66th ASH Annual Meeting: 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Poster I

Symposia: Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational Oral and Poster Abstracts
Poster

Research, Fundamental Science, Artificial intelligence (AI), Bone Marrow Failure Syndromes, Translational Research, CHIP, Genomics, Bioinformatics, Hematopoiesis, Diseases, Immune Disorders, Cell expansion, Immunodeficiency, Neutropenia, Metabolism, Computational biology, White blood cell disorders, Biological Processes, Myeloid Malignancies, Emerging technologies, Technology and Procedures, Molecular biology, Study Population, Profiling, Animal model, Machine learning, Omics technologies

Halls G-H (San Diego Convention Center)

1271

The Sterile Alpha Motif Protein-1 Transcription Factor Controls Hematopoiesis through Modulation of H3K4 Methylation

Meg Schaefer¹^*, Venkatasai Rahul Dogiparthi, BS², Yichao Zhou² and Kyle J Hewitt, PhD²

¹University of Nebraska Medical Center, Omaha, NE
²Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE

1272

Hematopoietic Stem Cell Function and Differentiation Is Regulated By DCAF7 through Polycomb Repressive Complex 1 (PRC1) Modulation

Johanna Melo-Cardenas, PhD¹, Lavanya Bezavada, MS²^*, Te Ling, PhD², Amber Broadhurst³^*, Anitria Cotton, MBA, BS²^*, Jeremy Chase Crawford, PhD⁴^*, Amanda Nourse⁵^*, Vishwajeeth Pagala⁶^*, Qiong Zhang⁷^*, Wojciech Rosikiewicz, PhD⁸^*, Hongjian Jin⁷^*, Dirk Loeffler, PhD⁶ and John D. Crispino, PhD²

¹Pathology, Northwestern University, Chicago, IL
²Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
³St Jude Children's Research Hospital, Memphis, TN
⁴Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN
⁵St Jude Children's Research Hospital, Germantown
⁶St. Jude Children's Research Hospital, Memphis, TN
⁷St Jude Children's Research Hospital, Memphis
⁸Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN

1273

CD38 Inhibition Enhances Human Hematopoietic Stem Cell Maintenance in Ex Vivo Cultures

Jianyi Ding¹^*, Daisuke Araki, MD¹, Yongqin Li¹^*, Ronald Holewinski²^*, Oladele A. Oluwayiose³^*, Poching Liu⁴^* and Andre Larochelle, MD, PhD¹

¹Cellular and Molecular Therapeutics Branch, National Heart Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD
²Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD
³Integrated Data Sciences Section (IDSS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
⁴DNA Sequencing and Genomics Core, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD

1274

RNA Sequestration Controls Hematopoietic Stem Cell Quiescence and Function

Caroline Sands^*, Srikanth Kodali, PhD^* and Bruno Di Stefano, PhD, MSc, BSc

Baylor College of Medicine, Houston, TX

1275

Ribosomal RNA Transcription Is Differentially Regulated Across the Hematopoietic Tree

Eleanor Sams¹^*, Victoria Feist¹^*, Erin Gray¹^*, Charles Antony, PhD², Jill Henrich¹^* and Vikram R Paralkar, MD²

¹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
²Department of Medicine, University of Pennsylvania, Philadelphia, PA

1276

Reticular Dysgenesis-Associated Adenylate Kinase 2 Deficiency Has Opposing Metabolic Consequences on Granulopoiesis and Lymphopoiesis

Wenqing Wang, PhD¹, Martin Arreola, BS²^*, Abdulvasey Mohammed, BS³^* and Katja G. Weinacht, MD, PhD²

¹Department of Pediactrics, Stanford University School of Medicine, Stanford, CA
²Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
³Department of Pediatrics, Stanford School of Medicine, Stanford, CA

1277

High Mobility Group A1 (HMGA1) Chromatin Regulators Maintain Quiescent, Regenerative HSC By Repressing IGF1 Networks That Promote Stem Cell Aging

Zanshe Thompson, PhD, MS¹, Li Z Luo, PhD²^*, Liping Li, MD, PhD³^*, Bowen Wang, MS⁴^*, Jung-Hyun Kim, PhD³^*, Lingling Xian, MD, PhD³^*, Bailey West, BS⁵^*, Leslie Cope, PhD⁶^*, John Lister, MD⁷ and Linda Resar, MD⁸

¹Division of Hematology, The Johns Hopkins University School of Medicine, Owings Mills, MD
²Department of Medicine, Division of Hematology, The Johns Hopkins University School of Medicine, Baltimore, MD
³The Johns Hopkins University School of Medicine, Baltimore, MD
⁴The Johns Hopkins University School of Medicine, Baltimore
⁵Pathobiology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Johns Hopkins University School of Medicine, Baltimore, MD
⁷Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA
⁸Division of Hematology, Departments of Medicine, Oncology & Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

1278

Daniel J Vail¹^*, Dongxu Jiang, PhD¹, Kunho Chung, PhD², Yahan Zhang, MS¹, Sophia Martinez, BS¹^*, Luca Guarnera, MD³^*, Yvonne Parker, MS³^*, J. Joseph Melenhorst, PhD², Daniel Lindner, MD, PhD³^*, Jaroslaw Maciejewski⁴ and Babal K. Jha, PhD^1,3

¹Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Center for Immunotherapy and Precision Immuno-Oncology, Cell Therapy & Immuno-Engineering Program, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁴Taussig Cancer Center, Cleveland, OH

1279

Mice Expressing a Germline Gata2^T354M Mutation Phenocopy the GATA2 Deficiency Syndrome of Humans

Casey Katerndahl, PhD

Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN

1280

The Cell-Type-Specific Essentiality of the Tricarboxylic Acid (TCA) Cycle in the Hematopoietic System

Yafeng Li, PhD¹, Joseph Rose III¹^*, Edward Owusu Kwarteng, PhD, BSc, MSc¹ and Michalis Agathocleous, PhD^1,2

¹Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX
²Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX

1281

Hallmarks of Transcriptional Heterogeneity in Human Hematopoietic Stem Cells across 382 Donors

Sayyam Shah¹^*, Murtaza S. Nagree, PhD¹^*, Chhiring Lama²^*, Anna S. Nam, MD², Andy G.X. Zeng, BSc^1,3, Stephanie Z Xie, PhD⁴ and John E. Dick, PhD^1,3

¹Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
³Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
⁴Princess Margaret Cancer Centre, Toronto, ON, Canada

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^*signifies non-member of ASH

501.P1.36 501. Hematopoietic Stem and Progenitor Cells and Hematopoiesis: Basic and Translational: Poster I