Laura Poisa-Beiro, PhD^1*, Jonathan JM Landry, PhD^2*, Bowen Yan, PhD^3*, Michael Kardorff^1*, Volker Eckstein, PhD^1*, Laura Villacorta^4*, Anne-Claude Gavin, PhD^5*, Judith Zaugg, PhD^6*, Vladimir Benes^7*, Simon Raffel, MD^1*, Daohong Zhou, MD^8* and Anthony D Ho, MD¹

¹Department of Medicine V, Universität Heidelberg, Heidelberg, Germany
²EMBL, Heidelberg, BW, DEU
³University of Florida, Gainesville, FL
⁴Genomic Core Facility, European Molecular Biology Laboratories, Heidelberg, Heidelberg, Germany
⁵Department for Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
⁶European Molecular Biology Laboratories, Heidelberg, Germany
⁷Genomic Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
⁸Department of Biochemistry and Structural Biology and Center for Innovative Drug Discovery, University of Texas Health Science Center at San Antonio, San Antonio, TX

Ellen Nuttall Musson^1*, Yvette Hoade, BSc^2*, Phoebe Dace, BSc^3*, Helen Brown, PhD^2*, Madison Hill, Biomed (hons)^2*, Alexandra Lubin, PhD², Katie-Jo Miller, BSc^2*, Catherine Zhu, FRCPath, MA, MBBChir^2*, Javier Herrero, PhD^2*, Andrew Steptoe, DPhil, DSc, FBA, FMedSci, FRSB^4*, Spiros Denaxas, PhD^5,6* and Elspeth Payne, MD, PhD, FRCPath^2,7

¹UCL Cancer Institute, University College London, London, ENG, United Kingdom
²UCL Cancer Institute, University College London, London, United Kingdom
³The Francis Crick Institute, London, United Kingdom
⁴Institute of Epidemiology and Health Care, University College London, London, United Kingdom
⁵Institute of Health Informatics, University College London, London, United Kingdom
⁶British Heart Foundation Data Science Centre, London, United Kingdom
⁷University College London Hospitals NHS Foundation Trust, London, United Kingdom

Sarah J Mackie^1*, Matthew Sadler^2*, Maroof Hasan^3*, Lynette Graver^4*, Rupavidhya Mondi Anandhakrishna^5*, Fulye Argunhan^5*, Louis-Francois Handfield^1*, Hosanna Assefa-Kebede^6*, Laarni Bogaanay^7*, Prodromos Chatzikyriakou, Ph.D.^8*, Pilar Casares Alaez^9*, Antonio Cannata^5*, Mohammad Al-Agil^10*, Amandine Tan^1*, Maria Ortiz Estevez^11*, Ching-Pin Chang^12*, Rajasekhar N.V.S. Suragani, PhD¹³, Anita K. Gandhi, PhD¹⁴, Ajay Shah^15*, Theresa McDonagh^16*, Aleksander Ivetic^16*, Ghulam Mufti^1*, Giorgio Napolitani, PhD^1*, Daniel Bromage^2* and Lynn Quek, MD, Ph.D.^8*

¹Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
²British Heart Foundation Centre, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom
³Hematology, Translational Medicine and Disease Team, Bristol Myers Squibb, Summit, NJ
⁴Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, london, United Kingdom
⁵School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, london, United Kingdom
⁶Department of Cardiology, King's College Hospital London, London, United Kingdom
⁷School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁸Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
⁹Myeloid Leukaemia Genomics and Biology Group, School of Cancer and Pharmaceutical Sciences, King’s College London, London, United Kingdom
¹⁰CogStack Department, King's College Hospital London, London, United Kingdom
¹¹Bristol Myers Squibb, Sevilla, Spain
¹²Bristol Myers Squibb, Princeton, NJ
¹³Hematology Translational Medicine, Bristol Myers Squibb, Cambridge, MA
¹⁴Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
¹⁵School of Cardiovascular and Metabolic Medicine & Sciences, King's College Hospital London, London, United Kingdom
¹⁶School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London, United Kingdom

Armel L. Batchi-Bouyou, MD, MPH^1*, Duc Tran, PhD^1*, Michael Raddatz, MD, PhD^2*, Teng Gao, PhD^3*, Caitlyn Vlasschaert, MD, PhD^4*, Brian Sharber, MS^5*, Jie Liu, MBBS, PhD¹, Giulia Petrone, MD, MBBS⁶, Irenaeus C.C. Chan, MSc^1*, J. Scott Beeler, MD, PhD^1*, Griffen Mustion, MS^1*, Sean M. Devlin, PhD^7*, Alexander G. Bick, MD, PhD^5* and Kelly Bolton, MD, PhD⁸

¹Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
²Department of Medicine, University of California, Los Angeles, Los Angeles, CA
³Department of Biomedical Informatics, Harvard University, Cambridge, MA
⁴Department of Medicine, Queen’s University, Kingston, ON, Canada
⁵Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN
⁶Washington University, Saint Louis, MO
⁷Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Washington University School of Medicine, St. Louis, MO

Kavita Bisht, PhD¹, Svetlana Shatunova^1*, Valerie Barbier^1*, Ingrid G Winkler^2* and Jean-Pierre Levesque, PhD^1*

¹Mater Research Institute-The University of Queensland, Woolloongabba, QLD, Australia
²Mater Research Institutee - The University of Queensland, Brisbane, AUS

Marco M Buttigieg, MSc^1*, Caitlyn Vlasschaert, MD, PhD^2*, Robert J Vanner, MD, PhD^3,4 and Michael J. Rauh, MD, PhD¹

¹Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
²Department of Medicine, Queen’s University, Kingston, ON, Canada
³Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁴Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

LaShanale Wallace, PhD¹, Mark Engelken^1*, Jacquelyn A. Myers^1*, John Harper^1*, Brandi Clark, PhD^2*, David Cullins^3*, Jaquelyn T. Zoine, PhD⁴, Raghuvaran Shanmugam^2*, Stefan Schattgen, PhD^2*, M. Paulina Velasquez, MD⁴, Heather Sheppard, DVM, PhD^5*, Jeremy Chase Crawford, PhD^2*, Paul G. Thomas, PhD^2* and Esther A. Obeng, MD, PhD⁶

¹Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
²Department of Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN
³Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁴Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN
⁵Comparative Pathology Core, St Jude Children's Research Hospital, Memphis, TN
⁶St. Jude Children's Research Hospital, Memphis, TN

Romain Loyaux^1*, Julien Hadoux^2*, Sandrine Oziel^3*, Alice Durand^4*, Karine Bouhier-Leporrier^5*, Lavinia Vija^6*, Magalie Haissaguerre^7*, Aurelie Ferru^8*, Livia Lamartina^2*, Desiree Déandreis^2*, Laura Gerard^4*, Arnaud Pages, MD; PhD^9*, Rachel El-Ferkh^2*, Amira Habza^2*, Galina Jepiral^2*, Michel Ducreux^10*, Christophe Marzac, MD^11*, Thomas Walter^4*, Nathalie Charrier^3*, Noémie Simon-Tillaux^2*, Eric Baudin^12* and Jean-Baptiste Micol, MD¹³

¹Gustave Roussy, VILLEJUIF, France
²Gustave Roussy, Villejuif, France
³INSTITUT PAOLI CALMETTES, Marseille, France
⁴CHU LYON, LYON, France
⁵CHU CAEN, CAEN, France
⁶IUCT Oncopole, TOULOUSE, France
⁷CHU BORDEAUX, BORDEAUX, France
⁸CHU POITIERS, POITIERS, France
⁹Gustave Roussy Institute, Villejuif, France
¹⁰Institut Gustave Roussy, Villejuif, FRA
¹¹Institut Gustave Roussy, Villejuif, France
¹²Gustave Roussy, Service De MéDecine NucléAire, Villejuif, FRA
¹³Hematology Department, Gustave Roussy Institute, Villejuif, France

Stephan Emmrich, PhD¹ and Nicola Vannini^2*

¹Department of Oncology, University of Lausanne, Epalinges, Switzerland
²University of Lausanne, Epalinges, Switzerland

Aidan Patrick Miller^1*, Wesley Shin^1*, Marie E McConkey, PhD^1*, Justin CT Loke, MD PhD^1,2, Geon Geon Kim, MD^1* and Benjamin L. Ebert, MD, PhD^1,3,4

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²University of Birmingham, Birmingham, United Kingdom
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Howard Hughes Medical Institute, Boston, MA

Patrick Stelmach, MD^1*, Dominik Vonficht, PhD^2*, Anne Kathrin Merbach, PhD^3*, Dawn S Lin, PhD^1*, Sergi Beneyto-Calabuig, PhD^4*, Marina Scheller, PhD^5*, Aino-Maija Leppä, PhD^1*, Florian Grünschläger, PhD^2*, George S Vassiliou, MD, PhD⁶, Simon Haas, PhD^7,8*, Lars Velten, PhD^4*, Carsten Müller-Tidow, MD^9,10* and Andreas Trumpp, PhD^1,11

