Michael H. Kramer, MD, PhD¹, Stephanie N Richardson^2*, Yang Li, MD PhD^2*, Tiankai Yin, BA², Nichole Helton^2*, Daniel George^2*, Michelle Cai, MD^2*, Sai Mukund Ramakrishnan, MS^2*, Christopher A Miller, PhD^2* and Timothy J Ley, MD²

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO
²Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Michael S Bowman, PhD^1*, Maria A. Telpoukhovskaia, PhD^2*, Jennifer J. Trowbridge, PhD² and Robert L. Bowman, PhD¹

¹Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA
²The Jackson Laboratory, Bar Harbor, ME

Neetij Krishnan^1*, Stephanie Crowley¹, Lynn S. White^1*, Wei Yang, PhD^2*, Jeffrey A. Magee, MD, PhD¹ and Jeffrey J. Bednarski, MD, PhD¹

¹Department of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine, Saint Louis, MO
²Department of Genetics, Washington University School of Medicine, Saint Louis, MO

Monica Nathan, BS^1*, Ahmed Mahmoud, MD^2*, Nancy BJ Arthur, PhD², Agata Gruszczynska^3*, Stephen Sykes, PhD⁴ and Francesca Ferraro, MD, PhD⁵

¹Internal Medicine, Oncology, Washington Univeristy in Saint Louis, Saint Louis, MO
²Department of Internal Medicine, Division of Oncology, Washington University of Saint Louis, School of Medicine, Saint Louis
³Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
⁴Department of Pediatrics, Washington University School of Medicine, St Louis, MO
⁵Department of Internal Medicine, Division of Oncology, Washington University of Saint Louis, School of Medicine, SAINT LOUIS, MO

Qiong Wu, PhD^1*, Chunjie Yu, PhD^1*, Fang Yu, PhD^1*, Yiran Guo, PhD^2*, Yue Sheng, PhD³, Liping Li, MD^4*, Yafang Li, PhD^1*, Yutao Zhang^3*, Chao Hu, MD^5*, Jue Wang, PhD^1*, Tong-Chuan He, PhD^6*, Yong Huang, PhD^7*, Hongyu Ni, MD⁸, Zhigang Hou, PhD^9*, Wenshu Wu, PhD^5*, Greg G Wang, PhD^10*, Jianxin Lyu, PhD^11* and Zhijian Qian¹

¹Division of Hematology/Oncology, Department of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL
²Department of Pharmacology and Cancer Biology, Duke University, Durham, NC
³Division of Hematology/Oncology, Department of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville
⁴Department of Pathology at Geisinger Medical Center, Danville
⁵University of Illinois at Chicago, Chicago
⁶University of Chicago, Chicago
⁷University of Virginia, Charlottesville
⁸Cedars Sinai Medical Center, Los Angeles, CA
⁹Department of Biostatistics, University of Florida, Gainesville
¹⁰Department of Pharmacology and Cancer Biology, Duke University, Durham
¹¹People's Hospital of Hangzhou Medical College, Hangzhou, CHN

Hongwei Peng^1*, Wan Jiaqi^1*, Jinfang Hu^2*, Fei Li^3,4,5 and Xintong Yang^6*

¹Nanchang University, Nanchang, China
²Department of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
³First Affiliated Hospital of Nanchang University, Nanchang, China
⁴Department of Hematology, Jiangxi Clinical Research Center for Hematologic Disease, Jiangxi Provincial Key Laboratory of Hematological Diseases, The First Affiliated Hospital, Jiangxi Medical College, Nanchang, Jiangxi Province, China
⁵Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China
⁶School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, China

Josephine Jagd Brysting^1,2*, Christian Rohde, PhD^3,4*, Laura Villacorta^5*, Vladimir Benes^6*, Simon Renders, MD^7,8*, Judith Zaugg^9* and Carsten Müller-Tidow, MD^8,10*

