Christina Lisk, PhD^1*, Francesca I Cendali, BS², Delany Swindle^1*, Gemlyn George, MD^1*, Rachelle Nuss, MD^3*, Kathryn Louise Hassell, MD¹, Paul Buehler, PharmD, PhD^4*, Angelo D'Alessandro, PhD⁵ and David Irwin, Ph.D^1*

¹University of Colorado Anschutz Medical Campus, Aurora, CO
²University of Colorado School of Medicine, Anschutz, Aurora, CO
³Center for Cancer and Blood Disorders, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Center for Blood Oxygen Transport and Hemostasis, University of Maryland, Baltimore, MD
⁵Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO

Caroline Vinit, MD^1,2*, Corinne Guitton, MD^3*, Mariane de Montalembert, MD, PhD^4,5, Patricia Benhaim, MD^6*, Lahoueri Amor-Chelihi, MD^6*, Brigitte Bader-Meunier, MD^7*, Florence Missud, MD^8*, Isabelle Melki, MD, PhD^2*, Vincent Gajdos, MD, PhD^9*, Cecile Arnaud, MD^10*, Annie Kamden, MD^11*, Oussama Charara, MD^12*, Véronique Hentgen, MD^12*, Sylvie Nathanson, MD, PhD^12*, Coralie Bloch, MD, PhD^13,14*, Ulrich Meinzer, MD, PhD^2*, Pierre Quartier, MD, PhD^7*, Isabelle Kone-Paut, MD, PhD^15*, Loïc De Pontual, MD, PhD^1* and Luu-Ly Pham, MD^1,16*

¹Pediatrics Department, Jean Verdier Hospital, AP-HP, Bondy, France
²Pediatrics and Internal Medicine Department, Robert Debré Hospital, AP-HP, Paris, France
³Pediatrics and Sickle Cell Center, Bicêtre Hospital, AP-HP, Le Kremlin-Bicêtre, France
⁴Laboratory of Excellence GR-Ex, Université Paris-Cité, Paris, France
⁵Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Paris, France
⁶Pediatrics Department and Sickle Cell Center, Jean Verdier Hospital, AP-HP, Bondy, France
⁷Pediatrics Immunology, Hematology and Rheumatology Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France
⁸Referral Center For Sickle Cell Disease, Robert Debré Hospital, AP-HP, Paris, France
⁹General Pediatrics Department, Antoine-Béclère Hospital, AP-HP, Paris-Saclay University, Clamart, France
¹⁰Referral Center for Sickle Cell Disease, Hopital Intercommunal de Créteil, Creteil, France
¹¹Pediatrics Department, Intercommunal Hospital, Creteil, France
¹²Pediatrics Department, Versailles Hospital, Le Chesnay, France
¹³Clinical Research Unit, University Hospital Paris-Seine-Saint-Denis, Paris, France
¹⁴Imagine Institut, Imagine Institut INSERM UMR1163, Paris, France
¹⁵Pediatrics Rheumatology Department, Bicêtre Hospital, AP-HP, Le Kremlin-Bicêtre, France
¹⁶UMR 1137 IAME, INSERM, Université Sorbonne Paris Nord, Paris, France

Evangelia Vlachodimitropoulou, Maternal Fetal Medicine consultant^1*, Tharshini Balasubramanian^2*, Nadine Shehata, MD, FRCPC, MSc^3,4, Richard Ward, MBBS, MRCP, FRCPath^5*, Kevin H.M. Kuo, MD, MSc, FRCPC⁶, John Kingdom, MD, MSc, FRCSC^2* and A. Kinga Malinowski, MD, MSc, FRCSC⁷

¹King's College London, London, United Kingdom
²Mount Sinai Hospital, Toronto, ON, Canada
³Department of Medicine, Mount Sinai Hospital, Toronto, ON, Canada
⁴Department of Medicine, University of Toronto, Toronto, ON, Canada
⁵Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, ON, Canada
⁶Division of Hematology, University of Toronto, Toronto, ON, Canada
⁷Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, Toronto, ON, Canada

Ahmad Basharat^1*, Yuanli Lei^2*, Jawad Noor, MD^3*, Atif N Khan^4*, Ateeq Rehman^2*, Maleeha Ajmal^5*, Gul Nawaz^6*, Hania Latif Sami^7*, Aqsa Mumtaz, MD, MBBS^8* and Moazzam Shahzad, MD⁹

¹Marshfield Clinic Health System, Marshfield, Wisconsin, Marshfield, WI
²Marshfield clinic Health system, Marshfield, Wisconsin, Marshfield, WI
³St Dominic hospital, Madison, MS
⁴Larkin community hospital, Miami, FL
⁵Marshfield clinic Health system, Marshfield, Wisconsin, Marshfield
⁶Marshfield clinic Hospital, Marshfield
⁷Shalamar Medical and dental College, Lahore, Pakistan, Lahore, Pakistan
⁸Mikael Rayaan Foundation Global Health Consortium, Kansas City, KS
⁹Department of Oncological Sciences, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL

Moritz Saxenhofer, PhD^1,2*, Mattheus Wildschut^2,3*, Carlos Perez Roca^2,3*, Gregory J. Kato⁴, Justine Brodard^5*, Christelle Chirlias^6*, Linet Njue^5*, Ioannis Chanias^5*, Ana Batista Mesquita Sauvage^6*, Cesare Medri^5*, Gerasimos Tsilimidos^6*, Lucas Veuthey^6*, Anna Schnell^2,3*, Stefanie Graeter^2,3*, Jacqueline Adam^2,3*, Thomas Gentinetta^2,3*, Sandra Mena Perez^2,3*, Daniel Couto^2,3*, Nicole Hadorn^5*, Mila Keiser^5*, Alan G. Haynes^7*, Kathrin Bieri^7*, Lorenzo Alberio^6*, Francesco Grandoni^6*, Ramona Merki^8*, Emmanuel Levrat^9*, Kaveh Samii^10*, Anne Angelillo-Scherrer⁵, Alexander Schaub^2,3*, Mathilde Gavillet, MD, PhD^11* and Alicia Rovó⁵

¹CSL Behring, Bern, AL, Switzerland
²Swiss Institute for Translational and Entrepreneurial Medicine, sitem-insel, Bern, Switzerland
³CSL Behring, Bern, Switzerland
⁴CSL Behring, King of Prussia, PA
⁵Inselspital, Bern University Hospital, Bern, Switzerland
⁶Lausanne University Hospital (CHUV), Lausanne, Switzerland
⁷University of Bern, Bern, Switzerland
⁸Aarau Cantonal Hospital, Aarau, Switzerland
⁹Hôpital Cantonal Fribourg, Fribourg, Switzerland
¹⁰Geneva University Hospitals (HUG), Geneva, Switzerland
¹¹Service and Central Laboratory of Hematology, Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland

Hatoon Ezzat, MBBS, FRCP¹, Meshal Alshehri^2*, Ibrahim Alghamdi^2*, Fayez Alshehri^2*, Najwa Kariri^2*, Fayzah Albalawi^2*, Nourah Aldoaiji^2* and Mohammed Al Abdulaali^2*

¹Ministry of Health, Dammam, AL, Saudi Arabia
²Ministry of Health, Riyadh, Saudi Arabia

Dunia Hatabah, MD¹, Rawan Korman, MD¹, Giorgi Maziashvili, MD^1*, Lou Ann Brown, PhD^2*, Frank Harris^2*, Chris A. Rees, MD^3*, Carlton Dampier, MD³ and Claudia R. Morris, MD³

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Emory University School of Medicine, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA

Rawan Korman, MD¹, Dunia Hatabah, MD¹, Giorgi Maziashvili, MD^1*, Lou Ann Brown, PhD^2*, Frank Harris^2*, Chris A. Rees, MD^3*, Carlton Dampier, MD³ and Claudia R. Morris, MD³

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
²Emory University School of Medicine, Atlanta, GA
³Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA

Peter Bruun-Rasmussen^1*, Elena Dudukina^1*, Lars Peter Korsholm^1*, Julie Derving Karsbøl^1*, Inga Hegemann^2* and Maarten Jan Wensink^1*

¹Novo Nordisk A/S, Søborg, Denmark
²Novo Nordisk Health Care AG, Zurich, Switzerland

Miguel Brito, PhD^1*, Catarina Ginete, MSc^2*, Baba P.D. Inusa, MD, PhD³, Manuela Mendes, MD^4*, Roberto Afonso, BSc^4*, Adriano Siatembo, BSc^5* and Jocelyne Neto Vasconcelos, MSc^5*

¹H&TRC, Escola Superior de Tecnologia da Saude de Lisboa, Lisbon, AL, Portugal
²H&TRC, Escola Superior de Tecnologia da Saúde de Lisboa, Lisbon, Portugal
³King's College London, London, United Kingdom
⁴Hospital Materno Infantil Dr Manuel Pedro Azancot de Menezes, Luanda, Angola
⁵Centro de Investigação em Saúde de Angola, Caxito, Angola, Caxito, Angola

Abraham Attah, MD¹, Mohamad Ali Tfaily, MD^1*, Morgan L. McLemore, MD^1,2, Ross M. Fasano, MD^3* and Fuad El Rassi, MD^1,2

¹Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA
²Georgia Comprehensive Sickle Cell Center at Grady Health System, Atlanta, GA
³Center for Transfusion Medicine and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA

Shaina Willen, MD^1,2, Ann Brunson, MS^3*, Oyebimpe Adesina, MD, MS^4*, Olubusola Oluwole, MD, MS⁵ and Ted Wun, MD^6,7

¹Division of Pulmonology, UC Davis Medical Center Department of Pediatrics, Sacramento, CA
²Division of Hematology/Oncology, UC Davis Medical Center Department of Pediatrics, Sacramento, CA
³Center for Oncology Hematology Outcomes Research and Training (COHORT), Division of Hematology and Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA
⁴UC Davis Comprehensive Cancer Center, SACRAMENTO, CA
⁵Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
⁶UC Davis Clinical and Translational Science Center, Division of Hematology and Oncology, UC Davis Comprehensive Cancer Center, Sacramento, CA
⁷Division of Hematology/Oncology, University of California Davis Department of Medicine, Sacramento, CA

Ahmad Basharat^1*, Yuanli Lei^2*, Jawad Noor, MD^3*, Atif N Khan^4*, Ateeq Rehman^2*, Maleeha Ajmal^5*, Hania Latif Sami^6*, Aqsa Mumtaz, MD, MBBS^7* and Moazzam Shahzad, MD⁸

¹Marshfield Clinic Health System, Marshfield, Wisconsin, Marshfield, WI
²Marshfield clinic Health system, Marshfield, Wisconsin, Marshfield, WI
³St Dominic hospital, Madison, MS
⁴Larkin community hospital, Miami, FL
⁵Marshfield clinic Health system, Marshfield, Wisconsin, Marshfield
⁶Shalamar Medical and dental College, Lahore, Pakistan, Lahore, Pakistan
⁷Mikael Rayaan Foundation Global Health Consortium, Kansas City, KS
⁸H Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Yan Zheng, MD, PhD^1*, Jeffery Gossett^2*, Guolian Kang, PhD³, Pei-Lin Chen, MPH^4* and Clifford M. Takemoto, MD⁵

¹Pathology, St. Jude Children’s Research Hospital, Memphis, TN
²Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis
³St. Jude Children's Research Hospital, Memphis, TN
⁴St. Jude Children’s Research Hospital, Memphis, TN
⁵Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN

Muhammad Kashif Amin, MD^1*, Umar Akram^2*, Shahzaib Ahmed^3*, Eeman Ahmad^3*, Shoaib Ahmad^4*, Fatima Tuz Zahra, MBBS⁵, Zeeshan Sattar^6*, Muhammad Umair Mushtaq^1,7,8, Michael V. Jaglal, MD⁹ and Moazzam Shahzad, MD¹⁰

¹Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS
²Allama Iqbal Medical College, Lahore, Pakistan
³Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan
⁴Punjab Medical College, Faisalabad, Pakistan
⁵H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL
⁶University of Kansas Medical Center, Kansas City, KS
⁷Mikael Rayaan Foundation Global Health Consortium, Kansas City, KS
⁸US Myeloma Innovations Research Collaborative (USMIRC), Kansas City, KS
⁹Department of Hematology/Oncology, Moffitt Cancer Center, Tampa, FL
¹⁰Department of Oncological Sciences, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL

Sara Ferrer^1,2*, Paloma Ropero Gradilla^2,3*, Miguel Gómez Álvarez^2,4*, Jorge Martínez Nieto^2,5*, Belén Ortega Montero^4*, Rafel López del Amo^2,6*, Laura García Moreno^4*, Laura Lo Riso^7*, Valle Recasens Flores^8*, María Ángeles Montañés García^9*, Jaime Arbeteta Juanis^10*, Míriam Vara^11*, Mariola Abío Calvete^12*, María Angustias Molina Arrebola^13*, Marta Moreno Carbonell, MD^14*, Montserrat López Rubio^15*, Eduardo José Salido Fiérrez^16*, María José Muruzábal Sitges^17*, Sergio Fernandez Garcia^18*, María Ordoñez García^19*, Aránzazu García Mateo, PhD^20*, María Luisa Martín Mateos, PhD^21*, Soraya Ramiro León^22*, María Josefa Torrejón Martínez^6*, Fernando Ataulfo Gonzalez Fernandez^4*, Ana Villegas, MD²³, Celina Benavente Cuesta^24* and Grupo Español de Eritropalogía Sehh^25*

¹Hematología, Hospital Clínico San Carlos, Madrid, Madrid, Spain
²Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain
³HOSPITAL CLINICO SAN CARLOS, MADRID, Spain
⁴Hospital Clínico San Carlos, Madrid, Spain
⁵Hospital Clínico San Carlos, MADRID, ESP
⁶Hospital Clínico San Carlos, Madrid, Madrid, Spain
⁷. Hospital Universitario Son Espases., Palma de Mallorca, Spain
⁸Hospital Universitario Miguel Servet., Zaragoza, Spain
⁹Hospital Universitario Miguel Servet, Zaragoza, Spain
¹⁰Hematología, Hospital Universitario de Guadalajara, Guadalajara, Spain
¹¹Hematology and Hemoterapy Department, Hospital Universitario Cruces, Vizcaya, Spain
¹²Hospital General Universitario de Toledo, Toledo, Spain
¹³Hospital Universitario Poniente., El Ejido. Almería, Spain
¹⁴Hospital General Universitario Gregorio Marañón, Madrid, Spain
¹⁵Hospital Universtario Príncipe de Asturias., Alcalá de Henares (Madrid), Spain
¹⁶Hospital Clínico Universitario Virgen de la Arrixaca., Murcia, Spain
¹⁷Hospital Universitario Marqués de Valdecilla, Santander, Spain
¹⁸Hospital Comarcal de Laredo, Laredo, ESP
¹⁹Hospital Universitario de Móstoles, Móstoles (Madrid), Spain
²⁰Department of Hematology, Hospital General de Segovia, Segovia, Spain
²¹Complejo Asistencial Universitario de Salamanca, SALAMANCA, AL, ESP
²²Servicio de Genética, Hospital Universitario de Getafe, Getafe, Spain
²³Servicio De Hematologia, Hospital Clinico San Carlos, Madrid, madrid, ESP
²⁴Department of Hematology and Hemotherapy, Hospital Clínico San Carlos, Madrid, Spain
²⁵Sociedad Española de Hematología y Hemoterapia, Madrid, Spain

Natasha Archer, MD, MPH¹, Coralea Stephanou^2*, Maria Xenophontos^3*, Leon Tshilolo, MD PhD^4*, Franck Nzengu Lukusa^5*, Sylvain Fazili^5*, Obiageli E Nnodu, MD⁶, Maxwell Nwegbu^7*, Ali Dahiru Waziri, MD^8*, Sani Awwalu^9*, Soteroula Christou^10*, Irene Savvidou^11*, Ann Rekleiti^11*, Anna Minaidou^3*, Michail D Diamantidis, MD, PhD, MSc¹², Norafiza Mohd Yasin, MD^13*, Norasmidar Abdul Aziz^14,15*, Veena Selvaratnam, MBBS, FRCPath^16*, Ezalia Esa^17*, Andreas Glenthoej, MD, PhD¹⁸, Sophia Delicou^19*, Livingstone Gayus Dogara, FMCPath^20*, Maria Dimopoulou, MD^21*, Raja Sabudin^22*, Norunaluwar Jalil^23*, C-Khai Loh^24*, Sie-Chong Doris Lau^24*, Bin Alwi Zilfalil^25*, Norsarwany Mohamad^25*, Syahiran Mohammad^25*, Ahmad-Zafrullahafham Ahmad-Fakri^25*, Halim-Fikri Hashim^25*, Morohuntodun O. Oni^26*, Antonieta Lukangu^27*, Ligia Alves, MD^27*, Miguel Brito, PhD^28*, Viviana Giannuzzi^29*, Fedele Bonifazi^29*, Kyriaki Michailidou^30*, Sotiroula Chatzimatthaiou^31*, Carsten Lederer^31* and Petros Kountouris, PhD^32*

