-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

642.O2.3 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Treating Refractory Disease-Novel Agents and Quality-of-Life

Symposia: Chronic Lymphocytic Leukemia: Clinical and Epidemiological Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Lymphoid Leukemias, Clinical trials, Adult, Combination therapy, Translational Research, CLL, Lymphomas, Bispecific Antibody Therapy, Non-Hodgkin lymphoma, Clinical Research, B Cell lymphoma, Chimeric Antigen Receptor (CAR)-T Cell Therapies, Diseases, Immune mechanism, Patient-reported outcomes, Treatment Considerations, Biological therapies, Lymphoid Malignancies, Biological Processes, Study Population, Human, Measurable Residual Disease
Monday, December 9, 2024: 2:45 PM-4:15 PM
Marriott Grand Ballroom 5-6 (Marriott Marquis San Diego Marina)
Moderators:
Lucrecia Yanez San Segundo, MD, PhD, Hospital Universitario Marqués de Valdecilla (IDIVAL) and Adam S Kittai, MD, Icahn School of Medicine at Mount Sinai
Disclosures:
Kittai: AstraZeneca: Consultancy, Research Funding, Speakers Bureau; BeiGene: Consultancy, Research Funding, Speakers Bureau; BMS: Consultancy; Abbvie: Consultancy; Eli-Lilly: Consultancy; Galapagos: Consultancy.

Immunotherapy and degraders as standalone treatment and/or in combination in relapsed/refractory CLL
2:45 PM

Alexey Danilov, MD, PhD1, Bita Fakhri, MD, MPH2, Farrukh T. Awan, MD3, Hans Herluf Bentzen, MD4*, Herbert A. Eradat, MD5, Carsten Utoft Niemann, MD, PhD6*, Fritz Offner, MD, PhD7, Christian Bjørn Poulsen, MD, PhD8*, Thor Hoeyer, MD9*, Mar Bellido, MD, PhD10*, Damien Roos Weil, MD11*, Alessandra Ferrajoli, MD12, Meghan C. Thompson, MD13, Jacob Haaber Christensen, MD, PhD14*, Ann Janssens, MD, PhD15*, Tamar Tadmor, MD16*, Mazyar Shadman, MD, MPH17*, Pegah Jafarinasabian, MD, PhD18*, Jimin Zhang, PhD19*, Marcia Rios, MBA19*, Alexandra Kuznetsova, PhD20*, Rebecca Valentin, MD, PhD20* and Arnon P. Kater, MD, PhD21

1City of Hope, Duarte, CA
2Stanford Cancer Institute, Stanford University, Palo Alto, CA
3University of Texas Southwestern Medical Center, Dallas, TX
4Aarhus University Hospital, Aarhus, Denmark
5David Geffen School of Medicine at UCLA, Los Angeles, CA
6Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
7Universitair Ziekenhuis Ghent, Ghent, Belgium
8Department of Hematology, Zealand University Hospital, Roskilde, Denmark
9Aalborg University Hospital, Aalborg, Denmark
10University Medical Center Groningen and University of Groningen, Groningen, Netherlands
11Sorbonne Université, Department of Clinical Haematology, APHP, Hôpital Pitié-Salpêtrière, Paris, France
12Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
13Memorial Sloan Kettering Cancer Center, New York, NY
14Odense University Hospital, Odense, Denmark
15University Hospitals Leuven, Leuven, Belgium
16Hematology Unit, Bnai Zion Medical Center, Haifa, Israel
17Fred Hutchinson Cancer Center, Seattle, WA
18AbbVie Inc, North Chicago, IL
19Genmab, Plainsboro, NJ
20Genmab, Copenhagen, Denmark
21Amsterdam UMC, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, Netherlands

3:00 PM

Nirav N. Shah, MD1,2, Zulfa Omer, MD3, Graham P. Collins4, Francesco Forconi5*, Alexey Danilov, MD, PhD6, John C. Byrd, MD7, Dima El-Sharkawi8*, Emma Searle, MD, PhD9,10*, Alvaro J Alencar, MD11, Shuo Ma, MD, PhD12, Sarah Injac13* and Talha Munir, MBBS, PhD14