¹Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL), University of Heidelberg, Heidelberg, Germany
²Department of Internal Medicine V, Hematology, Rheumatology, Oncology, University Hospital Heidelberg, Heidelberg, AL, Germany
³Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
⁴Molecular Medicine Partnership Unit, European Molecular Biology Lab (EMBL), Heidelberg, Germany
⁵Genomic Core Facility, European Molecular Biology Laboratories, Heidelberg, Heidelberg, Germany
⁶Genomic Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
⁷Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany
⁸Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁹Molecular Medicine Partnership Unit, European Molecular Biology Laboratory (EMBL) and University Hospital Heidelberg, Heidelberg, Germany
¹⁰European Molecular Biology Lab (EMBL), Molecular Medicine Partnership Unit, Heidelberg, Germany

Ke Wang, PhD^1*, Shayan Saniei^1*, Nikita Poddar^1*, Subrina Persaud^1*, Meghana Sreenath^1*, Miguel Quijada-álamo, PhD^1*, Grace Freed^1*, Anna Huo Chang Mei^1*, Noshin Rahman^1*, Jerry Chipuk^1* and Elvin Wagenblast, PhD^1,2,3

¹Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
²Department of Pediatrics, Division of Pediatric Hematology-Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
³Black Family Stem Cell Institute, Tisch Cancer Institute, Mindich Child Health & Development Institute, Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY

Mariam Hakobyan^1,2,3*, Jens Langstein, Dr. rer. nat.^1,4*, Emely Kleinert^5*, Maximilian Schoenung, Dr. rer. nat.^1,5*, Mark Hartmann, Dr. rer. nat.^1*, Hannah Rohdjess, M.Sc.^1,5*, Jessica Wojtarowicz, B.Sc.^1,5*, Sina Staeble, Dr. rer. nat.^1,6*, Rainer Claus, MD^7*, Lars Bullinger⁸, Christopher C. Oakes, PhD⁹, Katharina Zoldan, Dr.^10*, Michael Cross, Dr.^10*, Uwe Platzbecker, MD¹¹, Niclas Kneisel, Dr. rer. nat.^12*, Simon Raffel, MD^13*, Ulrich Germing, MD^14*, Gregor Hoermann, PhD^15*, Karsten Rippe, PhD^16*, Stefan Fröhling, MD^17,18,19*, Stefan Pusch, Dr. rer. nat.^20*, Christoph Plass, Dr. rer. nat.^21*, Michael D. Milsom, PhD^22,23 and Daniel Lipka, MD^1,5,24*

¹NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany
²Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, AL, Germany
³Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
⁴NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, German Cancer Research Center, Heidelberg, Germany
⁵Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center, Heidelberg, Germany
⁶Section of Translational Cancer Epigenomics, Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, German Cancer Research Center, Heidelberg, Germany
⁷Personalized Tumor Medicine and Molecular Oncology, University Hospital Augsburg, Augsburg, DEU
⁸Department of Hematology, Oncology, Tumor Immunology, Charité University Medicine, Berlin, Germany
⁹Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH
¹⁰Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, University Medical Center Leipzig, Leipzig, Germany
¹¹Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹²SERVIER Germany, Munich, Germany
¹³Department of Medicine V, Universität Heidelberg, Heidelberg, Germany
¹⁴Department of Hematology, Oncology and Clinical Immunology, University Medical Center Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany
¹⁵MLL Munich Leukemia Laboratory, Munich, Germany
¹⁶German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁷Division of Translational Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany
¹⁸German Cancer Consortium (DKTK), Heidelberg, Germany
¹⁹Institute of Human Genetics, Heidelberg University, Heidelberg, Germany
²⁰Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany
²¹Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany
²²The Heidelberg Institute for Stem Cell Technology and Experimental Medicine GmbH, Heidelberg, Germany
²³Division of Experimental Hematology, German Cancer Research Center, Heidelberg, Germany
²⁴Division of Translational Medical Oncology, German Cancer Research Center, Heidelberg, Germany

Sarada Ketharnathan, PhD¹, Keon Collett, BSc^2*, Anna Pawelko^3*, Benno Orr^4*, Sergey V Prykhozhij, PhD^1*, Martin Hirst, PhD, BSc^5* and Jason N. Berman, MD¹

¹CHEO Research Institute, Ottawa, ON, Canada
²Cumming School of Medicine, University of Calgary, Calgary, Canada
³University of Ottawa, Ottawa, Canada
⁴Department of Molecular Genetics, University of Toronto, Toronto, Canada
⁵Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada

Michael E Lawler^1*, Jennifer Romer-Seibert, PhD^2*, Michael S Bowman, PhD^3*, Ramkrishna Mitra, PhD^2*, Christine Eischen, PhD^2*, Robert L. Bowman, PhD³ and Sara E. Meyer, PhD²

¹Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA
²Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, PA
³Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA

Taishi Yonezawa, PhD¹, Mikolaj Slabicki, PhD^2*, Justine Rutter^3*, Venkatasubramaniam Sundaramurthy, MS^4,5, Gandhar Datar, BS¹, Benjamin Levine Ebert, MD, PhD^3,6,7,8,9 and Margaret Goodell, PhD^4,10,11

¹Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX
²Massachusetts General Hospital Cancer Center, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston
⁵Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
⁶Center for Prevention of Progression, Dana-Farber Cancer Institute, Boston, MA
⁷Broad Institute of MIT and Harvard, Cambridge
⁸Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston
⁹Harvard Medical School, Boston, MA
¹⁰Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston
¹¹Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX

Xiaoting Liang, Ph.D.^1*, Yijie Zhai^2*, Siqi Li, M.D.^3*, Huiyun Peng, Ph.D.^4*, Yun Huang^5*, Youxin Feng^5*, Tiebang Kang, Ph.D.^6*, Yizhou Zou, Ph.D.^7*, Xiao Jun Huang, M.D.³, Yingjun Chang, MD^3* and Mi Deng, PhD^1*

¹Peking University International Cancer Institute, Peking University, Beijing, China
²Department of Immunology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing, China
³Department of Hematology, Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China
⁴Nanchang University, Nanchang, China
⁵Peking University Cancer Hospital & Institute, Beijing, China
⁶Sun Yat-Sen University Cancer Center, Guangzhou, China
⁷Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, China

Jasmin Straube^1,2*, Julian Grabek, MBBS, FRACP, FRCPA^1,3*, Leanne Cooper^3*, Rohit Haldar^3*, Caroline McNamara, MBBS, FRACP, FRCPA^4*, David M Ross, MD, PhD, FRACP, FRCPA^5*, Andrew Charles Perkins, MBBS, PhD⁶, Megan Bywater, PhD^1,3* and Steven W Lane, MBBS, PhD, FRCPA, FRACP^1,4,7

¹The University of Queensland, Brisbane, Australia
²Cancer Research Program, QIMR Berghofer, Brisbane, Australia
³Cancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
⁴Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia
⁵Royal Adelaide Hospital, Adelaide, SA, Australia
⁶Australian Centre for Blood Diseases, Monash University, South Yarra, VIC, Australia
⁷Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia

Paniz Tavakoli, PhD^1,2*, Megan Bywater, PhD^1,2*, Jasmin Straube^2,3*, Victoria Ling, MBBS, PhD^1,2*, Emily Cooper^1*, Rohit Haldar^1*, Yashaswini Janardhanan^1*, Leanne Cooper^1*, Claudia Bruedigam, PhD^1,2*, Carolyn S. Grove, MBBS, FRACP, FRCPA, PhD⁴ and Steven W Lane, MBBS, PhD, FRCPA, FRACP^2,5,6

¹Cancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
²The University of Queensland, Brisbane, Australia
³Cancer Research Program, QIMR Berghofer, Brisbane, Australia
⁴School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
⁵Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia
⁶Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

Alessandra Hartke^1,2*, Julia Klotz^1,2*, Axel Künstner, PhD^2,3*, Anke Fähnrich, PhD^2,3*, Hauke Busch, PhD^2,3*, Timo Gemoll, PhD^2,4*, Jasmin Osius^1,2*, Steffen Koschmieder, MD^5,6, Tim H. H. Brummendorf, MD^6,7, Heike L. Pahl, PhD^8*, Florian H. Heidel, MD⁹, Konstanze Döhner, MD¹⁰, Martin Griesshammer, Prof. Dr. med.¹¹, Andreas Reiter, MD¹², Justus Duyster, MD^13*, Nikolas C. C. von Bubnoff, Prof. Dr. med.^1,2* and Sivahari P. Gorantla, PhD^1,2*

¹University Hospital Schleswig-Holstein, Department of Hematology and Oncology, Lübeck, Germany
²University Cancer Center Schleswig-Holstein, Lübeck, Germany
³Group for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany
⁴University Hospital Schleswig-Holstein, Translationale Chirurgische Onkologie und Biomaterialbanken, Lübeck, Germany
⁵Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University, Medical Faculty, Aachen, Germany
⁶Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany
⁷Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, University Medical Center Aachen, Aachen, Germany
⁸Universitätsklinikum Freiburg, Klinik für Hämatologie und Onkologie, Freiburg, Germany
⁹Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
¹⁰Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹¹University Clinic for Hematology, Oncology, Hemostasis and Palliative Care, Johannes Wesling Medical Center, University of Bochum, Minden, Germany
¹²Department of Hematology and Oncology, University Medical Centre Mannheim, Mannheim, Germany
¹³University Hospital Freiburg, Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg, Germany

Christopher Peter Mill, PhD, BA¹, Warren C. Fiskus, BSc, PhD², Christine Birdwell, PhD¹, John A. Davis^1*, Kaberi Das, PhD^2*, Hanxi Hou^3*, Surbhi Sharma, PhD⁴, Koji Sasaki, MD⁵, Sanam Loghavi, MD⁶, Tapan M. Kadia, MD⁵, Naval Daver, MD¹, Courtney D. DiNardo, MD, MSc⁷, Lu Wang^8* and Kapil N. Bhalla, MD²

¹MD Anderson Cancer Center, Houston, TX
²UT MD Anderson Cancer Center, Houston, TX
³The University of Texas MD Anderson Cancer Center, Houston, TX
⁴The UT MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁸Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL

César Alexander Ortiz Rojas, PhD^1*, Diego A. Pereira-Martins, Ph.D.^2,3,4*, Carol Thomé, PhD^5*, Germano Ferreira, PhD^6*, Thiago Mantello Bianco, Ph.D.^7*, Isabel Weinhäuser, PhD^8,9*, Cleide Lúcia Araújo Silva, PhD^10*, Lorena Pontes^11*, Vitor Faça, PhD^5*, Emanuele Ammatuna, MD, PhD^8*, Gerwin Huls³, Jan Jacob Schuringa, Prof. Dr.⁸ and Eduardo M. Rego, MD, PhD¹²

¹Laboratório de Investigação Médica (LIM) 31, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, University of São Paulo, São Paulo, AL, Brazil
²Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, University of São Paulo Medical School, São Paulo, Brazil
³Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, Netherlands
⁴Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University Medical Center Groningen, Groningen, Netherlands
⁵Center for Cell-Based Therapy, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, São Paulo, Brazil
⁶Medical School of Ribeirao Preto, University of São Paulo, Ribeirão Preto, BRA
⁷Department of Medical Images, Haematology, and Clinical Oncology, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Brazil
⁸Department of Experimental Hematology, University Medical Center Groningen, Groningen, Netherlands
⁹Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
¹⁰Blood Center of Ribeirao Preto, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Ribeirão Preto, Brazil
¹¹4Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil
¹²Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, University of São Paulo Medical School, São Paulo, São Paulo, Brazil

Maximilian Holz^1,2*, Bertram Klinger^3,4*, Felix Stuckenbrok^1,5,6*, Stefanos A. Bamopoulos, MD^7,8*, Sanket Gosavi^5*, Caroline Bräuning^9*, Janine Altmüller^9*, Roland Rad^10*, Torsten Haferlach, MD⁶, Nils Blüthgen^11,12*, Ulrich Keller^13,14,15,16*, Thomas Conrad^17* and Francis Baumgartner^1,5,6,12*

¹Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
²Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité, Berlin, DEU
³Institute of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany
⁴Institute for Theoretical Biology, Humboldt-Universität zu Berlin, Berlin, Germany
⁵Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁶MLL Munich Leukemia Laboratory, Munich, Germany
⁷Max-Delbrück-Center for Molecular Medicine,, Berlin, Germany
⁸Department of Hematology, Oncology and Tumor Immunology (Campus Benjamin Franklin), Charité University Medicine Berlin, Berlin, DEU
⁹Genomics Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
¹⁰Institute of Molecular Oncology and Functional Genomics, Technical University of Munich, Munich, Germany
¹¹Institute of Pathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
¹²German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Berlin, Germany
¹³German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁴Max-Delbrück-Center, Berlin, Germany
¹⁵Hematology, Oncology and Cancer Immunology, Charité - University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany
¹⁶German Cancer Consortium (DKTK) partner site Berlin, a partnership between DKFZ and Charité – Universitätsmedizin Berlin, Berlin, Germany
¹⁷Genomics Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, DEU

Rebecca Voss, MD^1*, Wenqing Qi^1*, Yen-Chun Liu, MD, PhD^2*, Jing Ma, PhD^3*, La'Ron Browne, MBBS, MSc^1*, Mahsa Khanlari, MD¹, Juan M Barajas, PhD³, Melvin Thomas III, PhD⁴, Victor B Pastor Loyola, PhD^2*, Hui Cao^5*, Seth E. Karol, MD⁶, Jeffrey E. Rubnitz, MD, PhD⁷, Jeffery M Klco, MD, PhD³ and Lu Wang, MD, PhD^2*

¹St. Jude Children's Research Hospital, Memphis, TN
²Department of Pathology, St. Jude Children's Research Hospital, Memphis
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴St. Jude Children's Research Hospital, Bartlett, TN
⁵St. Jude Children's Research Hospital, Memphist, TN
⁶Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
⁷Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

Pia Christin Radszuweit^1,2*, Barbara Mankel^3*, Fulya Korkmaz^2*, Hildegard Keppeler^2*, Claudia Lengerke, MD⁴, Dominik Schneidawind^1,2* and Corina Schneidawind, MD, PhD^1,2*

¹Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
²Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany
³Institute of Pathologie, Tübingen, DEU
⁴Department for Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tuebingen, Germany

Lingli He, PhD^1,2,3*, Ting Zhao, PhD^2*, Wei Zhong Leong, Ph.D.^1*, Azeem Sharda^1*, Christina Mayerhofer, MD^2*, Shenglin Mei, PhD^2*, Gracia M. Bonilla, PhD^4*, Juan Bautista Menendez-Gonzalez, PhD^1*, Karin Gustafsson, PhD^2*, Tsuyoshi Fukushima, MD, PhD^2*, Trine A. Kristiansen, PhD^2*, Ji-Won Lee, PhD^2*, Yanxin Xu, PhD^2*, Bogdan Budnik, PhD^5*, Ruslan Sadreyev, PhD^4*, Zhixun Dou, PhD^2*, David B. Sykes, MD, PhD² and David Scadden, MD^1,2,3

¹Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
²Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
³Harvard Stem Cell Institute, Cambridge, MA
⁴Department of Molecular Biology, Massachusetts General Hospital, Boston, MA
⁵Mass Spectrometry and Proteomics Research Laboratory, Harvard University, Cambridge, MA

Lu Zhang^1*, Xuefeng Wang^2,3*, Dongmei Hu^4*, Shijie Li^4*, Mingshan Sun^4*, Qian Liu^4*, Huimin Feng^4*, Minran Zhou^4*, Chen Chunyan, MD⁴, Huan Zhou^2,3* and Sai Ma^4*

¹Department of Hematology, Qilu Hospital of Shandong University, Jinan, AL, China
²National Drug Clinical Trial Institution, the First Affiliated Hospital of Bengbu Medical University, Bengbu, China
³Key Laboratory of Innovative Drug Pharmaceutical Research and Clinical Evaluation Jointly Established Disciplines in Anhui Province, Hefei, China
⁴Department of Hematology, Qilu Hospital of Shandong University, Jinan, China

Xuefei Ma, MS^1,2*, Weifen Sun, PhD^3*, Yilu Li, PhD^3*, Yun Tan, PhD³, Xuefeng Wang, MD, PhD^2* and Kankan Wang, MD, PhD^4*

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai, China
²Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
³Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⁴Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China