¹Dana-Farber/Boston Children's Cancer and Blood Disorder Ctr., Boston, MA
²The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus
³The Cyprus Institute of Neurology & Genetics, Nicosia, CYP
⁴Centre Hospitalier Monkole, Kinshasa, Congo (The Democratic Republic of the)
⁵CEFA-Monkole Institut de Recherche Biomédicale, Kinshasa, Congo (The Democratic Republic of the)
⁶Centre of Excellence for Sickle Cell Disease Research and Training, Department of Haematology and Blood Transfusion, College of Health Sciences, University of Abuja, Abuja, Nigeria
⁷4Centre of Excellence for Sickle Cell Disease Research and Training, University of Abuja, Abuja, Nigeria
⁸Ahmadu Bello University Teaching Hospital, Kaduna, NGA
⁹5Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria
¹⁰Thalassemia Centre, Archbishop Makarios III Hospital, Nicosia, Cyprus
¹¹Thalassemia Centre, Archbishop Makarios III Hospital, Nicosia, Greece
¹²General Hospital of Larissa, Larissa, GRC
¹³Haematology Unit, Cancer Research Centre, Selangor, MYS
¹⁴Hospital Pulau Pinang, Pulau Pinang, MYS
¹⁵Hospital Sultanah Bahiyah, Kedah, Malaysia
¹⁶Ampang Hospital, Kuala Lumpur, Malaysia
¹⁷Cancer Research Centre, Selangor, Malaysia
¹⁸Danish Red Blood Cell Center, Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
¹⁹Hippokrateio General Hospital, Athens, Greece
²⁰Kaduna State University, Kaduna, Nigeria
²¹Laiko General Hospital, Athens, Greece
²²Department of Pathology, UKM Medical Centre, Kuala Lampur, Malaysia
²³Department of Laboratory Diagnostics Services, UKM Specialist Children's Hospital, Kuala Lumpur, Malaysia
²⁴UKM Specialist Children's Hospital, Kuala Lumpur, Malaysia
²⁵Universiti Sains Malaysia, Kubang Kerian, Malaysia
²⁶Dana-Farber / Boston Children’s Cancer and Blood Disorders Center, Brookline, MA
²⁷Maternidade Lucrécia Paim, Luanda, Angola
²⁸H&TRC, Escola Superior de Tecnologia da Saude de Lisboa, Lisbon, AL, Portugal
²⁹Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus, Bari, Italy
³⁰The Cyprus Institute of Neurology and Genetics, Nicosia, CYP
³¹The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
³²Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, CYP

Nathaniel Goldfarb, BSc/ MSc^1*, Joseph R Stanek, MS^2*, Joseph Walden^3*, Melissa J Rose, DO⁴, Kathleen Nicol, MD^5*, Anthony Villella, MD⁵, Jennifer Young^5* and Susan Elizabeth Creary, MD, MSc⁶

¹Center for Child Health Equity Outcomes and Research, Nationwide Children's Hospital, Columbus, OH
²Division of Pediatric Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH
³University of Cincinnati College of Medicine, Cincinnati, OH
⁴Division of Pediatric Hematology Oncology, Nationwide Children’s Hospital, Columbus, OH
⁵Nationwide Children's Hospital, Columbus, OH
⁶Nationwide Children's Hospital Research Institute, Columbus, OH