1Medical College of Wisconsin, Brookfield, WI
2Medical College of Wisconsin, Milwaukee, WI
3Division of Hematology, University of Cincinnati, Cincinnati, OH
4Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
5School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
6City of Hope National Medical Center, Duarte, CA
7Department of Internal Medicine, University of Cincinnati, Cincinnati, OH
8The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
9The Christie NHS Foundation Trust, Manchester, United Kingdom
10The University of Manchester, Manchester, United Kingdom
11Sylvester Comprehensive Cancer Center, Division of Hematology, University of Miami, Miller School of Medicine, Miami Beach, FL
12Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL
13Nurix Therapeutics, Inc., San Francisco, CA
14Department of Haematology, St. James's University Hospital, Leeds, United Kingdom

3:15 PM

Meghan C. Thompson, MD1, Ricardo D. Parrondo, MD2, Anna Maria Frustaci, MD3*, John N. Allan, MD4, Paolo Ghia, MD, PhD5,6, Irina Mocanu, MD7*, Constantine S. Tam, MD, MBBS8, Judith Trotman, FRACP9, Inhye E. Ahn, MD10, Stephan Stilgenbauer, MD11, Lydia Scarfo, MD5,6, Xiangmei Chen12*, Kunthel By, PhD13*, Shannon Fabre13*, Daniel O. Persky, MD13, Amit Agarwal13* and John F. Seymour, MBBS, PhD14

1Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
2Division of Hematology-Oncology, Mayo Clinic-Florida, Jacksonville, FL
3ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy
4Division of Hematology and Oncology, Weill Cornell Medicine, Long Island City, NY
5Università Vita-Salute San Raffaele, Milano, Italy
6IRCCS Ospedale San Raffaele, Milano, Italy
7Institute of Oncology, ARENSIA Exploratory Medicine, Düsseldorf, Germany
8Alfred Hospital and Monash University, Melbourne, VIC, Australia
9Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia
10Dana-Farber Cancer Institute, Boston, MA
11Ulm University, Ulm, Germany
12BeiGene (Shanghai) Co, Ltd, Shanghai, China
13BeiGene USA, Inc, San Mateo, CA
14Department of Clinical Haematology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

3:30 PM

Jeff P. Sharman, MD1, Talha Munir, MBBS, PhD2, Sebastian Grosicki, MD, PhD3*, Lindsey Roeker, MD4, John M. Burke5, Christine I Chen, MHPE, MD6, Norbert Grzasko, PhD, MD7*, George Follows, MA, BM, BCh, PhD, FRCP, FRCPath8*, Zoltán Mátrai, MD, PhD9*, Alessandro Sanna, MD10*, Shuhua Yi, MD11*, Ru Feng12*, Vu Minh Hua, MBBS PhD FRACP FRCPA13*, Jadwiga Holodja14*, Wojciech Jurczak, MD, PhD15, Matthias Ritgen, MD16*, Lu-Gui Qiu, M.D.17, Francesc Bosch, MD, PhD18, Catherine C. Coombs, MD19, Katherine Bao, PhD20*, Vishalkumar Patel, MD20*, Bin Liu, MSc, MPH20*, Livia Compte, MD, PhD20*, Ananya Guntur, PhD20*, Ying (Denise) Wang, PhD20*, Marisa Hill, MD, MS20*, Ching Ching Leow20*, Paolo Ghia, MD, PhD21 and Paul M Barr, MD22

1Willamette Valley Cancer Institute and Research Center, US Oncology Research, Eugene, OR
2Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
3Medical University of Silesia, Katowice, Poland
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5US Oncology Hematology Research Program, Rocky Mountain Cancer Centers, Aurora, CO
6Princess Margaret Cancer Centre - University Health Network, Toronto, ON, Canada
7Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland
8Department of Haematology, Addenbrooke’s Hospital NHS Trust, Cambridge, United Kingdom
9Central Hospital of Southern Pest, National Institute for Haematology and Infectology, Budapest, HUN
10Department of Hematology, AOU Careggi - University of Florence, Florence, Italy
11Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
12Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China
13Hematology Department, Liverpool Hospital, Sydney, NSW, Australia
14Department of Hematology, City Hospital, Legnica, Poland
15Maria Sklodowska-Curie National Research Institute of Oncology, Krakow, Malopolskie, Poland
16Universitätsklinik Schleswig-Holstein, Campus Kiel, Kiel, DEU
17State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
18Department of Haematology, University Hospital Vall d'Hebron, Autonomous University, Barcelona, Spain
19University of California, Irvine, Irvine, CA
20Eli Lilly and Company, Indianapolis, IN
21Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milano, Italy
22University of Rochester, Rochester, NY

