Susan DeWolf, MD¹, Nicholas Ceglia, PhD^2*, Matthew Zatzman, PhD^3*, Brianna Gipson^4*, Yuval Elhanati, PhD^5*, Zoe Katsamakis^6*, Hannah Lees, PhD^3*, Kenyon Weis^7*, Gustavo Yepes^8*, Barbara Oliveira^8*, Ana Figueiredo Longhini^8*, Natalie Grier Smith, BA⁹, Katherine Nichols^4*, Eliyahu Havasov^3*, Karen Zhao^8*, Brigita Meskauskaite^8*, Ignas Masilionis^8*, Alexander M. Lewis^7*, Maria Adriana Cuibus^8*, M. Kazim Pajwani, PhD^8*, Simone A Minnie, PhD¹⁰, Ronan Chaligne, PhD^11*, Andri Leo L Lemarquis, MD, PhD^4*, Aaron D. Goldberg, MD, PhD¹², Katharine C. Hsu, MD, PhD⁴, Eytan M. Stein, MD¹³, Benjamin D. Greenbaum, PhD^3*, Omar Abdel-Wahab, MD¹, Sohrab P. Shah, PhD^2* and Marcel R.M. van den Brink, MD, PhD¹⁴

¹Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
³Computational Oncology, Memorial Sloan Kettering Cancer Center, New York
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Computational Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY
⁶Department of Pediatrics, Immune Discovery and Modeling Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Memorial Sloan Kettering Cancer Center, New York
⁹Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY
¹⁰Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
¹¹Single Cell Analytics and Innovation Lab, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Department of Medicine; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY
¹⁴Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA

Logan K. Wallace, MSc^1*, Jack H. Peplinski, MSc^1*, Rhonda E. Ries, MA^1*, Danielle C. Kirkey, MD¹, Xiaotu Ma, PhD² and Soheil Meshinchi, MD, PhD^1,3

¹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²St. Jude Children's Research Hospital, Memphis, TN
³Department of Pediatrics, University of Washington, Seattle, WA

Yotaro Ochi, MD, PhD^1,2*, Markus Liew-Littorin^3*, Yasuhito Nannya^1,4*, Sofia Bengtzén^5*, Petar Antunovic^6*, Stefan Deneberg, MD^5*, Martin Jadersten, MD, PhD^5*, Vladimir Lazarevic^7,8*, Bertil Uggla^3*, Lovisa Wennström, MD, PhD^9*, Emma Olander^10*, Senji Kasahara^11*, Nobuhiro Hiramoto^12*, Nobuhiro Kanemura, MD, PhD¹³, Nobuo Sezaki^14*, Maki Sakurada^15*, Makoto Iwasaki, MD, PhD¹⁵, Junya Kanda, MD, PhD^15*, Yasunori Ueda^16*, Satoshi Yoshihara, MD, PhD¹⁷, Tom Erkers, PhD^18*, Nona Struyf^18*, Masanori Motomura, MD^1*, Masahiro M Nakagawa, MD, PhD¹, Ryunosuke Saiki, MD, PhD^1*, Hidehito Fukushima, MD^4*, Koji Okazaki, MD^1*, Akinori Yoda, PhD^1*, Rurika Okuda, MSc, BS^1*, Guoxiang Xie^19*, Albin Osterroos, MD^19*, Lanying Zhao, MD, PhD^1*, Yuichi Shiraishi, PhD^20*, Takayuki Ishikawa, MD, PhD¹², Satoru Miyano, PhD^21,22*, Hiroshi I Suzuki^23,24,25,26*, Akifumi Takaori-Kondo, MD, PhD¹⁵, Olli Kallioniemi^18*, Gunnar Juliusson, MD, PhD^7,8, Martin Höglund, MD, PhD¹⁹, Soren Lehmann, MD, PhD^5,19* and Seishi Ogawa, MD, PhD^1,2,27

¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan
³Division of Hematology, Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
⁴Division of Hematopoietic Disease Control, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⁵Center for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden
⁶Department of Hematology, Linköping University Hospital, Linköping, Sweden
⁷Department of Hematology, Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden
⁸Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden
⁹Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden
¹⁰Department of Hematology, Sundsvall Hospital, Sundsvall, Sweden
¹¹Department of Hematology, Gifu Municipal Hospital, Gifu, Japan
¹²Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
¹³Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan
¹⁴Department of Hematology, Chugoku Central Hospital, Hiroshima, Japan
¹⁵Department of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁶Department of Hematology/Oncology, Kurashiki Central Hospital, Kurashiki, Japan
¹⁷Department of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya, Japan
¹⁸Science for Life Laboratory and Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
¹⁹Department of Medical Sciences, Hematology, Uppsala University, Uppsala, Sweden
²⁰Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan
²¹Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
²²Department of Integrated Analytics, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
²³Division of Molecular Oncology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
²⁴Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan
²⁵Center for One Medicine Innovative Translational Research (COMIT), Nagoya University, Nagoya, Japan
²⁶Inamori Research Institute for Science (InaRIS), Kyoto, Japan
²⁷Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden

Maddalena Benetton^1*, Ambra Da Ros^1*, Alberto Peloso^1*, Giorgia Longo^1*, Katia Polato^1*, Sara Perpinello^1*, Silvia Bresolin^2*, Claudia Tregnago^1*, Benjamin J Huang, MD³, Soheil Meshinchi, MD, PhD⁴, Franco Locatelli, MD⁵ and Martina Pigazzi, PhD^1,2*

¹Department of Women's and Children's Health, Onco-hematology lab and clinic, University of Padova, Padova, Italy
²Foundation Istituto Ricerca Pediatrica (IRP), Padova, Italy
³Department of Pediatrics, University of California, San Francisco, San Francisco, CA
⁴Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
⁵Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Catholic University of the Sacred Heart, Rome, Italy

Lorenz Oelschläger¹, Deedra Nicolet, MS^2*, Krzysztof Mrózek, MD, PhD², Daniel Schnell^3*, Najla Alotaibi^4*, Christopher J. Walker, PhD⁴, Alice Mims, MD⁴, James S. Blachly, MD⁴, Bayard L Powell, MD⁵, Jonathan E Kolitz, MD⁶, Eunice S. Wang, MD⁷, Andrew J. Carroll, PhD⁸, Lynn van Rosmalen^9,10*, Bettina Nadorp, PhD^11,12*, Nathan Salomonis, PhD³, H. Leighton Grimes, PhD¹, Maarten Fornerod, PhD^9,13* and Ann-Kathrin Eisfeld, MD²

¹Division of Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH
²The Ohio State University Comprehensive Cancer Center, Columbus, OH
³Division of Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
⁴Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁵Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC
⁶Zucker School of Medicine at Hofstra/Northwell, Zuckerberg Cancer Center, Lake Success, NY
⁷Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁸Department of Genetics, University of Alabama at Birmingham, Birmingham, AL
⁹Department of Cell Biology, Erasmus Medical Center, Rotterdam, Netherlands
¹⁰Department of Pediatric Oncology Hematology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, Netherlands
¹¹NYU Grossman School of Medicine, Division of Precision Medicine, Department of Medicine, New York, NY
¹²NYU Grossman School of Medicine, Department of Pathology, New York, NY
¹³Department of Pediatric Oncology Hematology,, Erasmus Medical Center- Sophia Childrens Hospital, Rotterdam, ZH, NLD

Sven Turkalj^1*, Bilyana Stoilova, PhD^2*, Angus J Groom, MSc^2*, Felix A Radtke, MD², Rabea Mecklenbrauck, MD^2*, Niels Asger Jakobsen, MD, PhD^2*, Curtis A Lachowiez, MD³, Marlen Metzner, MSc^2*, Batchimeg Usukhbayar, PhD^2*, Mirian Angulo Salazar, MSc^2*, Zhihong Zeng, MD⁴, Sanam Loghavi, MD⁵, Jennifer Marvin-Peek, MD⁴, Verena Körber, PhD^2*, Farhad Ravandi, MBBS⁶, Ghayas C. Issa, MD⁴, Tapan M. Kadia, MD⁴, Vasiliki Symeonidou, PhD^2*, Anne De Groot, MSc^2*, Hagop M. Kantarjian, MD⁴, Koichi Takahashi, MD, PhD⁴, Marina Konopleva⁷, Courtney D. DiNardo, MD, MSc⁴ and Paresh Vyas, FMedSci, DPhil, FRCPath^2*

¹MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, ENG, United Kingdom
²MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Medicine, University of Oxford, Oxford, United Kingdom
³Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁷Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY