Sun Loo, MBBS^1,2, Harry Iland, MBBS, FRACP, FRCPA³, Ing Soo Tiong, FRACP, FRCPA, MPhil^4,5,6, David Westerman, MBBS, FRCPA, FRACP^4,5, Jad Othman, FRACP, FRCPA, MBBS⁷, Paula Marlton^8*, Chong Chyn Chua, MBBS, FRACP, FRCPA^2,9, Duncan Purtill, MBBS, FRACP, FRCPA^10*, Hannah Rose^11*, Shaun Fleming, MBBS, FRACP, FRACPA^12*, Deepak Singhal, MBBS, MD, FRACP, FRCPA^13*, Anoop K Enjeti, MBBS, FRCPA, MD, MRCP^14,15, William S. Stevenson, MBBS, PhD⁷, Teng Fong Ng, BSc, MBBS, MRCP, FRACP, FRCPA^16,17*, McCulloch Derek^3*, Lachlin Vaughan, MBBS, PhD^18*, Robin Gasiorowski, MA, FRACP, FRCPA, MBBS¹⁹, Adam Ivey, PhD^20*, Amanda Souza^21*, Revati Pattani, PhD^21*, Natasha S. Anstee, PhD^2,22*, Rachel Koldej, PhD^23,24, David S. Ritchie, MBChB PhD^23,24,25, Sanam Loghavi, MD²⁶, Naval Daver, MD²⁷, Courtney D. DiNardo, MD, MSc²⁷, Andrew W. Roberts, MBBS, PhD^1,22,28, Carolyn S. Grove, MBBS, FRACP, FRCPA, PhD^29,30, John Reynolds, BSc, MSc, PhD^31* and Andrew H Wei, MBBS, PhD, FRACP, FRCPA^2,22,25

¹Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia
²The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia
³Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia
⁴Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia
⁵Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
⁶The Royal Melbourne Hospital, Melbourne, Australia
⁷Royal North Shore Hospital, Redfern, NSW, Australia
⁸Princess Alexandra Hospital and University of Queensland, Brisbane, QLD, Australia
⁹Monash Hospital and Monash University, Rosanna, VIC, Australia
¹⁰Haematology Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia
¹¹Department of Haematology, University Hospital Geelong, Geelong, Australia
¹²Department of Malignant Haematology & Stem Cell Transplantation, The Alfred Hospital, Melbourne, VIC, Australia
¹³Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
¹⁴Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia
¹⁵School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia
¹⁶Gold Coast University Hospital, Queensland, Australia
¹⁷Griffith University, QLD, Australia
¹⁸Westmead Hospital, Sydney, Australia
¹⁹Concord Hospital, University of Sydney, Concord, NSW, Australia
²⁰Human Molecular Pathology, The Alfred Hospital, Melbourne, Australia
²¹Australasian Leukaemia and Lymphoma Group, Melbourne, Australia
²²Department of Medical Biology, The University of Melbourne, Melbourne, Australia
²³Department of Medicine, The University of Melbourne, Melbourne, VIC, Australia
²⁴ACRF Translational Research Laboratory, The Royal Melbourne Hospital, Parkville, VIC, Australia
²⁵Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia
²⁶Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
²⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²⁸The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
²⁹Sir Charles Gairdner Hospital, Nedlands, Australia
³⁰School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
³¹Department of Malignant Haematology, Transplantation and Cellular Therapy Services, Alfred Health, Melbourne, Australia

