Johanna Maria Horns^1*, Thomas Beder^2,3*, Malwine J Barz, PhD^1,3*, Aeint-Steffen Ströh, MD^1*, Axel Künstner, PhD^4*, Sonja Bendig^2,3*, Guranda Chitadze, MD, PhD^3,5*, Cecilia Bozzetti, MD^1*, Nikos Darzentas, PhD^5*, Katharina Iben^2*, Michaela Kotrova, MD, PhD^5*, Martin Neumann, MD^2,3*, Wiebke Weßels, PhD^1*, Hauke Busch, PhD^4*, Lennart Lenk, PhD^6,7*, Judith S. Hecker, MD^8,9*, Stefan Knop, MD^10*, Boris Böll, MD^11*, Johannes Duell, MD^12*, Walter Fiedler, MD¹³, Christoph Faul, MD¹⁴, Christoph Röllig, MD, MSc^15*, Bernd Spriewald, MD^16*, Björn Steffen, MD^17*, Maher Hanoun, MD, PhD^18*, Nicola Goekbuget, MD¹⁷, Claudia D Baldus, MD^2,3*, Lorenz Bastian^3,19* and Monika Brüggemann, MD^2,3*

¹Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany
²University Medical Center Schleswig-Holstein, University Cancer Center Schleswig-Holstein, Kiel, Germany
³Clinical Research Unit CATCH ALL (KFO 5010/1) funded by the Deutsche Forschungsgemeinschaft, Kiel, Germany
⁴Group for Medical Systems Biology, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany
⁵Department of Internal Medicine II (Hematology/Oncology), University Hospital Schleswig-Holstein, Kiel, Germany
⁶Department of Pediatrics I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁷Department of Pediatrics I, Pediatric Hematology and Oncology, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany, Kiel, Germany
⁸Department of Medicine III, Hematology and Oncology, Technical University of Munich (TUM), School of Medicine and Health, Munich, Germany
⁹TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Munich, Germany
¹⁰Comprehensive Cancer Center Erlangen, Klinikum Nuremberg, Nuremberg, Germany
¹¹Department I of Internal Medicine and German Hodgkin Study Group (GHSG), University Hospital of Cologne; equal contribution, Cologne, Germany
¹²University of Wurzburg, Wurzburg, Germany
¹³Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
¹⁴Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tuebingen, Tübingen, Germany
¹⁵Department of Internal Medicine I, University Hospital Dresden, Dresden, Germany
¹⁶Department of Medicine 5, University Hospital of Erlangen, Erlangen, Germany
¹⁷Department of Medicine, Hematology/Oncology, Goethe University Frankfurt, University Hospital, Frankfurt, Germany
¹⁸Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany
¹⁹Medical Department II, Hematology and Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

Ruifeng Sun^1*, Jaewoong Lee, PhD^1,2*, Dewan Artadji^1*, Mark E Robinson, PhD^1*, Kohei Kume, PhD^1*, Zhangliang Cheng, BSc^1*, Kadriye Nehir Cosgun, PhD^1*, Lai N Chan, PhD¹, Etienne Leveille, MD^1*, Ning Ma, PhD^3*, Huimin Geng, PhD^4*, Elisabeth Paietta, PhD^5*, Nagarajan Vaidehi, PhD^3* and Markus Müschen, MD¹

¹Center of Molecular and Cellular Oncology, Yale University, New Haven, CT
²School of Biosystems and Biomedical Sciences, Korea University, Seoul, Korea, Republic of (South)
³Department of Systems Biology, City of Hope Comprehensive Cancer Center, Duarte, CA
⁴Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁵Department of Oncology, Montefiore Medical Center, Bronx, NY

Danielle Wolfe Cohen, MD¹, Clemence Aldebert, MD^2*, Emily Duan, MD^3*, Sylwia Jasinski, MD^4*, Xiaotu Ma, PhD⁵, Heather L. Mulder^6*, John Easton^7*, Jiyuan Hu, PhD^3*, Laura E. Hogan, MD^8*, David T. Teachey, MD⁹, Elizabeth A. Raetz, MD¹⁰, Nikki Evensen, PhD³ and William L. Carroll, MD¹¹

¹New York University Grossman School of Medicine, New York, NY
²NYU Langone Health, Laura and Isaac Perlmutter Cancer Center, New York, NY
³NYU Langone Health, New York, NY
⁴Department of Pediatrics, NYU Long Island School of Medicine, Mineola, NY
⁵St. Jude Children's Research Hospital, Memphis, TN
⁶St Jude Children's Research Hospital, Memphis, TN
⁷St. Jude Children’s Research Hospital, Memphis, TN
⁸Stony Brook University, Stony Brook, NY
⁹Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA
¹⁰Department of Pediatrics, NYU Langone Health, New York, NY
¹¹Perlmutter Cancer Center, Department of Pediatrics and Pathology, NYU Grossman School of Medicine, New York, NY

Andrew Hughes, MD, PhD¹, Rawan Shraim, PhD^1*, Lahari Uppuluri, PhD^1*, Haley Newman, MD¹, Gongping Shi, PhD^2*, Julie Asare, MD^3*, Theresa Ryan^4*, Elizabeth A. Raetz, MD⁵, James A. Whitlock⁶, Maureen M. O'Brien, MD⁷, Deepa Bhojwani, MD⁸, Rachel E. Rau, MD⁹, Kara L. Davis, DO^10*, Stacy Cooper¹¹, Patrick Brown^12*, Stephen P. Hunger, MD¹³, Mignon L. Loh, MD, PhD⁹, Laura E. Hogan, MD^14*, Stephan A. Grupp, MD, PhD¹⁵, Jun J. Yang, PhD¹⁶, David T. Teachey, MD¹⁷ and Caroline Diorio, MD¹

¹Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Oncology, Children's Hospital of Philadelphia, Philadelphia
³Johns Hopkins, Baltimore, MD
⁴Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, NYU Langone Health, New York, NY
⁶Division of Haematology/Oncology, The Hospital for Sick Children/University of Toronto, Toronto, Canada
⁷Colorado Children's Hospital, Colorado
⁸Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
⁹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA
¹⁰Stanford University, Stanford, CA
¹¹Johns Hopkins University, Baltimore, MD
¹²Bristol Myers Squibb, Princeton, NJ
¹³Division of Oncology, Childrens Hospital of Philadelphia, Philadelphia
¹⁴Stony Brook University, Stony Brook, NY
¹⁵Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁶Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
¹⁷Division of Oncology, Children's Hospital of Philadelphia, Rutledge, PA

Vojen Sadílek, MD, MSc^1*, Barbora Cabalkova^2*, Aneta Skotnicova^2*, Michaela Reiterova^2*, Martina Vaskova^2*, Marketa Zaliova^2*, Ondrej Hrusak^2*, Jan Trka², Tomas Kalina^2*, Eva Fronkova^2*, Ester Mejstrikova^2* and Jan Stuchly^2*

¹CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, AL, Czech Republic
²CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

Anna Dietterle^1*, Julia Heymann^1*, Anna Laqua^2*, Claas Reimer^1*, Denny Takudzwa Mahachi^1*, Carina Lynn Gehlert, PhD^3*, Dorothee Winterberg, PhD^3*, Maja Kowol^4*, Alexander Arthur Wurm^5,6*, Philipp Fanter^1*, Denis Pinkle^1*, Dennis Das Gupta^7*, Christian Vokuhl^8*, Jan Philipp Schmid^9*, Matthias Peipp, PhD^3*, Martin Schrappe, MD¹, Irène Baccelli^10*, Nicolas Poirier^10*, Monika Brüggemann, MD^2*, Gunnar Cario, MD^1*, Denis Martin Schewe^6* and Lennart Lenk, PhD^1*

¹Department of Pediatrics I, ALL-BFM Study Group, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany, Kiel, Germany
²Department of Medicine II, University Hospital Schleswig-Holstein, Kiel, Germany, Kiel, Germany
³Division of Antibody-Based Immunotherapy, Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
⁴Section for Stem Cell Transplantation and Immunotherapy, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany, Kiel, Germany
⁵Mildred Scheel Early Career Center, NCT/UCC Dresden, Dresden, Germany
⁶Department of Pediatric Hematology and Oncology, University Hospital Dresden, Dresden, Germany, Dresden, Germany
⁷Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany, Kiel, Germany
⁸Section of Pediatric Pathology, Department of Pathology, University Hospital Bonn, Bonn, Germany, Bonn, Germany
⁹Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, Feodor-Lynen-Str. 21, Munich, 81377, Germany, Munich, Germany
¹⁰OSE Immunotherapeutics, Nantes, France, Nantes, France