-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

503.P1.47 503. Clonal Hematopoiesis, Aging, and Inflammation: Poster I

Symposia: Clonal Hematopoiesis, Aging, and Inflammation Program: Oral and Poster Abstracts
Type: Poster
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Translational Research, CHIP, Clinical Research, Genomics, Hematopoiesis, Immune mechanism, Biological Processes, Multi-systemic interactions, Pathogenesis
Saturday, December 7, 2024: 5:30 PM-7:30 PM
Halls G-H (San Diego Convention Center)

Laura Poisa-Beiro, PhD1*, Jonathan JM Landry, PhD2*, Bowen Yan, PhD3*, Michael Kardorff1*, Volker Eckstein, PhD1*, Laura Villacorta4*, Anne-Claude Gavin, PhD5*, Judith Zaugg, PhD6*, Vladimir Benes7*, Simon Raffel, MD1*, Daohong Zhou, MD8* and Anthony D Ho, MD1

1Department of Medicine V, Universität Heidelberg, Heidelberg, Germany
2EMBL, Heidelberg, BW, DEU
3University of Florida, Gainesville, FL
4Genomic Core Facility, European Molecular Biology Laboratories, Heidelberg, Heidelberg, Germany
5Department for Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
6European Molecular Biology Laboratories, Heidelberg, Germany
7Genomic Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
8Department of Biochemistry and Structural Biology and Center for Innovative Drug Discovery, University of Texas Health Science Center at San Antonio, San Antonio, TX

Ellen Nuttall Musson1*, Yvette Hoade, BSc2*, Phoebe Dace, BSc3*, Helen Brown, PhD2*, Madison Hill, Biomed (hons)2*, Alexandra Lubin, PhD2, Katie-Jo Miller, BSc2*, Catherine Zhu, FRCPath, MA, MBBChir2*, Javier Herrero, PhD2*, Andrew Steptoe, DPhil, DSc, FBA, FMedSci, FRSB4*, Spiros Denaxas, PhD5,6* and Elspeth Payne, MD, PhD, FRCPath2,7

1UCL Cancer Institute, University College London, London, ENG, United Kingdom
2UCL Cancer Institute, University College London, London, United Kingdom
3The Francis Crick Institute, London, United Kingdom
4Institute of Epidemiology and Health Care, University College London, London, United Kingdom
5Institute of Health Informatics, University College London, London, United Kingdom
6British Heart Foundation Data Science Centre, London, United Kingdom
7University College London Hospitals NHS Foundation Trust, London, United Kingdom

Sarah J Mackie1*, Matthew Sadler2*, Maroof Hasan3*, Lynette Graver4*, Rupavidhya Mondi Anandhakrishna5*, Fulye Argunhan5*, Louis-Francois Handfield1*, Hosanna Assefa-Kebede6*, Laarni Bogaanay7*, Prodromos Chatzikyriakou, Ph.D.8*, Pilar Casares Alaez9*, Antonio Cannata5*, Mohammad Al-Agil10*, Amandine Tan1*, Maria Ortiz Estevez11*, Ching-Pin Chang12*, Rajasekhar N.V.S. Suragani, PhD13, Anita K. Gandhi, PhD14, Ajay Shah15*, Theresa McDonagh16*, Aleksander Ivetic16*, Ghulam Mufti1*, Giorgio Napolitani, PhD1*, Daniel Bromage2* and Lynn Quek, MD, Ph.D.8*

1Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
2British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom
3Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ
4Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, london, United Kingdom
5School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, london, United Kingdom
6Department of Cardiology, King's College Hospital London, London, United Kingdom
7School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
8Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
9Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
10CogStack Department, King's College Hospital London, London, United Kingdom
11Bristol Myers Squibb, Sevilla, Spain
12Bristol Myers Squibb, Princeton, NJ
13Hematology Translational Medicine, Bristol Myers Squibb, Cambridge, MA
14Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
15School of Cardiovascular and Metabolic Medicine & Sciences, King's College Hospital London, London, United Kingdom
16School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom

Armel L. Batchi-Bouyou, MD, MPH1*, Duc Tran, PhD1*, Michael Raddatz, MD, PhD2*, Teng Gao, PhD3*, Caitlyn Vlasschaert, MD, PhD4*, Brian Sharber, MS5*, Jie Liu, MBBS, PhD1, Giulia Petrone, MD, MBBS6, Irenaeus C.C. Chan, MSc1*, J. Scott Beeler, MD, PhD1*, Griffen Mustion, MS1*, Sean M. Devlin, PhD7*, Alexander G. Bick, MD, PhD5* and Kelly Bolton, MD, PhD8

1Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
2Department of Medicine, University of California, Los Angeles, Los Angeles, CA
3Department of Biomedical Informatics, Harvard University, Cambridge, MA
4Department of Medicine, Queen’s University, Kingston, ON, Canada
5Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN
6Washington University, Saint Louis, MO
7Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
8Washington University School of Medicine, St Louis, MO

Kavita Bisht, PhD1, Svetlana Shatunova1*, Valerie Barbier1*, Ingrid G Winkler2* and Jean-Pierre Levesque, PhD1*

1Mater Research Institute-The University of Queensland, Woolloongabba, QLD, Australia
2Mater Research Institutee - The University of Queensland, Brisbane, AUS

Marco M Buttigieg, MSc1*, Caitlyn Vlasschaert, MD, PhD2*, Robert J Vanner, MD, PhD3,4 and Michael J. Rauh, MD, PhD1

1Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
2Department of Medicine, Queen’s University, Kingston, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
4Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

LaShanale Wallace, PhD1, Mark Engelken1*, Jacquelyn A. Myers1*, John Harper1*, Brandi Clark, PhD2*, David Cullins3*, Jaquelyn T. Zoine, PhD4, Raghuvaran Shanmugam2*, Stefan Schattgen, PhD2*, M. Paulina Velasquez, MD4, Heather Sheppard, DVM, PhD5*, Jeremy Chase Crawford, PhD2*, Paul G. Thomas, PhD2* and Esther A. Obeng, MD, PhD6

1Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
2Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN
3Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
4Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
5Comparative Pathology Core, St Jude Children's Research Hospital, Memphis, TN
6St. Jude Children's Research Hospital, Memphis, TN

Romain Loyaux1*, Julien Hadoux2*, Sandrine Oziel3*, Alice Durand4*, Karine Bouhier-Leporrier5*, Lavinia Vija6*, Magalie Haissaguerre7*, Aurelie Ferru8*, Livia Lamartina2*, Desiree Déandreis2*, Laura Gerard4*, Arnaud Pages, MD; PhD9*, Rachel El-Ferkh2*, Amira Habza2*, Galina Jepiral2*, Michel Ducreux10*, Christophe Marzac, MD11*, Thomas Walter4*, Nathalie Charrier3*, Noémie Simon-Tillaux2*, Eric Baudin12* and Jean-Baptiste Micol, MD13

1Gustave Roussy, VILLEJUIF, France
2Gustave Roussy, Villejuif, France
3INSTITUT PAOLI CALMETTES, Marseille, France
4CHU LYON, LYON, France
5CHU CAEN, CAEN, France
6IUCT Oncopole, TOULOUSE, France
7CHU BORDEAUX, BORDEAUX, France
8CHU POITIERS, POITIERS, France
9Gustave Roussy Institute, Villejuif, France
10Institut Gustave Roussy, Villejuif, FRA
11Institut Gustave Roussy, Villejuif, France
12Gustave Roussy, Service De MéDecine NucléAire, Villejuif, FRA
13Hematology Department, Gustave Roussy Institute, Villejuif, France

Stephan Emmrich, PhD1 and Nicola Vannini2*

1Department of Oncology, University of Lausanne, Epalinges, Switzerland
2University of Lausanne, Epalinges, Switzerland

Aidan Patrick Miller1*, Wesley Shin1*, Marie E McConkey, PhD1*, Justin CT Loke, MD PhD1,2, Geon Kim, MD1 and Benjamin L. Ebert, MD, PhD1,3,4

1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
2University of Birmingham, Birmingham, United Kingdom
3Broad Institute of MIT and Harvard, Cambridge, MA
4Howard Hughes Medical Institute, Boston, MA

Patrick Stelmach, MD1*, Dominik Vonficht, PhD2*, Anne Kathrin Merbach, PhD3*, Dawn S Lin, PhD1*, Sergi Beneyto-Calabuig, PhD4*, Marina Scheller, PhD5*, Aino-Maija Leppä, PhD1*, Florian Grünschläger, PhD2*, George S Vassiliou, MD, PhD6, Simon Haas, PhD7,8*, Lars Velten, PhD4*, Carsten Müller-Tidow, MD9,10* and Andreas Trumpp, PhD1,11

1Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
2Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, DEU
3Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany
4The Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), Barcelona, ESP
5Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
6Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
7Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany
8Berlin Institute for Medical Systems Biology, MDC for Molecular Medicine in the Helmholtz Association, Berlin, Germany
9Department of Medicine V, Heidelberg University Hosptial, Heidelberg, Germany
10Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
11Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany

Martina Sarchi, MD, PhD1,2*, Sintra Stewart2*, Jason Kim2*, Ksenia R. Safina, PhD3*, Stephanie Busch2*, Hayden Gizinski2*, Nelli Aydinyan2*, Andreea Reilly, PhD2*, J. Philip Creamer IV, PhD2, Rochelle Bergantinos2*, Jasper Hsu2*, Jonathan Good3*, Malgorzata Olszewska4,5*, Anna Gallì6*, Luca Malcovati, MD6,7, Sioban Keel, MD2, David Wu, MD, PhD8*, Janis L. Abkowitz, MD2,9, Pamela S. Becker, MD, PhD10,11, Eirini Papapetrou, MD, PhD4,5, Kelley Harris, PhD9,12*, Peter van Galen, PhD3,13,14, Suleyman Gulsuner, MD, PhD15* and Sergei Doulatov, PhD2,9,16

1Department of Molecular Medicine, University of Pavia, Pavia, Italy
2Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA
3Division of Hematology, Brigham and Women's Hospital, Boston, MA
4Department of Oncological Sciences and Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
5Center for the Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
6Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy
7Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
8Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
9Department of Genome Sciences, University of Washington, Seattle, WA
10Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
11Department of Hematologic Malignancies Translational Science, City of Hope Beckman Research Institute, Duarte, CA
12Herbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA
13Broad Institute of MIT and Harvard, Cambridge
14Ludwig Center at Harvard, Harvard Medical School, Boston, MA
15Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA
16Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA

Mareike Peters1*, Jiajun Xie, MD2*, Sergiu Pasca3*, Hamzah Kharabsheh2*, Anna S Nam, MD4*, Lukasz P. Gondek, MD, PhD5 and Gabriel Ghiaur, MD, PhD6

1Johns Hopkins University, Baltimore, MD
2Johns Hopkins University, Baltimore
3Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
4Weill Cornell Medicine, New York
5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
6Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, John's Hopkins Hospital, Baltimore, MD

Yasmeen Choudhri, MSc, BSc1*, Olivia Lopes, MSc2*, Caitlyn Vlasschaert, MD, PhD3*, David M. Maslove, MD, MS4,5* and Michael J. Rauh, MD, PhD1

1Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
2Department of Medicine, University of Ottawa, Ottawa, ON, Canada
3Department of Medicine, Queen’s University, Kingston, ON, Canada
4Department of Medicine, Queen's University, Kingston, ON, Canada
5Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada

Afaf Osman, MD1, Julie Feusier, PhD2*, Brian Avery, PhD3*, Deborah M. Stephens, DO4, Michael Madsen, MStat5*, Justin Williams, MPH5*, Tony Pomicter, MS6*, Brandt Jones, BS5*, Adam Clayton7*, Philippe Szankasi, PhD2*, Jay Patel, MD8, Ramiro Garzon, MD9* and Nicola J Camp, PhD10*

1Department of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
2ARUP Laboratories, Salt Lake City, UT
3Huntsman Cancer Institute and School of Medicine, University of Utah, Salt Lake City, UT
4University of North Carolina Chapel Hill, Chapel Hill, NC
5Huntsman Cancer Institute, Salt Lake City, UT
6The University of Utah, Salt Lake City, UT
7ARUP laboratories, Salt Lake City
8University of Utah, ARUP Laboratories, Salt Lake City, UT
9Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah Health, Salt Lake City, UT
10Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

*signifies non-member of ASH