-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

621A.O2.6 621. Lymphomas: Translational – Molecular and Genetic: Molecular Profiling and Targets in Aggressive Lymphomas

Symposia: Lymphomas: Translational - Molecular and Genetic Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Research, Fundamental Science, Clinical trials, Adult, Combination therapy, Apoptosis, Translational Research, Lymphomas, Non-Hodgkin lymphoma, CHIP, Clinical Research, Genomics, B Cell lymphoma, Immune mechanism, Diseases, Indolent lymphoma, Real-world evidence, Immunology, Aggressive lymphoma, Treatment Considerations, Biological therapies, Immunotherapy, Registries, Lymphoid Malignancies, Computational biology, Biological Processes, Monoclonal Antibody Therapy, Molecular biology, Technology and Procedures, Study Population, Human, Pathogenesis, Measurable Residual Disease , Machine learning, Omics technologies
Saturday, December 7, 2024: 2:00 PM-3:30 PM
Pacific Ballroom Salons 15-17 (Marriott Marquis San Diego Marina)
Moderators:
Bertrand Nadel, PhD, Centre D'Immunologie De Marseille-Luminy and Jessica Okosun, MB BChir PhD, Barts Cancer Institute, Queen Mary University of London
Disclosures:
Okosun: Incyte: Consultancy; Genmab: Membership on an entity's Board of Directors or advisory committees, Research Funding; AstraZeneca: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BeiGene: Research Funding.

This session will present novel data pertaining to mechanisms of lymphoma genesis in aggressive B- and T-cell lymphomas and associated vulnerabilities
2:00 PM

Julius C. Enssle, MD1,2*, Björn Häupl, PhD3*, Arber Qoku3*, Boya Wang, PhD4, George W. Wright, PhD5*, Sharon Barrans6*, Matthew Anthony Care, PhD, MSc, BSc7*, Cathy Burton6*, Caitlin Gribbin, MD, MS8, Sebastian Scheich, MD1*, Sebastian Wolf1*, James D. Phelan, PhD4*, Da Wei Huang, MD4*, Andrea diFonzo1*, Martine Pape1*, Marion Bodach3*, Dominique Jahn3*, Uwe Plessmann9*, Daniel J Hodson, MD-PhD10, Bernhard Kuster11*, Roland Schmitz, PhD12*, Henning Urlaub9*, Reuben Tooze, MBBS, PhD, FRCPath13*, Giorgio Inghirami, MD14*, Florian Buettner, PhD3*, Louis M. Staudt, MD, PhD2 and Thomas Oellerich, MD15*

1Goethe-University Frankfurt, University Hospital, Department of Medicine II - Hematology and Oncology, Frankfurt, Germany
2Lymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
3German Cancer Consortium (DKTK), partner site Frankfurt, a partnership between German Cancer Research Center (DKFZ) and University Hospital Frankfurt, Frankfurt, Germany
4Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
5Biometric Research Program, National Cancer Institute, National Institutes of Health, Bethesda, MD
6Haematological Malignancy Diagnostic Service, St. James’ University Hospital, Leeds, United Kingdom
7Section of Experimental Haematology, University of Leeds, Leeds, United Kingdom
8Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
9Bioanalytical Mass Spectrometry Group, Max Planck Institute of Biochemistry, Göttingen, Germany
10Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
11Proteomics and Bioanalytics, School of Life Sciences, Technical University of Munich, Freising, Germany
12Department of Pathology, Justus Liebig University Giessen, Giessen, Germany
13Division of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom
14Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
15Goethe-University Frankfurt, University Hospital, Department of Medicine II - Hematology and Oncology, Frankfurt am Main, Germany

2:15 PM

Jens Löber1*, Nazli Serin2*, Salaheddine Ali2*, Petra Vockova3*, Marek Werth4*, Julia Richter5*, Marieluise Kirchner6*, Shashwat Sahay7*, Hanibal Bohnenberger8*, Kristyna Kupcova9*, Rebecca Wurm-Kuczera, MD2*, Claudia Chapuy10*, Kirsty Wienand10*, Kamil Bojarczuk10*, Viviane Grewe2*, Jenniffer Günther10*, Naveed Ishaque7*, Philipp Ströbel8*, Philipp Mertins, PhD6*, Ondrej Havranek, MD, PhD9, Wolfram Klapper, MD, Prof11*, Ulrich Keller2*, Tomas Etrych12*, Pavel Klener13* and Björn Chapuy2

1Charité, Berlin, Germany
2Hematology, Oncology and Cancer Immunology, Charité - University Medical Center Berlin, Campus Benjamin Franklin, Berlin, Germany
3Hematology, First Department of Medicine, University General Hospital and First Faculty of Medicine, Charles University Prague, Prague, Czech Republic
4University Hospital Frankfurt, Goethe University, Frankfurt Main, Germany
5Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
6Core Unit Proteomics, Berlin Institute of Health at Charité, Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
7Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Digital Health Center, Berlin, Germany
8Institute of Pathology, University Medical Center Göttingen (UMG), Göttingen, Germany
9BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic
10Hematology and Medical Oncology, University Medical Center Göttingen (UMG), Göttingen, Germany
11Department of Pathology, Hematopathology Section, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
12Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
131st Department of Medicine – Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

2:30 PM

Jasper Chun Hei Wong1*, Fabian Frontzek, MD1*, Andrew Lytle, MD, PhD1, Brett Collinge1, Laura Hilton, PhD1, Susana Ben-Neriah1*, Graham W. Slack, MD1*, Pedro Farinha1, Alina S. Gerrie, MD, MPH1, Yang Li2*, Corinna Kosnopfel, PhD2*, James R. Cook, MD, PhD3, Itziar Salaverria4*, Elías Campo5, German Ott, MD6*, Andreas Rosenwald, MD7*, Catalina Amador, MD8*, Elaine S Jaffe, MD9, Timothy C. Greiner, MS, MD10*, Phillipp W. Raess, MD, PhD11*, Joo Y. Song, MD12, Giorgio Inghirami, MD13*, Dennis D. Weisenburger, MD14, Wing Chung Chan, MD12, Harald Holte, MD, PhD15, Klaus Beiske, MD, PhD16*, Kai Fu, MD, PhD17, Jan Delabie, MD, PhD18*, Stefania Pittaluga, MD, PhD9*, Andrew L. Feldman, MD19, Kerry J. Savage, MD, MSc1, Andrew J. Mungall, BSc, PhD20*, Christian Steidl, MD, PhD1, Georg Lenz2, Lisa M. Rimsza, MD21, Ryan Morin, PhD22 and David W. Scott, MBChB, PhD1

1Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
2Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
3Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
4Institut D'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, ESP
5Hematopathology Section, Pathology Department, Hospital Clínic de Barcelona, Barcelona, Spain
6Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
7Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany
8Division of Hematopathology, University of Miami, Miami, FL
9National Cancer Institute, National Institute of Health, Bethesda, MD
10Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
11Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, OR
12Department of Pathology, City of Hope National Medical Center, Duarte, CA
13Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
14University of Nebraska Medical Center, Elkhorn, NE
15Department of Oncology, Oslo University Hospital, Oslo, NOR
16Oslo University Hospital, Oslo, Norway
17Department of Pathology & Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
18Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
19Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
20Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, Canada
21Department of Pathology and Laboratory Medicine, The University of Arizona, Tucson, AZ
22Simon Fraser University, Burnaby, BC, Canada

2:45 PM

Bachisio Ziccheddu1*, Michael D. Jain, MD, PhD2, Monika Chojnacka, B.S.3, Michael Durante, MD, PhD1*, Venu Venkatarame Gowda Saralamma, PhD4*, Austin Daniel Newsam, BS5*, Jerald Noble, PhD6*, Nicholas B Figura, MD7*, Meghan Menges8*, Ola Landgren9, Marco Davila, MD, PhD10, Jonathan H. Schatz, MD11, Francesco Maura, MD12 and Frederick L. Locke, MD13

1Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
2Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
3Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
43. Medical Scientist Training Program, University of Miami Miller School of Medicine, Miami
5University of Miami Miller School of Medicine Sheila and David Fuente Graduate Program in Cancer Biology, Miami, FL
6Moffitt Cancer Center, Dunnellon, FL
7Department of Radiation Oncology, Moffitt Cancer Center, Tamps, FL
8Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
9Sylvester Comprehensive Cancer Center, Miami, FL
10Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
11University of Miami, Miami, FL
12University of Miami, Coral Gables, FL
13Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL

3:00 PM

Chenguang Wang, PhD1, Suhaib Abdelrahman1*, Xiangrong Geng1*, Nermin Kady1*, Ira Maine1* and Ryan A. Wilcox, MD, PhD2

1Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
2Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI

3:15 PM

Amira Marouf, MD, PhD1, Sneha Mitra, PhD2*, Irem Isgor, MD3*, Ashlee Joseph, BS4*, Jahan Rahman5*, Ya-Hui Lin, MS6*, Meril Takizawa7*, Ronan Chaligne, PhD8*, Shenon Sethi, MBBS9*, Ahmet Dogan, MD, PhD10, Sandrine Roulland, PharmD, PhD11*, Gilles Salles, MD, PhD12, Christina Leslie, PhD13*, Anita Kumar, MD14 and Santosha A. Vardhana, MD, PhD4

1Human Oncology and Pathogenesis Program, Department of Medicine, Lymphome Service, Memorial Sloan Kettering Cancer Center, New York, NY
2Computational and Systems Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York
3Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York
4Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
5Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, NY
6Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY
7Single-cell Analytics Innovation Lab, MSKCC, NEW YORK, NY
8Single Cell Analytics and Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, NY
9Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
10Memorial Sloan Kettering Cancer Center, New York, NY
11Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France
12Lymphoma Service Chief, Memorial Sloan Kettering Cancer Center, New York, NY
13Computational and Systems Biology,Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York
14Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Short Hills, NJ

*signifies non-member of ASH