Xueer Wang, PhD¹, Honghai Zhang^2*, Lei Dong^3*, Xiaoxu Zhang^2*, Meilin Xue^4*, Lili Ren^2*, Hongjie Bi^2*, Lucy Y. Ghoda^5*, Mark Wunderlich, MS^6*, James C. Mulloy, PhD^7*, Chun-Wei David Chen, PhD⁸, Ling Li, PhD⁹, Lin Xu^3*, Bin Zhang⁵, Guido Marcucci¹⁰, Steven T. Rosen, MD¹¹, Nora Heisterkamp^12*, Marcin Kortylewski, PhD^13*, Jianjun Chen, PhD¹⁴ and Rui Su, PhD^15*

¹City of Hope National Medical Center, Duarte, CA
²City of hope national medical center, Monrovia, CA
³UT Southwestern Medical Center, Dallas, TX
⁴Ruijin Hospital, Shanghai, China
⁵Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope Medical Center and Beckman Research Institute, Duarte, CA
⁶Division of Experimental Hematology and Cancer Biology, Cancer & Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁷Cincinnati Children's Hospital, Cincinnati, OH
⁸Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, CA
⁹Department of Hematological Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁰City of Hope, Duarte, CA
¹¹Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute, City of Hope, Duarte, CA
¹²City of Hope Comprehensive Cancer Center, Monrovia, CA
¹³Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
¹⁴Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA
¹⁵City of hope, Monrovia, CA

Stefan Bjelosevic, PhD^1,2,3, Rahel Fauth^1,2,3*, Brian T Do^4,5,6*, Gabriela Alexe, PhD^1,3*, Birgitta Ryback, PhD^7*, Allen T Basanthakumar^1*, Lucy A Merickel^1*, Silvi Salhotra^1*, Audrey Taillon^1*, Thomas D Jackson, PhD^7,8*, Giulia DiGiovanni^1,3*, Muhammad Bin Munim^4,6*, Ryan Elbashir^4,6*, Shan Lin, PhD^1,3*, Pere Puigserver, PhD^7,8*, David E. Root, PhD^3*, Matthew G Vander Heiden, MD, PhD^4,6,9* and Kimberly Stegmaier, MD^1,2,3,10

¹Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
²Harvard Medical School, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA
⁵Harvard-MIT Health Sciences and Technology, Cambridge, MA
⁶Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
⁷Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
⁸Department of Cell Biology, Harvard Medical School, Boston, MA
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹⁰Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA

Isaac Wakiro, BSc^1*, Yue Huang^2*, Xuejing Yang, PhD^1*, Xueqin Xie, PhD^3*, Hanzhi Luo, PhD¹, Kathryn Chang^1*, Aspen Pierson^1*, Emily Batchelor^1*, Yuanming Cheng, PhD^4*, Diu T.T. Nguyen, PhD⁵, Zhaoqi Liu, PhD^2* and Michael G. Kharas, PhD¹

¹Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York City, NY
²Beijing Institute of Genomics, University of Chinese Academy of Sciences, Beijing, China
³Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Institute of Modern Biology, Nanjing University, Nanjing, China
⁵Center for Hemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Hassan Bjeije^1*, Wentao Han², Hamza Celik, PhD^3*, Yanan Li, PhD^4*, Michael P. Rettig, PhD¹, Andrew L Young, MD, PhD⁵, Saranajith Dunuwille, PhD^1*, Nancy Issa, MD^1*, Wei Yang, PhD^6*, Jeffrey A. Magee, MD, PhD^7,8 and Grant A Challen, PhD¹

¹Division of Oncology, Washington University School of Medicine, St. Louis, MO
²Division of Oncology, Washington University School of Medicine, Saint Louis, MO
³Incyte Corporation, Wilmington, DE
⁴Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO
⁵Division of Hematology, Washington University School of Medicine in St. Louis, St. Louis, MO
⁶Department of Genetics, Washington University School of Medicine, Saint Louis, MO
⁷Department of Genetics, Washington University School of Medicine, St. Louis, MO
⁸Department of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine, Saint Louis, MO

J. Philip Creamer IV, PhD¹, Suhita Ray, PhD^1,2*, Sintra Stewart^2*, Jacob S. Appelbaum, MD, PhD^3,4, Min Fang, MD, PhD^5,6, Elizabeth Swisher, MD^7,8* and Sergei Doulatov, PhD^1,2,9

¹Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA
²Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA
³Division of Hematology and Oncology, University of Washington School of Medicine, Seattle, WA
⁴Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁵University of Washington, Seattle, WA
⁶Fred Hutchinson Cancer Center, Seattle, WA
⁷Division of Gynecologic Oncology, University of Washington School of Medicine, Seattle, WA
⁸Clinical Research Division, Fred Hutch Cancer Center, Seattle, WA
⁹Department of Genome Sciences, University of Washington, Seattle, WA

Jihye Yoon¹, Elisabeth Denby^1*, Wei Yang, PhD^2*, Emily B. Casey^1*, Riddhi M. Patel^1*, Yanan Li, PhD^1*, J. Michael White^3*, Luis Batista, PhD⁴ and Jeffrey A. Magee, MD, PhD^1,5

¹Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO
²Department of Genetics, Washington University School of Medicine, Saint Louis, MO
³Department of Pathology and Immunobiology, Washington University School of Medicine, St. Louis, MO
⁴Department of Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, MO
⁵Department of Genetics, Washington University School of Medicine, St. Louis, MO