Caroline A. Coughlin, BS¹, Dhanvantri Chahar, PhD^2*, Marianna Lekakis^2*, Hsuan-Ting Huang, PhD², Abdessamad Youssfi Alaoui, PhD^3*, Lingxiao Li^4*, Evan Roberts^5*, Natalia Campos Gallego^6*, Claude-Henry Volmar^2*, Ola Landgren^5,7, Shaun Brothers^2*, Anthony Griswold^2*, Catalina Amador, MD^8*, Daniel Bilbao, PhD^9,10, Francesco Maura, MD^11,12 and Jonathan H. Schatz, MD^13,14,15

¹University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
²University of Miami Miller School of Medicine, Miami, FL
³Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
⁴GenScript ProBio, Nanjing, China
⁵Sylvester Comprehensive Cancer Center, Miami, FL
⁶University of Miami, miami, FL
⁷Sylvester Comprehensive Cancer Center, Myeloma Division, University of Miami, Miami, FL
⁸Division of Hematopathology, University of Miami, Miami, FL
⁹Cancer Modeling Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
¹⁰Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL
¹¹University of Miami, Coral Gables, FL
¹²University of Miami, Palmetto Bay, FL
¹³Department of Hematology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL
¹⁴University of Miami, Miami, FL
¹⁵Sylvester Comprehensive Cancer Center, University of Miami Miller School Medicine, Miami, FL

Carolin S. Escherich, MD^1*, Zhenhua Li, PhD², Kelly R. Barnett, PhD^3*, Yizhen Li, PhD^3*, Megan Walker, PhD^3*, Wenjian Yang, PhD^2*, Xin Huang, PhD^3*, Jiyang Yu, PhD^3*, Wendy Stock, MD⁴, Elisabeth Paietta, PhD^5*, Marina Konopleva, MD⁶, Steven M. Kornblau, MD⁷, Mark R. Litzow, MD⁸, Hiroto Inaba, MD, PhD³, Ching-Hon Pui, MD³, Mignon L. Loh, MD⁹, Daniel Savic, PhD³ and Jun J. Yang, PhD³

¹St. Jude Children’S Research Hospital, Memphis, TN
²Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
³St. Jude Children's Research Hospital, Memphis, TN
⁴University of Chicago, Chicago, IL
⁵Department of Oncology, Montefiore Medical Center, Bronx, NY
⁶Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Division of Hematology, Mayo Clinic, Rochester, MN
⁹Ben Towne Center for Childhood Cancer Research, Seattle Children’s Hospital, Fred Hutch Cancer Center, University of Washington, Seattle, WA

Maurizio Di Liberto, PhD^1*, Yang Hu, PhD^1*, Xiangao Huang, PhD^1*, Giorgio Inghirami, MD^1*, Kevin Wang, MD^1*, Christina Y. Lee, MD¹, Kami J. Maddocks, MD², Kristie A. Blum, MD³, Jia Ruan, MD, PhD⁴, John P. Leonard, MD¹, Nancy L. Bartlett, MD⁵, Peter Martin, MD⁴, Olivier Elemento, PhD, MS, BS⁶ and Selina Chen-Kiang, PhD⁷

¹Weill Cornell Medicine, New York, NY
²The James Cancer Center, The Ohio State University, Columbus, OH
³Winship Cancer Institute of Emory University, Atlanta, GA
⁴Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY
⁵Siteman Cancer Center, Washington University Sch. of Med. Siteman Cancer Center, Saint Louis, MO
⁶Englander Institute for Precision Medicine/ Weill Cornell Medicine, Weill Cornell Medicine, New York, NY
⁷Weill-Cornell Medical College, New York, NY

Yuting Yan, MD^1*, Dandan Shan^2*, Ying Yu^3*, Weihao Chen^4*, Xinyi Zhang^2*, Xiong Wenjie, MD^1*, Tingyu Wang^1*, Mu Hao, MD^5*, Gang An^5*, Lu-Gui Qiu⁵, Zhen Yu^6* and Shuhua Yi^7*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical Colleg, Tianjin, China
⁴State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjjn, China
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, CHN
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Tianjin, China

Yu Zhang^1*, Cong Wang^2*, Tiange Lu^1*, Ran Kong^3*, Liemei Lv^3*, Mei Ding^1* and Xiangxiang Zhou, MD¹

¹Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
²Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, AL, China
³Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, China

Shirong Liu, MD, PhD¹, John M Hatcher, PhD^1*, Amanda Kofides, BA^1*, Alexa G Canning, BA^1*, Dominic Pizzarella^1*, Jinhua Wang, PhD^2*, Xia Liu, MD^1*, Nickolas Tsakmaklis^1*, Maria Luisa Guerrera, MD¹, Christopher J Patterson, MPH, MBA^1*, Zachary R Hunter, PhD¹, Shayna R Sarosiek¹, Jorge J. Castillo, MD¹, Sara J. Buhrlage, PhD^2* and Steven P. Treon, MD, PhD, FRCP¹

¹Dana-Farber Cancer Institute, Bing Center for Waldenström Macroglobulinemia, Boston, MA
²Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA