66th ASH Annual Meeting: 201. Granulocytes, Monocytes, and Macrophages: Poster I

Symposia: Granulocytes, Monocytes, and Macrophages Oral and Poster Abstracts
Poster

Halls G-H (San Diego Convention Center)

Combined Ablation of PD-1 and Pparγ Synergistically Promotes M1-like Macrophage Polarization and Proinflammatory Differentiation

Monisha Kashyap, MBBS¹^*, Rushil Shah²^*, Rinku Pal, BS³^* and Vassiliki A Boussiotis, MD, PhD⁴

¹Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON, MA
²Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON
³Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA

1145

Higher Number of M1 Macrophages and Activated Dendritic Cells Linked to Longer Overall Survival in Patients with Acute Myeloid Leukemia

Paul Hanona, MD¹, Morgan Kiryakoza, MD²^*, Lorin Sallan, DO³^*, Neil Jairath⁴^*, Daniel Ezekwudo, MD, PhD⁵ and Ishmael A. Jaiyesimi, DO¹

¹Corewell Health William Beaumont University Hospital, Royal Oak, MI
²Corewell Health, Royal Oak, MI
³Corewell Health, Trenton, MI
⁴550 First Avenue, NYU Langone, New York, NY
⁵Hematology and Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI

1146

A Novel Engineering Platelet Platform Target the Macrophages to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis

Zhenyu Liu, Doctor¹^*, Ying Du, Doctor²^*, Rongfu Zhou, MD, PhD¹^*, Bing Chen¹ and Peipei Xu, MD¹^*

¹Department of Hematology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
²Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China

1147

Axatilimab Abrogates Inflammatory Cytokines and Chemokines and Interrupts the Differentiation of Monocytes to Macrophages, a Pathogenic Driver of Inflammation and Fibrosis in cGVHD

Anamika Bajpai^*, Linda Solomon^*, Angelina Volkova^*, Melissa Parker^*, James Kearns^*, Shekinah Cosby^* and Chryssa Kanellopoulou^*

Incyte Corporation, Wilmington, DE

1148

Control of Macrophage Fusion By Sensing the Physical Properties of Fibrin(ogen) Matrices

Nataly P. Podolnikova, PhD¹^*, Arnat Balabiyev, PhD¹^*, Woosuk S. Hur, PhD², Matthew J. Flick, PhD²^* and Tatiana P. Ugarova, PhD¹^*

¹Arizona State University, Tempe, AZ
²University of North Carolina At Chapel Hill, Chapel Hill, NC

1149

Blood Cell Homeostasis Is Maintained in the Absence of Resident Mononuclear Phagocytes in Fetal Liver and Bone Marrow in CSF1R Knockout Rats

Megan Roberts, BBiomedSc (Hons)¹^*, Dylan Carter-Cusack, BSc (Honours)²^*, Stephen Huang, PhD¹^*, Emma Maxwell¹^*, Kim Z Summers, PhD¹^*, Katharine M Irvine, BSc (Hons), LLB, PhD¹^* and David A Hume, BScHons, PhD¹^*

¹Translational Research Institute, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia
²Translational Research Institute, Brisbane, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia

1150

Transcriptomic Analysis of the Functions of CSF1R-Dependent Macrophages in Postnatal Development in the Rat

Dylan Carter-Cusack, BSc (Honours)¹^*, Stephen Huang, PhD²^*, Sahar Keshvari, PhD³^*, Omkar Patkar, PhD³^*, Anuj Sehgal, PhD³^*, Rachel Allavena⁴^*, Robert Byrne, PhD⁵^*, Paul Morgan, PhD⁵^*, Stephen Bush, PhD⁶^*, Kim Z Summers, PhD⁷^*, Katharine M Irvine, BSc (Hons), LLB, PhD⁷^* and David A Hume, BScHons, PhD⁷^*

¹Translational Research Institute, Brisbane, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia
²Translational Research Institute, Mater Research Institute - UQ, Brisbane, Australia
³Translational Research Institute, Mater Research Institute - University of Queensland, Brisbane, Australia
⁴University of Queensland, School of Veterinary Sciences, The University of Queensland, Brisbane, Australia
⁵Cardiff University, UK Dementia Research Institute Cardiff, School of Medicine Cardiff University, Cardiff, United Kingdom
⁶Xi'an Jiaotong University, School of Automation Science, Xi'an Jiaotong University, Xian, China
⁷Translational Research Institute, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia

1151

An Inactivating Mutation in Rat IL-34 Reveals Redundant and Nonredundant Functions of CSF1-IL-34 Signalling in Homeostasis and Inflammation

Stephen Huang, PhD^1,2^*, Omkar Patkar, PhD³^*, Sarah Schulze⁴^*, Dylan Carter-Cusack, BSc (Honours)⁵^*, Ginell Ranpura¹^*, Emma Maxwell¹^*, Sahar Keshvari, PhD³^*, Susan Millard⁶^*, Gary Cowin, PhD⁷^*, Nyoman Kurniawan, PhD⁷^*, Allison Pettit⁸^*, Katharine M Irvine, BSc (Hons), LLB, PhD¹^* and David A Hume, BScHons, PhD¹^*

¹Translational Research Institute, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia
²Translational Research Institute, Mater Research Institute - UQ, Brisbane, Australia
³Translational Research Institute, Mater Research Institute - University of Queensland, Brisbane, Australia
⁴Macrophage Biology Lab, Mater Research Institute - University of Queensland, Brisbane, Australia
⁵Translational Research Institute, Brisbane, Mater Research Institute-University of Queensland, Brisbane, QLD, Australia
⁶Mater Research Institute - The University of Queensland, Faculty of Medicine and, Woolloongabba, AUS
⁷Centre for Advanced Imaging The University of Queensland, Brisbane, Australia
⁸Mater Research Institute-The University of Queensland, Woolloongabba, QLD, Australia

1152

PU.1 Promotes Monocyte Development in Part By Transcriptionally Activating c-Fos, Egr-1 and Egr-2

Hafiza Sidra Bashir, MS, Binod G C, MSc and Fan Dong, M.D., Ph.D.

Department of Biological Sciences, University of Toledo, Toledo, OH

1153

Deciphering Inflammasome Activation in Gaucher Macrophages and Its Role in the Development of Multiple Myeloma

Vivien Reinecke¹^*, Daniel Hofbauer, MSc, BSc²^*, Jörg-Thomas Bittenbring, MD³^*, Christopher Lischer, MSc⁴^*, Johannes Berges¹^*, Gina Nusser¹^*, Katrin Bitterer, MTA⁴^*, Simon Voelkl, PhD^5,6,7^*, Dimitrios Mougiakakos, MD⁸, Andreas Mackensen, MD^5,9^* and Heiko Bruns¹⁰^*

¹University Hospital Erlangen, Erlangen, Germany
²Department of Internal Medicine 5 – Hematology/Oncology, University Hospital Erlangen, Erlangen, DEU
³4Department of Internal Medicine 1 (Oncology, Hematology, Clinical Immunology, and Rheumatology), Saarland University Medical School, Homburg, Homburg, DEU
⁴Department of Internal Medicine 5 – Hematology/Oncology, University Hospital Erlangen, Erlangen, Germany
⁵Bavarian Cancer Research Center (BZKF), Erlangen, Germany
⁶Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany
⁷Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany
⁸Health-Campus Immunology, Infectiology, and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany
⁹Department of Internal Medicine 5 - Hematology and Oncology, University Hospital of Erlangen, Erlangen, Germany
¹⁰University Hospital Erlangen, Nürnberg, Germany

1154

Regulation of Inflammation-Related Myeloid Cell Death By Polycomb Repressive Complex 1.1

Takanori Fukuta, MD¹^*, Yaeko Nakajima-Takagi, PhD²^*, Shuhei Koide, PhD²^*, Motohiko Oshima, PhD²^* and Atsushi Iwama³

¹Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Koto, TKY, Japan
²Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
³Division of Stem Cell and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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^*signifies non-member of ASH

201.P1.34 201. Granulocytes, Monocytes, and Macrophages: Poster I