-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

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113.P1.47 113. Sickle Cell Disease, Sickle Cell Trait, and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Poster I

Symposia: Sickle Cell Disease, Sickle Cell Trait, and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational Program: Oral and Poster Abstracts
Type: Poster
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Sickle Cell Disease, Combination therapy, Translational Research, Sickle Cell Trait, Drug development, Hemoglobinopathies, Diseases, Devices, Treatment Considerations, Non-Biological therapies, Pharmacology, Biological Processes, Molecular biology, Multi-systemic interactions, Pathogenesis
Saturday, December 7, 2024: 5:30 PM-7:30 PM
Halls G-H (San Diego Convention Center)
This session includes cross-sectional pre-clinical and translational studies on sickle cell disease.

Ayyanar Sivanantham, PhD1*, Omika Katoch, PhD2*, Nicholas Swendrowski, MS2* and Prithu Sundd, PhD2,3

1Thrombosis and Hemostasis Program, VERSISI BLOOD RESEARCH INSTITUTE AND BLOOD CENTER OF WISCONSIN, MILWAUKEE, WI
2Thrombosis and Hemostasis Program, VERSITI Blood Research Institute and Blood Center of Wisconsin, Milwaukee, WI
3Medical College of Wisconsin, Division of Hematology and Oncology, Milwaukee, WI

Zoe Sekyonda, BS1*, Solomon Oshabaheebwa, MSc, BSc2*, Ada Chang, BSc3*, Jane A. Little, MD3 and Umut Gurkan, PhD1

1Case Western Reserve University, Cleveland, OH
2Case Western Reserve University, Cleveland Heights, OH
3University of North Carolina, Chapel Hill, NC

Tomasz Kaminski, PharmD1, Nicholas Swendrowski, MS2*, Omika Katoch, PhD2* and Prithu Sundd, PhD2,3

1Thrombosis and Hemostasis Program, VERSITI Blood Research Institute, Milwaukee
2Thrombosis and Hemostasis Program, VERSITI Blood Research Institute, Milwaukee, WI
3Medical College of Wisconsin, Division of Hematology and Oncology, Milwaukee, WI

Marielle Margier, PhD1*, Giulia Scorrano, PhD1*, Cecile Cros, PhD2*, Julie Charmetant3*, Thiago Trovati Maciel, PhD4*, Ousmane Alfa Cisse, MD, MSc5*, Wassim El Nemer, PhD6,7 and Matthias Canault, PhD5*

1LGD SARL, Velaux, France
2Nuvamid SA, Nyon, Switzerland
3LGD SARL, Velaux, -- select, France
4Institut Imagine - INSERM U1163, Paris, France
5NUVAMID SA, NYON, Switzerland
6French Blood Establishment(EFS), Marseille, France
7Établissement Français du Sang PACA-Corse, Aix Marseille Université, CNRS, UMR 7268 ADES, Marseille, France

Laura Sinigaglia, PhD1*, Marcella O'Reilly, PhD2*, Rhea Bhalla, MSc3*, Khoa Chung, PhD2*, Pardis Piri Dizaji, MSc2*, Victoria Begley, PhD4*, Rose Hodgson, PhD2*, Gabriela Lin, PhD2*, Konstantinos Vanezis, PhD4*, Julieta Tesone, PhD4*, Helen Paterson, PhD4*, Shreyasi Swamy, MSc2*, Henrik Hansen, PhD5*, Natalia Izotova, PhD6*, Bruno Doreste, PhD6*, Yulia Lomonosova, PhD7*, Luke Haslett, PhD6*, Robert Habib, MBA8,9*, Robert F Place, PhD7*, Jon Voutila, PhD7*, Vikash Reebye, PhD8,10*, Troels Koch, PhD6* and Brid M Ryan, PhD7*

1Rare Genetic Diseases, MiNA Therapeutics Ltd, London, United Kingdom
2Rare Genetic Diseases, MiNA Therapeutics, London, United Kingdom
3Rare Genetic Diseases, MiNa Therapeutics, London, United Kingdom
4Rare Genetic Diseases, MiNA therapeutics, London, United Kingdom
5MiNA therapeutics, London, United Kingdom
6Rare Genetic Disease, MiNA therapeutics, London, United Kingdom
7Rare Genetic Disease, MiNA Therapeutics, London, United Kingdom
8Mina Therapeutics Ltd, London, United Kingdom
9Rare Genetic Disease, MiNA therapeutics, london, United Kingdom
10Imperial College London, London, United Kingdom