Meagan Jacoby, MD¹, David H Spencer, MD, PhD², Geoffrey L. Uy, MD³, Feng Gao^4*, Tasha Burton^5*, Sharon E Heath^5*, Feiyu Du^6*, Shelly O'Laughlin^6*, Robert Fulton^7*, Zeina A. Al-Mansour, MD⁸, Christopher R. Cogle, MD^9*, Eric J Huselton, MD^10*, John F. DiPersio, MD, PhD¹¹, Peter Westervelt, MD¹¹, Mark A. Schroeder, MD¹², Armin Ghobadi, MD¹², Iskra Pusic, MD¹¹, Keith Stockerl-Goldstein, MD¹², Brad S. Kahl, MD¹³, Amanda F. Cashen, MD¹⁴, Matt Christopher, MD¹⁵, Nathan Singh, MD¹⁴, Ravi Vij, MD, MBA¹⁴, Zachary D. Crees, MD¹¹, Ryan B. Day, MD, PhD¹⁶, Todd A Fehniger¹⁷, Karolyn Oetjen, MD⁶, Dilan A. Patel, MD^18*, Miriam Y Kim, MD¹⁴, Michael Slade, MD, MS¹¹, Daniel C. Link, MD³, Matthew J. Walter, MD¹⁹, Camille N. Abboud, MD¹⁴, Ramzi Abboud²⁰ and Timothy J Ley, MD²¹

¹Washington University-School of Medicine, St. Louis, MO
²Division of Oncology, Department of Medicine, Washington University School of Medicine in St. Louis, St Louis, MO
³Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO
⁴Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, Saint Louis, MO
⁵Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO
⁶Washington University School of Medicine, St. Louis
⁷McDonnell Genome Institute, St Louis, MO
⁸Department of Medicine/Division of Hematology Oncology, University of Florida, Gainesville, FL
⁹University of Florida, Gainesville, FL
¹⁰James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY
¹¹Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹²Division of Oncology, Washington University School of Medicine, St. Louis, MO
¹³Department of Medicine, Washington University School of Medicine, St. Louis, MO
¹⁴Washington University School of Medicine, Saint Louis, MO
¹⁵Washington University School of Medicine, St. Louis,, MO
¹⁶Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University in St. Louis School of Medicine, Saint Louis, MO
¹⁷Department of Medicine, Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹⁸Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO
¹⁹Washington University In St. Louis, Saint Louis, MO
²⁰Washington University School of Medicine, St. Louis, MO
²¹Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Carlos Jimenez-Vicente^1,2*, Aina Cardus^3*, Guillermo Ramil López, MD^4,5*, Guadalupe Onate, MD, PhD^6*, Iago Arribas, MD^7*, Sara Garcia-Avila, MD^8*, Lucia Gomez-Perez, MD^9*, Daniel Esteban, MD^10*, Antonella Sturla^11*, Francesca Guijarro, MD^12,13*, Mònica López-Guerra^14,15*, Sandra Castaño-Díez, MD^14,16*, Alexandra Martínez-Roca^12,17*, Albert Cortés-Bullich, MD^12,18*, Amanda Isabel Perez, MD^19*, Ines Zugasti^17*, Inés Monge-Escartin^20*, Jorge Sierra, MD²¹, Susana Vives, MD^22,23*, Helena Pomares^24*, Montserrat Arnan, MD, PhD^25*, Josep Nomdedeu^26*, Ana Garrido, MD^4*, Marta Pratcorona, MD, PhD^4,5*, Marina Díaz-Beyá, MD, PhD^14,16* and Jordi Esteve, MD, PhD^14,27

