Duran Canatan^1,2,3*, Serpil Delibaş^1*, Emel Altunsoy^3*, Yunus Budak^3*, Elif Gözde Gökkaya^2*, Sultan Aydın^4*, Defne Ay Tuncel^5*, Priyaleela Thota^6*, Akshat Jain, MD, MPH⁷ and Umut Gurkan, PhD⁸

¹Hemoglobinopathy Diagnosis Thalassemia Center of Mediterranean Blood Diseases Foundation, Antalya, Turkey
²Antalya Bilim University, Antalya, Turkey
³Antalya Genetic Diseases Assessment Center, Antalya, Turkey
⁴Thalassemia Center, Health Sciences University, Antalya Education and Research Hospital, Antalya, Turkey
⁵Pediatric Hematology Oncology Clinic, Health Sciences University, Adana City Training and Research Hospital, Adana, Turkey
⁶Hemex Health, USA, Portland, OR
⁷Clinical Medicine and Pediatrics, Division of Hematology,Oncology and Cell Therapy, Loma Linda University School of Medicine, Redlands, CA
⁸Case Western Reserve University, Shaker Heights, OH

Sylvia Titi Singer, MD¹, Yu Hou, PhD^2*, Rajesh Sharma, PhD, FACMG^3*, Elliott P. Vichinsky, MD⁴, Adriane Meyer, CGMBS^5*, Jennifer Martinez, CLS^5*, Cindy Wu, PhD^6*, Tracey Bishop^6* and Shabnam Tavassoli, PhD, CLS^5*

¹hematology/Oncology, UCSF Benioff Children's Hospital Oakland, Oakland, CA
²California Department of Public Helath, Genetic Disease Laboratory, Genetic Disease Screening Program, Richmond, CA
³Genetic Disease Screening Program, California Department of Public Health, Richmond, CA
⁴Department of Pediatrics, Division of Hematology, University of California San Francisco Benioff Children's Hospital, Oakland, CA
⁵Hemoglobin Reference Laboratory/UCSF Benioff Children's Hospital Oakland, Oakland, CA
⁶California Department of Public Health, Genetic Disease Screening Program, Richmond, CA

Xiao Liang^1*, Gaohui Yang^1*, Lingling Shi^1*, Lianjin Liu^1*, Zhenbin Wei^1*, Yumei Huang^1*, Jing Bai^2*, Yi Liang^2*, Lingyuan Pan^1*, Zhaoping Gan^1*, Yu Lin^1*, Yibin Yao^1*, Ying Tang^1*, Huicheng Huang^1*, Xuemei Zhou^1*, Qifa Liu, MD³, Yongrong Lai, MD^1,4,5* and Rongrong Liu, Doctor^1,4,5*

¹Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
²Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴NHC Key Laboratory of Thalassemia Medicine, Nanning, China
⁵Guangxi Key Laboratory of Thalassemia Research, Nanning, China

Kinza Khan^1*, Farah O'Boyle^2*, Kirstin Lund, MRCP, BSc^3*, Toni Petterson^4*, Sandrine Bremathas, RN^5*, Kelly Hennessy^6*, Adam Gassas, MD^7*, Leena Karnik, FRCPath, MRCP^8* and Josu de la Fuente, PhD FRCP^9,10,11,12

¹Imperial College London, Gillingham, ENG, United Kingdom
²St. Marys Hospital, London, United Kingdom
³St Marys Hospital, Imperial College London, London, GBR
⁴St Marys Hospital, Imperial College NHS Foundation Trust London, London, GBR
⁵IMPERIAL COLLEGE HEALTHCARE NHS TRUST, London, United Kingdom
⁶St Marys Hospital, Imperial College London, London, United Kingdom
⁷St Marys Hospital, Imperial College NHS Foundation Trust, London, United Kingdom
⁸St Marys Hospital, Imperial College NHS Foundation Trust, London, GBR
⁹Department of Paediatrics, St Mary’s Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
¹⁰Division of Immunology and Inflammation, Imperial College London, London, United Kingdom
¹¹Imperial College Healthcare Trust, St Mary's Hospital, London, United Kingdom
¹²Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom

Kasey Fu^1*, Katherine Lawson-Michod^2*, Michael Goodman^2*, Cathy Lally^2* and Jelili Ojodu, MPH^3*

¹Vertex Pharmaceuticals Incorporated, Boston, MA
²Epidemiologic Research & Methods, LLC, Atlanta, GA
³Association of Public Health Laboratories, Silver Spring, MD

Olubunmi Ogunsanya, MD^1*, Amrit Kirpalani, MD^1*, Jennifer Zavitz^2*, Ashley Geerlinks, MD¹ and Soumitra Tole, MD, MSc^1*

¹Department of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
²Children's Hospital, London Health Sciences Center, London, ON, CAN