Laura Bencheikh, PhD1*, Laura Matabishi-Bibi, PhD1*, Gabriela Luszczewska2*, Meghan Perkins, PhD1*, Nicolas Hebert, PhD3,4*, Nagamy Rose Balli2*, Yosr Zaouali5*, Vincent Malcor Deydier De Pierrefeu, PhD6*, Fatima Bensiradj, MD6*, Caroline Barau, PhD7*, France Pirenne, MD, PhD8,9,10, Carlo Brugnara, MD11, Martin H. Steinberg, MD12, Haydar Frangoul, MD13, Marie Cambot, PhD1* and Pablo Bartolucci, MD, PhD14*

1INNOVHEM, Créteil, France
2INNOVHEM, Creteil, France
3Université Paris-Est Créteil, INSERM, IMRB, Laboratory of excellence LABEX GRex, Créteil, France, Créteil, France
4University Paris-Est-Créteil, IMRB, Inserm U955, Laboratory of excellence LABEX, Établissement Français du Sang (EFS), Créteil, France
5Sickle Cell Referral Center - UMGGR, Plateforme D'Expertise Maladies Rares Grand Paris, Creteil, France
6Sickle Cell Referral Center, Department of Internal Medicine, Henri-Mondor University Hospital- UPEC, AP-HP, Creteil, France
7Plateforme de Ressources Biologiques, Henri Mondor Hospital, AP-HP, Creteil, France
8Université Paris-Est Créteil , Henri Mondor Hospital, Créteil, France
9Transfusion et maladies du globule rouge - Equipe Pirenne, Institut Mondor de Recherche Biomedicale (IMRB), Creteil, France
10Etablissement Francais Du Sang - Université Paris-Est Créteil Hospital, Creteil, France
11Lab of Medicine and Pathology, Children’s Hospital, Harvard Medical School, Boston, Boston, MA
12Boston University Chobanian & Avedisian School of Medicine, Boston, MA
13Sarah Cannon Research Institute at the Children's Hospital at TriStar Centennial, Nashville, TN
14University Paris-Est-Créteil, IMRB, Inserm U955,, Henri Mondor University Hospitals, APHP, Sickle Cell Referral Center-UMGGR, Creteil, France

Kennedy N Goldsborough, PhD1*, Israel Almeida2*, Ashwin P. Patel, MD, PhD, MPH3, John Paderi, PhD4* and Vivien Sheehan, MD, PhD5

1Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
2Department of Biology, Emory University, Atlanta, GA
3Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
4IHP Therapeutics, San Carlos, CA
5Emory University School of Medicine, Atlanta, GA

Trang Nguyen1*, Christy Ingersoll, MBA1*, Katie Lizotte, ScB2*, Chi-Chao Chen, MD, PhD2*, Erin Tsai, MS1*, Megan Wind-Rotolo, PhD1 and Hui Gao, PhD1*

1Agios Pharmaceuticals, Inc., Cambridge, MA
2Employee of Agios Pharmaceuticals, Inc. at time of research, Cambridge, MA

Kai Dou, PhD1*, Rikang Wang, PhD2*, Weili Bao, MS3*, Yunfeng Liu, PhD3, Shan Su, PhD3, Avital Mendelson, PhD4, Cheryl Lobo, PhD5, Patricia Shi, MD6, Xiuli An, MD, PhD7, Karina Yazdanbakhsh, PhD3 and Hui Zhong, PhD8

1Lab of immune regulation, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
2Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, China
3Laboratory of Complement Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
4Laboratory of Stem Cell Biology and Engineering, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
5Laboratory of Blood-Borne Parasites, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
6New York Blood Center, New York, NY
7Laboratory of Membrane Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY
8Laboratory of Immune Regulation, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY

Aline Renata Pavan, PhD1*, Victor Gabriel de Faria Pastre, BSc1*, Carolina Lanaro, BSc, PhD1*, Dulcineia Albuquerque, PhD1*, Joshua P. Smalley, PhD2*, Urvashi Patel, BSc2*, John W. R. Schwabe, PhD3*, Shaun M. Cowley, PhD4*, James T. Hodgkinson, PhD2*, Jean Leandro Dos Santos, PhD5* and Fernando Ferreira Costa, MD, PhD1

1Hematology and Hemotherapy Center, University of Campinas - UNICAMP, Campinas, Brazil
2Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Leicester, United Kingdom
3Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom
4Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom
5School of Pharmaceutical Sciences, Sao Paulo State University, Araraquara, Brazil

Anvita Kulshrestha1, Melanie E. Garrett, MS1*, Marilyn J. Telen, MD2 and Allison E. Ashley-Koch, PhD1*

1Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC
2Duke University Medical Center, Durham, NC

Malini Sharma, BA1, Fabliha Ahmed Chowdhury, PhD2, Stefanie Taiclet, BS2*, Brian J Philips, PhD3*, Katherine C Wood, PhD2,3, Adam C Straub, PhD2,3* and Julia Xu, MD, PhD, MS4,5

1University of Pittsburgh School of Medicine, Pittsburgh, PA
2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
3Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
4Division of Classical Hematology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
5University of Pittsburgh, Pittsburgh, PA

Marissa J.M. Traets, MD1*, Aida Kidane, MD2,3*, Jennifer Bos1*, Brigitte A. van Oirschot1*, Sigrid van der Veen, MSc4*, Mandy N. Lauw, MD, PhD5, Erfan Nur, MD, PhD6,7, Bart J. Biemond, MD, PhD8, Marjon H. Cnossen, MD, PhD9*, Eduard J. Van Beers, MD, PhD10, Richard van Wijk, PhD1 and Minke A.E. Rab, MD, PhD1,11

1Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht, Netherlands
2Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands
3Section on Social and Cognitive Developmental Neuroscience, National Institutes of Mental Health, Bethesda, MD
4Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands
5Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
6Department of Hematology, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands
7Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
8Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands
9Department of Pediatric Hematology and Oncology, Erasmus MC Sophia Children’s Hospital, Erasmus University Medical Center, Rotterdam, Netherlands
10Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
11Department of Hematology, Erasmus MC, Rotterdam, Netherlands

Bindu Parachalil Gopalan, PhD1*, Sayuri Kamimura, MS2*, Pradeep Dagur, PhD3*, Niharika Shah, MD4*, Martha Quezado, MD4*, Zenaide Quezado, MD2 and Arun S. Shet, MD, PhD1

1Sickle Thrombosis and Vascular Biology Lab, Cellular and Molecular Therapeutic Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
2Department of Perioperative Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD
3Flow Cytometry Core, National Heart Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD
4Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD

Nirupama Ramadas, PhD, MSc, BSc1*, Joshua Dutton2*, Ashlyn Lowery2* and Erica Sparkenbaugh, PhD3,4

1Blood Research Center, University of North Carolina at Chapel Hill, Carrboro, NC
2Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
3Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
4Blood Research Center, University of North Carolina Chapel Hill, Chapel Hill, NC

Chithra D. Palani, PhD1,2, Abraham Nudelman, PhD3*, Ada W. Rephaeli, PhD4*, Donald E. Lavelle, PhD5, Manickam Alagar, PhD6*, Nikhil Patel, MD7*, Zhi Wenbo, PhD8* and Betty S. Pace, MD2,9

1Department of Pediatrics, Augusta University, Augusta, GA
2Georgia Cancer Center, Augusta University, Augusta, GA
3Chemistry Department, Bar Ilan University, Ramat Gan, Israel
4Felsenstein Medical Research Center, Petach Tikva, Israel
5Department of Medicine, University of Illinois at Chicago, Chicago, IL
6Stem Cell Processing Lab, Transfusion Services, Wellstar MCG Health, Augusta, GA
7Department of Pathology and Laboratory Medicine, Medical College of Georgia at Augusta University, Augusta, GA
8Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA
9Division of Hematology/Oncology, Augusta University, Augusta, GA

*signifies non-member of ASH