¹Department of Hematology, ICAMS, Hospital Clínic de Barcelona, Barcelona, Spain
²Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS),, Barcelona, Spain
³Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
⁴Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⁵IIB-Sant Pau, Sant Pau Biomedical Research Institute, Barcelona, Spain
⁶Hematology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain
⁷Hematology Department. Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona., L'Hospitalet De Llobregat, Barcelona., Spain
⁸Hospital del Mar, Barcelona, Spain
⁹Department of Hematology, Hospital del Mar, Barcelona, Spain
¹⁰Hospital Universitari Germans Trias i Pujol - Institut Català d'Oncologia, Badalona, Spain
¹¹Servei d’Hematologia, Institut Català d’Oncologia, Hospital Duran i Reynals, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet, Spain
¹²Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
¹³Hematopathology Unit, Pathology Department, Hospital Clínic de Barcelona, Barcelona, Spain
¹⁴Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
¹⁵Hematopathology Section, Pathology Department, Hospital Clínic Barcelona, Barcelona, Spain
¹⁶Hematology Department, Hospital Clínic de Barcelona, Barcelona, Spain
¹⁷Hematology Department, Hospital Clinic de Barcelona, ICMHO, Barcelona, Spain
¹⁸Hospital Clínic de Barcelona, Barcelona, Spain
¹⁹Department of Hematology, ICAMS, Hospital Clínic de Barcelona, Barcelona, Spain., Barcelona, Spain
²⁰Pharmacy Department, Hospital Clinic De Barcelona, Barcelona, ESP
²¹Hematology and Hemotherapy Department, Hospital de la Sant Creu i Sant Pau. IIB-Sant Pau and José Carreras Leukemia Research Institutes. Universitat Autónoma de Barcelona, Barcelona, Spain
²²Hematology Department, Institut Catala d'Oncologia - Hospital Germans Trias i Pujol, Badalona, Spain
²³Hospital Germans Trias i Pujol, Badalona, ESP
²⁴Clinical Hematology Department, ICO-Hospitalet, Hospital Durán i Reynals. IDIBELL, Barcelona., Barcelona, Spain
²⁵Hematology Department. Institut Català d’Oncologia, Hospital Duran i Reynals. Institut d’Investigació Biomèdica de Bellvitge (IDIBELL). Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
²⁶Hospital de la Santa Creu i Sant Pau, Barcelona, AL, ESP
²⁷Hematology Department, Hospital Clínic Barcelona, ICAMS, Barcelona, Spain

Adriana Plesa^1*, Stéphanie Mathis, PharmD^2*, Florent Dumezy, PharmD^3*, Anne-Catherine Lhoumeau, PharmD, PhD^4*, Veronique Saada, PharmD^5*, Isabelle Arnoux, PharmD^6*, Jennifer Osman, PharmD^7*, Nicolas Chapuis, MD, PhD^8*, Franck Geneviève, MD^9*, Mikael Roussel, MD, PhD^10*, Delphine Manzoni, PharmD^11*, Anne Roggy, PharmD^12*, Remi Letestu, MD^13*, Veronique Harrivel, MD^14*, Elsa Bera, MD^15*, Jean Feuillard, MD, PhD^16*, Hélène Lapillonne, MD, PhD^17*, Richard Veyrat-Masson, MD^18*, Tatiana Raskovalova, MD^19*, Bouchra Badaoui, PharmD^20*, Valerie Bardet, PharmD, PhD^21*, Caroline Mayeur-Rousse, MD^22*, Francois Vergez, DVM, PhD^23*, Jean Philippe Vial, MD^24*, Valerie Goncalves Monteiro, PharmD^25*, Frédéric Feger, PharmD^26*, Dominique Penther, MD^27*, Isabelle Luquet, MD^28*, Eric Delabesse, MD, PhD^29*, Nicolas Duployez, PharmD, PhD^30*, Karine Celli-Lebras, RN^31*, Mathilde Hunault, MD, PhD^32*, Raphael Itzykson³³, Arnaud Pigneux, MD, PhD^34*, Christian Récher, MD, PhD³⁵, Hervé Dombret, MD, PhD^36,37, Claude Preudhomme, PharmD, PhD^38* and Christophe Roumier, PharmD^39*