Shakirat Gold-Olufadi, MBBS¹, Kayode Ogunniyi, MD, MRCP^2*, Toluwalase Awoyemi, MD, PhD^3*, Bukky Florence Tabiti, MD⁴, Henry Becerra, MD⁵, Dosbai Saparov, MD^5*, Kibwey Peterkin, MBBS^6*, Ifeanyi Nnamdi Uche, MBBS⁷, Nosakhare Paul Ilerhunmwuwa, MBBS, MSc⁸ and Esther Yemisi Oluwadeyi, MBChB⁹

¹Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY
²Department of Medicine, Richmond University Medical Center, Staten Island, NY
³Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
⁴, Northwestern University, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
⁵Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY
⁶Brookdale University Hospital and Medical Center, Brooklyn, NY
⁷Department of Medicine, One Brookdale University Hospital and Medical Center, Brooklyn, NY
⁸Department of Hematology, University of Pittsburgh Medical Center, Brooklyn, NY
⁹Brookdale University Hospital Medical Center, Brooklyn, NY

Johnny Mahlangu, MD¹, John James^2*, Biree Andemariam, MD³, John Waller^4*, Samar Al-Behaisi^4*, Gareth Morrell^5*, Raffaella Colombatti, MD, PhD^6* and Cassandra Trimnell^7*

¹University of the Witwatersrand, Johannesburg, South Africa
²Sickle Cell Society, London, United Kingdom
³University of Connecticut Health, Farmington, CT
⁴Novo Nordisk Health Care AG, Zurich, Switzerland
⁵Madano, London, United Kingdom
⁶University of Padova, Padova, Italy
⁷Sickle Cell 101, San Francisco, CA

Arvind Mallikarjunan, MS, BS^1,2*, Abhinav Gundala, MSc^2*, Jhana Parikh, BS, MS^2,3*, Elizabeth Hensley, BS^2*, Olivia Fernandez^4*, Caroline Vuong, MD^5*, Shannon Ford, PhD^2,6* and Nirmish Shah, MD⁷

¹Brody School of Medicine - East Carolina University, Durham, NC
²Nanbar Health LLC, Winterville, NC
³Campbell School of Osteopathic Medicine, Campbell University, Lillington, NC
⁴Department of Medicine, Division of Hematology - Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
⁵Department of Pediatric Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands
⁶School of Nursing, University of North Carolina at Wilmington, Wilmington, NC
⁷Department of Medicine, Division of Hematology - Duke Sickle Cell Comprehensive Care Unit, Duke University School of Medicine, Durham, NC

Biree Andemariam, MD¹, Johnny Mahlangu^2*, Raffaella Colombatti, MD, PhD³, John Waller^4*, Samar Al-Behaisi^4*, Gareth Morrell^5* and John James^6*

¹University of Connecticut Health, Farmington, CT
²University of the Witwatersrand, Johannesburg, South Africa
³University of Padova, Padova, Italy
⁴Novo Nordisk Health Care AG, Zurich, Switzerland
⁵Madano, London, United Kingdom
⁶Sickle Cell Society, London, United Kingdom

Anna Collado Gimbert, MD^1,2*, Sara Reidel, MSc^1*, Patricia Alonso de Apellániz, MSc^3*, Federico Alvarez, Prof, PhD^4*, Borja Arroyo Galende, MSc^5*, David Beneitez, MD^6,7*, Bart J. Biemond, MD, PhD⁸, Maria Paola Boaro, MD^9*, Betzabel Cajiao Garcia, MSc^10*, Gastone Castellani, PhD^11*, Elena Cela, MD, PhD^12*, Marjon H. Cnossen, MD, PhD^13*, Piero Fariselli, PhD^14*, Karin Fijnvandraat, MD, PhD^15*, Béatrice Gulbis, MD, PhD^16,17*, Amira Idrizovic, MSc, PhDc^1,18*, Petros Kountouris, PhD^19*, Vincent Malcor Deydier De Pierrefeu, PhD^20*, Sandra Manceau, PhD^21*, Elisabetta Mezzalira, RN, MS, PhDc^22*, Erfan Nur, MD, PhD²³, Kalia Orphanou, PhD^24*, Juan Parras, PhD^25*, Salvador Payán-Pernía, MD^26*, Anne-Laure Pham Hung D'Alexandry D'Orengiani, PhD^27*, Minke A.E. Rab, MD, PhD²⁸, Giulia Reggiani, MD^29*, Anita W. Rijneveld, MD, PhD³⁰, Cesare Rollo, PhD^14*, Anna Ruiz Llobet, MD^31*, Tiziana Sanavia, PhD^14*, Saskia EM Schols, MD, PhD^32*, Stella Tamana, PhD^24*, Marissa J.M. Traets, MD^33*, Silvia Uribe, PhD^34*, Sigrid van der Veen, MSc^35*, Santiago Zazo, Prof., PhD^36*, Pablo Bartolucci, MD, PhD^37*, Mariane De Montalembert, MD, PhD³⁸, Raffaella Colombatti, MD, PhD^39*, Eduard J. Van Beers, MD, PhD^40,41 and Maria del Mar Mañú-Pereira, PhD^1*