¹Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
²Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, DEU
³Department of Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁴The Barcelona Institute of Science and Technology, Centre for Genomic Regulation (CRG), Barcelona, ESP
⁵Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
⁶Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
⁷Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany
⁸Berlin Institute for Medical Systems Biology, MDC for Molecular Medicine in the Helmholtz Association, Berlin, Germany
⁹Department of Medicine V, Heidelberg University Hosptial, Heidelberg, Germany
¹⁰Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
¹¹Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany

Martina Sarchi, MD, PhD^1,2*, Sintra Stewart^2*, Jason Kim^2*, Ksenia R. Safina, PhD^3*, Stephanie Busch^2*, Hayden Gizinski^2*, Nelli Aydinyan^2*, Andreea Reilly, PhD^2*, J. Philip Creamer IV, PhD², Rochelle Bergantinos^2*, Jasper Hsu^2*, Jonathan Good^3*, Malgorzata Olszewska^4,5*, Anna Gallì^6*, Luca Malcovati, MD^6,7, Sioban Keel, MD², David Wu, MD, PhD^8*, Janis L. Abkowitz, MD^2,9, Pamela S. Becker, MD, PhD^10,11, Eirini Papapetrou, MD, PhD^4,5, Kelley Harris, PhD^9,12*, Peter van Galen, PhD^3,13,14, Suleyman Gulsuner, MD, PhD^15* and Sergei Doulatov, PhD^2,9,16

¹Department of Molecular Medicine, University of Pavia, Pavia, Italy
²Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA
³Division of Hematology, Brigham and Women's Hospital, Boston, MA
⁴Department of Oncological Sciences and Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Center for the Advancement of Blood Cancer Therapies, Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
⁶Department of Hematology, IRCCS S. Matteo Hospital Foundation, Pavia, Italy
⁷Department of Molecular Medicine, University of Pavia, Piazzale Golgi 2, Italy
⁸Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
⁹Department of Genome Sciences, University of Washington, Seattle, WA
¹⁰Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA
¹¹Department of Hematologic Malignancies Translational Science, City of Hope Beckman Research Institute, Duarte, CA
¹²Herbold Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA
¹³Broad Institute of MIT and Harvard, Cambridge
¹⁴Ludwig Center at Harvard, Harvard Medical School, Boston, MA
¹⁵Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA
¹⁶Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA

Mareike Peters^1*, Jiajun Xie, MD^2*, Sergiu Pasca^3*, Hamzah Kharabsheh^2*, Anna S Nam, MD^4*, Lukasz P. Gondek, MD, PhD⁵ and Gabriel Ghiaur, MD, PhD⁶

¹Johns Hopkins University, Baltimore, MD
²Johns Hopkins University, Baltimore
³Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁴Weill Cornell Medicine, New York
⁵Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Division of Hematologic Malignancies, Department of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, John's Hopkins Hospital, Baltimore, MD

Yasmeen Choudhri, MSc, BSc^1*, Olivia Lopes, MSc^2*, Caitlyn Vlasschaert, MD, PhD^3*, David M. Maslove, MD, MS^4,5* and Michael J. Rauh, MD, PhD¹

¹Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
²Department of Medicine, University of Ottawa, Ottawa, ON, Canada
³Department of Medicine, Queen’s University, Kingston, ON, Canada
⁴Department of Medicine, Queen's University, Kingston, ON, Canada
⁵Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada

Afaf Osman, MD¹, Julie Feusier, PhD^2*, Brian Avery, PhD^3*, Deborah M. Stephens, DO⁴, Michael Madsen, MStat^5*, Justin Williams, MPH^5*, Tony Pomicter, MS^6*, Brandt Jones, BS^5*, Adam Clayton^7*, Philippe Szankasi, PhD^2*, Jay Patel, MD⁸, Ramiro Garzon, MD^9* and Nicola J Camp, PhD^10*

¹Department of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT
²ARUP Laboratories, Salt Lake City, UT
³Huntsman Cancer Institute and School of Medicine, University of Utah, Salt Lake City, UT
⁴University of North Carolina Chapel Hill, Chapel Hill, NC
⁵Huntsman Cancer Institute, Salt Lake City, UT
⁶The University of Utah, Salt Lake City, UT
⁷ARUP laboratories, Salt Lake City
⁸University of Utah, ARUP Laboratories, Salt Lake City, UT
⁹Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah Health, Salt Lake City, UT
¹⁰Huntsman Cancer Institute, University of Utah, Salt Lake City, UT