¹Laboratory of Hematology and Flow cytometry, Coordinator of the AML French MRDflow LSC Network, Lyon University Hospital, CHU-HCL, Lyon Sud, Pierre Benite, France
²Laboratory of Hematology and Flow cytometry, Saint Louis Hospital, APHP, Paris, France
³Laboratory of Hematology and Flow cytometry, CHU Lille, Lille, France
⁴Laboratory of Hematology and Flow cytometry, Cancer Biology department, Institut Paoli-Calmettes, Marseille, France
⁵Laboratory of Hematology and Flow cytometry, Gustave Roussy Institute, VILLEJUIF, France
⁶Laboratory of Hematology and Flow cytometry, La Timone University Hospital, AP-HM, Marseille, France
⁷Laboratory of Hematology and Flow cytometry, CH Versailles Hospital, Le Chesnay, France
⁸Laboratory of Hematology and Flow cytometry, Cochin Hospital, AP-HP Paris, Paris, France
⁹Laboratory of Hematology and Flow cytometry, CHU Angers, Angers, France
¹⁰Laboratory of Hematology and Flow cytometry, CHU Rennes, Rennes, France
¹¹Laboratory of Hematology and Flow cytometry, CHU Lyon Sud, HCL, Pierre Bénite-Lyon Sud, France
¹²Laboratory of Hematology and Flow cytometry, CHU Besançon, Besançon, France
¹³Laboratory of Hematology and Flow cytometry, CHU Avicenne Hospital, Bobigny, France
¹⁴Laboratory of Hematology and Flow cytometry, CHU Amiens, Amiens, France
¹⁵Laboratory of Hematology and Flow cytometry, CHU Rouen, Rouen, France
¹⁶Laboratory of Hematology and Flow cytometry, CHU Limoges, Limoges, France
¹⁷Laboratory of Hematology and Flow cytometry, Trousseau Hospital, Paris, France
¹⁸Laboratory of Hematology and Flow cytometry, CHU Clermont Ferrand, Clermont Ferrand, France
¹⁹Laboratory of Hematology and Flow cytometry, CHU Grenoble, Grenoble, France
²⁰Laboratory of Hematology and Flow cytometry, Henri Mondor University Hospital, AP-HP, Créteil, France
²¹Laboratory of Hematology and Flow cytometry, Ambroise Pare Hospital, Boulogne, France
²²Laboratory of Hematology and Flow cytometry, CHU Strasbourg, Strasbourg, France
²³Laboratory of Hematology and Flow cytometry, CHU Toulouse, Toulouse, France
²⁴Laboratory of Hematology and Flow cytometry, CHU Bordeaux, Pessac Cedex, France
²⁵Laboratory of Hematology and Flow cytometry, CHU Reims, Reims, France
²⁶Laboratory of Hematology and Flow cytometry, Saint Antoine Hospital, AP-HP, Paris, France
²⁷Department of Genetic Oncology, Henri Becquerel Center, CHU Rouen, Rouen, France
²⁸Laboratory of Hematology, CHU Toulouse, Toulouse, France
²⁹Laboratory of Hematology, IUCT-Oncopole, CHU Toulouse, Toulouse, France
³⁰Laboratory of Hematology-Molecular Biology, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France
³¹ALFA Coordination, Hôpital Saint-Louis, Paris, France
³²Department of Clinical Hematology, CHU Angers, Angers, France
³³Hematology Department, Saint Louis University Hospital, AP-HP, Paris, France
³⁴Department of Clinical Hematology, Haut-Lévèque Hospital, CHU Bordeaux, Pessac, France
³⁵Department of Clinical Hematology, CHU Toulouse, Toulouse, France
³⁶Department of Clinical Hematology, Saint Louis University Hospital, Université Paris Cité-AP-HP, Paris, France
³⁷EA-3518, Saint Louis Research Institute, Université Paris Cité, Paris, France
³⁸Laboratory of Hematology-Molecular Biology, CHU Lille, Lille, France
³⁹Laboratory of Hematology and Flow cytometry, Coordinator of the AML French MRDflow LSC Network, CHU Lille, Lille, France

Loic Vasseur^1,2*, Matthieu Duchmann, MD, PhD^3,4*, Nicolas Duployez, PharmD, PhD^5,6*, Emmanuel Raffoux, MD^7*, Celine Berthon, MD, PhD^6,8*, Mael Heiblig, MD, PhD^9*, Alexis Genthon, MD^10*, Thorsten Braun, MD, PhD¹¹, Mathieu Leclerc, MD, PhD^12*, Delphine Lebon, MD^13*, Sylvain Chantepie, MD^14*, Jean-Baptiste Micol, MD¹⁵, Juliette Lambert, MD, PhD^16*, Christian Recher, MD, PhD^17*, Marie-Lorraine Chrétien, MD^18*, Thomas Cluzeau, MD, PhD¹⁹, Julien Vaidie, MD^20*, Jean-Valère Malfuson, MD^21*, Madalina Uzunov, MD^22*, Arnaud Pigneux, MD, PhD^23*, Pierre Peterlin^24*, Sihem Tarfi, PharmD^25*, Pierre Hirsch, MD, PhD^26*, Dominique Penther, MD^27*, Eric Jourdan, MD, PhD^28*, Karine Celli-Lebras, RN^29*, Claude Preudhomme, PharmD, PhD^5,6*, Hervé Dombret, MD, PhD^7,30, Jérôme Lambert, MD, PhD^2,31*, Nicolas Boissel, MD, PhD^1,30 and Raphael Itzykson^3,7

¹Adolescent and Young Adult Hematology Unit, Saint Louis University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France
²ECSTRRA team, Centre for Research in Epidemiology and Statistics, INSERM U1153, Université Paris Cité, Paris, France
³Unité 944/7212-GenCellDi, Saint-Louis Research Institute, INSERM, CNRS, Université Paris Cité, Paris, France
⁴Hematology Laboratory, Saint Louis University Hospital, AP-HP, Paris, France
⁵Laboratory of Hematology-Molecular Biology, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France
⁶ONCOLILLE - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, Univ. Lille, IRCL, CNRS-UMR9020, Inserm-U1277, Lille, France
⁷Hematology Department, Saint Louis University Hospital, AP-HP, Paris, France
⁸Hematology Department, CHU Lille, Lille, France
⁹Hematology Department, CHU de Lyon, Pierre-Bénite, France
¹⁰Hematology Department, Saint Antoine University Hospital, AP-HP, Paris, France
¹¹Hematology Department, Avicenne University Hospital, AP-HP, Bobigny, France
¹²Hematology Department, Henri Mondor University Hospital, AP-HP, Créteil, France
¹³Hematology Department, CHU Amiens, Amiens, France
¹⁴Basse-Normandie Institute of Hematology, CHU de Caen, Caen, France
¹⁵Hematology Department, Gustave Roussy Institute, Villejuif, France
¹⁶Clinical Hematology Department, Versailles Hospital, Le Chesnay-Rocquencourt, France
¹⁷Hematology Department, Cancer University Institute of Toulouse Oncopole, Toulouse, France
¹⁸Hematology Department, CHU Dijon, Dijon, France
¹⁹Department for Clinical Hematology, Nice University Hospital, Nice, France
²⁰Hematology Department, Dupuytren University Hospital, Limoges, France
²¹Clinical Hematology Department, Percy Army Training Hospital, Clamart, France
²²Clinical Hematology Department, Pitié-Salpétrière University Hospital, AP-HP, Paris, France
²³Department of Clinical Hematology, Haut-Lévèque Hospital, CHU Bordeaux, Pessac, France
²⁴Hematology Department, Hôtel-Dieu University Hospital, NANTES CEDEX 1, France
²⁵Hematology and Immunology Department, Henri Mondor University Hospital, AP-HP, Créteil, France
²⁶Hematology Laboratory, Saint Antoine University Hospital, AP-HP, Paris, France
²⁷Department of Genetic Oncology, Henri Becquerel Center, CHU Rouen, Rouen, France
²⁸Clinical Hematology Departement, CHU de Nimes, Nimes, France
²⁹ALFA Group Coordination, Saint Louis Research Institute, Paris, France
³⁰EA-3518, Saint Louis Research Institute, Université Paris Cité, Paris, France
³¹Biostatistics and Medical Information Department, Saint Louis University Hospital, AP-HP, Paris, France

Evangelia Antoniou, MD^1,2, Lina Marie Hoffmeister^1,2*, Nils Von Neuhoff, PhD^1,2*, Dirk Reinhardt, MD^1,2, Markus Schneider, PhD^1,2* and Stephanie Sendker, MD^2*

¹University Children’s Hospital Essen. Department of Pediatric Hematology and Oncology, Essen, Germany
²AML-BFM Study Group, Essen, Germany