¹Rare Anemia Disorders Research Laboratory, Cancer and Blood Disorders in Children, Vall d'Hebron Research Institute / Vall d'Hebron University Hospital, Barcelona, Spain
²Pediatric Oncology and Hematology, Vall d'Hebron Barcelona Hospital, Barcelona, Spain
³Information Processing and Telecommunications Center, Universidad Politécnica de Madrid, Madrid, Spain
⁴Universidad Politécnica de Madrid, Madrid, Spain
⁵Grupo de Aplicación de las Telecomunicaciones Visuales, Universidad Politécnica de Madrid, Madrid, Spain
⁶Hematology Department, Vall d'Hebron Hospital Universitari/Vall d'Hebron Research Institute (VHIR)/Vall d'Hebron Institute of Oncology (VHIO)/Universitat Autònoma de Barcelona (UAB)/ERN-EuroBloodNet, Barcelona, Spain
⁷Vall d'Hebron Institute of Oncology, Vall d'Hebron Hospital Universitari, Universitat Autonoma de Barcelona, Barcelona, Spain
⁸Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁹Department of Women’s and Children’s Health, Padova University, Padova, Italy
¹⁰Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, University Medical Center Utrecht, Utrecht, Netherlands
¹¹Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
¹²Pediatric Hematology and Oncology, Hospital Gregorio Marañón. Universidad Complutense de Madrid, Madrid, Spain
¹³Department of Pediatric Hematology and Oncology, Erasmus MC Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands
¹⁴Computational Biomedicine Unit, Department of Medical Sciences, University of Torino, Turin, Italy
¹⁵Department of Pediatric Hematology, Amsterdam UMC, Emma Children's Hospital, Amsterdam, Netherlands
¹⁶Hopital Erasme U.L.B, Brussels, BEL
¹⁷Centre of Human genetics, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium
¹⁸Genetics and Microbiology department, Universitat Autonoma de Barcelona, Barcelona, Spain
¹⁹Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, CYP
²⁰Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
²¹Laboratoire d'Excellence GR-Ex, Paris, France., Paris, France
²²Pediatric Hematology, Oncology and Stem Cell Transplant Division, Maternal and Child Health Department, Università degli Studi di Padova, Padova, Italy
²³Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
²⁴Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
²⁵Information Processing and Telecommunications Center, ETSI Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain
²⁶Servicio de Hematologia, Hospital Universitario Virgen del RocÍo, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain
²⁷University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Créteil, FRA
²⁸Department of Hematology, University Medical Center Utrecht, Utrecht, Netherlands
²⁹Department of Women’s and Children’s Health, University of Padua, Padova, Italy
³⁰Department of Hematology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, Netherlands
³¹Pediatric Hematology, Hospital Sant Joan de Déu, Barcelona, Barcelona, ESP
³²Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands
³³Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
³⁴Escuela Técnica Superior de Ingeniería de Sistemas Informáticos-Departamento de Sistemas Informáticos, Universidad Politécnica de Madrid, Madrid, Spain
³⁵Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
³⁶Centro de I+D+i en Procesado de la Información y Telecomunicaciones (IPTC), Universidad Politécnica de Madrid, Madrid, Spain
³⁷University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France
³⁸Department of General Pediatrics and Pediatric Infectious Diseases, Sickle Cell Center, Necker-Enfants Malades Hospital, Neuilly, France
³⁹Department for Woman's and Child's Health, University of Padova, Padova, Italy
⁴⁰Department of Hematology, Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
⁴¹Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

