalia Cavallo^2*, Alejandra Garcia^2*, Gastón Soria³, Yue Wei, PhD^4*, Courtney D. DiNardo, MD, MSc⁵, Guillermo Montalban-Bravo, MD⁶ and Brandon Turunen, PhD^1*

¹Solu Therapeutics, Boston
²OncoPrecision, Córdoba, Argentina
³OncoPrecision, Maplewood, NJ
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston
⁵Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Ana-Leticia Maragno^1*, Katherine Seiss^2*, Rick Newcombe, MS^3*, Prakash Mistry, PhD^4*, Christian R Schnell, PhD^4*, Fabian Von Arx^4*, Julie Koenig^4*, Anthony S Malamas, PhD^5*, Gaetane Le Toumelin-Braizat^6*, Laura Bresson, PhD^1*, Francesca Rocchetti, PhD^6*, Didier Demarles, PharmD^7*, Esther Kurth^5*, Lorena Renteria^5*, Dominik Hainzl, PhD^8*, Volker Engelhardt^9*, Caroline Liot, PharmD, PhD^10*, Vincent Madelain, PhD^6*, Vesela Kostova, PhD^6*, Jérôme-Benoit Starck, PhD^6*, Damien Valour, PhD^6*, Georges-Alain Franzetti, PhD^6*, Frederic Colland, PhD^11*, Helena Vostiarova^9*, William R Tschantz, PhD^2*, Nicholas Bachmann^12*, Sebastian Palacio-Ramirez^12*, Matthew T Burger, PhD^13*, Jennifer M Campbell, PhD^13*, Zhuoliang Chen, PhD^14*, Robert Koenig^13*, Eric McNeill, PhD^13*, Ruowei Mo^13*, Katsumasa Nakajima, PhD^13*, Mark G Palermo^13*, Yiping Shen^13*, Bing Yu^13*, Mark Zambrowski^13*, Alan Zhang, PhD^13*, Frederic Zecri, PhD^14*, Alberto Broniscer, MD^15,16, Olivier Geneste^17*, Kristin Horton, PhD^18* and Joseph A D’Alessio, PhD^19*

¹Oncology Research and Development Unit, Institut de Recherches Servier, Gif-sur-Yvette, France
²Novartis Institutes For Biomedical Research, Cambridge, MA
³ONC, Biological chemistry, Novartis, Cambridge, MA
⁴ONC, Pharmacology, Novartis, Basel, Switzerland
⁵ONC, Pharmacology, Novartis, Cambridge, MA
⁶Institut de Recherches Servier, Gif-sur-Yvette, France
⁷Technologie Servier, Gif-sur-Yvette, France
⁸PKS (Pharmacokinetic Sciences), Novartis, Cambridge, MA
⁹PKS (Pharmacokinetic Sciences), Novartis, Basel, Switzerland
¹⁰Oncology Research and Development Unit, Institut de Recherches Servier, Gif-sur-Yvette, France
¹¹Pierre Fabre Laboratories, Paris, France
¹²BRC (Biologics Research Center), Novartis, Cambridge, MA
¹³GDC (Global Discovery Chemistry), Novartis, Cambridge, MA
¹⁴Novartis, Cambridge, MA
¹⁵Bio-Innovation, Servier Pharmaceuticals, Boston, MA
¹⁶Therapeutic Area Oncology, Servier, Arlington, MA
¹⁷Institut de Recherches International Servier, Gif-sur-Yvette, FRA
¹⁸Bio-Innovation, Servier, Boston, MA
¹⁹ONC, Biotherapeutics, Novartis, Cambridge, MA

Sudipta Biswas, PhD^1*, Zeinab Albadry M. Zahran, MD^2,3*, Xiaorong Gu, PhD^2*, Lisa Cardone, BSc^1*, Akriti G. Jain, MD⁴, Kateryna Fedorov, MD⁵, Ben K. Tomlinson, MD^6,7, Mendel Goldfinger^8,9*, Amit Verma, MD^10,11 and Yogenthiran Saunthararajah, MD¹²

¹Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
⁴Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH
⁵Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN
⁶Department of Hematology and Stem Cell Transplant, University Hospitals Seidman Cancer Center, Cleveland, OH
⁷Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH
⁸Hematology/Oncology, Montefiore Medical Center/ Albert Einstein College of Medicine, Bronx, NY
⁹Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
¹⁰Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, NY
¹¹Montefiore Einstein Comprehensive Cancer Center, Blood Cancer Institute, Department of Oncology, Montefiore Health System, Inc., Bronx, NY
¹²Department of Translational Hematology and Oncology Research, Cleveland Clinic Case Western Reserve Univ., Cleveland, OH

Ilias Sinanidis, MD^1*, Panagiotis Tsakiroglou, PhD^1*, Rebecca Foertsch^1*, Julia Gondek^1*, Benjamin Dubner^1*, InYoung Choi, PhD^1*, Bogdan Paun, MD^1*, Liang Zhao, PhD^2*, Everett Stone, PhD^3*, George Georgiou, PhD^4*, Gabriel Ghiaur, MD, PhD⁵ and William Brian Dalton, MD, PhD¹

¹Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD
²Metabolomics, Complete Omics, Baltimore, MD
³Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX
⁴Department of Chemical Engineering, The University of Texas at Austin, Austin, TX
⁵Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, John's Hopkins Hospital, Baltimore, MD

Jessica Atkins^1*, Anna-Mariya Kukuyan, PhD^1*, Malgorzata Drzewiecka^2*, Tomasz Sliwinski^2*, Monika Toma, PhD^1*, Umeshkumar Vekariya, PhD^1*, Adam Karami^1* and Tomasz Skorski, MD, PhD¹

¹Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine, Philadelphia, PA
²University of Lodz, Lodz, Poland

Larissa Balaian, PhD^1*, Jessica Pham, BS^2*, Anna Kulidjian, MD^3*, Edward D. Ball, MD⁴, Thomas Whisenant, PhD^5*, Michael Burkart, Ph.D^6* and Catriona Jamieson, MD, PhD⁷

¹Division of Regenerative Medicine, Department of Medicine, and Sanford Stem Cell Institute, UCSD, La Jolla, CA
²University of California San Diego, La Jolla, CA
³Scripps Health Clinic, La Jolla, CA
⁴Division of Bone and Marrow Transplantation, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA
⁵Center for Computational Biology and Bioinformatics, UCSD, La Jolla, CA
⁶Department of Chemistry and Biochemistry, UCSD, La Jolla, CA
⁷Sanford Stem Cell Institute, CIRM UC San Diego Alpha Stem Cell Clinic, La Jolla, CA

Hongfei Zhu^1*, Yongzhen Lin^1*, Luxia Tang^1*, Lihan Dai^1*, Meiru Su^1*, Ruohan Weng^1*, Minghu Liao^1*, Lingxi Chen^1*, Muzi Wen^1*, Qifa Liu, MD² and Qianli Jiang^2*

¹Southern Medical University, Guangzhou, China
²Nanfang Hospital, Southern Medical University, Guangzhou, China

Yanxia Shi, PhD^1*, Fengli He^1*, Li Hu^1*, Nannan Yu^1*, Linxin Li, DPhil^1*, Cuifang Zheng^1*, Shuzhen Jiang^1*, Tingting Yan^1*, Shuo Zhang^1*, Yinghui Li^1*, Xiangyu Hong^1*, Yun Liu, PhD^2*, Yixin Ai^3*, Jiuyang Zhao, PhD^4*, Jingrong Cao, PhD⁵ and Yihan Wang, PhD^5*

¹Department of Biological and Translational Research, Shenzhen TargetRx, Inc., Shenzhen, China
²Department of Preclinical Management, Shenzhen TargetRx, Inc., Shenzhen, China
³Department of Computational Chemistry, Shenzhen TargetRx, Inc., Shenzhen, China
⁴Department of Synthetic Chemistry, Shenzhen TargetRx, Inc., Shenzhen, China
⁵Shenzhen TargetRx, Inc., Shenzhen, China

Simone Frascolla^1*, Sara Milovanovic^2*, Giulia Perticari^3*, Andrea Cossa^1*, Yinxiu Zhan^4*, Thalia Vlachou^5*, Franco Locatelli, MD^{6,7,8,9,10,11,12,13} and Pier Giuseppe Pelicci, MD, PhD^14,15*

¹Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
²Dom zdravlja, Belgrade, Serbia
³Princess Maxima Center, Utrecht, Netherlands
⁴DIMA Laboratory, IEO, European Institute of Oncology IRCCS, Milan, Italy
⁵Purposeful, Athens, Greece
⁶Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy
⁷Bambino Gesù Children's Hospital, Rome, Italy
⁸Catholic University of the Sacred Heart, Rome, Italy
⁹IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
¹⁰IRCCS Ospedale Pediatrico Bambino Gesù, Catholic University of the Sacred Heart, Rome, Italy
¹¹Department of Hematology-Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy
¹²IRCCS, Ospedale Pediatrico Bambino Gesù Rome, Catholic University of the Sacred Heart, Rome, Italy
¹³Department of Pediatric Hematology and Oncology, Sapienza University of Rome, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
¹⁴Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy
¹⁵Università degli Studi di Milano, Milan, Italy

Kotoko Yamatani, MD^1*, Kaori Saito^1*, Abhishek Maiti, MBBS², Abdullah Khasawneh^1*, Faith Jessica Paran, PhD^3*, Tastuya Suzuki, PhD^4*, Toru Okamoto, PhD^4*, Kala Hayes, PhD^5*, Zhihong Zeng, MD⁵, Courtney D. DiNardo, MD, MSc⁵, Michael Andreeff, MD, PhD⁶, Marina Konopleva, MD⁷ and Yoko Tabe, MD, PhD^1,5*

¹Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
²Department of Leukemia, The University of Texas Health Science Center At Houston, Houston, TX
³Intractable Disease Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
⁴Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY

Anya L Levinson, MD¹, Nicolas Bland^2*, Benjamin J Huang, MD¹, Karensa Tjoa^2*, Steven P. Angus, PhD^3*, Yunlong Liu, PhD^4*, Luca Gerosa^5*, Darlene Dela Cruz^6*, Elisabeth A. Lasater, PhD^7*, Udi Segal^6*, Scott Foster^8* and Kevin Shannon, MD^1*

¹Department of Pediatrics, University of California, San Francisco, San Francisco, CA
²University of California, San Francisco, San Francisco, CA
³Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis
⁴Indiana University, Indianapolis, IN
⁵Department of Oncology Bioinformatics, Genentech, Inc, South San Francisco
⁶Department of Translational Oncology, Genentech, Inc., South San Francisco
⁷UCSF, South San Francisco, CA
⁸Department of Discovery Oncology, Genentech, Inc., South San Francisco

Harish Kumar, PhD¹, Mostafa Mohamed^2*, Aditi Dhir, MD^3*, George M Burslem^4*, Xinyang Zhao, PhD¹, Rui Lu, PhD⁵, Erin Ahn, PhD² and Ravi Bhatia, MD⁶

¹University of Alabama At Birmingham, Birmingham, AL
²Department of Pathology, University of Alabama at Birmingham, Birmingham, AL
³University of Alabama at Birmingham, Birmingham, AL
⁴Department of Biochemistry and Biophysics, University of Pennsylvania, Pennsylvania, PA
⁵Department of Medicine, Division of Hematology/Oncology, University of Alabama At Birmingham, Birmingham, AL
⁶Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL

Marina Able^1*, Marc-André Kasper^2,3,4*, Binje Vick, PhD^5,6*, Jonathan Schwach^7*, Xiang Gao, MD^8*, Saskia Schmitt^2*, Belay Tizazu^1*, Amrei Fischer^1,5,9*, Sarah Künzl^1*, Marit Leilich, MD^10*, Isabelle Mai^2*, Philipp Ochtrop^2,3*, Andreas Stengl^7*, Mark A.R. de Geus^3*, Michael von Bergwelt-Baildon, MD, PhD^11,12,13*, Dominik Schumacher^2,3,4*, Jonas Helma^2,7*, Katharina S. S. Götze, MD^5,10,14, Irmela Jeremias, MD^6,15,16, Michaela Feuring, md^17* and Karsten Spiekermann, MD^1,5,14*

¹Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
²Tubulis GmbH, Munich, Germany
³Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin, Berlin, Germany
⁴Department of Chemistry, Humboldt Universität zu Berlin, Berlin, Germany
⁵German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany
⁶Research Unit Apoptosis in Hematopoietic Stem Cells (AHS), Helmholtz Munich, German Research Center for Environmental Health (HMGU), Munich, Germany
⁷Faculty of Biology, Human Biology and BioImaging, LMU Munich, Planegg-Martinsried, Germany
⁸Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁹German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁰Department of Medicine III, Hematology and Oncology, Technical University of Munich School of Medicine, Munich, Germany
¹¹Bavarian Cancer Research Center (BZKF), Munich, Germany
¹²Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹³German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
¹⁴Bavarian Cancer Research Center (BZKF), partner site Munich, Munich, Germany
¹⁵Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Munich, Germany
¹⁶German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and the Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany
¹⁷Ulm University Hospital, Ulm, Germany

Dominique Sternadt^1*, Diego A. Pereira-Martins, Ph.D.^1,2*, Douglas RA Silveira, MD, PhD^3*, Isabel Weinhaeuser, PhD^1,3*, Ming Yang, PhD^4*, Prodromos Chatzikyriakou, Ph.D.^3*, Pilar Casares Alaez^5*, Ayşegül Erdem, Ph.D.^6*, Lieve Oudejans, MSc^1*, Shanna Hogeling^1*, Emanuele Ammatuna, MD, PhD^1*, Gerwin Huls¹, Christian Frezza, PhD^4*, Lynn Quek, MD, Ph.D.^3* and Jan Jacob Schuringa, Prof. Dr.¹

¹Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
²Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
³Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁴University of Cologne, Cologne Excellence Cluster on Stress Responses in Ageing-Associated Diseases, Cologne, Germany
⁵Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
⁶Cellular Metabolism and Microenvironment Laboratory, de Duve Institute, UCLouvain, Brussels, Belgium

Vivek M. Shastri, PhD¹, Srideshikan Sargur Madabushi, PhD², Susanta Hui, PhD^2* and Jatinder K. Lamba, PhD^1,3

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL
²Radiation Oncology, City of Hope National Medical Center, Duarte, CA
³UF Health Cancer Center, University of Florida, Gainesville, FL

Carmen Jimenez^1*, Jose Francisco Lopez^2*, Estela Garcia, PhD^3*, Laura Diaz Regalado^2*, Alejandro Panjkovich^2*, Sophie Peng^4*, Rama Krishna Narla^4*, Noelia Purroy^5*, Mark Rolfe⁴, Daniel W. Pierce^6* and Soraya Carrancio, PhD^4*

¹Bristol Myers Squibb, Seville, CA
²Bristol Myers Squibb, Seville, Spain
³CITRE, Bristol Myers Squibb, Sevilla, Spain
⁴Research and Development, Bristol Myers Squibb, San Diego, CA
⁵Bristol Myers Squibb, San Francisco, CA
⁶Research and Development, Bristol Myers Squibb, Brisbane, CA

John C. Byrd, MD¹, Amy Burd, PhD^2*, Brian Ledwith, PhD^2*, Fraser Pickersgill^2*, Kate Dokukina, MD, PhD^2*, Ruben Karapetian, PhD^3*, Megan E. Johnstone, PhD¹, Erin K. Hertlein, PhD¹, Ola A. Elgamal, PhD¹, Alexei Pushechnikov, PhD^2*, Nikolay Savchuk, PhD^2* and Iain Dukes, DPhil^2*

¹Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
²Eilean Therapeutics, Philadelphia, PA
³ChemDiv Inc, San Diego, CA

Franziska Brauneck^1*, Stefan Menzel^2*, Niklas Kruppa^3*, Fritz Koch-Nolte^4*, Walter Fiedler, MD³ and Jasmin Wellbrock, Dr.^5*

¹Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hubertus Wald Tumor Center - University Cancer Center Hamburg Department of Oncology, Hematology and Bone Marrow Transplantatio, Hamburg, Germany
²Department of Immunology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
³Hubertus Wald Tumor Center - University Cancer Center Hamburg Department of Oncology, Hematology and Bone Marrow Transplantatio, Hamburg, Germany
⁴University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁵University Medical Center Hamburg-Eppendorf, Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hamburg, Germany

Lianjun Zhang, PhD^1*, Yu-Hsuan Fu, MS¹, Wei-Kai Hua^2*, Le Xuan Truong Nguyen^3*, Xin He, MD^4*, Wancheng Guo, MD^5*, Yinghui Zhu^6*, Ying-Chieh Chen, PhD^1*, Zhenhua Chen, PhD^7*, Haojie Dong, PhD^4*, Lei Zhang, PhD, MD^4*, Bin Zhang⁸, Jeremy Stark^9*, Ling Li, PhD⁴, Guido Marcucci¹⁰ and Ya-Huei Kuo, PhD¹¹

¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
²GenomeFrontier Therapeutics, New Taipei City, Taiwan
³Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope National Medical Center and Beckman Research Institute, South El Monte, CA
⁴Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁵City of Hope Medical Center, Duarte, CA
⁶State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, Shanghai, China
⁷Department of Systems Biology, City of Hope, Arcadia, CA
⁸Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
⁹Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁰Department of Hematologic Malignancies Translational Science, Duarte, CA
¹¹Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope Natl. Medical Center, Duarte, CA

Wing Lam^1,2*, Koon C. Chan^2,3*, Kwui-Wa Tong^2,3*, Ka-Lam Ng, PhD^2,3*, Mark R Bray, PhD^4,5*, Tak-Wah Mak, PhD^2,4,5,6*, Cheuk-Him Man, PhD^3* and Anskar Y. H. Leung, MD, PhD^2,3,7

¹Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
²Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China
³Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⁴Treadwell Therapeutics Canada Inc, Toronto, Canada
⁵Princess Margaret Cancer Centre, The Campbell Family Institute for Breast Cancer Research, Toronto, Canada
⁶Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⁷The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Liang Zhang, PhD^1*, Ran Zhao, MSc^1*, Hiroki Akiyama, MD, PhD^1,2, Jalen Nguyen^1*, Kazuharu Kamachi^1*, Saurabh Kumar Gupta, PhD^1*, Valeria Impedovo^3*, G. Lavender Hackman^3*, Michael Andreeff, MD, PhD¹, Alessia Lodi, PhD^3* and Jo Ishizawa, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan
³Department of Nutritional Sciences, College of Natural Sciences, The University of Texas at Austin, Austin, TX

Shiyuan Zhang^1*, Mengyuan Li^1,2*, Xiaojian Zhu^1*, Hao Zhou^3*, Bin Xu^1*, Xiwen Tong^1*, Su Shuai^1*, Yi Zhu^1*, Yi Xiao^1*, Liang Huang⁴, Dengju Li^1*, Wei Huang^1*, Jia Wei¹, Mei Huang^1* and Donghua Zhang^1*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Department of hematology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
³Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⁴Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China