3:45 PM

William G. Wierda1, Kathleen Dorritie, MD2, Jordan Gauthier, MD, MSc3*, Rajneesh Nath, MD4*, Thomas J. Kipps, MD5, Peter A. Riedell, MD6, Herbert A. Eradat, MD7, Saad S. Kenderian, MD8, Mohamed A. Kharfan-Dabaja, MD, MBA9, Nirav N. Shah, MD10, Scott R. Solomon, MD11, Daniel A. Ermann, MD12, Jon E. Arnason, MD13, Abhinav Deol, MD14*, Tatyana Feldman, MD15*, Charalambos Andreadis, MD, MS16*, Monalisa Ghosh, MD17, Shuo Ma, MD, PhD18, Stephen J. Schuster, MD19, Usama Gergis, MD, MBA20, Julie M. Vose, MD, MBA21, Jacob D. Soumerai, MD22, Koen van Besien, MD, PhD23, Sherilyn A. Tuazon, MD24*, Serena K. Perna, MD25*, San-San Ou, MS24*, Neha Rane, MD25*, Eniko Papp, PhD24*, Yizhe Chen, PhD25* and Tanya Siddiqi, MD, MBBS26*

1The University of Texas MD Anderson Cancer Center, Houston, TX
2UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA
3Fred Hutchinson Cancer Center, Seattle, WA
4Banner MD Anderson Cancer Center, Gilbert, AZ
5Division of Hematology Oncology, Department of Medicine, University of California, San Diego, La Jolla, CA
6David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago, IL
7University of California, Los Angeles, Santa Monica Cancer Center, Santa Monica, CA
8Mayo Clinic, Rochester, MN
9Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL
10Medical College of Wisconsin, Milwaukee, WI
11Northside Hospital Cancer Institute, Atlanta, GA
12Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
13Beth Israel Deaconess Medical Center, Boston, MA
14Karmanos Cancer Institute/Wayne State University, Detroit, MI
15John Theurer Cancer Center at Hackensack Meridian Health, HMH School of Medicine, Hackensack, NJ
16University of California, San Francisco, San Francisco, CA
17University of Michigan Health System, Ann Arbor, MI
18Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL
19Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
20Thomas Jefferson University, Philadelphia, PA
21University of Nebraska Medical Center, Omaha, NE
22Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA
23Weill Cornell Medical College, New York, NY
24Bristol Myers Squibb, Seattle, WA
25Bristol Myers Squibb, Princeton, NJ
26City of Hope National Medical Center, Duarte, CA

4:00 PM

Laura Elisabeth Maria Eurelings, MD, PhD1,2*, Emelie Curovic Rotbain, MD, PhD3*, Sabina Kersting, MD, PhD4*, Lina Van Der Straten5*, Lisbeth Enggaard6*, Gerrit Jan Veldhuis, MD7*, Rogier Mous, MD PhD8*, Christian Bjørn Poulsen, MD, PhD9*, Henrik Frederiksen, MD, PhD10, Ann Janssens, MD11*, Ida Schjoedt6*, Ellen C Dompeling12*, Juha Ranti, MD13*, Christian Brieghel, MD, PhD14*, Mattias Mattsson, MD15*, Mar Bellido, MD, PhD16*, Hoa T Tran, MD, PhD17*, Claudia A M Stege, MD, PhD18*, Kazem Nasserinejad, PhD19,20*, Arnon P. Kater, MD, PhD21, Carsten Utoft Niemann, MD, PhD3* and Mark-David Levin22

1Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands
2Albert Schweitzer Hospital, Barendrecht, Netherlands
3Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
4Department of Hematology, Haga Ziekenhuis, Den Haag, Netherlands
5Albert Schweitzer Hospital, Dordrecht, Netherlands
6Rigshospitalet, Copenhagen University Hospital, Copenhagen, DNK
7Department of Hematology, Antonius Ziekenhuis, Sneek, Netherlands
8Department of Hematology, University Medical Center Utrecht, Amsterdam, Netherlands
9Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
10Department of Hematology, Odense University Hospital, Odense, DNK
11University Hospitals Leuven, Leuven, Belgium
12Isala Ziekenhuis, Zwolle, NLD
13Department of Hematology, Turku University Central Hospital, Turku, Finland
14Department of Hematology, Copenhagen University Hospital, Rigshospitalet, København Ø, Denmark
15Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
16University Medical Center Groningen and University of Groningen, Groningen, Netherlands
17Akershus University Hospital, LøRenskog, NOR
18Department of Hematology, Erasmus Medical Center, Rotterdam, Netherlands
19Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
20HOVON foundation, Rotterdam, Netherlands
21Dept of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands
22Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands

*signifies non-member of ASH