Biree Andemariam, MD¹, Adam Wufsus², Erik Hecht^2* and Cassandra Trimnell^3*

¹University of Connecticut Health, West Hartford, CT
²Novo Nordisk Inc., Plainsboro, NJ
³Sickle Cell 101, San Francisco, CA

Simone Villaboni^1,2*, Barbara Gianesin^3*, Maddalena Casale^4*, Silverio Perrotta^4*, Filippo Mazzi^1,2*, Jacopo Ceolan^1,2*, Roberto Pirrone^5*, Antonia Gigante^3*, Valeria Maria Pinto^6*, Michaela Calvillo^7*, Raffaella Origa^8*, Gian Luca Forni^3,7* and Lucia De Franceschi^2,9

¹Dept. of engineering for innovative medicine, University of Verona, Verona, Italy
²Azienda Ospedaliera Universitaria di Verona, Verona, Italy
³For Anemia Foundation, Genoa, Italy
⁴Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italy
⁵MOST s.r,l., Turin, Italy
⁶S.S.D. Microcythemia, Congenital Anemias and Iron Dysmetabolism, Galliera Hospital, Genoa, Italy
⁷Hematology Unit, IRCCS Giannina Gaslini, Genoa, Italy
⁸S.C. Centro delle Microcitemie e Anemie Rare, Università di Cagliari, ASL Cagliari, Cagliari, Italy
⁹University of Verona, Verona, Italy

Matthew Hsieh, MD¹, Priscilla Pollack^2*, Elizabeth Harvey^2*, Triscia Martin^2*, Neal Jeffries, PhD^3*, Wendy W Pang, MD, PhD⁴ and John Tisdale, MD²

¹Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD
²Cellular and Molecular Therapeutics Branch, NIH-NHLBI, Bethesda, MD
³Office of Biostatistics Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Jasper Therapeutics, Redwood City, CA

Abdulrahman Nasiri, MD^1,2, Sarah Samarkandi, MD^2*, Reem Alasbali, MD^2*, Ahmed Alahmadi^2*, Marwa Nassar, MD^2*, Huda Alfattah^2*, Yousef Bukhari^2*, Anas Fallatah^2*, Hadeel Samarkandi^3*, Tariq Alzahrani^3*, Haya Alothaimeen^4*, Tusneem Ahmed M Elhassan, PhD^4*, Fahad Alotaibi^4*, Ahmed Kotb Abdrabou, MD^2*, Alfadil Haroon, MD^5*, Mostafa Saleh^2*, Riad Elfakih, MD^2*, Saud Alhayli, MD^2*, Amr Hanbali, MD^2*, Feras Abdulaziz Alfraih, MD^2*, Walid Rasheed², Syed Osman Ahmed, MD^2*, Naeem A. Chaudhri², Ahmad S. Alotaibi, MD^2*, Said Yousuf Ahmed, MD^6*, Hazza Alzahrani, MD^2*, Mahmoud Aljurf^2*, Fahad Almohareb² and Ali Alahmari, MD^2*

¹College of medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
²Department of Hematology, Stem Cell Transplantation, and Cellular Therapy, Cancer Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
³Department of pharmacy, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
⁴Clinical Research Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
⁵Department of Hematology, Stem Cell Transplantation, and Cellular Therapy, Cancer Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, AL, Saudi Arabia
⁶Ministry of Health, Riyadh, Saudi Arabia

Christina Lisk, PhD^1*, Francesca I Cendali, BS², Delany Swindle^1*, Gemlyn George, MD^1*, Kathryn Louise Hassell, MD¹, Rachelle Nuss, MD^3*, Paul Buehler, PharmD, PhD^4*, Angelo D'Alessandro, PhD⁵ and David Irwin, Ph.D^1*

¹University of Colorado Anschutz Medical Campus, Aurora, CO
²University of Colorado School of Medicine, Anschutz, Aurora, CO
³Center for Cancer and Blood Disorders, University of Colorado Anschutz Medical Campus, Aurora, CO
⁴Center for Blood Oxygen Transport and Hemostasis, University of Maryland, Baltimore, MD
⁵Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO